The role of eosinophils in sepsis and acute respiratory distress syndrome: a scoping review, Canadian journal of anaesthesia
Conclusion: Persistent peripheral eosinopenia is a marker of bacterial sepsis and is independently associated with poor outcomes. Bronchoalveolar lavage eosinophil counts are low in early-phase ARDS, but increase in late-phase ARDS, while elevated markers of eosinophil activity correlate with ARDS severity. Further studies understanding the mechanisms leading to eosinopenia in sepsis and increased eosinophil activity in ARDS are needed. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news
Machine learning methods to improve bedside fluid responsiveness prediction in severe sepsis or septic shock: an observational study, British journal of anaesthesia
Conclusions: Machine learning generated several models for predicting fluid responsiveness that were comparable with the haemodynamic response to PLR. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news
Predictive value of geriatric-quickSOFA in hospitalized older people with sepsis, BMC geriatrics
Background: QuickSOFA, a prognostic score proposed for patients with infection, has shown a poor predictive value in the geriatric population, probably because of the inappropriateness of the Glasgow Coma Scale (GCS) in assessing acute alteration of mental status in older patients. Indeed, the GCS might result chronically low in older patient with pre-existing cognitive disorders. The aim of this study was to develop an alternative quickSOFA (geriatric-quickSOFA), using the presence of delirium, assessed according to DSM-5 criteria, instead of GCS assessment, to predict mortality in hospitalized older patients with sepsis....
Source: Current Awareness Service for Health (CASH) - May 6, 2021 Category: Consumer Health News Source Type: news
Adherence to CMS SEP-1 measures found to have variable effects on patient outcomes
(American College of Physicians) A longitudinal study found that adherence to the Medicare Severe Sepsis and Septic Shock Early Management Bundle (SEP-1) had variable effects on sepsis treatment and patient outcomes in its current iteration, which requires that a patient receive all measure components for their treatment to be considered compliant. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news
Federal policy to reduce deaths from sepsis was mostly ineffective
(University of Pittsburgh) The first large-scale, multi-hospital evaluation of an " all or none " federal policy intended to improve results in sepsis patients finds that the guidelines are a wash - on average they neither helped nor hurt outcomes despite significant investments in their implementation. The findings indicate ways the Severe Sepsis and Septic Shock: Management Bundle, known as " SEP-1, " could be built upon and changed to potentially result in future improvements. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2021 Category: Infectious Diseases Source Type: news
Prognostic value of lactate levels and lactate clearance in sepsis and septic shock with initial hyperlactatemia: A retrospective cohort study according to the Sepsis-3 definitions, Medicine
This study evaluated the prognostic value of lactate levels and lactate clearance for 30-day mortality in patients with sepsis and septic shock diagnosed in the emergency department.We performed a retrospective cohort study of sepsis patients with initial lactate levels of ≥2 mmol/L. All patients met the Sepsis-3 definitions. The prognostic value of 6-hour lactate levels, 6-hour lactate clearance, 6-hour lactate metrics (≥2 mmol/L), and lactate clearance metrics ( (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
Comparing mortality between positive and negative blood culture results: an inverse probability of treatment weighting analysis of a multicenter cohort, BMC Infectious Diseases
Conclusions: Culture-positive sepsis patients had comparable early mortality but worse late mortality than culture-negative sepsis patients in this cohort. Persistent Staphylococcal bacteremia may have contributed to the increased late mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19, Frontiers in immunology
Sepsis is a life-threatening systemic illness attributed to a dysregulated host response to infection. Sepsis is a global burden killing ~11 million persons annually. In December 2019, a novel pneumonia condition termed coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged and has resulted in more than 1,535,982 deaths globally as of 8 th December 2020. These two conditions share many pathophysiological and clinical features. Notably, both sepsis and COVID-19 patients experience consumptive thrombocytopenia, haemolytic anaemia, vascular microthrombosis, multi-o...
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
Early Recognition and Management of Sepsis in the Elderly: A Case Study, Critical Care Nursing Quarterly
This article aims to inform clinicians and nurses of the importance of early recognition of subtle signs and symptoms and the management of sepsis in the elderly. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 9, 2021 Category: Consumer Health News Source Type: news
The pandemic has given me extra time with my teenage sons
It ’s been a tough time to be 17 or 18, but there have been some upsides, tooMy sons are 18 and 17. It was the younger ’s birthday this week and I made an awful cake that definitely breached myminimum cake standards (I hesitate to criticise Nigella, but there is such a thing as too much peanut butter). He looked a bit overwhelmed when we sang happy birthday, and I worried all day about him and his 17-year-old pandemic life, without access to the places and people that help being 17 make sense. There is nothing I can do about that, so I am fixating on the cake, sitting here wondering if I have time to make a replacement...
Source: Guardian Unlimited Science - March 13, 2021 Category: Science Authors: Emma Beddington Tags: Life and style Family Children Parents and parenting Psychology Science Health & wellbeing Source Type: news
Adrecizumab: an investigational agent for the biomarker-guided treatment of sepsis, Expert opinion on investigational drugs 30(2): 95-102
Sepsis is a major health problem with a high incidence and mortality. ADM, a free-circulating peptide mainly expressed and secreted by vascular endothelial cells, shows vasodilatory properties and causes hypotension when present in higher concentrations during sepsis. Areas covered : Adrecizumab (ADZ) (HAM 8101) is a humanized targeted therapy directed against the N-terminus of adrenomedullin (ADM). ADZ inhibits excessive circulating sepsis-induced ADM and stimulates protective effects on the endothelial barrier, and decreases interstitial vasodilatory effects. ADZ demonstrated a promising safety profile in healthy subject...
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news
Pediatric infection and sepsis in five age subgroups: single-center registry, Wiener medizinische Wochenschrift,171(1-2): 29-35
Conclusion: With this registry, children divided into five age subgroups with infection or sepsis were evaluated and treatment strategies were examined. We have shown that our findings on children treated in our pediatric intensive care unit conform with current literature about pediatric sepsis. In addition to maintaining strict hygiene standards, optimal aspects of sepsis care should be stringently observed, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 4, 2021 Category: Consumer Health News Source Type: news
Sepsis and Septic Shock Definitions in Patients With Cancer Admitted in ICU, Journal of Intensive Care Medicine 36(34): 255-261
Conclusion: The new definition of sepsis and septic shock is applicable in an ICU oncological population with the same reliability as in the general population. The SOFA score is more accurate than qSOFA and SIRS criteria to predict hospital mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news
Is lactate lower in septic patients who are prescribed beta blockers? Retrospective cohort study of an intensive care population, Emergency Medicine Australasia 33(1): 82-87
Conclusions: In our cohort pre‐existing beta blocker treatment was associated with lower serum lactate measurements in patients presenting with sepsis. Pre‐existing beta blocker treatment may reduce serum lactate at presentatio n in patients with sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 3, 2021 Category: Consumer Health News Source Type: news
Sepsis in patients with haematological versus solid cancer: a retrospective cohort study
Study (n=442) found solid tumour patients with sepsis or septic shock are at the same risk of mortality as patients with haematological tumours. However, haematological malignancy patients admitted with sepsis or septic shock had higher rates of bacteraemia. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 18, 2021 Category: Consumer Health News Source Type: news
