Sint Maarten Health Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart
J Physiol. 2023 Jul 21. doi: 10.1113/JP284936. Online ahead of print.ABSTRACTPotassium channel subfamily K member 3 (KCNK3), encoded by the KCNK3 gene, is part of the two-pore domain potassium channel family, constitutively active at resting membrane potentials in excitable cells, including smooth muscle and cardiac cells. Several physiological and pharmacological mediators, such as intracellular signalling pathways, extracellular pH, hypoxia and anaesthetics, regulate KCNK3 channel function. Recent studies show that modulation of KCNK3 channel expression and function strongly influences pulmonary vascular cell and cardiom...
Source: The Journal of Physiology - July 21, 2023 Category: Physiology Authors: Ana ïs Saint-Martin Willer Joana Santos-Gomes Rui Ad ão Carmen Br ás-Silva M élanie Eyries Francisco P érez-Vizcaino V éronique Capuano David Montani Fabrice Antigny Source Type: research

Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - June 27, 2023 Category: Cytology Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research

Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research

Investigating genotype-to-phenotype correlation in CHARGE syndrome by deep phenotyping and multiparametric clustering
Clin Genet. 2023 May 26. doi: 10.1111/cge.14363. Online ahead of print.ABSTRACTCHARGE syndrome, due to CHD7 pathogenic variations, is an autosomal dominant disorder characterized by a large spectrum of severity. Despite the great number of variations reported, no clear genotype-to-phenotype correlation has been reported. Unsupervised machine learning and clustering was undertaken using a retrospective cohort of 42 patients, after deep radiologic and clinical phenotyping, to establish genotype-phenotype correlation for CHD7-related CHARGE syndrome. It resulted in three clusters showing phenotypes of different severities. Wh...
Source: Clinical Genetics - May 27, 2023 Category: Genetics & Stem Cells Authors: J érémy Dana Guillaume Dorval Christine Saint Martin Kahina Belhous Raphael Levy Sandrine Marlin Isabelle De Bie Manon Mautret-Godefroy Antonio Rausell Marl ène Rio Elise Boucher-Brischoux Tania Atti é-Bitach Nathalie Boddaert V éronique Pingault Source Type: research