Combining Fecal 16S rRNA Sequencing and Spinal Cord Metabolomics analysis to explain the modulatory effect of PPAR α on Neuropathic Pain

CONCLUSION: Our study shows that PPARα can promote M2-type microglia polarization, as well as alter gut microbiota and metabolites in CCI mice. This study enhances our understanding of the mechanism of PPARα in the treatment of neuropathic pain.PMID:38614408 | DOI:10.1016/j.brainresbull.2024.110943
Source: Brain Research Bulletin - Category: Neurology Authors: Source Type: research