The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research
The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research
Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study
Conclusions: This study provides evidence for the efficacy of LT in improving sleep quality and circadian rhythm alignment in adults with insomnia. Despite limitations, such as a small sample size and short study duration, the results underscore the potential of LT as a viable non-pharmacological approach for insomnia. Future research should expand on these results with larger and more diverse cohorts followed over a longer period to validate and further elucidate the value of LT in sleep medicine. Trial registration: The trial was registered with the Clinical Research Information Service (KCT0008501).PMID:38674278 | PMC:P...
Source: Medicina (Kaunas) - April 27, 2024 Category: Universities & Medical Training Authors: Jihyun Yoon Seok-Jae Heo Hyangkyu Lee Eun-Gyeong Sul Taehwa Han Yu-Jin Kwon Source Type: research
Associations of lifestyle and genetic risks with obesity and related chronic diseases in the UK Biobank: a prospective cohort study
CONCLUSIONS: Higher LRS was associated with higher obesity prevalence and risks of related chronic diseases regardless of GRS, highlighting the broad benefits of healthy lifestyles. Additive gene-lifestyle interactions emphasize the public health importance of lifestyle interventions among people with high genetic risks.PMID:38677521 | DOI:10.1016/j.ajcnut.2024.04.025 (Source: Am J Clin Nutr)
Source: Am J Clin Nutr - April 27, 2024 Category: Nutrition Authors: Yanbo Zhang Yang Li Rita Peila Tao Wang Xiaonan Xue Robert C Kaplan Andrew J Dannenberg Qibin Qi Thomas E Rohan Source Type: research
Associations of lifestyle and genetic risks with obesity and related chronic diseases in the UK Biobank: a prospective cohort study
CONCLUSIONS: Higher LRS was associated with higher obesity prevalence and risks of related chronic diseases regardless of GRS, highlighting the broad benefits of healthy lifestyles. Additive gene-lifestyle interactions emphasize the public health importance of lifestyle interventions among people with high genetic risks.PMID:38677521 | DOI:10.1016/j.ajcnut.2024.04.025 (Source: The American Journal of Clinical Nutrition)
Source: The American Journal of Clinical Nutrition - April 27, 2024 Category: Nutrition Authors: Yanbo Zhang Yang Li Rita Peila Tao Wang Xiaonan Xue Robert C Kaplan Andrew J Dannenberg Qibin Qi Thomas E Rohan Source Type: research
Atypical isolated cataplexy: two case reports and a mini-review
We describe two cases of isolated cataplexy with different outcomes, highlighting the diagnostic and prognostic challenges. There is conflicting literature as to whether it is a legitimate standalone diagnosis or an early warning sign of narcolepsy. Our cases do not fit with current diagnostic criteria for narcolepsy, yet still share some clinical or laboratory features. These ambiguous cases question what the mechanistic relationship between narcolepsy and cataplexy may be.PMID:38678310 | DOI:10.1080/13554794.2024.2347606 (Source: Neurocase)
Source: Neurocase - April 27, 2024 Category: Neurology Authors: Vinay Mandagere Dane Rayment Source Type: research
Prevalence of FMS Diagnosis According to ACR 2016 Revised Criteria in a Pain Therapy Centre in Italy: Observational Study
Conclusions: This prospective observational study confirmed the diagnostic challenge with FMS, as demonstrated by the moderate grade of agreement between the FMS diagnosis at discharge and the positivity for 2016 ACR criteria. In our opinion, the use of widely accepted diagnostic guidelines should be implemented in clinical scenarios and should become a common language among clinicians who evaluate and treat patients reporting widespread pain and FMS-suggestive symptoms. Further methodologically stronger studies will be necessary to validate our observation.PMID:38674245 | DOI:10.3390/medicina60040599 (Source: Pain Physician)
Source: Pain Physician - April 27, 2024 Category: Anesthesiology Authors: Vittorio Schweiger Alvise Martini Marta Nizzero Eleonora Bonora Giovanna Del Balzo Leonardo Gottin Lorena Torroni Luca Polati Giada Zuliani Erica Secchettin Enrico Polati Source Type: research
Perivascular space diffusivity and brain microstructural measures are associated with circadian time and sleep quality
J Sleep Res. 2024 Apr 27:e14226. doi: 10.1111/jsr.14226. Online ahead of print.ABSTRACTThe glymphatic system is centred around brain cerebrospinal fluid flow and is enhanced during sleep, and the synaptic homeostasis hypothesis proposes that sleep acts on brain microstructure by selective synaptic downscaling. While so far primarily studied in animals, we here examine in humans if brain diffusivity and microstructure is related to time of day, sleep quality and cognitive performance. We use diffusion weighted images from 916 young healthy individuals, aged between 22 and 37 years, collected as part of the Human Connectome ...
