Methods for Phenotyping Adult Patients in Sepsis and Septic Shock: A Scoping Review L
Despite its heterogeneous phenotypes, sepsis or life-threatening dysfunction in response to infection is often treated empirically. Identifying patient subgroups with unique pathophysiology and treatment response is critical to the advancement of sepsis care. However, phenotyping methods and results are as heterogeneous as the disease itself. This scoping review evaluates the prognostic capabilities and treatment implications of adult sepsis and septic shock phenotyping methods. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 14, 2022 Category: Consumer Health News Source Type: news
Outcomes of CMS-mandated fluid administration among fluid-overloaded patients with sepsis: A systematic review and meta-analysis
The outcomes of large-volume IVF administration to septic shock patients with comorbid congestive heart failure (CHF) and/or end-stage renal disease (ESRD) are uncertain and widely debated in the existing literature. Despite this uncertainty, CMS continues to recommend that 30 ml/kg of an intravenous crystalloid solution be administered to patients in septic shock starting within 3 h of presentation. We performed a systematic review and meta-analysis to assess the relationship between adherence to this guideline and outcomes among patients whose underlying comorbidities present a risk of fluid overload. (Source: Current Aw...
Source: Current Awareness Service for Health (CASH) - June 10, 2022 Category: Consumer Health News Source Type: news
Evaluating Vitamin C in Septic Shock Evaluating Vitamin C in Septic Shock
IV vitamin C administration has been investigated as a possible treatment strategy for septic shock in the ICU, but how effective is it?Critical Care Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2022 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news
Impact of extended emergency department stay on antibiotic re-dosing delays and outcomes in sepsis
For patients with sepsis and septic shock, the initial administration of antibiotics should occur as soon as possible, preferably within one hour of sepsis recognition. While clinicians are focused on providing first-doses of antibiotics quickly upon presentation, re-dosing issues may arise in patients who have an extended emergency department (ED) length of stay (LOS). Limited studies have been conducted that assess the impact of re-dosing delays. The purpose of this study was to assess the association of an extended ED LOS ≥ 6 h with antibiotic re-dosing delays in patients with sepsis and examine outcomes.; Methods: A ...
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news
Early Lactate-Guided Resuscitation of Elderly Septic Patients
Early lactate-guided resuscitation was endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease the mortality of patients admitted to the ICU department with septic shock. However, its effectiveness in elderly Asian patients is uncertain.; : For critically ill patients (elderly Asian patients) admitted to the ICU department with hyperlactatemia, early lactate-guided treatment reduced ICU needs but did not reduce mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news
An international survey of adherence to Surviving Sepsis Campaign Guidelines 2016 regarding fluid resuscitation and vasopressors in the initial management of septic shock
Our survey aimed to evaluate adherence to Surviving Sepsis Campaign (SSC) Guidelines 2016 among intensive care practitioners and to identify issues that remain controversial or lack clarity.; Methods: Members of the European Society of Intensive Care Medicine (ESICM) were surveyed using an anonymous web-based survey written by an international group of experts. The primary outcome measure was the rate of adherence to specific recommendations. Secondary outcomes were to describe areas of controversy and lack of data and to associate specific practices with clinician characteristics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news
Mortality Benefit From the Passive Leg Raise Maneuver in Guiding Resuscitation of Septic Shock Patients: A Systematic Review and Meta-Analysis of Randomized Trials
Fluid therapy plays a major role in the management of critically ill patients. Yet assessment of intravascular volume in these patients is challenging. Different invasive and non-invasive methods have been used with variable results. The passive leg raise (PLR) maneuver has been recommended by international guidelines as a means to determine appropriate fluid resuscitation. We performed this systematic review and meta-analysis to determine if using this method of volume assessment has an impact on mortality outcome in patients with septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 13, 2022 Category: Consumer Health News Source Type: news
Muhammad Ali: Boxing legend died from 'extreme' septic shock - condition explained
MUHAMMAD ALI is widely recognised as one of the most significant and celebrated heavyweight boxers of all time. Named the Sports Personality of the Century back in 1999, news of Ali's death in 2016 shocked and saddened the world. The sportsman died at the age of 74, from septic shock - a life-threatening condition that happens when your blood pressure drops to a dangerously low level following an infection. (Source: Daily Express - Health)
Source: Daily Express - Health - April 4, 2022 Category: Consumer Health News Source Type: news
Initial Fluid Balance Associated Outcomes in Children With Severe Sepsis and Septic Shock.
This study aimed to clarify the possible association of initial 24 hours ' fluid balance with poor outcomes in pediatric patients with sepsis.
Methods: Retrospective data analysis included pediatric patients admitted with suspected or proven sepsis or septic shock to pediatric intensive care unit (PICU) of a tertiary care teaching hospital in Saudi Arabia.
Results: The study included 47 patients; 13 (28%) died, and mortality rate was significant in children with neurologic failure (P (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 14, 2022 Category: Consumer Health News Source Type: news
Necrotizing Soft Tissue Infections in Intensive Care
Background: Necrotizing soft tissue infections (NSTIs) are typically characterized by extensive soft tissue destruction with systemic signs of toxicity, ranging from sepsis to septic shock. Our aim was to analyze the clinical characteristics, microbiological results, laboratory data, therapies, and outcome of patients with NSTIs admitted to an intensive care unit (ICU).
Methods: A monocentric observational study of patients admitted to the ICU of a university hospital between January 2009 and December 2017. The demographic characteristics, comorbidities, clinical features, microbiology and laboratory results, organ dysfun...
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news
The Role of Histones and Heparin in Sepsis: A Review.
Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into t...
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news
Adverse effects of delayed antimicrobial treatment and surgical source control in adults with sepsis: results of a planned secondary analysis of a cluster-randomized controlled trial.
Conclusions: Our findings suggest that management of sepsis is time critical both for antimicrobial therapy and source control. Also patients, who are not yet in septic shock, profit fro m early anti-infective treatment since it can prevent further deterioration. Trial registration ClinicalTrials.gov ( NCT01187134 ). Registered 23 August 2010, NCT01187134. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 10, 2022 Category: Consumer Health News Source Type: news
Relationship between time of emergency department admission and adherence to the Surviving Sepsis Campaign bundle in patients with septic shock.
Conclusion: Septic shock patients admitted to the ED during the daytime exhibited lower sepsis bundle compliance than those admitted at night. Both the higher number of admitted patients and the higher patients to medical staff ratio during daytime may be factors that are responsible for lowering the compliance. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 2, 2022 Category: Consumer Health News Source Type: news
Systemic infections associated with tattoos or permanent makeup: A systematic review.
Conclusions: Bacterial bloodstream infections should be considered in subjects developing fever and rigour after tattoos, regardless of local symptoms. A shift in causative organisms has been documented, when comparing with historical reports. NTM are emerging organisms causing lymphadenopathy. Strict hygiene conditions are essential when performing a tattoo. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 2, 2022 Category: Consumer Health News Source Type: news
Unfractionated Heparin Improves the Clinical Efficacy in Sepsis Unfractionated Heparin Improves the Clinical Efficacy in Sepsis
This study evaluated the clinical efficacy of unfractionated heparin in sepsis, septic shock, and disseminated intravascular coagulation in adult patients.BMC Anesthesiology (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - February 18, 2022 Category: Intensive Care Tags: Anesthesiology Journal Article Source Type: news
