Response to a Letter to the Editor: Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart
J Physiol. 2024 Apr 22. doi: 10.1113/JP286650. Online ahead of print.NO ABSTRACTPMID:38648379 | DOI:10.1113/JP286650 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 22, 2024 Category: Physiology Authors: Ana ïs Saint-Martin Willer V éronique Capuano David Montani Fabrice Antigny Source Type: research
Comment on: 'Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart' by Saint-Martin Willer et al
J Physiol. 2024 Apr 12. doi: 10.1113/JP286611. Online ahead of print.NO ABSTRACTPMID:38607230 | DOI:10.1113/JP286611 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Merten Pr üser Felix Wiedmann Constanze Schmidt Source Type: research
Comment on: 'Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart' by Saint-Martin Willer et al
J Physiol. 2024 Apr 12. doi: 10.1113/JP286611. Online ahead of print.NO ABSTRACTPMID:38607230 | DOI:10.1113/JP286611 (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 12, 2024 Category: Physiology Authors: Merten Pr üser Felix Wiedmann Constanze Schmidt Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: Am J Respir Cell Mol... - March 28, 2024 Category: Respiratory Medicine Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: Mol Biol Cell - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: Am J Respir Cell Mol... - March 28, 2024 Category: Respiratory Medicine Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: Am J Respir Cell Mol... - March 28, 2024 Category: Respiratory Medicine Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: Am J Respir Cell Mol... - March 28, 2024 Category: Respiratory Medicine Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Role of KCNK3 Dysfunction in Dasatinib-associated PAH and Endothelial Cell Dysfunction
Am J Respir Cell Mol Biol. 2024 Mar 28. doi: 10.1165/rcmb.2023-0185OC. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is severe cardiopulmonary disease that may be triggered by exposure to drugs such as dasatinib or facilitated by genetic predispositions. The incidence of dasatinib-associated PAH is estimated at 0.45%, suggesting individual predispositions. The mechanisms of dasatinib-associated PAH are still incomplete. We discovered a KCNK3 gene (coding for outward K+ channel) variant in a patient with dasatinib-associated PAH, and we investigated the impact of this variant on KCNK3 function. Additio...
Source: American Journal of Respiratory Cell and Molecular Biology - March 28, 2024 Category: Molecular Biology Authors: H élène Le Ribeuz Ana ïs Saint-Martin Willer Benoit Chevalier Maria Sancho Bastien Masson M élanie Eyries Vincent Jung Ida Chiara Guerrera Mary Dutheil Kristelle El Jekmek Loann Laubry Gilles Carpentier Francisco Perez-Vizcaino Ly Tu Christophe Guigna Source Type: research
Drug-resistant generalized epilepsies: Revisiting the frontiers of idiopathic generalized epilepsies
Rev Neurol (Paris). 2024 Mar 19:S0035-3787(24)00471-5. doi: 10.1016/j.neurol.2024.03.001. Online ahead of print.ABSTRACTThe 2017 International League Against Epilepsy (ILAE) classification suggested that the term "genetic generalized epilepsies" (GGEs) should be used for the broad group of epilepsies with so-called "generalized" seizure types and "generalized" spike-wave activity on EEG, based on a presumed genetic etiology. Within this framework, idiopathic generalized epilepsies (IGEs) are described as a subset of GGEs and include only four epileptic syndromes: childhood absence epilepsy, juvenile absence epilepsy, juven...
Source: Revue Neurologique - March 20, 2024 Category: Neurology Authors: L Gauer S Baer M-P Valenti-Hirsch A De Saint-Martin E Hirsch Source Type: research
