High-Dose IV Vitamin C Does Not Speed Resolution of Septic Shock
FRIDAY, Jan. 24, 2020 -- Treatment with intravenous vitamin C, hydrocortisone, and thiamine does not improve the duration of time alive and vasopressor administration-free compared with intravenous hydrocortisone alone among patients with septic... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 24, 2020 Category: Pharmaceuticals Source Type: news

Rescue stem cell allograft in intensive care unit patients during septic shock with multi-organ failure
We describe what we believe to be the first two cases of patients who received an allograft in intensive care unit (ICU) despite severe septic shock with multi-organ failure (MOF). Allograft should be considered as a rescue therapy in ICU for patients with aplasia, during septic shock with multi-organ failure, however close multidisciplinary discussion is required between intensivists and onco-hematologists. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

From a pressure-guided to a perfusion-centered resuscitation strategy in septic shock: Critical literature review and illustrative case
We support a paradigm shift in the management of septic shock from pressure-guided to perfusion-centered, expected to improve outcome while reducing adverse effects from vasopressor therapy and aggressive fluid resuscitation. We propose focusing the hemodynamic management of septic shock on reversing organ hypoperfusion instead of attaining a predefined MAP target as the key strategy for improving outcome. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

Fluid resuscitation in patients with end-stage renal disease on hemodialysis presenting with severe sepsis or septic shock: A case control study
Due to the potential risk of volume overload, physicians are hesitant to aggressively fluid-resuscitate septic patients with end-stage renal disease (ESRD) on hemodialysis (HD). Our study indicates that aggressive fluid resuscitation appears to be safe in ESRD patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

Endotoxin Removal in Septic Shock with the Alteco ® LPS Adsorber was Safe But Showed No Benefit Compared to Placebo in the Double-Blind Randomized Controlled Trial - the Asset Study.
Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco ® LPS Adsorber for LPS removal in early Gram-negative septic shock was feasible and safe. Also, effect on endotoxin level, inflammatory response and organ function were assessed. In a small cohort of patients with presumed Gram-negative septic shock, levels of circulating endotoxin were low and no adverse effects within 28 days after LPS adsorber-treatment were observed. No benefit compared to a sham device was seen when using a LPS adsorber in addition to standard care. (Source: Current Aw...
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

Delay in Antibiotic Administration Is Associated With Mortality Among Septic Shock Patients With Staphylococcus aureus Bacteremia.
The relationship between the timing of antibiotics and mortality among septic shock patients has not been examined among patients specifically with Staphylococcus aureus bacteremia. The results of this study further support the importance of prompt appropriate antibiotic administration for patients with septic shock. Physicians should consider acting quickly to administer antibiotics with S. aureus coverage to any patient suspected of having septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

Circulating Complement C3-Alpha Chain Levels Predict Survival of Septic Shock Patients
Circulating complement C3 fragments released during septic shock might contribute to the development of complications such as profound hypotension and disseminated intravascular coagulation. The role of C3 in the course of septic shock varies in the literature, possibly because circulating C3 exists in different forms indistinguishable via traditional ELISA-based methods. We sought to test the relationship between C3 forms, measured by Western blotting with its associated protein size differentiation feature, and clinical outcomes. Circulating C3-alpha chain levels is a significant independent predictor of survival in sept...
Source: Current Awareness Service for Health (CASH) - January 23, 2020 Category: Consumer Health News Source Type: news

Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies Vitamin Cocktail for Sepsis Fails; PPI for Stress Ulcer Prevention May Be Risky: ICU Studies
A major new study of intensive care unit (ICU) patients with septic shock failed to find a benefit of giving an intravenous cocktail of vitamin C, hydrocortisone and thiamine, relative to hydrocortisone alone.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - January 22, 2020 Category: Intensive Care Tags: Critical Care News Source Type: news

Vitamin C-B1-steroid combo linked to lower septic shock mortality in kids
(Ann& Robert H. Lurie Children's Hospital of Chicago) Treating septic shock in children with a combination of intravenous vitamin C, vitamin B1 and hydrocortisone (a commonly used steroid) is associated with lower mortality, according to a study from Ann& Robert H. Lurie Children's Hospital of Chicago. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 21, 2020 Category: International Medicine & Public Health Source Type: news

North Carolina cheerleader, 15, dies of flu and septic shock
Lacie Rian Fisher, 15, of Pisgah, North Carolina, died on December 30 after she contracted influenza B, responsible for most pediatric flu deaths this season, which sent her into septic shock. (Source: the Mail online | Health)
Source: the Mail online | Health - January 21, 2020 Category: Consumer Health News Source Type: news

VITAMINS trial report on vitamin C, hydrocortisone, thiamine for septic shock
(JAMA Network) In this   randomized clinical trial of about 200 patients with septic shock, combination treatment with intravenous vitamin C, hydrocortisone and thiamine compared with intravenous hydrocortisone alone didn't significantly improve the amount of time patients were alive and free of medicines that raise blood pressure (vasopressors) over seven days. The study findings are being released to coincide with presentation at the Critical Care Reviews Meeting 2020 in Belfast, Northern Ireland. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 17, 2020 Category: International Medicine & Public Health Source Type: news

New York boy, 11, dies from the flu after the virus attacked his heart
Luca Calanni, 11, of Hamburg, New York, passed away from the flu on Saturday after the virus attacked his heart while he was being treated for septic shock and he suffered cardiac arrest. (Source: the Mail online | Health)
Source: the Mail online | Health - January 14, 2020 Category: Consumer Health News Source Type: news

Septic Shock
(Source: eMedicineHealth.com)
Source: eMedicineHealth.com - January 10, 2020 Category: General Medicine Source Type: news

Cost-effectiveness of second-line vasopressors for the treatment of septic shock.
We determine the cost-effectiveness of escalating doses of norepinephrine or norepinephrine plus the adjunctive use of vasopressin or angiotensin II as a second-line vasopressor for septic shock. Vasopressin is the most cost-effective second-line vasopressor in both the short- and long-term evaluations. Vasopressor price is a minor contributor to overall cost. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news

Machine learning for prediction of septic shock at initial triage in emergency department.
We hypothesized utilizing machine learning (ML) algorithms for screening septic shock in ED would provide better accuracy than qSOFA or MEWS. ML classifiers significantly outperforms clinical scores in screening septic shock at ED triage. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - January 3, 2020 Category: Consumer Health News Source Type: news