Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality

Background: Despite growing interest in treatment strategies that limit oxygen exposure in ICU patients, no studies have compared conservative oxygen with standard oxygen in postsurgical patients with sepsis/septic shock, although there are indications that it may improve outcomes. It has been proven that high partial pressure of oxygen in arterial blood (PaO 2 ) reduces the rate of surgical-wound infections and mortality in patients under major surgery. The aim of this study is to examine whether PaO 2 is associated with risk of death in adult patients with sepsis/septic shock after major surgery.; Methods: We performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU. Patients were stratified in two groups whether they had hyperoxemia, defined as PaO 2> 100 mmHg (n = 216), or PaO 2 ≤ 100 mmHg (n = 238) at the day of sepsis/septic shock onset according to SEPSIS-3 criteria maintained during 48 h. Primary end-point was 90-day mortality after diagnosis of sepsis. Secondary endpoints were ICU length of stay and time to extubation.; Results: In patients with PaO 2 ≤ 100 mmHg, we found prolonged mechanical ventilation (2 [8] vs. 1 [4] days, p

Source: Current Awareness Service for Health (CASH) - February 10, 2022 Category: Consumer Health News Source Type: news