Source: Journal of Sleep Research - April 27, 2024 Category: Sleep Medicine Authors: Kristoffer Brendstrup-Brix Sara Marie Ulv Larsen Hong-Hsi Lee Gitte Moos Knudsen Source Type: research
The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research
The physiological role of TRP channels in sleep and circadian rhythm
J Cell Mol Med. 2024 May;28(9):e18274. doi: 10.1111/jcmm.18274.ABSTRACTTRP channels, are non-specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store-operated calcium entry, thermosensation and functionality of the nervous system. Here we choose to look at the evidence that decisively shows how TRP channels modulate human neuron plasticity as it relates to the molecular neurobiology of sleep/circadian rhythm. There are numerous model organisms of sleep and circadian rhythm that are the results...
Source: J Cell Mol Med - April 27, 2024 Category: Molecular Biology Authors: Geoffrey Woodard Juan A Rosado He Li Source Type: research
Noradrenaline enhances Na ‐K ATPase subunit expression by HuR‐induced mRNA stabilization and their transportation to the cell surface through PLC and PKC mediated pathway: Implications with REMS‐loss associated disorders
Rapid eye movement sleep deprivation associated elevated noradrenaline (NA) increases nucleus-to-cytoplasmic translocation of HuR. The latter then decreases degradation of the Na-K ATPase mRNA, resulting in stability of its mRNA, which in turn increased its translation without increasing the transcription. The increased Na-K ATPase subunit are then translocated to the neuronal membrane. Our findings not only explain a fundamental molecular mechanism of Na-K ATPase subunit expression, but it may also be exploited to ameliorate REMS-loss associated symptoms and disorders. AbstractRapid eye movement sleep (REMS) maintains bra...
Source: Journal of Neurochemistry - April 27, 2024 Category: Neuroscience Authors: Manjeet Kaur,
Rachna Mehta,
Rohini Muthuswami,
Birendra Nath Mallick Tags: ORIGINAL ARTICLE Source Type: research
Sleep Apnea in Children and Adults
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA (Source: Otolaryngologic clinics of North America)
Source: Otolaryngologic clinics of North America - April 27, 2024 Category: ENT & OMF Authors: Stacey L. Ishman, Carol Li, Reena Dhanda Patil Source Type: research
Assessment of Sleep Disorders in Patients with CVID
AbstractInborn errors of immunity have been associated with reduced health-related quality of life and increased fatigue. Sleep disorders, which have been shown to contribute to fatigue and other health concerns, are prevalent in the general population, but there are limited studies evaluating these conditions in patients with common variable immunodeficiency (CVID). Our aim was to evaluate the prevalence of fatigue, sleep disturbances, and sleep-disordered breathing in adults with CVID. Patients completed 4 validated, self-administered questionnaires and a 1-night disposable home sleep apnea test. Our results demonstrated...
Source: Journal of Clinical Immunology - April 27, 2024 Category: Allergy & Immunology Source Type: research
Sensors, Vol. 24, Pages 2803: In-Laboratory Polysomnography Worsens Obstructive Sleep Apnea by Changing Body Position Compared to Home Testing
Conclusions: In-lab polysomnography may artificially increase OSA severity in a subset of patients by inducing marked changes in body position compared to home tests. The location of the sleep test seems to interfere with the evaluation of patients with more severe OSA. (Source: Sensors)
Source: Sensors - April 27, 2024 Category: Biotechnology Authors: Raquel Chartuni Pereira Teixeira Michel Burihan Cahali Tags: Article Source Type: research
The effect of exercise on sleep habits of children with type 1 diabetic: a randomized clinical trial
Adequate sleep and exercise are important components of the human lifestyle. Paying attention to these two factors is very important to improve the condition of children with type 1 diabetes. Therefore, this s... (Source: BMC Pediatrics)
Source: BMC Pediatrics - April 27, 2024 Category: Pediatrics Authors: Nastaran Amiri, Kimia Karami, Fatemeh Valizadeh and Yaser Mokhayeri Tags: Research Source Type: research
