Pediatric sepsis survival in pediatric and general emergency departments
Conclusions: In a nationally representative sample, pediatric mortality from severe sepsis or septic shock was lower in pediatric EDs than in general EDs. Identifying features of pediatric ED care associated with improved sepsis mortality could translate into improved survival for children wherever they present with sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Biomarkers for sepsis: more than just fever and leukocytosis-a narrative review
A biomarker describes a measurable indicator of a patient ' s clinical condition that can be measured accurately and reproducibly. Biomarkers offer utility for diagnosis, prognosis, early disease recognition, risk stratification, appropriate treatment (theranostics), and trial enrichment for patients with sepsis or suspected sepsis. In this narrative review, we aim to answer the question, " Do biomarkers in patients with sepsis or septic shock predict mortality, multiple organ dysfunction syndrome (MODS), or organ dysfunction? " We also discuss the role of pro- and anti-inflammatory biomarkers and biomarkers associated wit...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
Conclusion: Timely administration of antibiotics improved outcomes in patients with septic shock; however, the association between early antibiotic administration and outcome was not as clear in patients with sepsis without shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Implementation and evaluation of sepsis surveillance and decision support in medical ICU and emergency department
Conclusions: A sepsis surveillance system incorporating decision support or completion feedback was not associated with improved sepsis care and patient outcomes. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality
Background: Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, although there are indications that it may improve outcomes. It has been proven that high partial pressure of oxygen in arterial blood (PaO 2 ) reduces the rate of surgical-wound infections and mortality in patients under major surgery. The aim of this study is to examine whether PaO 2 is associated with risk of death in adult patients with sepsis/septic shock after major surgery.; Methods: We performed a...
Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news
Septic Shock Linked to Mortality in Hematologic Malignancies
Mortality rate increases with increasing sequential organ failure assessment score on admission, respiratory failure, maximum lactate level (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - January 26, 2022 Category: Cancer & Oncology Tags: Infections, Nursing, Oncology, Critical Care, Emergency Medicine, Journal, Source Type: news
Septic Shock Linked to Mortality in Hematologic Malignancies
WEDNESDAY, Jan. 26, 2022 -- For patients with hematologic malignancies, septic shock is associated with high mortality rates and poor 90-day survival, according to a study published in the January issue of the Journal of the National Comprehensive... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 26, 2022 Category: Pharmaceuticals Source Type: news
Evaluating Vitamin C in Septic Shock
RCT (n=124) found vitamin C monotherapy (1000mg bolus followed by continuous infusion 250 mg/hr for 96 hours) failed to significantly reduce mortality (all-cause 28-day mortality: 26.7% vitamin C vs. 40.6% placebo; p=0.10), not supporting routine clinical use for this purpose. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 14, 2022 Category: Consumer Health News Source Type: news
Beyond the bundle: Clinical controversies in the management of sepsis in emergency medicine patients
Sepsis is a condition characterized by life-threatening organ dysfunction caused by a dysregulated host response to infection. The emergency department (ED) serves as a crucial entry point for patients presenting with sepsis. Given the heterogeneous presentation and high mortality rate associated with sepsis and septic shock, several clinical controversies have emerged in the management of sepsis. These include the use of novel therapeutic agents like angiotensin II, hydrocortisone, ascorbic acid, thiamine ( " HAT " ) therapy, and levosimendan, Additionally, controversies with current treatments in vasopressor dosing, and ...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news
Blood purification in sepsis and systemic inflammation
Purpose of Review: Sepsis and septic shock are life-threatening diseases with high mortality. Although efforts have made to improve the survivals, the outcomes are still frustrating. Blood purification was thought to be a promising adjunctive therapy to regulate the excessive cytokine storm or to reduce the endotoxin activity caused by sepsis. Critically ill COVID-19 characterized with the similar disease to sepsis may also benefit from blood purification.
Recent Findings: The recent studies mainly focused on hemadsorption materials. The results of the clinical trials showed a tendency in decrease of cytokine levels and e...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news
The Effect of Body Mass Index and Weight-Adjusted Fluid Dosing on Mortality in Sepsis.
Conclusions: An exponential, dose-effect increase in mortality w as observed for underweight patients not receiving 30by3. Therefore, the mortality impact of under-dosing may be amplified using ABW for underweight patients. Fluid dosing did not impact mortality for obese patients, but we caution against deviation from guidelines without further studies. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news
Sepsis Definitions: I Know It When I See It*
Over the past 3 –4 decades, efforts have been made to define sepsis, severe sepsis, and septic shock more objectively. For purposes of this editorial, “sepsis” will include the full spectrum of sepsis, severe sepsis, and septic shock. Why is sepsis so difficult to define? There are many signs, symptoms, and l aboratory abnormalities that commonly occur in patients with sepsis, but there is not a single “gold standard” definition or criterion that clinicians can all agree on and that facilitates the prompt recognition of the syndrome. The manifestations of sepsis are highly variable, and an infecting organism is n...
Source: Current Awareness Service for Health (CASH) - January 11, 2022 Category: Consumer Health News Source Type: news
Blood purification in sepsis and systemic inflammation
Purpose of Review: Sepsis and septic shock are life-threatening diseases with high mortality. Although efforts have made to improve the survivals, the outcomes are still frustrating. Blood purification was thought to be a promising adjunctive therapy to regulate the excessive cytokine storm or to reduce the endotoxin activity caused by sepsis. Critically ill COVID-19 characterized with the similar disease to sepsis may also benefit from blood purification.
Recent Findings: The recent studies mainly focused on hemadsorption materials. The results of the clinical trials showed a tendency in decrease of cytokine levels and e...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news
Effect of Undertriage on the Outcomes of Cancer Patients with Febrile Neutropenia, Sepsis, and Septic Shock
The objective was to study whether patients with neutropenia, sepsis, and septic shock were identified appropriately at triage and receive timely treatment within the emergency setting. Also, we investigated the effect of undertriage on key treatment outcomes. We conducted a retrospective analysis of all accessible records of admitted adult cancer patients with febrile neutropenia, sepsis, and septic shock. Our results identified that the majority of patients were inappropriately triaged to less urgent triage categories. Patients ' undertriage significantly prolonged multiple emergency timeliness indicators and extended le...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news
Macrocirculatory and Microcirculatory Endpoints in Sepsis Resuscitation
Sepsis is a common disease process encountered by physicians. Sepsis can lead to septic shock, which carries a hospital mortality rate in excess of 40%. Although the Surviving Sepsis Guidelines recommend targeting a mean arterial pressure (MAP) of 65 mmHg and normalization of lactate, these endpoints do not necessarily result in tissue perfusion in states of shock. While MAP and lactate are commonly used markers in resuscitation, clinicians may be able to improve their resuscitation by broadening their assessment of the microcirculation, which more adequately reflects tissue perfusion. As such, in order to achieve a succes...
Source: Current Awareness Service for Health (CASH) - December 8, 2021 Category: Consumer Health News Source Type: news
