Evolution of platelet activation parameters during septic shock in intensive care unit
During severe sepsis, platelet activation may induce disseminate microvascular thrombosis, which play a key role in critical organ failure. Crucially, most of the studies in this field have explored platelet-leukocyte interactions in animal models, or explored platelets under the spectrum of thrombocytopenia or disseminated intravascular coagulation and have not taken into account the complex interplay that might exist between platelets and leukocytes during human septic shock nor the kinetics of platelet activation. Here, we assessed platelet activation parameters at the admission of patients with sepsis to the intensive ...
Source: Current Awareness Service for Health (CASH) - September 5, 2022 Category: Consumer Health News Source Type: news
Surviving Sepsis Campaign Guidelines 2021: highlights for the practicing clinician
The 2021 Surviving Sepsis Campaign Guidelines provided evidence-based recommendations for adult patients with sepsis and septic shock. This iteration of the guidelines placed increased emphasis on a diverse, global perspective, as well as on the long-term sequelae of sepsis experienced by patients and their families. The guidelines encompassed the following sections: 1) screening and early treatment; 2) infection; 3) hemodynamic management; 4) ventilation; 5) additional therapies; and 6) goals of care and long-term outcomes. In this review, we provide a summary of key recommendations of interest to the practicing clinician...
Source: Current Awareness Service for Health (CASH) - September 5, 2022 Category: Consumer Health News Source Type: news
Coupled plasma filtration adsorption for the treatment of sepsis or septic shock: a systematic review and meta-analysis
Conclusions: The treatment of CPFA failed to decrease all-cause mortality of sepsis or septic shock patients. Further large-scale randomized controlled trials (RCTs) evaluating the ability of this therapy to improve clinical outcomes are still required to confirm these results. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 5, 2022 Category: Consumer Health News Source Type: news
A pilot study on the melatonin treatment in patients with early septic shock: results of a single-center randomized controlled trial.
Conclusions: Our pilot study supported the potential benefits of melatonin in treating septic shock. Further clinical evidence is required for expanding and confirming these findings. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news
A 2-year retrospective analysis of the prognostic value of MqSOFA compared to lactate, NEWS and qSOFA in patients with sepsis
Purpose: Sepsis is a life-threating organ dysfunction caused by a dysregulated host response to infection. Being a time-dependent condition, the present study aims to compare a recently established score, i.e., modified quick SOFA (MqSOFA), with other existing tools commonly applied to predict in-hospital mortality. Methods: All cases of sepsis and septic shock consecutively observed at St. Anna University Hospital of Ferrara, Italy, from January 2017 to December 2018 were included in this study. Each patient was evaluated with MqSOFA, lactate assay, NEWS and qSOFA. Accurate statistical and logistic regression analyses wer...
Source: Current Awareness Service for Health (CASH) - August 15, 2022 Category: Consumer Health News Source Type: news
What Is the Narrative You Hear When Faced With Uncertainty?
(MedPage Today) -- The first week of my big attending job, I saw a patient with fever, sore throat, no cough, and tonsillar exudates. Well-trained to manage septic shock, but having no idea how to practice in a primary care clinic, I crafted a... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - July 27, 2022 Category: American Health Source Type: news
Evaluating the impact of severe sepsis 3-hour bundle compliance on 28-day in-hospital mortality: A propensity adjusted, nested case-control study
Conclusions: Three-hour bundle compliance did not impact 28-day in-hospital mortality in patients with severe sepsis. Further research is needed to understand the impact of 3-hour bundle compliance on mortality in severe sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 25, 2022 Category: Consumer Health News Source Type: news
Benefits of esmolol in adults with sepsis and septic shock: An updated meta-analysis of randomized controlled trials
Conclusions: Esmolol treatment may be safe and effective in decreasing 28-day mortality, controlling heart rate, and providing cardioprotective function, but has no effect on lung injury in patients with sepsis or septic shock after early fluid resuscitation. Improvement in cardiac function may be related to changes in serum inflammatory mediators. No significant adverse effects on tissue perfusion and oxygen utilization were observed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 15, 2022 Category: Consumer Health News Source Type: news
Arterial catheterization and in-hospital mortality in sepsis: a propensity score-matched study.
Background: Despite the extensive use of arterial catheterization (AC), clinical effectiveness of AC to alter the outcomes among patients with sepsis and septic shock has not been evaluated. The purpose of this study is to examine the association between the use of AC and in-hospital mortality in septic patients.
Methods: Adult patients with sepsis from Medical Information Mart for Intensive Care database were screened to conduct this retrospective observational study. Propensity score matching (PSM) was employed to estimate the relationship between arterial catheterization (AC) and in-hospital mortality. Multivariable lo...
Source: Current Awareness Service for Health (CASH) - June 27, 2022 Category: Consumer Health News Source Type: news
IV Vitamin C Fares Poorly in Latest Septic Shock Trial IV Vitamin C Fares Poorly in Latest Septic Shock Trial
The findings of a randomized, placebo-controlled trial of 963 patients throw into doubt the use of vitamin C for people with sepsis. In organ dysfunction, the treatment did worse than placebo.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - June 23, 2022 Category: Surgery Tags: Critical Care News Source Type: news
When Giving IV Fluids in Septic Shock Cases, Less Is Not More When Giving IV Fluids in Septic Shock Cases, Less Is Not More
Restricting intravenous fluids in ICU patients with septic shock does not lower the 90-day death rate, a large European study of 1554 adults concludes.Reuters Health Information (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - June 21, 2022 Category: Intensive Care Tags: Critical Care News Source Type: news
No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock
Rates of death at 90 days, SAEs did not differ for patients with septic shock receiving restricted versus standard IV fluid therapy in the ICU (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 17, 2022 Category: Cancer & Oncology Tags: Infections, Nursing, Oncology, Critical Care, Conference News, Source Type: news
No Fewer Deaths Seen With Restricted IV Fluid for Septic Shock
FRIDAY, June 17, 2022 -- For adults in the intensive care unit (ICU) with septic shock, intravenous fluid restriction does not result in fewer deaths at 90 days than standard intravenous fluid therapy, according to a study published online June 17... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 17, 2022 Category: Pharmaceuticals Source Type: news
Developing a shared sepsis data infrastructure: a systematic review and concept map to FHIR Br
The development of a shared data infrastructure across health systems could improve research, clinical care, and health policy across a spectrum of diseases, including sepsis. Awareness of the potential value of such infrastructure has been heightened by COVID-19, as the lack of a real-time, interoperable data network impaired disease identification, mitigation, and eradication. The Sepsis on FHIR collaboration establishes a dynamic, federated, and interoperable system of sepsis data from 55 hospitals using 2 distinct inpatient electronic health record systems. Here we report on phase 1, a systematic review to identify cli...
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news
Sepsis and the microcirculation: the impact on outcomes
Purpose of review: Advances in the treatment of septic shock have historically focused on resuscitation endpoints, mainly mean arterial pressure and cardiac output. As the definitions of sepsis and septic shock have shifted to focus on the diversity of causes of dysregulated host-response we have seen an emerging phenotype where tissue hypoxia persists despite adequate macrocirculatory parameters. Interest in the topic of microcirculation is re-emerging as validated bedside techniques for hemodynamic monitoring, such as video microscopes, are becoming available. We review the current understanding of how sepsis induced hyp...
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news
