IV Vitamin C Fares Poorly in Latest Septic Shock Trial IV Vitamin C Fares Poorly in Latest Septic Shock Trial
The findings of a randomized, placebo-controlled trial of 963 patients throw into doubt the use of vitamin C for people with sepsis. In organ dysfunction, the treatment did worse than placebo.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - June 23, 2022 Category: Surgery Tags: Critical Care News Source Type: news

When Giving IV Fluids in Septic Shock Cases, Less Is Not More When Giving IV Fluids in Septic Shock Cases, Less Is Not More
Restricting intravenous fluids in ICU patients with septic shock does not lower the 90-day death rate, a large European study of 1554 adults concludes.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - June 21, 2022 Category: Intensive Care Tags: Critical Care News Source Type: news

No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock
Rates of death at 90 days, SAEs did not differ for patients with septic shock receiving restricted versus standard IV fluid therapy in the ICU (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 17, 2022 Category: Cancer & Oncology Tags: Infections, Nursing, Oncology, Critical Care, Conference News, Source Type: news

No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock
FRIDAY, June 17, 2022 -- For adults in the intensive care unit (ICU) with septic shock, intravenous fluid restriction does not result in fewer deaths at 90 days than standard intravenous fluid therapy, according to a study published online June 17... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 17, 2022 Category: Pharmaceuticals Source Type: news

Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR Br
The development of a shared data infrastructure across health systems could improve research, clinical care, and health policy across a spectrum of diseases, including sepsis. Awareness of the potential value of such infrastructure has been heightened by COVID-19, as the lack of a real-time, interoperable data network impaired disease identification, mitigation, and eradication. The Sepsis on FHIR collaboration establishes a dynamic, federated, and interoperable system of sepsis data from 55 hospitals using 2 distinct inpatient electronic health record systems. Here we report on phase 1, a systematic review to identify cli...
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news

Sepsis and the microcirculation: the impact on outcomes
Purpose of review: Advances in the treatment of septic shock have historically focused on resuscitation endpoints, mainly mean arterial pressure and cardiac output. As the definitions of sepsis and septic shock have shifted to focus on the diversity of causes of dysregulated host-response we have seen an emerging phenotype where tissue hypoxia persists despite adequate macrocirculatory parameters. Interest in the topic of microcirculation is re-emerging as validated bedside techniques for hemodynamic monitoring, such as video microscopes, are becoming available. We review the current understanding of how sepsis induced hyp...
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news

Methods for Phenotyping Adult Patients in Sepsis and Septic Shock: A Scoping Review L
Despite its heterogeneous phenotypes, sepsis or life-threatening dysfunction in response to infection is often treated empirically. Identifying patient subgroups with unique pathophysiology and treatment response is critical to the advancement of sepsis care. However, phenotyping methods and results are as heterogeneous as the disease itself. This scoping review evaluates the prognostic capabilities and treatment implications of adult sepsis and septic shock phenotyping methods. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news

Outcomes of CMS-mandated fluid administration among fluid-overloaded patients with sepsis: A systematic review and meta-analysis
The outcomes of large-volume IVF administration to septic shock patients with comorbid congestive heart failure (CHF) and/or end-stage renal disease (ESRD) are uncertain and widely debated in the existing literature. Despite this uncertainty, CMS continues to recommend that 30 ml/kg of an intravenous crystalloid solution be administered to patients in septic shock starting within 3 h of presentation. We performed a systematic review and meta-analysis to assess the relationship between adherence to this guideline and outcomes among patients whose underlying comorbidities present a risk of fluid overload. (Source: Current Aw...
Source: Current Awareness Service for Health (CASH) - June 10, 2022 Category: Consumer Health News Source Type: news

Evaluating Vitamin C in Septic Shock Evaluating Vitamin C in Septic Shock
IV vitamin C administration has been investigated as a possible treatment strategy for septic shock in the ICU, but how effective is it?Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

Impact of extended emergency department stay on antibiotic re-dosing delays and outcomes in sepsis
For patients with sepsis and septic shock, the initial administration of antibiotics should occur as soon as possible, preferably within one hour of sepsis recognition. While clinicians are focused on providing first-doses of antibiotics quickly upon presentation, re-dosing issues may arise in patients who have an extended emergency department (ED) length of stay (LOS). Limited studies have been conducted that assess the impact of re-dosing delays. The purpose of this study was to assess the association of an extended ED LOS ≥ 6 h with antibiotic re-dosing delays in patients with sepsis and examine outcomes.; Methods: A ...
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news

Early Lactate-Guided Resuscitation of Elderly Septic Patients
Early lactate-guided resuscitation was endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease the mortality of patients admitted to the ICU department with septic shock. However, its effectiveness in elderly Asian patients is uncertain.; : For critically ill patients (elderly Asian patients) admitted to the ICU department with hyperlactatemia, early lactate-guided treatment reduced ICU needs but did not reduce mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news

An international survey of adherence to Surviving Sepsis Campaign Guidelines 2016 regarding fluid resuscitation and vasopressors in the initial management of septic shock
Our survey aimed to evaluate adherence to Surviving Sepsis Campaign (SSC) Guidelines 2016 among intensive care practitioners and to identify issues that remain controversial or lack clarity.; Methods: Members of the European Society of Intensive Care Medicine (ESICM) were surveyed using an anonymous web-based survey written by an international group of experts. The primary outcome measure was the rate of adherence to specific recommendations. Secondary outcomes were to describe areas of controversy and lack of data and to associate specific practices with clinician characteristics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news

Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials
Fluid therapy plays a major role in the management of critically ill patients. Yet assessment of intravascular volume in these patients is challenging. Different invasive and non-invasive methods have been used with variable results. The passive leg raise (PLR) maneuver has been recommended by international guidelines as a means to determine appropriate fluid resuscitation. We performed this systematic review and meta-analysis to determine if using this method of volume assessment has an impact on mortality outcome in patients with septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news

Muhammad Ali: Boxing legend died from 'extreme' septic shock - condition explained
MUHAMMAD ALI is widely recognised as one of the most significant and celebrated heavyweight boxers of all time. Named the Sports Personality of the Century back in 1999, news of Ali's death in 2016 shocked and saddened the world. The sportsman died at the age of 74, from septic shock - a life-threatening condition that happens when your blood pressure drops to a dangerously low level following an infection. (Source: Daily Express - Health)
Source: Daily Express - Health - April 4, 2022 Category: Consumer Health News Source Type: news

Initial Fluid Balance Associated Outcomes in Children With Severe Sepsis and Septic Shock.
This study aimed to clarify the possible association of initial 24 hours ' fluid balance with poor outcomes in pediatric patients with sepsis. Methods: Retrospective data analysis included pediatric patients admitted with suspected or proven sepsis or septic shock to pediatric intensive care unit (PICU) of a tertiary care teaching hospital in Saudi Arabia. Results: The study included 47 patients; 13 (28%) died, and mortality rate was significant in children with neurologic failure (P (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 14, 2022 Category: Consumer Health News Source Type: news