Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions
Ageing Res Rev. 2024 Apr 26:102315. doi: 10.1016/j.arr.2024.102315. Online ahead of print.ABSTRACTLung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and ...
Source: Ageing Research Reviews - April 28, 2024 Category: Genetics & Stem Cells Authors: Saurav Kumar Jha Gabriele De Rubis Shankar Raj Devkota Yali Zhang Radhika Adhikari Laxmi Akhileshwar Jha Kunal Bhattacharya Samir Mehndiratta Gaurav Gupta Sachin Kumar Singh Nisha Panth Kamal Dua Philip M Hansbro Keshav Raj Paudel Source Type: research
Prevalence and determinants of behavioral risk factors for noncommunicable diseases among students aged 13-19 years in Turkey
CONCLUSION: The prevalence of clustering of modifiable risk factors for NCDs was high among students aged 13-19 years in Turkey, and there is a need to mount effective interventions. Risk factors for these diseases are often preventable: Appropriate health interventions before, during, and after pregnancy as well as throughout childhood and adolescence can significantly reduce their prevalence.PMID:38679546 | DOI:10.1016/j.arcped.2024.01.009 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - April 28, 2024 Category: Pediatrics Authors: Hasan H üseyin Çam Fadime Ustuner Top Source Type: research
A bupropion modulatory site in Gloeobacter violaceus ligand-gated ion channel
Biophys J. 2024 Apr 27:S0006-3495(24)00289-3. doi: 10.1016/j.bpj.2024.04.027. Online ahead of print.ABSTRACTBupropion is an atypical antidepressant and smoking cessation drug that causes adverse effects such as insomnia, irritability, and anxiety. Bupropion inhibits dopamine and norepinephrine reuptake transporters and eukaryotic cation-conducting pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine (nACh) and serotonin type 3A (5-HT3A) receptors, at clinically relevant concentrations. Here, we demonstrate that bupropion also inhibits a prokaryotic homolog of pLGICs, the Gloeobacter violaceus liga...
Source: Biophysical Journal - April 28, 2024 Category: Physics Authors: Hoa Quynh Do Elham Pirayesh Garren Ferreira Akash Pandhare Zackary Ryan Gallardo Michaela Jansen Source Type: research
Distribution of Urinary Trace Element Exposure and Dietary Sources in Women Over 50 in an Agricultural Region- A community-based KoGES cohort study
CONCLUSIONS: Our study underscores the significant gap in understanding urinary concentrations of trace elements in women aged over 50. With higher concentrations of certain elements compared to previous studies and significant correlations between age, smoking, and specific food sources, it is imperative to address this gap through targeted dietary source-specific risk management.PMID:38679278 | DOI:10.1016/j.envres.2024.118973 (Source: Environmental Research)
Source: Environmental Research - April 28, 2024 Category: Environmental Health Authors: Nam H Cho Sohyeon Choi Min Joo Kim Young Joo Park Aram Lee Min Kyong Moon Gowoon Lee Inae Lee Kyungho Choi Joon-Hyop Lee Jeongim Park Source Type: research
Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions
Ageing Res Rev. 2024 Apr 26:102315. doi: 10.1016/j.arr.2024.102315. Online ahead of print.ABSTRACTLung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and ...
Source: Ageing Research Reviews - April 28, 2024 Category: Genetics & Stem Cells Authors: Saurav Kumar Jha Gabriele De Rubis Shankar Raj Devkota Yali Zhang Radhika Adhikari Laxmi Akhileshwar Jha Kunal Bhattacharya Samir Mehndiratta Gaurav Gupta Sachin Kumar Singh Nisha Panth Kamal Dua Philip M Hansbro Keshav Raj Paudel Source Type: research
Prevalence and determinants of behavioral risk factors for noncommunicable diseases among students aged 13-19 years in Turkey
CONCLUSION: The prevalence of clustering of modifiable risk factors for NCDs was high among students aged 13-19 years in Turkey, and there is a need to mount effective interventions. Risk factors for these diseases are often preventable: Appropriate health interventions before, during, and after pregnancy as well as throughout childhood and adolescence can significantly reduce their prevalence.PMID:38679546 | DOI:10.1016/j.arcped.2024.01.009 (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - April 28, 2024 Category: Pediatrics Authors: Hasan H üseyin Çam Fadime Ustuner Top Source Type: research
Cellular Senescence in Lung Cancer: Molecular Mechanisms and Therapeutic Interventions
Ageing Res Rev. 2024 Apr 26:102315. doi: 10.1016/j.arr.2024.102315. Online ahead of print.ABSTRACTLung cancer stands as the primary contributor to cancer-related fatalities worldwide, affecting both genders. Two primary types exist where non-small cell lung cancer (NSCLC), accounts for 80-85% and SCLC accounts for 10-15% of cases. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Smoking, second-hand smoke, radon gas, asbestos, and other pollutants, genetic predisposition, and COPD are lung cancer risk factors. On the other hand, stresses such as DNA damage, telomere shortening, and ...
