Mesenchymal stem cell-derived exosomes as new drug carrier for the treatment of spinal cord injury: A review
Chin J Traumatol. 2024 Mar 26:S1008-1275(24)00036-1. doi: 10.1016/j.cjtee.2024.03.009. Online ahead of print.ABSTRACTSpinal cord injury (SCI) is a devastating traumatic disease seriously impairing the quality of life in patients. Expectations to allow the hopeless central nervous system to repair itself after injury are unfeasible. Developing new approaches to regenerate the central nervous system is still the priority. Exosomes derived from mesenchymal stem cells (MSC-Exo) have been proven to robustly quench the inflammatory response or oxidative stress and curb neuronal apoptosis and autophagy following SCI, which are th...
Source: Chinese Journal of Traumatology - April 3, 2024 Category: Orthopaedics Authors: Lin-Fei Cheng Chao-Qun You Cheng Peng Jia-Ji Ren Kai Guo Tie-Long Liu Source Type: research
Mesenchymal stem cell-derived exosomes as new drug carrier for the treatment of spinal cord injury: A review
Chin J Traumatol. 2024 Mar 26:S1008-1275(24)00036-1. doi: 10.1016/j.cjtee.2024.03.009. Online ahead of print.ABSTRACTSpinal cord injury (SCI) is a devastating traumatic disease seriously impairing the quality of life in patients. Expectations to allow the hopeless central nervous system to repair itself after injury are unfeasible. Developing new approaches to regenerate the central nervous system is still the priority. Exosomes derived from mesenchymal stem cells (MSC-Exo) have been proven to robustly quench the inflammatory response or oxidative stress and curb neuronal apoptosis and autophagy following SCI, which are th...
Source: Chinese Journal of Traumatology - April 3, 2024 Category: Orthopaedics Authors: Lin-Fei Cheng Chao-Qun You Cheng Peng Jia-Ji Ren Kai Guo Tie-Long Liu Source Type: research
Adenylyl cyclase isoforms 5 and 6 in the cardiovascular system: complex regulation and divergent roles
Adenylyl cyclases (ACs) are crucial effector enzymes that transduce divergent signals from upstream receptor pathways and are responsible for catalyzing the conversion of ATP to cAMP. The ten AC isoforms are categorized into four main groups; the class III or calcium-inhibited family of ACs comprises AC5 and AC6. These enzymes are very closely related in structure and have a paucity of selective activators or inhibitors, making it difficult to distinguish them experimentally. AC5 and AC6 are highly expressed in the heart and vasculature, as well as the spinal cord and brain; AC6 is also abundant in the lungs, kidney, and l...
Source: Frontiers in Pharmacology - April 3, 2024 Category: Drugs & Pharmacology Source Type: research
Using the benefit-harm trade-off method to determine the smallest worthwhile effect of intensive motor training on strength for people with spinal cord injury
Spinal Cord, Published online: 03 April 2024; doi:10.1038/s41393-024-00979-6Using the benefit-harm trade-off method to determine the smallest worthwhile effect of intensive motor training on strength for people with spinal cord injury (Source: Spinal Cord)
Source: Spinal Cord - April 3, 2024 Category: Research Authors: Keira E. Tranter Joanne V. Glinsky Marsha Ben Helen Patterson Lynn Blecher Jackie Chu Lisa A. Harvey Source Type: research
Clinical characteristics analysis of pediatric spinal cord injury without radiological abnormality in China: a retrospective study
This study aims to analyze the clinical characteristics of Chinese children with spinal cord injury (SCI) without radiographic abnormality (SCIWORA) and explore their contributing factors and mechanisms of occ... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 3, 2024 Category: Pediatrics Authors: Renfeng Liu, Qizhi Fan, Jingpeng He, Xin Wu, Wei Tan, Zuyun Yan, Weiguo Wang, Zhiyue Li and You-Wen Deng Tags: Research Source Type: research
PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF- κB/STAT6 signaling pathway
In conclusion, PTPRO inhibition improves spinal cord injury through facilitating M2 microglia polarization via the NF-κB/STAT6 signaling pathway, which is probably controlled by SOX4.PMID:38565385 | DOI:10.1016/j.bbadis.2024.167141 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Haocong Zhang Liangbi Xiang Hong Yuan Hailong Yu Source Type: research
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
Cell Stem Cell. 2024 Mar 26:S1934-5909(24)00089-4. doi: 10.1016/j.stem.2024.03.007. Online ahead of print.ABSTRACTNeonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process has remained elusive. Here, we found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans, compared to those of adult spinal cord. Decellularized spinal cord ECM from neonatal (DNSCM) and adult (DASCM) rabbits preserved the...
Source: Cell Stem Cell - April 2, 2024 Category: Stem Cells Authors: Zheng Sun Zhenni Chen Man Yin Xianming Wu Bo Guo Xiaokang Cheng Rui Quan Yuting Sun Qi Zhang Yongheng Fan Chen Jin Yanyun Yin Xianglin Hou Weiyuan Liu Muya Shu Xiaoyu Xue Ya Shi Bing Chen Zhifeng Xiao Jianwu Dai Yannan Zhao Source Type: research
PTPRO inhibition ameliorates spinal cord injury through shifting microglial M1/M2 polarization via the NF- κB/STAT6 signaling pathway
In conclusion, PTPRO inhibition improves spinal cord injury through facilitating M2 microglia polarization via the NF-κB/STAT6 signaling pathway, which is probably controlled by SOX4.PMID:38565385 | DOI:10.1016/j.bbadis.2024.167141 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 2, 2024 Category: Biochemistry Authors: Haocong Zhang Liangbi Xiang Hong Yuan Hailong Yu Source Type: research
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
Cell Stem Cell. 2024 Mar 26:S1934-5909(24)00089-4. doi: 10.1016/j.stem.2024.03.007. Online ahead of print.ABSTRACTNeonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process has remained elusive. Here, we found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans, compared to those of adult spinal cord. Decellularized spinal cord ECM from neonatal (DNSCM) and adult (DASCM) rabbits preserved the...
