Single crystal growth of BaZrO3 from the melt at 2700 °C using optical floating zone technique and growth prospects from BaB2O4 flux at half its melting temperature
We report the growth of BaZrO3 single crystals by the optical floating zone technique and the investigation on its flux growth using BaB2O4 as a solvent. 6-mm long colorless and... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - December 10, 2018 Category: Chemistry Authors: Cong Xin Source Type: research
[ASAP] Experimental and Theoretical Studies on the Implications of Halide-Dependent Aqueous Solvation of Sm(II)
Journal of the American Chemical SocietyDOI: 10.1021/jacs.8b09857 (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - November 26, 2018 Category: Chemistry Authors: Alejandro Ram írez-Solís, Caroline O. Bartulovich, Tesia V. Chciuk, Jorge Hernández-Cobos, Humberto Saint-Martin, Laurent Maron, William R. Anderson , Jr., Anna M. Li, Robert A. Flowers II Source Type: research
Results of the Pivotal STORM Study (Part 2) in Penta-Refractory Multiple Myeloma (MM): Deep and Durable Responses with Oral Selinexor Plus Low Dose Dexamethasone in Patients with Penta-Refractory MM
Conclusions: Results of the pivotal STORM Part 2 in penta (PI, IMiD, dara)-refractory MM demonstrated that oral selinexor plus low-dose dexamethasone (Sd) was highly active with an ORR of 26.2%. Importantly, responses were rapid and deep with 2 patients achieving sCRs (both MRD negative) in these heavily pre-treated penta-refractory MM pts (median 7 prior regimens, 53% high risk). AEs are a function of dose/schedule/disease severity and can be managed with dose modifications and supportive care. No major organ toxicity was observed and AEs were typically transient and reversible. Sd is an all-oral, first in class mechanism...
Source: Blood - November 21, 2018 Category: Hematology Authors: Chari, A., Vogl, D. T., Dimopoulos, M. A., Nooka, A. K., Huff, C. A., Moreau, P., Cole, C. E., Richter, J., Dingli, D., Vij, R., Tuchman, S. A., Raab, M. S., Weisel, K., Delforge, M., Kaminetzky, D., Cornell, R. F., Stewart, A. K., Hoffman, J., Godby, K. Tags: 653. Myeloma: Therapy, excluding Transplantation: Antibodies and Targeted Therapies Source Type: research
Deep and Durable Responses with Selinexor, Daratumumab, and Dexamethasome (SDd) in Patients with Multiple Myeloma (MM) Previously Exposed to Proteasome Inhibitors and Immunomodulatory Drugs: Results of Phase 1b Study of SDd
Conclusions - Selinexor 100 mg QW can be combined safely with dara (per approved dosing) and dex. The preliminary ORR of 74% with SDd in patients with PI/IMiD refractory MM who are dara naïve is promising and compares favorably to 21% ORR of Dara and Sd in quad refractory myeloma. This once weekly regimen is well tolerated with no major organ toxicities to date. Data from the full phase 1 dose expansion will be presented.DisclosuresGasparetto: Takeda: Honoraria; Bristol-Myers Squibb: Consultancy, Honoraria, Other: Travel; Janssen: Consultancy, Honoraria, Other: Travel; Celgene: Consultancy, Honoraria, Other: Travel, R...
Source: Blood - November 21, 2018 Category: Hematology Authors: Gasparetto, C. J., Lentzsch, S., Schiller, G. J., Bensinger, W., Bahlis, N., Sutherland, H. J., White, D. J., Sebag, M., Kotb, R., Venner, C. P., Leblanc, R., Chen, C. I., Del Col, A., Shah, J. J., Jeha, J., Saint-Martin, J.-R., Kauffman, M. G., Shacham, Tags: 653. Myeloma: Therapy, excluding Transplantation: Antibodies and Targeted Therapies Source Type: research
ATG2B/Gskip in De Novo Acute Myeloid Leukemia (AML): High Prevalence of Germline Predisposition in French West Indies and Potential Role of Overexpression in Acquired AML
In this study, we looked at the presence of this CNVdup14 in a cohort of Caribbean islands patients (pts) with non-secondary aggressive hematological malignancies (HM). We also studied the expression of ATG2B and GSKIP genes in a cohort of acquired AML pts.This is a retrospective multicenter study of adults Caribbean islands pts treated at Gustave Roussy Cancer Center (Villejuif, France) and at the French West Indian hospitals (Martinique and Guadeloupe) between May 2000 and May 2018. We included pts with AML, acute undifferentiated leukemia (AUL), acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LL). Pts wit...
