Methylene Blue Adds Value in Treating Septic Shock Methylene Blue Adds Value in Treating Septic Shock
Intravenous methylene blue significantly shortened time to shock reversal in patients within 24 hours of septic shock.Medscape Medical News (Source: Medscape Emergency Medicine Headlines)
Source: Medscape Emergency Medicine Headlines - February 15, 2023 Category: Emergency Medicine Tags: Critical Care News Source Type: news
Defining Posttraumatic Sepsis for Population-Level Research
Key PointsQuestion: Do existing administrative data methods commonly used for quality and research purposes adequately capture sepsis events in critically ill patients with traumatic injury?
Findings: In this cohort study that included 3194 adults, using automated clinical database (Third International Consensus Definitions for Sepsis and Septic Shock [Sepsis-3]) criteria identified significantly more cases of sepsis, with worse morbidity outcomes, compared with using the National Trauma Data Bank and administrative coding methods.
Meaning: The results of this study suggest that administrative classification methods mis...
Source: Current Awareness Service for Health (CASH) - February 9, 2023 Category: Consumer Health News Source Type: news
SGLT2 Inhibitors and the Risk of Pneumonia and Septic Shock SGLT2 Inhibitors and the Risk of Pneumonia and Septic Shock
SGLT2 inhibitors are commonly used in the treatment of type 2 diabetes. Could these agents also help lower the risk of pneumonia and septic shock in these patients?Journal of Clinical Endocrinology & Metabolism (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 1, 2023 Category: Consumer Health News Tags: Diabetes & Endocrinology Journal Article Source Type: news
Citrobacter freundii induces sepsis with new-onset status seizure in an adult: A case report and literature review. [Review]
RATIONALE: Sepsis with brain abscess induced by Citrobacter freundii in adults has rarely been reported and is extremely pathogenic with a high mortality rate. Early diagnosis of the infection still remains challenging. PATIENT CONCERNS: A 27-year-old woman was transferred to our emergency department for fever, status seizure and refractory hypotension. Administration of midazolam, propofol and sodium valproate could not attenuate the seizure except for the addition of vecuronium. The blood white blood cell count was 42.91 (109/L) with 80% neutrophils, and procalcitonin was 22.46ng/mL. DIAGNOSES: Both deoxyribonucleic acid...
Source: Current Awareness Service for Health (CASH) - January 26, 2023 Category: Consumer Health News Source Type: news
For Septic Shock, Another Toss-up Between Emphasizing Vasopressors Vs Fluids
(MedPage Today) -- SAN FRANCISCO -- For sepsis-induced hypotension, a restrictive fluid strategy with earlier vasopressor use didn't impact mortality compared with liberal fluids, the CLOVERS trial showed.
The restrictive strategy had its intended... (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - January 22, 2023 Category: Cardiology Source Type: news
Esophageal perforation and septic shock after accidental coin ingestion in elderly person - Ishizuka Y, Nishiori H, Matsumura Y.
An 88-year-old man ingested coins accidentally and developed mediastinitis and septic shock. Esophageal injuries by sharped-shape foreign bodies are often reported, but esophageal perforation by round coins is rare. Even rounded-shape foreign bodies that a... (Source: SafetyLit)
Source: SafetyLit - December 26, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Evidence-based updates to the 2021 Surviving Sepsis Campaign guidelines Part 2
This article, second in a 2-part series, presents evidence updates and discusses implications for NPs. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 13, 2022 Category: Consumer Health News Source Type: news
Sepsis Performance Improvement Programs: From Evidence Toward Clinical Implementation
Since its launch in the early 2000s, the international Surviving Sepsis Campaign (SSC) has provided guidelines for the management of sepsis, most recently updated in 2021. The SSC aims to provide a standard of care for sepsis while increasing awareness among healthcare professionals and the general public. The goal is to reduce morbidity and mortality from sepsis and septic shock worldwide Sepsis performance improvement programs can optimize compliance to sepsis care protocols, which have been associated with improved patient outcomes in various studies. These programs should ideally combine screening tools, process change...
