Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression.
Abstract
Autoantibodies against CASPR2 (contactin-associated protein-like 2) have been linked to autoimmune limbic encephalitis that manifests with memory disorders and temporal lobe seizures. According to the growing number of data supporting a role for CASPR2 in neuronal excitability, CASPR2 forms a molecular complex with transient axonal glycoprotein-1 (TAG-1) and shaker-type voltage-gated potassium channels (Kv1.1 and Kv1.2) in compartments critical for neuronal activity and is required for Kv1 proper positioning. Whereas the perturbation of these functions could explain the symptoms observed in patien...
Source: Journal of Autoimmunity - June 4, 2019 Category: Allergy & Immunology Authors: Saint-Martin M, Pieters A, Déchelotte B, Malleval C, Pinatel D, Pascual O, Karagogeos D, Honnorat J, Pellier-Monnin V, Noraz N Tags: J Autoimmun Source Type: research
Cancers, Vol. 11, Pages 755: Functional Interaction of Hypoxia-Inducible Factor 2-Alpha and Autophagy Mediates Drug Resistance in Colon Cancer Cells
We examined the effects of stable knockdown of HIF-1α or HIF-2α expression on autophagy and drug resistance in colon cancer cells. We found that under normoxic conditions, malignant cells exhibit increased basal levels of autophagy, compared with non-malignant cells, in addition to the previously reported coexpression of HIF-1α and HIF-2α. Knockdown of HIF-1α or HIF-2α expression resulted in increased autophagic and apoptotic cell death, indicating that the survival of cells is HIF-dependent. Cytotoxic-induced cell death was significantly i...
Source: Cancers - May 29, 2019 Category: Cancer & Oncology Authors: Abril Saint-Martin Jacobo Mart ínez-Ríos M. Cristina Casta ñeda-Patlán Miguel Angel Sarabia-S ánchez Nydia Tejeda-Mu ñoz Alberto Chinney-Herrera Gloria Soldevila Roberto Benelli Paula Santoyo-Ramos Alessandro Poggi Martha Robles-Flores Tags: Article Source Type: research
Electroporation optimizes the uptake of boron-10 by tumor for boron neutron capture therapy (BNCT) mediated by GB-10: a boron biodistribution study in the hamster cheek pouch oral cancer model.
Abstract
Boron neutron capture therapy (BNCT) is a promising cancer binary therapy modality that utilizes the nuclear capture reaction of thermal neutrons by boron-10 resulting in a localized release of high- and low-linear energy transfer (LET) radiation. Electrochemotherapy (ECT) is based on electroporation (EP) that induces opening of pores in cell membranes, allowing the entry of compounds. Because EP is applied locally to a tumor, the compound is incorporated preferentially by tumor cells. Based on the knowledge that the therapeutic success of BNCT depends centrally on the boron content in tumor and n...
Source: Radiation and Environmental Biophysics - May 22, 2019 Category: Physics Authors: Garabalino MA, Olaiz N, Portu A, Saint Martin G, Thorp SI, Pozzi ECC, Curotto P, Itoiz ME, Monti Hughes A, Colombo LL, Nigg DW, Trivillin VA, Marshall G, Schwint AE Tags: Radiat Environ Biophys Source Type: research
Towards the synthesis of mixed oxides with controlled stoichiometry from Prussian Blue analogues
We present here the transformation of the Co4[Fe(CN)6]2.7 Prussian Blue Analogue (PBA) into the... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - May 13, 2019 Category: Chemistry Authors: Virgile Trannoy Source Type: research
Long-Term Memory Dysfunction in Limbic Encephalitis
Niels Hansen1,2*
1Department of Epileptology, University of Bonn Medical Center, Bonn, Germany2Department of Psychiatry and Psychotherapy, University of Goettingen, Goettingen, Germany
Limbic encephalitis (LE) is an autoimmune disease defined by clinical criteria, such as seizures, psychiatric and in particular working memory abnormalities in conjunction with apparative criteria underlying structural or functional changes in the temporal lobe according to autoimmune encephalitis guidelines (1). Working memory encompasses a transient encoding of information in readiness for further processing within a time windo...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research
Blood anti-müllerian hormone is a possible determinant of recurrent early miscarriage, yet not conclusive in predicting a further miscarriage
ConclusionAn altered ovarian reserve is a possible determinant of unexplained recurrent early miscarriage. However, AMH blood level predicts neither the delay nor the outcome of a subsequent pregnancy. (Source: Reproductive BioMedicine Online)
Source: Reproductive BioMedicine Online - April 12, 2019 Category: Reproduction Medicine Source Type: research
Photons without bolus versus electrons with bolus after upfront mastectomy without immediate reconstruction in breast cancer patients
To evaluate locoregional control and outcome after mastectomy in patients treated by post-mastectomy highly conformal electron radiotherapy (PMERT) with bolus compared to patients treated by highly conformal photon radiotherapy (PMPhRT) without bolus. A total of 583 received PMERT and 224 received PMPhRT. No significant difference in overall survival was observed between the 2 groups. The risk of locoregional recurrence, was significantly higher with PMPhRT than with PMERT. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 25, 2019 Category: Radiology Authors: Geoffroy Boulle, Caroline Saint-Martin, Brigitte De La Lande, Fatima Laki, Nathalie Fournier Bidoz, Fr édérique Berger, Arnaud Veret, Christelle Bragard, Alain Fourquet, Youlia M. Kirova Tags: Clinical Investigation Source Type: research
Acts of life: Assessing entheseal change as an indicator of social differentiation in postmedieval Aalst (Belgium)
This study investigates this proposed link between EC as a physical activity marker and SES within one well‐defined temporo‐ geographic context. EC data from 16 entheses in three skeletal collections from the postmedieval town of Aalst, Belgium, were evaluated using the Coimbra method. The skeletal assemblages represent distinct socio‐economic groups, evidenced by historical and dietary isotope data. The Louis D'Haesele erstraat sample represents lower class individuals (n = 46), the Hopmarkt sample middle‐class individuals (n = 110), and the Saint Martin's church (n = 13) higher class individuals. EC data ar...