Source: Blood - November 21, 2018 Category: Hematology Authors: Pegliasco, J., Panneau-Schmaltz, B., Martin, J.-E., Chraibi, S., Legoupil, C., Pasquier, F., Willekens, C., Bera, O., Caron, O., Bourhis, J.-H., Tang, R., Ben-Ali, A., Lopez, M., Cotteret, S., Saada, V., Auger, N., Delaunay, J., Cornillet-Lefebvre, P., Re Tags: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I Source Type: research
Single Agent Oral Selinexor Demonstrates Deep and Durable Responses in Relapsed/Refractory Diffuse Large B-Cell Lymphoma (DLBCL) in Both GCB and Non-GCB Subtypes: The Phase 2b Sadal Study
Conclusion: Single agent oral selinexor is active in pts with R/R DLBCL across both GCB and non-GCB subtypes. Responses were deep with CRs noted on therapy and durable, with some responses >24 months, consistent with significant clinical benefit. Importantly, response to therapy (≥PR) was associated with significant improvement in OS of 9.0 months vs 4.1 months for those with ≤SD. Enrollment completion is expected by September 2018. Full study results (N=130) will be presented, including longer follow up (DOR and OS) of pts from the original interim analysis. Pts enrolled in SADAL represent an unmet medical need p...
Source: Blood - November 21, 2018 Category: Hematology Authors: Maerevoet, M., Vermaat, J., Canales, M. A., Casasnovas, R.-O., Van Den Neste, E., Goy, A., Hill, B. T., Thieblemont, C., De La Cruz, M. D. F., Cavallo, F., Follows, G., Choquet, S., Gurion, R., Bouabdallah, R., Jaeger, U., Nagy, A., Kuruvilla, J., Warzoch Tags: 626. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)-Results from Prospective Clinical Trials: Poster I Source Type: research
Selinexor Plus Pomalidomide and Low Dose Dexamethasone (SPd) in Patients with Relapsed or Refractory Multiple Myeloma
Conclusions- Enrollment is ongoing to evaluate once weekly selinexor in combination with Pd , (SPd). This all-oral SPd combination has clinical activity with an ORR 55% in pom-naive pts with heavily pretreated MM compared to previously published data of 30% ORR for Pd alone. Similarly, the PFS on SPd is 10.3 months vs. <4 months for Pd alone. No unexpected adverse events were noted. Phase 1 dose escalation of the combination of SPd is ongoing to define the optimal RP2D.DisclosuresChen: Amgen: Honoraria. Sebag: Janssen Inc.: Membership on an entity's Board of Directors or advisory committees; Amgen Canada: Membership on ...
Source: Blood - November 21, 2018 Category: Hematology Authors: Chen, C. I., Sutherland, H. J., Kotb, R., Sebag, M., White, D. J., Bensinger, W., Gasparetto, C. J., Leblanc, R., Venner, C. P., Lentzsch, S., Schiller, G. J., Lipe, B., Del Col, A., Shah, J. J., Jeha, J., Saint-Martin, J.-R., Kauffman, M. G., Shacham, S. Tags: 653. Myeloma: Therapy, excluding Transplantation: Poster I Source Type: research
Initial forensic evaluation of Takotsubo syndrome and its causal relationship to a traumatic event.
PMID: 30442528 [PubMed - as supplied by publisher] (Source: Archives of Cardiovascular Diseases)
Source: Archives of Cardiovascular Diseases - November 12, 2018 Category: Cardiology Authors: Savall F, Hérin F, Rerolle C, Delmas C, Telmon N, Saint Martin P Tags: Arch Cardiovasc Dis Source Type: research
Background parenchymal enhancement and fibroglandular tissue on breast MRI in women with high genetic risk: are changes before and after risk-reducing salpingo-oophorectomy associated with breast cancer risk?