Source: Current Awareness Service for Health (CASH) - December 13, 2022 Category: Consumer Health News Source Type: news
Outcomes in hospitalised patients with sepsis, severe sepsis or septic shock and reported penicillin allergy: a retrospective cohort study.
Objective To determine outcomes in hospitalised patients with sepsis and reported penicillin allergy (PcnA). Design Observational retrospective cohort study using data from electronic health records. Setting A large single health system with 11 hospitals of small, medium and large sizes including a 630-bed tertiary care teaching hospital. Participants Patients (n=5238) ≥18 years of age, hospitalised with sepsis, severe sepsis or septic shock between 1 January 2016 and 31 December 2018, received antibacterial agents, and had documented PcnA status. Patients (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - December 13, 2022 Category: Consumer Health News Source Type: news
Septic shock prediction and knowledge discovery through temporal pattern mining
Sepsis is the body ' s adverse response to infection which can lead to septic shock and eventually death if not treated in a timely manner. Analyzing patterns in sepsis patients ' health status over time can help predict septic shock before its onset allowing healthcare providers to be more proactive. Temporal pattern mining methods can be used to identify trends in a patient ' s health status over time. If these methods return too many patterns, however, this can hinder knowledge discovery and practical implementation at the bedside in acute care settings. We propose a framework to find a small number of relevant temporal...
Source: Current Awareness Service for Health (CASH) - November 2, 2022 Category: Consumer Health News Source Type: news
Evaluation of the effectiveness of an automated sepsis predictive tool on patient outcomes
Conclusions: The intervention to facilitate timely sepsis care did not improve patient outcomes among those with severe sepsis or septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - November 2, 2022 Category: Consumer Health News Source Type: news
Hydrocortisone, Vitamin C, and Thiamine in Septic Shock Hydrocortisone, Vitamin C, and Thiamine in Septic Shock
Does this early combination therapy prove to be a safe and effective treatment option for septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news
Melatonin: A window into the organ-protective effects of sepsis.
Sepsis is an uncontrolled host response to infection. In some cases, it progresses to multi-organ insufficiency, leading to septic shock and increased risk of mortality. Various organ support strategies are currently applied clinically, but they are still inadequate in terms of reducing mortality. Melatonin is a hormone that regulates sleep and wakefulness, and it is associated with a reduced risk of death in patients with sepsis. Evidence suggests that melatonin may help protect organ function from sepsis-related damage. Here, we review information related to the role of melatonin in protecting organ function during sepsi...
Source: Current Awareness Service for Health (CASH) - October 7, 2022 Category: Consumer Health News Source Type: news
Hospital outcomes for patients with pulmonary arterial hypertension in sepsis and septic shock.
Background: Pulmonary arterial hypertension (PAH) is associated with increased morbidity and mortality risk. The risk for adverse outcomes in patients with PAH in sepsis or septic shock (SSS) is uncertain.
Methods: Adult patients diagnosed with SSS were identified in the National Readmissions Database over the years 2016-2017. A 2:1 ratio nearest propensity matching method was employed for several demographic, social, and clinical variables. In-hospital outcomes were compared between patients with PAH and those without, using t-test and chi-squared test as appropriate. Patients with cardiogenic shock were excluded. Releva...
Source: Current Awareness Service for Health (CASH) - October 7, 2022 Category: Consumer Health News Source Type: news
Red blood cell distribution width as prognostic factor in sepsis: A new use for a classical parameter
Purpose: To evaluate Red blood cell distribution width (RDW) as a sepsis prognostic biomarker.
Methods: 203 septic patients admitted to the ICU. Analysis of RDW dynamics, hospital mortality discrimination ability and the added value when incorporated to the SOFA, LODS, SAPS-II and APACHE-II scores using the AUC-ROC.
Results: Non-survivors presented higher RDW values during the first week after ICU admission (p = 0.048). Only SOFA and RDW were independently associated with mortality when adjusted by Charlson, immunosuppression, nosocomial infection, NEWS2, SAPS-II, septic shock and haemoglobin (p (Source: Current Awarenes...
Source: Current Awareness Service for Health (CASH) - September 30, 2022 Category: Consumer Health News Source Type: news