Source: Cell Research - April 28, 2024 Category: Cytology Authors: Saurav Kumar Jha Gabriele De Rubis Shankar Raj Devkota Yali Zhang Radhika Adhikari Laxmi Akhileshwar Jha Kunal Bhattacharya Samir Mehndiratta Gaurav Gupta Sachin Kumar Singh Nisha Panth Kamal Dua Philip M Hansbro Keshav Raj Paudel Source Type: research
A bupropion modulatory site in Gloeobacter violaceus ligand-gated ion channel
Biophys J. 2024 Apr 27:S0006-3495(24)00289-3. doi: 10.1016/j.bpj.2024.04.027. Online ahead of print.ABSTRACTBupropion is an atypical antidepressant and smoking cessation drug that causes adverse effects such as insomnia, irritability, and anxiety. Bupropion inhibits dopamine and norepinephrine reuptake transporters and eukaryotic cation-conducting pentameric ligand-gated ion channels (pLGICs), such as nicotinic acetylcholine (nACh) and serotonin type 3A (5-HT3A) receptors, at clinically relevant concentrations. Here, we demonstrate that bupropion also inhibits a prokaryotic homolog of pLGICs, the Gloeobacter violaceus liga...
Source: Biophysical Journal - April 28, 2024 Category: Physics Authors: Hoa Quynh Do Elham Pirayesh Garren Ferreira Akash Pandhare Zackary Ryan Gallardo Michaela Jansen Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina
Conclusions. In conclusion, the outcomes of this study align with existing research, underscoring the effectiveness of the HEAR score in risk stratification for patients with chest pain. In practical terms, the implementation of the HEAR score in clinical decision-making processes holds significant promise.PMID:38674303 | PMC:PMC11052023 | DOI:10.3390/medicina60040657 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Armin Šljivo Nemanja Luki ć Aladin Altic Slobodan Tomi ć Arian Abdulkhaliq Leopold Reiter Diana Maria Bota Eljakim Mahendran Wisam Natour Fatima Gavrankapetanovi ć Emira Kapisazovi ć Haris Duljevi ć Lana Leki ć Dragana Radoi čić Sanja D Tomi ć Source Type: research
Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia
Conclusions: While the prevalence of multimorbidity in Indonesia is generally similar to that observed in previous studies, we have identified patient characteristics related to nonadherence. We suggest that patient's nonadherence was primarily dictated by their self-perception of health and treatment complexity. With the longstanding issue of nonadherence, this study indicated the need to consider creating patient-tailored treatment programs in clinical practice to improve adherence by considering individual patients' characteristics.PMID:38674280 | PMC:PMC11052292 | DOI:10.3390/medicina60040634 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ivan Surya Pradipta Kevin Aprilio Yozi Fiedya Ningsih Mochammad Andhika Aji Pratama Sofa Dewi Alfian Rizky Abdulah Source Type: research
Investigation of the Association between Bilateral Selective Anterograde Cerebral Perfusion and Postoperative Ischemic Stroke in Obese Patients with Emergency Surgery for Acute Type A Aortic Dissection
Conclusions: A patient-tailored strategy for cerebral perfusion should be considered in obese patients, considering the high atheromatous burden of the supra-aortic vessels in these patients and the potential risk of atheromatous embolization associated with this technique.PMID:38674307 | PMC:PMC11052173 | DOI:10.3390/medicina60040661 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Mircea Robu Bogdan Radulescu Irina Maria Margarint Cornel Robu Ovidiu Stiru Andrei Iosifescu Silvia Preda Mihai Cacoveanu Cristian Voica Vlad Anton Iliescu Horatiu Moldovan Source Type: research
Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina
Conclusions. In conclusion, the outcomes of this study align with existing research, underscoring the effectiveness of the HEAR score in risk stratification for patients with chest pain. In practical terms, the implementation of the HEAR score in clinical decision-making processes holds significant promise.PMID:38674303 | PMC:PMC11052023 | DOI:10.3390/medicina60040657 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Armin Šljivo Nemanja Luki ć Aladin Altic Slobodan Tomi ć Arian Abdulkhaliq Leopold Reiter Diana Maria Bota Eljakim Mahendran Wisam Natour Fatima Gavrankapetanovi ć Emira Kapisazovi ć Haris Duljevi ć Lana Leki ć Dragana Radoi čić Sanja D Tomi ć Source Type: research
Treatment Nonadherence among Multimorbid Chronic Disease Patients: Evidence from 3515 Subjects in Indonesia
Conclusions: While the prevalence of multimorbidity in Indonesia is generally similar to that observed in previous studies, we have identified patient characteristics related to nonadherence. We suggest that patient's nonadherence was primarily dictated by their self-perception of health and treatment complexity. With the longstanding issue of nonadherence, this study indicated the need to consider creating patient-tailored treatment programs in clinical practice to improve adherence by considering individual patients' characteristics.PMID:38674280 | PMC:PMC11052292 | DOI:10.3390/medicina60040634 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Ivan Surya Pradipta Kevin Aprilio Yozi Fiedya Ningsih Mochammad Andhika Aji Pratama Sofa Dewi Alfian Rizky Abdulah Source Type: research
Assessment and Application of the Hear Score in Remote Emergency Medicine Outposts in Bosnia and Herzegovina
Conclusions. In conclusion, the outcomes of this study align with existing research, underscoring the effectiveness of the HEAR score in risk stratification for patients with chest pain. In practical terms, the implementation of the HEAR score in clinical decision-making processes holds significant promise.PMID:38674303 | PMC:PMC11052023 | DOI:10.3390/medicina60040657 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Armin Šljivo Nemanja Luki ć Aladin Altic Slobodan Tomi ć Arian Abdulkhaliq Leopold Reiter Diana Maria Bota Eljakim Mahendran Wisam Natour Fatima Gavrankapetanovi ć Emira Kapisazovi ć Haris Duljevi ć Lana Leki ć Dragana Radoi čić Sanja D Tomi ć Source Type: research
