Feasibility and safety of sildenafil to repair brain injury secondary to birth asphyxia (SANE-01): A randomized, double-blind, placebo-controlled phase Ib clinical trial
To test feasibility and safety of administering sildenafil in neonates with neonatal encephalopathy (NE), developing brain injury despite therapeutic hypothermia (TH). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - December 21, 2023 Category: Pediatrics Authors: Pia Wintermark, Anie Lapointe, Robin Steinhorn, Emmanouil Rampakakis, J ürgen Burhenne, Andreas D. Meid, Gzona Bajraktari-Sylejmani, May Khairy, Gabriel Altit, Marie-Therese Adamo, Alishia Poccia, Guillaume Gilbert, Christine Saint-Martin, Daniela Toffol Tags: Original Articles Source Type: research
The impact of comorbidities and sociodemographic predictors on pneumococcal vaccination coverage in adults with coronary heart disease
Future Cardiology, Ahead of Print. (Source: Future Cardiology)
Source: Future Cardiology - December 19, 2023 Category: Cardiology Authors: Saint-Martin Allihien Sammudeen Ibrahim Favour Markson Walter Y Agyeman Setri Fugar Onoriode Kesiena Source Type: research
Real-life data comparing the efficacy of vigabatrin and oral steroids given sequentially or combined for infantile epileptic spasms syndrome
Eur J Paediatr Neurol. 2023 Nov 27;48:61-66. doi: 10.1016/j.ejpn.2023.11.009. Online ahead of print.ABSTRACTAIMS: The prognosis of Infantile epileptic spasm syndrome (IESS), relates to the underlying etiology and delay in controlling epileptic spasms. Based on the spasm-free rate, a randomized controlled trial has demonstrated the superiority of combining oral steroids and vigabatrin over oral steroids alone but confirmation in real-life conditions is mandatory.METHODS: We compared two real-life IESS cohorts: a multicenter, retrospective cohort of 40 infants treated with vigabatrin followed by a sequential (ST) addition of...
Source: European Journal of Paediatric Neurology - December 2, 2023 Category: Neurology Authors: Blandine Dozieres-Puyravel Hala Nasser Fran çois-Xavier Mauvais Anne De Saint Martin Caroline Perriard Chlo é Di Meglio Claude Cances Caroline Hachon-LE Camus Mathieu Milh St éphane Auvin Source Type: research
Real-life data comparing the efficacy of vigabatrin and oral steroids given sequentially or combined for infantile epileptic spasms syndrome
Eur J Paediatr Neurol. 2023 Nov 27;48:61-66. doi: 10.1016/j.ejpn.2023.11.009. Online ahead of print.ABSTRACTAIMS: The prognosis of Infantile epileptic spasm syndrome (IESS), relates to the underlying etiology and delay in controlling epileptic spasms. Based on the spasm-free rate, a randomized controlled trial has demonstrated the superiority of combining oral steroids and vigabatrin over oral steroids alone but confirmation in real-life conditions is mandatory.METHODS: We compared two real-life IESS cohorts: a multicenter, retrospective cohort of 40 infants treated with vigabatrin followed by a sequential (ST) addition of...
Source: European Journal of Paediatric Neurology - December 2, 2023 Category: Neurology Authors: Blandine Dozieres-Puyravel Hala Nasser Fran çois-Xavier Mauvais Anne De Saint Martin Caroline Perriard Chlo é Di Meglio Claude Cances Caroline Hachon-LE Camus Mathieu Milh St éphane Auvin Source Type: research
Mechanisms of type I interferon production by chicken TLR21
In this study, we focused on TLR21, an avian TLR that recognizes DNA motifs commonly found in bacterial genomic DNA, specifically unmethylated CpG motifs. TLR21 is believed to act as a functional homologue to mammalian TLR9. By analysing TLR21 signalling in chickens, we sought to elucidate avian TLR21 activation outputs in parallel to that of other nucleic acid species. Our analyses revealed that chicken TLR21 (chTLR21) triggers the activation of NF-κB and induces a potent type-I interferon response in chicken macrophages, similar to the signalling cascades observed in mammalian TLR9 activation. Notably, the transcription...
Source: Developmental and Comparative Immunology - November 11, 2023 Category: Allergy & Immunology Authors: Rodrigo Guabiraba Damaris Ribeiro Rodrigues Paul T Manna M élanie Chollot Vincent Saint-Martin Sascha Trapp Marisa Oliveira Clare E Bryant Brian J Ferguson Source Type: research
Congenital mirror movements are associated with defective polymerisation of RAD51
Conclusion
Our study demonstrates that RAD51 haploinsufficiency, including loss-of-function of non-truncating variants, results in CMM. The incomplete penetrance likely results from post-transcriptional compensation. Changes in RAD51 levels and/or polymerisation properties could influence guidance of the corticospinal axons during development. Our findings open up new perspectives to understand the role of RAD51 in neurodevelopment. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - October 24, 2023 Category: Genetics & Stem Cells Authors: Trouillard, O., Dupaigne, P., Dunoyer, M., Doulazmi, M., Herlin, M. K., Frismand, S., Riou, A., Legros, V., Chevreux, G., Veaute, X., Busso, D., Fouquet, C., Saint-Martin, C., Meneret, A., Trembleau, A., Dusart, I., Dubacq, C., Roze, E. Tags: Neurogenetics Source Type: research
Bilateral extensive sclerochoroidal calcifications
J Fr Ophtalmol. 2023 Oct 6:S0181-5512(23)00333-9. doi: 10.1016/j.jfo.2023.04.005. Online ahead of print.NO ABSTRACTPMID:37806936 | DOI:10.1016/j.jfo.2023.04.005 (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - October 8, 2023 Category: Opthalmology Authors: P-H Cazarre P Kantor F Varenne G de Saint-Martin P Fournie V Soler Source Type: research
Ruptured Internal Carotid Artery Mycotic Pseudoaneurysm as Sequela to a Retropharyngeal Abscess in an Immunocompetent Child
Ear Nose Throat J. 2023 Sep 13:1455613231198990. doi: 10.1177/01455613231198990. Online ahead of print.NO ABSTRACTPMID:37705374 | DOI:10.1177/01455613231198990 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 14, 2023 Category: ENT & OMF Authors: Catherine F Roy Christine Saint-Martin Marco Mascarella Elie Girsowicz Sam J Daniel Joshua Gurberg Melanie Duval Jeffrey C Yeung Source Type: research
Ruptured Internal Carotid Artery Mycotic Pseudoaneurysm as Sequela to a Retropharyngeal Abscess in an Immunocompetent Child
Ear Nose Throat J. 2023 Sep 13:1455613231198990. doi: 10.1177/01455613231198990. Online ahead of print.NO ABSTRACTPMID:37705374 | DOI:10.1177/01455613231198990 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - September 14, 2023 Category: ENT & OMF Authors: Catherine F Roy Christine Saint-Martin Marco Mascarella Elie Girsowicz Sam J Daniel Joshua Gurberg Melanie Duval Jeffrey C Yeung Source Type: research
