Epidemiology of intra-abdominal infection and sepsis in critically ill patients: " AbSeS " , a multinational observational cohort study and ESICM Trials Group Project

We describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. Antimicrobial resistance is equally common in community-acquired as in hospital-acquired infection.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Publication date: Available online 4 December 2019Source: Current Medicine Research and PracticeAuthor(s): Tulsi ChughAbstractAntimicrobial resistance (AMR) is a serious public health threat worldwide, and is leading to resurgence of untreatable infectious diseases. However, AMR surveillance in low and middle-income countries (LMICs) may not be of appropriate level. Optimum utilisation of clinical microbiology services requires an integrated effort of several hospital services including supportive management and dedicated nursing staff. It requires regular and persistent motivation at all levels of the healthcare.
Source: Current Medicine Research and Practice - Category: General Medicine Source Type: research
ConclusionsA high prevalence of antibiotic use was observed in the 18 Brazilian hospitals. The antibiotics were prescribed mainly empirically. Intravenous broad-spectrum antibiotics were the most frequent antimicrobials used, showing that reinforcement of de-escalation strategy is needed. The Global-PPS data can be very useful for monitoring stewardship programmes and intervention.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
The objective of our study was to evaluate the impact of a multidisciplinary program on the adequacy of antibiotic prescriptions with local guidelines in terms of indication, molecule, dosage and treatment duration during the 48-72h reassessment in an internal medicine department. METHOD: This was a before/after monocentric, prospective study. All patients hospitalized in the internal medicine department who were treated with antibiotics for at least 48h were included. The intervention had two components: training of residents about antibiotic treatment and development of a multidisciplinary 48-72h reassessment team. O...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Authors: Escudero-Acha P, Blanco Huelga C, González-Castro A PMID: 31791805 [PubMed - as supplied by publisher]
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Conclusion: Initiatives will grow across LMICs to reduce inappropriate prescribing and dispensing of antimicrobials for URTIs as part of NAPs and other activities, and these will be monitored. PMID: 31794332 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
ConclusionGenome sequence data revealed an intertwined occurrence of plant probiotic traits and resistance to antimicrobials in the rice root endophyte LS-044.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Fluoroquinolones are used to treat serious bacterial infections, including those caused by Escherichia coli and Salmonella enterica. The emergence of plasmid-mediated quinolone resistance (PMQR) represent a new challenge to the successful treatment of Gram-negative infections. As part of a long-term strategy to generate a reference database of closed plasmids from antimicrobial resistant foodborne bacteria, we performed long-read sequencing of 11 E. coli isolates from retail meats that were non-susceptible to ciprofloxacin. Each of the isolates had PMQR genes, including qnrA1, qnrS1, and qnrB19. The four qnrB19 genes were ...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsIncreasing age and number of preoperative complications, in addition to ASA classification III or IV, were independent factors of increased risk of death in the population studied. The mortality rate was 30.8%, and infection followed by septic shock was the leading cause of death.ResumoJustificativa e objetivosO manejo perioperatório das fraturas de fêmur em pacientes idosos tem sido estudado com o intuito de determinar causas modificáveis de complicações e óbito. Este estudo tem por objetivo avaliar taxa de mortalidade e suas causas na população idosa com F...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Pharmaceutical companies won ’t develop fast, cheap and effective diagnostic tools on their own — they need incentives to tackle antimicrobial resistance.
Source: The Pharmaceutical Journal - Category: Drugs & Pharmacology Source Type: research
AbstractPurposeTo identify the predictors for recovery of pyogenic liver abscess (PLA) patients treated with percutaneous catheter drainage (PCD) and antibiotics, and then develop an effective nomogram to predict the recovery time.Materials and methodsThe retrospective study included consecutive PLA patients treated with PCD and antibiotics. We defined the overall recovery time (ORT) as the time from the PCD procedure to the time of clinical success or failure. Based on the ORT, its predictors were identified with univariate and multivariate analyses. Then, a nomogram was developed to predict the ORT, and was internally va...
Source: Abdominal Imaging - Category: Radiology Source Type: research
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