Source: International Journal of Osteoarchaeology - March 5, 2019 Category: Science Authors: Jessica L.A. Palmer,
Andrea L. Waters ‐Rist Tags: RESEARCH ARTICLE Source Type: research
[ASAP] Femtosecond Laser-Induced Crystallization in Glasses: Growth Dynamics for Orientable Nanostructure and Nanocrystallization
Crystal Growth& DesignDOI: 10.1021/acs.cgd.8b01802 (Source: Crystal Growth and Design)
Source: Crystal Growth and Design - February 28, 2019 Category: Chemistry Authors: Jing Cao, Matthieu Lancry, Fran çois Brisset, Léo Mazerolles, Romuald Saint-Martin, Bertrand Poumellec Source Type: research
Infantile Horner syndrome due to ectopic cervical thymus gland.
PMID: 30851785 [PubMed - in process] (Source: Canadian Journal of Ophthalmology)
Source: Canadian Journal of Ophthalmology - January 31, 2019 Category: Opthalmology Authors: Modabber M, Saint-Martin C, Khan A, Zakrzewski H, Toffoli D Tags: Can J Ophthalmol Source Type: research
[Retinal arterial variant: Report of 2 cases].
[Retinal arterial variant: Report of 2 cases].
J Fr Ophtalmol. 2019 Jan 21;:
Authors: Pipelart V, Bresson T, de Saint-Martin G
PMID: 30679120 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - January 28, 2019 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Acts of life: Assessing entheseal change as an indicator of social differentiation in post ‐medieval Aalst (Belgium)
This study investigates this proposed link between EC as a physical activity marker and socio‐economic status within one well‐ defined temporo‐geographic context. EC data from 16 entheses in three skeletal collections from the post‐medieval town of Aalst, Belgium, were evaluated using the Coimbra method. The skeletal assemblages represent distinct socio‐economic groups, evidenced by historical and dietary isotope data . The Louis D'haeseleerstraat sample represents lower class individuals (n=46), the Hopmarkt sample middle class individuals (n=110), and the Saint Martin's church (n=13) higher class individuals. E...
Source: International Journal of Osteoarchaeology - January 23, 2019 Category: Science Authors: Jessica L.A. Palmer,
Andrea L. Waters ‐Rist Tags: RESEARCH ARTICLE Source Type: research
Races, racism, and physical anthropology in Mexico.
Authors: Peña-Saint-Martin F, Vera-Cortés JL
Abstract
PMID: 30640721 [PubMed - as supplied by publisher] (Source: Journal of Anthropological Sciences)
Source: Journal of Anthropological Sciences - January 15, 2019 Category: Science Tags: J Anthropol Sci Source Type: research
Single crystal growth of BaZrO3 from the melt at 2700 °C using optical floating zone technique and growth prospects from BaB2O4 flux at 1350 °C
CrystEngComm, 2019, Advance Article DOI: 10.1039/C8CE01665H, PaperCong Xin, Philippe Veber, Mael Guennou, Constance Toulouse, Nathalie Valle, Monica Ciomaga Hatnean, Geetha Balakrishnan, Raphael Haumont, Romuald Saint Martin, Matias Velazquez, Alain Maillard, Daniel Rytz, Michael Josse, Mario Maglione, Jens Kreisel Growth of BaZrO3 crystals at 2700 °C in a mirror furnace and growth prospects at 1350 °C using BaB2O4 flux are reported. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - December 14, 2018 Category: Chemistry Authors: Cong Xin Source Type: research
Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma
Selinexor is an oral inhibitor of the nuclear export protein exportin 1. Preclinical studies demonstrated synergistic antimyeloma activity between selinexor and proteasome inhibitors (PI) through suppression of NF-B signaling and nuclear retention of tumor suppressor proteins. We tested selinexor in combination with low-dose bortezomib and dexamethasone (SVd) for the treatment of relapsed or refractory multiple myeloma (MM). The primary objectives of this study were to determine the safety profile, overall response rate (ORR), and a recommended phase 2 dose (RP2D) of SVd. We enrolled 42 patients to receive selinexor (60, 8...
Source: Blood - December 13, 2018 Category: Hematology Authors: Bahlis, N. J., Sutherland, H., White, D., Sebag, M., Lentzsch, S., Kotb, R., Venner, C. P., Gasparetto, C., Del Col, A., Neri, P., Reece, D., Kauffman, M., Shacham, S., Unger, T. J., Jeha, J., Saint-Martin, J.-R., Shah, J., Chen, C. Tags: Multiple Myeloma, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
