Circulating Complement C3-Alpha Chain Levels Predict Survival of Septic Shock Patients
Circulating complement C3 fragments released during septic shock might contribute to the development of complications such as profound hypotension and disseminated intravascular coagulation. The role of C3 in the course of septic shock varies in the literature, possibly because circulating C3 exists in different forms indistinguishable via traditional ELISA-based methods. We sought to test the relationship between C3 forms, measured by Western blotting with its associated protein size differentiation feature, and clinical outcomes. Circulating C3-alpha chain levels is a significant independent predictor of survival in sept...
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news
Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies
A major new study of intensive care unit (ICU) patients with septic shock failed to find a benefit of giving an intravenous cocktail of vitamin C, hydrocortisone and thiamine, relative to hydrocortisone alone.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 22, 2020 Category: Intensive Care Tags: Critical Care News Source Type: news
Vitamin C-B1-steroid combo linked to lower septic shock mortality in kids
(Ann& Robert H. Lurie Children's Hospital of Chicago) Treating septic shock in children with a combination of intravenous vitamin C, vitamin B1 and hydrocortisone (a commonly used steroid) is associated with lower mortality, according to a study from Ann& Robert H. Lurie Children's Hospital of Chicago. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 21, 2020 Category: International Medicine & Public Health Source Type: news
North Carolina cheerleader, 15, dies of flu and septic shock
Lacie Rian Fisher, 15, of Pisgah, North Carolina, died on December 30 after she contracted influenza B, responsible for most pediatric flu deaths this season, which sent her into septic shock. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2020 Category: Consumer Health News Source Type: news
VITAMINS trial report on vitamin C, hydrocortisone, thiamine for septic shock
(JAMA Network) In this randomized clinical trial of about 200 patients with septic shock, combination treatment with intravenous vitamin C, hydrocortisone and thiamine compared with intravenous hydrocortisone alone didn't significantly improve the amount of time patients were alive and free of medicines that raise blood pressure (vasopressors) over seven days. The study findings are being released to coincide with presentation at the Critical Care Reviews Meeting 2020 in Belfast, Northern Ireland. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 17, 2020 Category: International Medicine & Public Health Source Type: news
New York boy, 11, dies from the flu after the virus attacked his heart
Luca Calanni, 11, of Hamburg, New York, passed away from the flu on Saturday after the virus attacked his heart while he was being treated for septic shock and he suffered cardiac arrest. (Source: the Mail online | Health)
Source: the Mail online | Health - January 14, 2020 Category: Consumer Health News Source Type: news
Septic Shock
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 10, 2020 Category: General Medicine Source Type: news
Cost-effectiveness of second-line vasopressors for the treatment of septic shock.
We determine the cost-effectiveness of escalating doses of norepinephrine or norepinephrine plus the adjunctive use of vasopressin or angiotensin II as a second-line vasopressor for septic shock. Vasopressin is the most cost-effective second-line vasopressor in both the short- and long-term evaluations. Vasopressor price is a minor contributor to overall cost. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news
Machine learning for prediction of septic shock at initial triage in emergency department.
We hypothesized utilizing machine learning (ML) algorithms for screening septic shock in ED would provide better accuracy than qSOFA or MEWS. ML classifiers significantly outperforms clinical scores in screening septic shock at ED triage. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news
Gender differences in mortality and quality of life after septic shock: A post-hoc analysis of the ARISE study.
We assess the impact of gender and pre-menopausal state on short- and long-term outcomes in patients with septic shock. This post-hoc analysis of a large multi-center trial in early septic shock has shown no short- or long-term survival effect for women overall as well as in the pre-menopausal age-group. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news
Prognosis of β-adrenergic blockade therapy on septic shock and sepsis: A systematic review and meta-analysis of randomized controlled studies.
β-adrenoceptor antagonist (β-blocker) may have potential in the treatment of septic shock and sepsis. However, the relevant research findings are still controversial. β-blocker of esmolol is safe and effective in improving 28-day mortality and controlling ventricular rate in patients with sepsis after fluid resuscitation, and has no significant adverse effect on tissue perfusion. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news
Epidemiology of intra-abdominal infection and sepsis in critically ill patients: " AbSeS " , a multinational observational cohort study and ESICM Trials Group Project
We describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression...
Source: Current Awareness Service for Health (CASH) - November 28, 2019 Category: Consumer Health News Source Type: news
Sepsis: Precision-Based Medicine for Pregnancy and the Puerperium
Sepsis contributes significantly to global morbidity and mortality, particularly in vulnerable populations. Pregnant and recently pregnant women are particularly prone to rapid progression to sepsis and septic shock, with 11% of maternal deaths worldwide being attributed to sepsis. The impact on the neonate is considerable, with 1 million neonatal deaths annually attributed to maternal infection or sepsis. Pregnancy specific physiological and immunological adaptations are likely to contribute to a greater impact of infection, but current approaches to the management of sepsis are based on those developed for the non-pregna...
Source: Current Awareness Service for Health (CASH) - November 28, 2019 Category: Consumer Health News Source Type: news
Every 15 Minutes, Someone In The US Dies Of A Drug-Resistant Superbug
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention.
That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report.
The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance.
Genetic research shows germs have become especially adep...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 16, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Featured Health Antibiotics Bacteria CNN Superbugs Source Type: news
Antibiotic-Resistant ‘ Superbugs ’ A Growing Health Crisis, New Report Finds
By Elizabeth Cohen and Nadia Kounang, CNN
(CNN) — Every 15 minutes, someone in the United States dies of a superbug that has learned to outsmart even our most sophisticated antibiotics, according to a new report from the US Centers for Disease Control and Prevention.
That’s about 35,000 deaths each year from drug-resistant infections, according to the landmark report.
The report places five drug-resistant superbugs on the CDC’s “urgent threat” list — two more germs than were on the CDC’s list in 2013, the last time the agency issued a report on antibiotic resistance.
Genetic rese...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston Antibiotics CNN Source Type: news
