All Obstructive Sleep Apnea Events Are Not Created Equal: The Relationship between Event-related Hypoxemia and Physiologic Response
Annals of the American Thoracic Society,Volume 21, Issue 5, Page 794-802, May 2024. (Source: Annals of the American Thoracic Society)
Source: Annals of the American Thoracic Society - May 1, 2024 Category: Respiratory Medicine Authors: Mohammadreza Hajipour A. J. Hirsch Allen Andrew E. Beaudin Jill K. Raneri Rachel Jen Glen E. Foster Stuart Fogel Tetyana Kendzerska Fr éderic Series Robert P. Skomro Rebecca Robillard R. John Kimoff Patrick J. Hanly Sidney Fels Amrit Singh Ali Azarbarzin Source Type: research
Moving Ear Syndrome: A rare and treatable phenomenon
Background: The external ear muscles are vestigial muscles innervated by the facial nerve that only 1 in 5 people can voluntarily contract. Ear dyskinesia, namely Moving Ear Syndrome (MES), is a phenomenologically rare disorder consisting in a rhythmic/semirhythmic contraction of external ear muscles, typically disappearing with sleep and voluntary face movements, and causing pain or discomfort. Ear dyskinesia has no clear etiology yet, however it has been repeatedly associated with neuroactive drugs (e.g., SSRIs, neuroleptics, methylphenidate). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: V. Yahya, R.C. Chavez, L. Campiglio, M. Zardoni, A. Priori Source Type: research
Association between serum lipid levels and dopamine loss in idiopathic rapid eye movement sleep behavior disorder
Background: Although potential role of lipid metabolism in the development of Parkinson ’s disease or other synucleinopathies are increasingly reported, its significance in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD), a prodromal status for future synucleinopathy, remains elusive. Herein, we investigated the potential association among serum lipid level, dopami ne loss, and clinical measures in patients with iRBD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y. Sun, H.K. Na, S.J. Kim, J.H. Jung, Y.H. Sohn, C.H. Lyoo, P.H. Lee Source Type: research
Implications of midbrain perivascular space in REM sleep behavior disorder and motor progression in drug-na ïve Parkinson’s disease
Background: Glymphatic dysfunction may play a pivotal role in the pathogenesis of REM sleep behavior disorder (RBD), and Parkinson ’s disease (PD), but the mechanism is still not elucidated. We investigated the clinical correlation of enlarged perivascular space (ePVS), a marker of glymphatic dysfunction, and its potential role in predicting motor outcomes in drug-naïve PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J. Ha, S. Lee, J.S. Lee, W. Kim, H. Kim, J.W. Cho, E.Y. Joo, J. Youn Source Type: research
Sleep disturbances are associated with accelerated postural instability and death in Parkinson ’s disease
Background: Due to the progressive nature of Parkinson ’s disease (PD), many individuals will develop complications such as falls, dementia, institutionalisation, and even death. Understanding the factors that contribute to these ‘milestones’ may lead to new therapeutic avenues. Sleep disturbances are amongst the commonest non-motor symptoms in PD . The aim of this study was to investigate the prevalence and prognostic significance of sleep disturbances in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: S.A. Griti, M. Camacho, R. Barker, D. Breen Source Type: research
Head Position During Sleep: Potential Implications for Patients with Neurodegenerative Disorders
Background: In 2015, Lee et al. observed sleeping position influenced the efficiency of glymphatic clearance of β-amyloid in anesthetized rats with the lateral position being more efficient than supine. In 2018, Levendowski et al. reported supine sleep> 2-hours per night was associated with neurodegenerative disorders (NDD) independent of age, sex, obstructive sleep apnea, and snoring. In 2019, Simka et al. revealed that in lateral positions the internal jugular vein above the heart partially collapses to optimize cerebral venous outflow and glymphatic clearance while in the supine position both internal jugular veins are...