Source: Cell Stem Cell - April 2, 2024 Category: Stem Cells Authors: Zheng Sun Zhenni Chen Man Yin Xianming Wu Bo Guo Xiaokang Cheng Rui Quan Yuting Sun Qi Zhang Yongheng Fan Chen Jin Yanyun Yin Xianglin Hou Weiyuan Liu Muya Shu Xiaoyu Xue Ya Shi Bing Chen Zhifeng Xiao Jianwu Dai Yannan Zhao Source Type: research
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
Cell Stem Cell. 2024 Mar 26:S1934-5909(24)00089-4. doi: 10.1016/j.stem.2024.03.007. Online ahead of print.ABSTRACTNeonatal spinal cord tissues exhibit remarkable regenerative capabilities as compared to adult spinal cord tissues after injury, but the role of extracellular matrix (ECM) in this process has remained elusive. Here, we found that early developmental spinal cord had higher levels of ECM proteins associated with neural development and axon growth, but fewer inhibitory proteoglycans, compared to those of adult spinal cord. Decellularized spinal cord ECM from neonatal (DNSCM) and adult (DASCM) rabbits preserved the...
Source: Cell Stem Cell - April 2, 2024 Category: Stem Cells Authors: Zheng Sun Zhenni Chen Man Yin Xianming Wu Bo Guo Xiaokang Cheng Rui Quan Yuting Sun Qi Zhang Yongheng Fan Chen Jin Yanyun Yin Xianglin Hou Weiyuan Liu Muya Shu Xiaoyu Xue Ya Shi Bing Chen Zhifeng Xiao Jianwu Dai Yannan Zhao Source Type: research
Global research trends and hotspots of artificial intelligence research in spinal cord neural injury and restoration —a bibliometrics and visualization analysis
ConclusionWe pinpointed three research hotspots for AI research in spinal cord neural injury and restoration: (1) intelligent robots and limb exoskeletons to assist rehabilitation training; (2) brain-computer interfaces; and (3) neuromodulation and noninvasive electrical stimulation. In addition, many new hotspots were discussed: (1) starting with image segmentation models based on convolutional neural networks; (2) the use of AI to fabricate polymeric biomaterials to provide the microenvironment required for neural stem cell-derived neural network tissues; (3) AI survival prediction tools, and transcription factor regulat...
Source: Frontiers in Neurology - April 2, 2024 Category: Neurology Source Type: research
Prostate Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
AbstractPurpose of ReviewIn this review, the current literature available to patients and providers on the diagnosis and management of prostate cancer in patients with neurogenic bladder will be discussed. Topics include prostate cancer screening and diagnosis, radical prostatectomy and radiotherapy for prostate cancer, as well as surveillance.Recent FindingsNeurogenic lower urinary tract dysfunction (NLUTD) patients are living longer due to better care, and cancer is becoming more frequent. This is partly due to the aging of this population, as well as intrinsic factors related to the underlying condition or urinary diver...
Source: Current Bladder Dysfunction Reports - April 2, 2024 Category: Urology & Nephrology Source Type: research
Bladder Cancer Diagnosis and Treatment for Patients with Neurogenic Bladder: Does the Literature Support a Different Approach?
AbstractPurpose of ReviewIn this review, the current literature available to patients and providers on the diagnosis and management of bladder cancer in patients with neurogenic bladder will be discussed. Topics include bladder cancer epidemiology in the neurogenic population and unique features of this tumor in this subset of patients, current screening recommendations, and differences in the treatment for this patient population, outlining specific changes in the surgical approach.Recent FindingsNeurogenic lower urinary tract dysfunction (NLUTD) patients are living longer due to better care, and cancer is becoming more f...
Source: Current Bladder Dysfunction Reports - April 2, 2024 Category: Urology & Nephrology Source Type: research
OTULIN Can Improve Spinal Cord Injury by the NF- κB and Wnt/β-Catenin Signaling Pathways
AbstractSpinal cord injury (SCI) is a significant health concern, as it presently has no effective treatment in the clinical setting. Inflammation is a key player in the pathophysiological process of SCI, with a number of studies evidencing that the inhibition of the NF- κB signaling pathway may impede the inflammatory response and improve SCI. OTULIN, as a de-ubiquitination enzyme, the most notable is its anti-inflammatory effect. OTULIN can inhibit the NF-κB signaling pathway to suppress the inflammatory reaction via de-ubiquitination. In addition, OTULIN may pr omote vascular regeneration through the Wnt/β-catenin pa...
Source: Molecular Neurobiology - April 2, 2024 Category: Neurology Source Type: research
A therapist-administered self-report version of the Walking Index for Spinal Cord Injury II (WISCI): a psychometric study
Spinal Cord, Published online: 02 April 2024; doi:10.1038/s41393-024-00985-8A therapist-administered self-report version of the Walking Index for Spinal Cord Injury II (WISCI): a psychometric study (Source: Spinal Cord)
Source: Spinal Cord - April 2, 2024 Category: Research Authors: Marsha Ben Federica Tamburella Matteo Lorusso Joanne V. Glinsky Keira E. Tranter Giorgio Scivoletto Lynn Blecher Anneliese Harris Giovanni Galeoto Joshua Wan Lisa A. Harvey Source Type: research
