Transfer hospitalizations for pediatric severe sepsis or septic shock: resource use and outcomes
Sepsis is a major cause of child mortality and morbidity. To enhance outcomes, children with severe sepsis or septic shock often require escalated care for organ support, sometimes necessitating interhospital transfer. The association between transfer admission for the care of pediatric severe sepsis or septic shock and in-hospital patient survival and resource use is poorly understood. One in four children with severe sepsis or septic shock required interhospital transfer for specialized care associated with greater use of invasive medical devices and specialized technology. Despite higher crude mortality and resource con...
Source: Current Awareness Service for Health (CASH) - July 24, 2019 Category: Consumer Health News Source Type: news
Will This Be the Holy Grail for Sepsis? Will This Be the Holy Grail for Sepsis?
An effective intervention for severe sepsis and septic shock can ' t come soon enough.Medscape Infectious Diseases (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - July 2, 2019 Category: Infectious Diseases Tags: Infectious Diseases Commentary Source Type: news
EU Panel Backs Angiotension II (Giapreza) for Septic Shock EU Panel Backs Angiotension II (Giapreza) for Septic Shock
Giapreza is for refractory hypotension in adults with septic or other distributive shock who remain hypotensive despite adequate volume restitution and application of catecholamines.International Approvals (Source: Medscape Pharmacist Headlines)
Source: Medscape Pharmacist Headlines - June 28, 2019 Category: Drugs & Pharmacology Tags: Critical Care News Alert Source Type: news
EU Panel Backs Angiotensin II (Giapreza) for Septic Shock EU Panel Backs Angiotensin II (Giapreza) for Septic Shock
Giapreza is for refractory hypotension in adults with septic or other distributive shock who remain hypotensive despite adequate volume restitution and application of catecholamines.International Approvals (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - June 28, 2019 Category: Primary Care Tags: Critical Care News Alert Source Type: news
Comparative Efficacy of Vasoactive Drugs in Septic Shock Comparative Efficacy of Vasoactive Drugs in Septic Shock
How do different kinds of vasoactive medications compare in terms of mortality and adverse events?Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 27, 2019 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news
Association between increased arterial stiffness and clinical outcomes in patients with early sepsis: a prospective observational cohort study.
This study aims to investigate arterial stiffness in early sepsis and its association with clinical outcomes. Patients with severe sepsis and septic shock admitted to intensive care have higher arterial stiffness than in the general population. No convincing association was found between pulse wave velocity at admission and the progression of multiple organ or cardiovascular failure, although the group with pulse wave velocity> 24.7 m/s had shorter survival time. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis
Sepsis is characterized by a complex immune response. This meta-analysis evaluated the clinical effectiveness of intravenous IgM-enriched immunoglobulin (IVIgGM) in patients with sepsis and septic shock. Administration of IVIgGM to adult septic patients may be associated with reduced mortality. Treatment effects tended to be smaller or less consistent when including only those studies deemed adequate for each indicator. The available evidence is not clearly sufficient to support the widespread use of IVIgGM in the treatment of sepsis. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
Risk Factors for 30-Day Mortality in Neonatal Gram-Negative Bacilli Sepsis
Multidrug-resistant gram-negative bacilli (MDR-GNB) have emerged globally as a serious threat and with a high case fatality rate (CFR). Neonates suspected of sepsis with septic shock need broad-spectrum empirical antimicrobial therapy until the second successive negative culture, especially in high MDR areas. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - June 19, 2019 Category: Consumer Health News Source Type: news
News: Early Norepinephrine Has Potential for Septic Shock
No abstract available (Source: Emergency Medicine News)
Source: Emergency Medicine News - June 1, 2019 Category: Emergency Medicine Tags: News Source Type: news
Broad Spectrum Vasopressors Broad Spectrum Vasopressors
Learn more about the concept of broad spectrum vasopressors -- and how this method may offer a new approach to the treatment of septic shock.Critical Care (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 31, 2019 Category: Consumer Health News Tags: Critical Care Journal Article Source Type: news
Cardiovascular determinants of resuscitation from sepsis and septic shock
We hypothesized that the cardiovascular responses to Surviving Sepsis Guidelines (SSG)-defined resuscitation are predictable based on the cardiovascular state. The cardiovascular response to SSG-based resuscitation is highly heterogeneous but predictable from pre-treatment measures of cardiovascular state. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Quality of Life and 1-Year Survival in Patients With Early Septic Shock: Long-Term Follow-Up of the Australasian Resuscitation in Sepsis Evaluation Trial
To examine long-term survival and quality of life of patients with early septic shock. In patients presenting to the emergency department with early septic shock, early goal-directed therapy compared with usual care did not reduce mortality nor improve health-related quality of life at either 6 or 12 months. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
Vitamin C, Hydrocortisone, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Analysis of Real-World Application
A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrospective observational cohort study at an academic tertiary care hospital. When compared to standard care, triple therapy did not improve hospital or ICU mortality in patients with septic shock. A randomized controlled trial evaluating the effects of triple therapy is necessary prior to implementing vita...
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news
IRF2 transcriptionally induces GSDMD expression for pyroptosis
Gasdermin-D (GSDMD) is cleaved by caspase-1, caspase-4, and caspase-11 in response to canonical and noncanonical inflammasome activation. Upon cleavage, GSDMD oligomerizes and forms plasma membrane pores, resulting in interleukin-1β (IL-1β) secretion, pyroptotic cell death, and inflammatory pathologies, including periodic fever syndromes and septic shock—a plague on modern medicine. Here, we showed that IRF2, a member of the interferon regulatory factor (IRF) family of transcription factors, was essential for the transcriptional activation of GSDMD. A forward genetic screen with N-ethyl-N-nitrosourea (ENU)&...
Source: Signal Transduction Knowledge Environment - May 20, 2019 Category: Science Authors: Kayagaki, N., Lee, B. L., Stowe, I. B., Kornfeld, O. S., O'Rourke, K., Mirrashidi, K. M., Haley, B., Watanabe, C., Roose-Girma, M., Modrusan, Z., Kummerfeld, S., Reja, R., Zhang, Y., Cho, V., Andrews, T. D., Morris, L. X., Goodnow, C. C., Bertram, E. M., Tags: STKE Research Articles Source Type: news
The Restrictive IV Fluid Trial in Severe Sepsis and Septic Shock (RIFTS): A Randomized Pilot Study
RCT (n=109) demonstrates a restrictive resuscitation strategy can successfully reduce the amount of IV fluid administered to patients with severe sepsis and septic shock compared with usual care. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - May 15, 2019 Category: Consumer Health News Source Type: news
