Diagnosis Sepsis: Is Newer Better?
In hospitalized patients who deteriorated from suspected infection, Sepsis-3 septic shock criteria predicted in-hospital mortality better than systemic inflammatory response syndrome-based criteria. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Open abdominal management for perforative peritonitis with septic shock: a retrospective analysis on usefulness of a standardized treatment protocol
Damage control surgery (DCS) with open abdominal management (OAM) has been increasingly expanded to include critically ill non-trauma patients. However, there is limited data regarding the usefulness of this protocol for the treatment of severe perforative peritonitis (PP), especially with septic shock (SS). Here, we retrospectively evaluated the usefulness of our OAM protocol for PP with SS. A standardized protocol for OAM may improve the outcomes of patients with SS due to PP. This damage control approach can be applied for the treatment of severe abdominal sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Association of septic shock definitions and standardized mortality ratio in a contemporary cohort of critically ill patients
The newly proposed septic shock definition has provoked a substantial controversy in the emergency and critical care communities. We aim to compare new (SEPSIS-III) versus old (SEPSIS-II) definitions for septic shock in a contemporary cohort of critically ill patients. Compared to SEPSIS-II, SEPSIS-III definition of septic shock identifies patients further along disease trajectory with higher likelihood of poor outcome. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature
The administration of β-blockers in patients with sepsis is a trending topic in intensive care medicine since the landmark study by Morelli and colleagues, showing a striking decrease in 28-day mortality compared to standard care. While the available evidence suggests that the use of β-blockers in septic shock is safe, the effects on hemodynamics are controversial. In this paper, we review the effect of β-blockade in septic shock on hemodynamics from animal models to critically ill patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Comparison of the accuracy of three early warning scores with SOFA score for predicting mortality in adult sepsis and septic shock patients admitted to intensive care unit.
The purpose of this study was to compare the accuracy of the Modified Early Warning Score (MEWS), National Early Warning Score (NEWS) and Search Out Severity (SOS), with the quick Sequential Organ Failure Assessment (qSOFA) and SOFA scores, to predict outcomes in sepsis patients. The SOS presents nearly as good as the SOFA score, to predict mortality among sepsis patients admitted to the ICU. The early warning score is another, alternative tool to use for risk stratification and sepsis screening for ICU sepsis patients. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
Cost-effectiveness of rapid diagnostic assays that perform directly on blood samples for the diagnosis of septic shock
Molecular diagnostic assays that test directly whole blood provide the ability to decrease inappropriate antimicrobial therapy and improve survival in patients with septic shock. We developed a decision analysis model to evaluate the cost-effectiveness of the addition of molecular assays to blood cultures in adults admitted to medical ICUs with septic shock. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - April 25, 2019 Category: Consumer Health News Source Type: news
The Safety of Vasopressin Receptor Agonists in Septic Shock The Safety of Vasopressin Receptor Agonists in Septic Shock
What do we currently know about the effects and safety of vasopressin receptor agonists in septic shock patients?Critical Care (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - April 23, 2019 Category: Intensive Care Tags: Critical Care Journal Article Source Type: news
Women went into septic shock after surgeons snagged her intestine during 'routine' surgery
Bonnie Judge, 35, of Utah, went under the knife in September last year to clear a blockage in her bowel ahead of having her appendix removed. Her inflamed colon caused the 'nick'. (Source: the Mail online | Health)
Source: the Mail online | Health - April 16, 2019 Category: Consumer Health News Source Type: news
Cochrane Clinical Answers related to COVID-19
Readable, clinically-focused, actionable answers to inform point-of-care decision-making for health professionals. Cochrane Clinical Answers (CCAs) provide a readable, digestible, clinically-focused entry point to rigorous research from Cochrane Reviews. They are designed to be actionable and to inform point-of-care decision-making. Each CCA contains a clinical question, a short answer, and data for the outcomes from the Cochrane Review deemed most relevant to practising healthcare professionals. The evidence is displayed in a user-friendly tabulated format that includes narratives, data, and links to graphics.The follow...
Source: Cochrane News and Events - April 9, 2019 Category: Information Technology Authors: Muriah Umoquit Source Type: news
Sepsis and septic shock: current approaches to management
Sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is recognised by the World Health Organization as a global health priority. Each year, 5000 of the 18 000 adults with sepsis treated in Australian intensive care units die, with survivors suffering long-term physical, cognitive and psychological dysfunction, which is poorly recognised and frequently untreated. There are currently no effective pharmacological treatments for sepsis, making early recognition, resuscitation and immediate treatment with appropriate antibiotics the key to reducing the burden of result...
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news
Analysis of a new best-practice advisory on time to initiation of antibiotics in surgical intensive care unit patients with septic shock
Early administration of antibiotics in septic shock is associated with decreased mortality. Promptly identifying sepsis and eliciting a response are necessary to reduce time to antibiotic administration. A new best-practice advisory has been effective at eliciting a rapid response and reducing the time-to-antibiotics in surgical intensive care unit patients with septic shock. Team notification and pharmacist response are associated with decreased time-to-antibiotics. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news
Adherence to fluid resuscitation guidelines and outcomes in patients with septic shock: Reassessing the " one-size-fits-all " approach
The Surviving Sepsis Campaign and Centers for Medicare and Medicaid Services (CMS) Severe Sepsis and Septic Shock Management Bundle (SEP-1) recommend rapid crystalloid infusion ( ≥30 mL/kg) for patients with sepsis-induced hypoperfusion or septic shock. We aimed to assess compliance with this recommendation, factors associated with non-compliance, and how compliance relates to mortality. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - March 28, 2019 Category: Consumer Health News Source Type: news
Woman who lost limbs after dog bite says sepsis foundation will save lives
An Ottawa woman who lost both her legs and one of her arms after a dog bite sent her into septic shock says a new foundation designed to spread awareness about sepsis and connect survivors will save lives. (Source: CBC | Health)
Source: CBC | Health - March 25, 2019 Category: Consumer Health News Tags: News/Canada/Ottawa Source Type: news
Left ventricular systolic function evaluated by strain echocardiography and relationship with mortality in patients with severe sepsis or septic shock: a systematic review and meta-analysis
Sepsis-induced myocardial dysfunction is associated with poor outcomes, but traditional measurements of systolic function such as left ventricular ejection fraction (LVEF) do not directly correlate with prognosis. Global longitudinal strain (GLS) utilizing speckle-tracking echocardiography (STE) could be a better marker of intrinsic left ventricular (LV) function, reflecting myocardial deformation rather than displacement and volume changes. The authors sought to investigate the prognostic value of GLS in patients with sepsis and/or septic shock. Worse GLS (less negative) values are associated with higher mortality in pati...
Source: Current Awareness Service for Health (CASH) - February 22, 2019 Category: Consumer Health News Source Type: news
Intra-abdominal sepsis: new definitions and current clinical standards
The abdomen is the second most common source of sepsis and is associated with unacceptably high morbidity and mortality. Recently, the essential definitions of sepsis and septic shock were updated (Third International Consensus Definitions for Sepsis and Septic Shock, Sepsis-3) and modified. The purpose of this review is to provide an overview of the changes introduced by Sepsis-3 and the current state of the art regarding the treatment of abdominal sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - February 22, 2019 Category: Consumer Health News Source Type: news