ConclusionPatients in whom BPE decreases after RRSO might be at higher risk of subsequent breast cancer compared to patients with stable BPE. This finding is consistent with the concept of increased risk associated with high initial BPE, which could be of higher clinical relevance than post-RRSO BPE reduction. A similar trend was observed with high initial FGT. (Source: European Journal of Radiology)
Source: European Journal of Radiology - November 3, 2018 Category: Radiology Source Type: research
Pathology diagnosis of an atypical thyroid cartilage lesion
We report the case of a decedent, whose body was found in an advanced stateof putrefaction, at the bottom of a ledge, after a one-month disappearance. The face and neck were skeletised. The autopsy found multiple traumatic injuries. The hyoid bone was separatedfrom the other laryngeal structures and seemed to be macroscopically normal. However, the thyroid cartilage had a thin notch at the base of the right upper horn. (Source: Legal Medicine)
Source: Legal Medicine - October 19, 2018 Category: Forensic Medicine Authors: A. Delbreil, A. Gambier, T. Lefrancq, M. Taris, P. Saint-Martin, M. Sapanet Source Type: research
Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.
Abstract
Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). Belonging to the well-known neurexin superfamily, CASPR2 has been suggested to be a central node in the molecular networks controlling neurodevelopment. Distinct from other subfamilies in the neurexin superfamily, the CASPR subfamily features a unique discoidin (Disc) domain. As revealed by our and others' recent studies, CASPR2 Disc domain bears a major epitope for autoantibodies. However, structural information on CASPR2 recognition by autoant...
Source: Journal of Autoimmunity - October 15, 2018 Category: Allergy & Immunology Authors: Liang W, Zhang J, Saint-Martin M, Xu F, Noraz N, Liu J, Honnorat J, Liu H Tags: J Autoimmun Source Type: research
Chikungunya virus outbreak in Sint Maarten: Long-term arthralgia after a 15-month period.
The objective of this study was to describe the presence of persisting clinical manifestations, specifically arthralgia, in CHIKV-infected patients on the Caribbean Island, Sint Maarten, 15 months after onset of the disease.
Methods: This retrospective cohort study included confirmed CHIK patients that were recorded by the participating general practitioners (GPs) during the chikungunya outbreak in 2014 in Sint Maarten. Between March and July 2015, 15 months after the onset of disease, patients were interviewed via telephone about the presence, duration and impact of clinical CHIKV manifestations.
Results: ...
Source: Journal of Vector Borne Diseases - October 4, 2018 Category: Infectious Diseases Tags: J Vector Borne Dis Source Type: research
No detection of Zika virus infection in asymptomatic Dutch military personnel after deployment in high endemic areas (Belize, Curacao, Saint Martin) from December 2016 to December 2017
Dear Editor, at the start of the Zika outbreak we reported on imported infections in Dutch travellers [1]. Since late 2015, a large outbreak of Zika virus disease has spread across South and Central America. Concurrently, strong evidence has emerged that the virus, which usually only causes mild disease in adults, is the cause of various degrees of fetal developmental disorders, which was dramatically illustrated by an unusual number of microcephaly cases among newborns in Brazil. An important and unanswered question to date is the actual risk of sexual transmission from (symptomatic or asymptomatic) males returning from Z...
Source: Travel Medicine and Infectious Disease - September 20, 2018 Category: Infectious Diseases Authors: Cornelis A. De Pijper, Martin P. Grobusch, Abraham Goorhuis, Cornelis Stijnis, Gerrit Koen, Janke Schinkel Source Type: research
An ophthalmologic complication of Whipple's disease: Case report.
Authors: de Saint-Martin G, Urbanski G, Beucher AB, Ebran JM
PMID: 30213606 [PubMed - as supplied by publisher] (Source: Journal Francais d Ophtalmologie)
Source: Journal Francais d Ophtalmologie - September 16, 2018 Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Cervical instability in patients with Trisomy 21: The eternal gamble.
Abstract
Patients with Trisomy 21 are particularly at risk of cervical instability due to ligamentous laxity and osseous abnormalities. Up to 30% of Trisomy 21 patients are affected by atlanto-axial or atlanto-occipital instability, but only 1%-2% of cases are symptomatic. The radiologic assessment of cervical instability is not unanimously considered mandatory. The dynamic cervical spine radiograph is the most common screening tool for ruling out cervical spine instability in patients with Trisomy 21, and it is often requested before surgery. Several measurements have been investigated to assess the prese...
Source: Paediatric Anaesthesia - September 12, 2018 Category: Anesthesiology Authors: Bertolizio G, Saint-Martin C, Ingelmo P Tags: Paediatr Anaesth Source Type: research
