New York boy, 11, dies from the flu after the virus attacked his heart

Luca Calanni, 11, of Hamburg, New York, passed away from the flu on Saturday after the virus attacked his heart while he was being treated for septic shock and he suffered cardiac arrest.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Pancreaticoduodenectomy is a complex operation that has become safer over the past 3 decades but is still associated with a high complication rate. Much of this morbidity is attributable to leakage of the pancreatic anastomosis and the ensuing postoperative pancreatic fistula (POPF), which contributes to deep-space infection, delayed gastric emptying, hemorrhage, and systemic complications, including septic shock, organ failure, and death. Many groups have sought to reduce the risk of POPF using novel anastomotic techniques, topical agents, and medical treatments. A fundamental technical variation is whether the pancreas i...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
AbstractThe aim of the present study was to identify predictors of fatality among patients withS. aureus infections requiring hospitalization. Cases hospitalized withS. aureus infections at the University General Hospital of Patras, Greece, during a 4-year period (2013 –2016) were studied.mecA, lukS/lukF-PV (Panton-Valentine leukocidin, PVL),tst (toxic shock syndrome toxin),fnbA (fibronectin-binding protein A),eta, andetb (epidermolytic toxins) genes ’ carriage was detected by PCR in 149 selected patients. Among 464 patients, 346 were included (118 with missing data). Primary bacteremia predominated (44.2%), fo...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Condition:   Septic Shock Interventions:   Device: increase of mean arterial pressure at 80-85 mmHg.;   Device: increase of mean arterial pressure at 65-70 mmHg. Sponsor:   University Hospital, Angers Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
(sphingotec GmbH) AdrenOSS-2 Phase II trial shows that modulating the Adrenomedullin plasma level with the therapeutic antibody Adrecizumab demonstrates an improvement of survival in patients with septic shock.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
ConclusionNivolumab appeared to be safe and effective in Taiwanese patients. These interim results suggest that nivolumab is a suitable treatment option for this population.Clinical trial registrationNCT02582125.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
CONCLUSION: During bacterial pneumonia, circulating counts predict the outcome of transfusing granulocytes. With low but normal counts, transfusing granulocytes does not improve survival and injures the lung, whereas for animals with very low counts, but not absolute neutropenia, granulocyte transfusion improves lung function. PMID: 32086946 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
We report a case of a 37-year-old previously healthy patient who presented to the emergency, four days after vaginal delivery, with abdominal pain and septic shock. Acute peritonitis was diagnosed and peritoneal and blood culture revealed group A streptococci. Unfortunately, the patient died within 12 hours despite adequate resuscitation and antimicrobials. The present case report highlights the importance of an early diagnosis with an adequate therapy in case of GAS peritonitis after vaginal delivery.
Source: IDCases - Category: Infectious Diseases Source Type: research
Toddalolactone (TA-8) is a main compound isolated from Toddalia asiatica (L.) Lam., and its anti-inflammatory activity and anti-inflammatory mechanism are less studied. In the present study, we investigated the anti-inflammatory effects of TA-8. Our experimental results showed that TA-8 inhibited the production of pro-inflammatory cytokines by both lipopolysaccharide (LPS)-activated RAW 264.7 cells and septic mice. Moreover, TA-8 suppressed the NF-κB transcriptional activity, reduced the nuclear translocation and phosphorylation of NF-κB, blocked the translocation of HMGB1 from the nucleus to cytosol, and decre...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Scott HF, Colborn KL, Sevick CJ, Bajaj L, Kissoon N, Deakyne Davies SJ, et al. Development and Validation of a Predictive Model of the Risk of Pediatric Septic Shock Using Data Known at the Time of Hospital Arrival. J Pediatr 2019;217:146-52.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Current Best Evidence Source Type: research
Authors: Handke J, Piazza O, Larmann J, Tesoro S, De Robertis E Abstract Presepsin is the soluble fragment of CD14, a multifunctional glycoprotein expressed on the surface of innate immune cells. In healthy individuals, presepsin is present in very low concentrations with reference values ranging from 60 to 382 pg/ml. Several studies have shown that presepsin is a valuable biomarker for sepsis diagnosis in adults. Only lately, presepsin has been evaluated for prediction and early detection of neonatal sepsis and septic shock. Elevated plasma presepsin concentration has also been reported in patients undergoing card...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
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