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Levendowski, L. Yack, C. Walsh, D. Tsuang, B. Boeve, E. St. Louis, T. Neylan Source Type: research
Plasma neurofilament light chain level in isolated REM sleep behavior disorders, Parkinson ’s disease and multiple system atrophy
Background: Rapid-Eye-Movement (REM) sleep behavior disorder (RBD) has emerged as a specific prodromal sign of α-synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). Individuals with isolated RBD represent an ideal population for the identification of biomarkers capable of monitoring the neurodegenerative process. The neurofilament light chain protein (NfL), a neuron-specific component of the axons, is a promising biomarker in various neurodegenerative diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A. Calculli, D. Di Martino, G. Ongari, S. Gagliardi, P. Grillo, E. Capriglia, C. Fazio, D. Comolli, M. Terzaghi, A. Pisani Source Type: research
Deep learning-based automatic REM sleep detection in patients with REM sleep behavior disorder: Is it reliable?
The objectives of this study were to propose an automated REM sleep detector, only using EOG and EEG and to evaluate its performance using real-world polysomnographic data in patients with RBD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Y.J. Jung, S. Kim, S.H. Kim, W. Kim, D.-W. Ryu, Y.H. Choi, Y. Hwang, J. Jung Source Type: research
Differences in sleep behavior disorders between clinical types of idiopathic Parkinson ’s disease
This study sought to evaluate quality of sleep in patients with different subtypes of Parkinson ’s disease (PD) and analyze their clinical characteristics and related factors. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: F. Lou, M. Li Source Type: research
Therapeutic effects of hyperbaric oxygen on Parkinson disease - A systematic review and meta-analysis.
Background: Hyperbaric oxygen therapy of Motor disorders, Sleep dysfunctions and Cognitive dysfunctions in Parkinson disease —A Systematic Review. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: Q. Zhao, S. Bu, L. Jin Source Type: research
Two parallel nigrostriatal subcircuits mediate arousal effect of dopaminergic neurons in substantia nigra pars compacta
This study systematically investigates the role of dopaminergic (DA) neurons in SNc in wakefulness-sleep regulation and delves into the circuit mechanisms, aiming to provide new clues for the pathogenesis of EDS in PD. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: H. Liu, J. Li, Z. Hu, S. Ren, N. Xiong Source Type: research
Sleep Biomarker-Based Characterization of Neurodegenerative Disorder Risk in Parkinsonian Spectrum Disorder Patients
Background: In this pilot study, the diagnostic agreement for sleep biomarker-based neurodegenerative disorder (NDD) risk probabilities was evaluated in patients with isolated REM sleep behavior disorder (iRBD), Parkinson ’s disease (PD) Lewy body disease (LBD), progressive supranuclear palsy (PSP), and controls (CG). (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Levendowski, J. Anderson, Y. Cho, C. Walsh, L. Yack, D. Tsuang, J. Lee-Iannotti, B. Boeve, T. Neylan, S. Lewis, E. St. Louis Source Type: research
Are peripheral α-synuclein isoforms biomarkers for diagnosis and prognosis of isolated REM sleep behavior disorder?
Background: Isolated REM sleep behavior disorder (IRBD), a parasomnia characterized by nightmares and vigorous behaviors during REM sleep, is an early manifestation of synucleinopathies including Multiple System Atrophy, Parkinso ńs disease (PD) and dementia with Lewy bodies (DLB). PD and DLB are Lewy body diseases characterized by Lewy body pathology developing through the abnormal oligomerization and aggregation of α-synuclein in vulnerable brain areas. Increased α-synuclein gene (SNCA) expression in the brain is crucia l during the development these diseases. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: L. Arnaldo, D. Vilas, L. Ispierto, R. Alvarez, P. Pastor, A. Iranzo, K. Beyer Source Type: research
Automated detection of REM Sleep Without Atonia: Description and Technical Evaluation
This study describes and evaluates techniques developed to address these challenges. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: D. Levendowski, V. Velimirovic, B. Veljkovic, E. St. Louis Source Type: research
Effects of Sleep Hygiene on Sleep Disturbance in Patients with Parkinsonism
Background: Patients with Parkinsonism often encounter various sleep-related issues, including insomnia, sleep fragmentation, REM sleep behavior disorder(RBD), Restless Legs Syndrome(RLS), Excessive Daytime Sleepiness(EDS), and circadian rhythm disruptions. However, to date, the focus has primarily centered on alleviating symptoms through medical interventions, with limited research addressing the enhancement of sleep disturbances through sleep hygiene practices. We conducted a cross-sectional study to examine the impact of sleep hygiene on sleep disturbance in Parkinsonism patients. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: J.Y. Yun, C.Y. Lee, H. Kim Source Type: research
