Diffusion Weighted Magnetic Resonance Imaging of Spinal Cord Injuries After Instrumented Fusion Stabilization
Journal of Neurotrauma, Ahead of Print. (Source: Journal of Neurotrauma)
Source: Journal of Neurotrauma - April 10, 2024 Category: Neurology Authors: Kevin M. Koch Andrew S. Nencka Shekar Kurpad Matthew D. Budde Source Type: research
Retraction Note to: PPAR- α Modulates the Anti-Inflammatory Effect of Melatonin in the Secondary Events of Spinal Cord Injury
(Source: Molecular Neurobiology)
Source: Molecular Neurobiology - April 10, 2024 Category: Neurology Source Type: research
Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells
Cell Transplant. 2024 Jan-Dec;33:9636897241241998. doi: 10.1177/09636897241241998.ABSTRACTSpinal cord injury (SCI) is associated with currently irreversible consequences in several functional components of the central nervous system. Despite the severity of injury, there remains no approved treatment to restore function. However, with a growing number of preclinical studies and clinical trials, cell transplantation has gained significant potential as a treatment for SCI. Researchers have identified several cell types as potential candidates for transplantation. To optimize successful functional outcomes after transplantati...
Source: Cell Transplantation - April 9, 2024 Category: Cytology Authors: Alex Roman Anne Huntemer-Silveira Madison A Waldron Zainab Khalid Jeffrey Blake Ann M Parr Walter C Low Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats
J Physiol. 2024 Apr 9. doi: 10.1113/JP286151. Online ahead of print.ABSTRACTWhen the foot dorsum contacts an obstacle during locomotion, cutaneous afferents signal central circuits to coordinate muscle activity in the four limbs. Spinal cord injury disrupts these interactions, impairing balance and interlimb coordination. We evoked cutaneous reflexes by electrically stimulating left and right superficial peroneal nerves before and after two thoracic lateral hemisections placed on opposite sides of the cord at 9- to 13-week interval in seven adult cats (4 males and 3 females). We recorded reflex responses in ten hindlimb an...
Source: The Journal of Physiology - April 9, 2024 Category: Physiology Authors: Stephen Mari Charly G Lecomte Ang èle N Merlet Johannie Audet Sirine Yassine Oussama Eddaoui Gabriel Genois Charl ène Nadeau Jonathan Harnie Ilya A Rybak Boris I Prilutsky Alain Frigon Source Type: research
Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells
Cell Transplant. 2024 Jan-Dec;33:9636897241241998. doi: 10.1177/09636897241241998.ABSTRACTSpinal cord injury (SCI) is associated with currently irreversible consequences in several functional components of the central nervous system. Despite the severity of injury, there remains no approved treatment to restore function. However, with a growing number of preclinical studies and clinical trials, cell transplantation has gained significant potential as a treatment for SCI. Researchers have identified several cell types as potential candidates for transplantation. To optimize successful functional outcomes after transplantati...
Source: Cell Transplantation - April 9, 2024 Category: Cytology Authors: Alex Roman Anne Huntemer-Silveira Madison A Waldron Zainab Khalid Jeffrey Blake Ann M Parr Walter C Low Source Type: research
Immunotherapy of M2 macrophage derived from exosome-based nanoparticles for spinal cord injury
Int Immunopharmacol. 2024 Apr 8;132:111983. doi: 10.1016/j.intimp.2024.111983. Online ahead of print.ABSTRACTDeveloping biomimetic nanoparticles without off-target side-effects remains a major challenge in spinal cord injury (SCI) immunotherapy. In this paper, we have conducted a drug carrier which is biocompatible macrophages-exocytosed exosome-biomimetic manganese (Mn)-iron prussian blue analogues (MPBs) for SCI immunotherapy. Exosome-sheathed MPBs (E-MPBs) exhibit promoted microglia accumulation, alleviation from H2O2-induced microenvironment and inhibition of apoptosis and inflammation in vitro. In addition, E-MPBs pos...
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Lu Bai Jinpeng Gao Peng Zhang Sen Lin Chuanjie Zhang Source Type: research
Understanding exosomes: Part 2-Emerging leaders in regenerative medicine
Periodontol 2000. 2024 Apr 9. doi: 10.1111/prd.12561. Online ahead of print.ABSTRACTExosomes are the smallest subset of extracellular signaling vesicles secreted by most cells with the ability to communicate with other tissues and cell types over long distances. Their use in regenerative medicine has gained tremendous momentum recently due to their ability to be utilized as therapeutic options for a wide array of diseases/conditions. Over 5000 publications are currently being published yearly on this topic, and this number is only expected to dramatically increase as novel therapeutic strategies continue to be developed. T...
