Decreasing Time to Antibiotics for Patients with Sepsis in the Emergency Department
Sepsis is a significant cause of morbidity and mortality. Patients may present in a spectrum, from nonsevere sepsis through septic shock. Literature supports improvement in patient outcomes with timely care. This project describes an effort to improve delays in antibiotic administration in patients with sepsis spectrum disease presenting to a pediatric emergency department (PED). This initiative improved prioritization and efficiency of care of sepsis, and overall time to antibiotics in this population. The results of this project demonstrate the effectiveness of a multidisciplinary team working to improve an essential tim...
Source: Current Awareness Service for Health (CASH) - October 30, 2019 Category: Consumer Health News Source Type: news

Administration of Iloprost and Eptifibatide in Septic Shock Administration of Iloprost and Eptifibatide in Septic Shock
Is dual therapy with iloprost and eptifibatide a safe and effective option that might help improve outcomes among patients with septic shock?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2019 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

Bacteria Are Likely Hiding In Your Household Washing Machine
(CNN) — When multidrug-resistant pathogens kept reappearing on the skin of premature babies in a German hospital’s neonatal intensive care unit, investigators were confused. Tests for contamination in the incubators, as well as among healthcare workers who came into contact with the preemies, were all coming up negative, according to a report on the case published Friday by the American Society for Microbiology. But tests showed the babies were continually being reinfected with Klebsiella oxytoca, a bacteria notorious for hospital-acquired infections such as pneumonia, urinary tract infection, soft tissue infec...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - September 27, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Offbeat CNN Source Type: news

Sepsis in patients with cirrhosis awaiting liver transplantation: new trends and management
Bacterial infections are more frequent and severe in patients with advanced liver disease and, therefore, in liver transplant candidates. The increased risk of infection in these patients parallels the severity of the immune dysfunction associated with cirrhosis, featured by systemic inflammation and progressive immunodeficiency. Other factors contribute to this risk, such as genetic polymorphisms, proton-pump inhibitor overuse, the numerous invasive procedures and hospitalizations these patients go through, or the immunosuppressive effects of malnutrition or alcohol abuse. Bacterial infections have a great impact...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

Sepsis information-seeking behaviors via Wikipedia between 2015 and 2018: A mixed methods retrospective observational study
Raising public awareness of sepsis, a potentially life-threatening dysregulated host response to infection, to hasten its recognition has become a major focus of physicians, investigators, and both non-governmental and governmental agencies. While the internet is a common means by which to seek out healthcare information, little is understood about patterns and drivers of these behaviors. We sought to examine traffic to Wikipedia, a popular and publicly available online encyclopedia, to better understand how, when, and why users access information about sepsis. Clickstream analysis suggests that most sepsis and se...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

A Machine Learning Algorithm to Predict Severe Sepsis and Septic Shock: Development, Implementation, and Impact on Clinical Practice
Develop and implement a machine learning algorithm to predict severe sepsis and septic shock and evaluate the impact on clinical practice and patient outcomes. Our machine learning algorithm can predict, with low sensitivity but high specificity, the impending occurrence of severe sepsis and septic shock. Algorithm-generated predictive alerts modestly impacted clinical measures. Next steps include describing clinical perception of this tool and optimizing algorithm design and delivery. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock
Rapid fluid resuscitation has become standard in sepsis care, despite " low-quality " evidence and absence of guidelines for populations " at risk " for volume overload. Our objectives include as follows: 1) identify predictors of reaching a 30 mL/kg crystalloid bolus within 3 hours of sepsis onset (30by3); 2) assess the impact of 30by3 and fluid dosing on clinical outcomes; 3) examine differences in perceived " at-risk " volume-sensitive populations, including end-stage renal disease, heart failure, obesity, advanced age, or with documentation of volume " overload " by bedside examination. Failure to reach 30by3 ...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

Vitamin C and Thiamine for Sepsis and Septic Shock
Sepsis and septic shock are medical emergencies resulting in significant morbidity and mortality. Intravenous (IV) vitamin C, thiamine, and hydrocortisone have shown promise in reducing hospital mortality. The Memphis Veterans Affairs Medical Center (VAMC) similarly implemented this regimen, called the vitamin C protocol, for patients presenting in sepsis or septic shock in the intensive care unit (ICU). Although no significant mortality benefit was observed, the vitamin C protocol was not associated with patient harm. In this Veteran population, there was reduced ICU length of stay, suggesting possible benefit. Th...
Source: Current Awareness Service for Health (CASH) - September 19, 2019 Category: Consumer Health News Source Type: news

Blood Purification and Mortality in Sepsis and Septic Shock Blood Purification and Mortality in Sepsis and Septic Shock
This study examined the potential benefit of hemoperfusion, hemofiltration, and plasmapheresis in the treatment of sepsis or septic shock. Can these blood purification techniques reduce mortality?Anesthesiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - September 5, 2019 Category: Intensive Care Tags: Anesthesiology Journal Article Source Type: news

Sepsis in 2018: a review
This article provides a summary of the most recent clinical evidence and professional guidelines for the diagnosis and treatment of the sepsis in the critical care setting. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news

Epidemiology and Changes in Mortality of Sepsis After the Implementation of Surviving Sepsis Campaign Guidelines
We set out to determine the epidemiology and outcome of severe sepsis and septic shock after 9 years of the implementation of the Surviving Sepsis Campaign (SSC) and to build a mortality prediction model. Although the incidence of sepsis/septic shock remained unchanged during a 10-year period, the implementation of the SSC guidelines resulted in a marked decrease in the overall mortality. The lower severity of patients on ICU admission and the reduced early mortality suggest an improvement in early diagnosis, better initial management, and earlier antibiotic treatment. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news

The Comparative Epidemiology of Pediatric Severe Sepsis
To determine whether the coding strategies used to identify severe sepsis in administrative data sets could identify cases with comparable case mix, hospitalization characteristics, and outcomes as a cohort of children diagnosed with severe sepsis using strict clinical criteria. The ICD-9-CM codes for " severe sepsis " and " septic shock " identify smaller but higher acuity cohorts of patients that more closely resemble the children enrolled in the largest clinical trial of pediatric severe sepsis to date. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - September 4, 2019 Category: Consumer Health News Source Type: news

Adjunctive Corticosteroid Treatment in Septic Shock Adjunctive Corticosteroid Treatment in Septic Shock
This article reviews the continuing uncertainty and the current state of the evidence regarding the utility of corticosteroids in treatment of septic shock. What are the implications for practice?Anesthesiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 29, 2019 Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news

Extracorporeal Membrane Oxygenation for Septic Shock Extracorporeal Membrane Oxygenation for Septic Shock
What benefits may extracorporeal membrane oxygenation offer to patients with septic shock?Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 6, 2019 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news