Source: Atherosclerosis - April 9, 2024 Category: Cardiology Authors: Richard J Miron Nathan E Estrin Anton Sculean Yufeng Zhang Source Type: research
Cell Transplantation for Repair of the Spinal Cord and Prospects for Generating Region-Specific Exogenic Neuronal Cells
Cell Transplant. 2024 Jan-Dec;33:9636897241241998. doi: 10.1177/09636897241241998.ABSTRACTSpinal cord injury (SCI) is associated with currently irreversible consequences in several functional components of the central nervous system. Despite the severity of injury, there remains no approved treatment to restore function. However, with a growing number of preclinical studies and clinical trials, cell transplantation has gained significant potential as a treatment for SCI. Researchers have identified several cell types as potential candidates for transplantation. To optimize successful functional outcomes after transplantati...
Source: Cell Transplantation - April 9, 2024 Category: Cytology Authors: Alex Roman Anne Huntemer-Silveira Madison A Waldron Zainab Khalid Jeffrey Blake Ann M Parr Walter C Low Source Type: research
Immunotherapy of M2 macrophage derived from exosome-based nanoparticles for spinal cord injury
Int Immunopharmacol. 2024 Apr 8;132:111983. doi: 10.1016/j.intimp.2024.111983. Online ahead of print.ABSTRACTDeveloping biomimetic nanoparticles without off-target side-effects remains a major challenge in spinal cord injury (SCI) immunotherapy. In this paper, we have conducted a drug carrier which is biocompatible macrophages-exocytosed exosome-biomimetic manganese (Mn)-iron prussian blue analogues (MPBs) for SCI immunotherapy. Exosome-sheathed MPBs (E-MPBs) exhibit promoted microglia accumulation, alleviation from H2O2-induced microenvironment and inhibition of apoptosis and inflammation in vitro. In addition, E-MPBs pos...
Source: International Immunopharmacology - April 9, 2024 Category: Allergy & Immunology Authors: Lu Bai Jinpeng Gao Peng Zhang Sen Lin Chuanjie Zhang Source Type: research
Mertk Reduces Blood-Spinal Cord Barrier Permeability Through the Rhoa/Rock1/P-MLC Pathway After Spinal Cord Injury
AbstractDisruption of the blood-spinal cord barrier (BSCB) is a critical event in the secondary injury following spinal cord injury (SCI). Mertk has been reported to play an important role in regulating inflammation and cytoskeletal dynamics. However, the specific involvement of Mertk in BSCB remains elusive. Here, we demonstrated a distinct role of Mertk in the repair of BSCB. Mertk expression is decreased in endothelial cells following SCI. Overexpression of Mertk upregulated tight junction proteins (TJs), reducing BSCB permeability and subsequently inhibiting inflammation and apoptosis. Ultimately, this led to enhanced ...
Source: Neuroscience Bulletin - April 9, 2024 Category: Neuroscience Source Type: research
A portable system to measure knee extensor spasticity after spinal cord injury
The pendulum test is a quantitative method used to assess knee extensor spasticity in humans with spinal cord injury (SCI). Yet, the clinical implementation of this method remains limited. The goal of our stud... (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - April 9, 2024 Category: Rehabilitation Authors: Dalia De Santis and Monica A. Perez Tags: Methodology Source Type: research
The Perfect Step is the first one: Improving the quality of life for patients with spinal cord injuries through structured exercise
CONCLUSION/CLINICAL RELEVANCE: Patients with SCI engaging in a structured exercise program demonstrated sustainable, longitudinal improvements in mood, pain control, independence, and fewer impairments related to bladder function and pressure ulcers. Physicians should consider the integration of structured exercise into the rehabilitation program alongside traditional medical care to optimize the quality of life for those with SCI. Future research should involve a direct comparison of QoL in patients with SCI participating in structured exercise versus those who are not.PMID:38588028 | DOI:10.1080/10790268.2024.2336276 (So...
Source: Journal of Spinal Cord Medicine - April 8, 2024 Category: Orthopaedics Authors: Ellie M Fratt Alex McDonald Hal Hargrave Robert Sallis Source Type: research
Trends in the characteristics and outcomes of older patients with non-traumatic spinal cord injury treated in inpatient rehabilitation facilities: 2013-2018
CONCLUSIONS: Between 2013 and 2018, the number of Medicare patients with NTSCI treated in IRFs increased by more than 22 percent. While patient complexity increased, the median length of stay remained 12 days across the years. Discharge self-care and mobility function increased slightly, and the percent of patients discharged home ranged from 73.7 to 75.2 across the years.PMID:38588027 | DOI:10.1080/10790268.2024.2335414 (Source: Journal of Spinal Cord Medicine)
Source: Journal of Spinal Cord Medicine - April 8, 2024 Category: Orthopaedics Authors: Anne Deutsch Jennifer Burns John Potelle Allison Kessler Source Type: research
SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization
CONCLUSION: SP1 transcriptionally activated HTR2B to aggravate traumatic SCI by shifting microglial M1/M2 polarization.PMID:38589918 | DOI:10.1186/s13018-024-04678-z (Source: Cell Research)
Source: Cell Research - April 8, 2024 Category: Cytology Authors: Qifei Xu Fanguo Kong Guanghui Zhao Junwei Jin Shengkai Feng Ming Li Source Type: research
