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Drug: Insulin
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How online peer support affects management efficacy and mitigates difficulties of parents caring for children with type 1 diabetes
Prim Care Diabetes. 2023 Sep 18:S1751-9918(23)00162-6. doi: 10.1016/j.pcd.2023.09.003. Online ahead of print.ABSTRACTThe proper management of pediatric type 1 diabetes depends substantially on the parents of affected children. Parental psychological traits specifically related to diabetes caregiving influence the quality of their care and management of the disease in their children. Parents often use Facebook groups as sources of peer support and information about diabetes care. The present study aimed to examine the influence of devices used in diabetes management, ascertain the impact of Facebook peer-support groups on p...
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Norbert Buz ás M ária Dóra Horváth Zsanett Tesch Emese Hallgat ó Source Type: research
Are menstrual disorders in adolescent girls related to metabolic disorders?
CONCLUSIONS: Adolescent girls with menstrual disorders are insulin resistant, regardless of PCOS diagnosis. The severity of menstrual disorders may be related to the incidence of lipid disorders in adolescent girls.PMID:37728458 | PMC:PMC10411084 | DOI:10.5114/pedm.2023.125364
Source: Pediatric Endocrinology, Diabetes, and Metabolism - September 20, 2023 Category: Endocrinology Authors: El żbieta Foryś Adrianna Baran Aleksandra Dziurdzia Ewelina Jarosz-W ójcik Pawe ł Matusik Aneta Gawlik Ryszard Tomaszewski Agnieszka Zachurzok Source Type: research
In vitro oxygen imaging of acellular and cell-loaded beta cell replacement devices
This article aims to establish the protocols and demonstrate a few examples of in vitro oxygen imaging of BAP devices using EPROI. All pO2 measurements were performed using a recently introduced 720 MHz/25 mT preclinical oxygen imager instrument, JIVA-25™. We began by performing pO2 calibration of the biomaterials used in BAPs at 25 mT magnetic field since no such data exist. We compared the EPROI pO2 measurement with a single-point probe for a few selected materials. We also performed trityl OX071 toxicity studies with fibroblasts, as well as insulin-producing cells (beta TC6, MIN6, and human islet cells). Finally, we p...
Source: Cancer Control - September 20, 2023 Category: Cancer & Oncology Authors: Mrignayani Kotecha Longhai Wang Safa Hameed Navin Viswakarma Minglin Ma Cherie Stabler Corinne A Hoesli Boris Epel Source Type: research
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats
CONCLUSIONS: These findings indicate that MOSA can exert prolonged adverse effects manifested as metabolic dysfunction in male offspring. Therefore, surveillance and management of OSA during pregnancy may be necessary to prevent and alleviate MAFLD in offspring.PMID:37730152 | DOI:10.1016/j.bbadis.2023.166889
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ruhua Wang Wei Feng Yan Wang Yonghong Jiang Yiguang Lin Xueqing Chen Source Type: research
Protein tyrosine phosphatase 1B is a regulator of alpha-actinin4 in the glomerular podocyte
This study aims to uncover novel substrates of PTP1B in podocytes and validate a leading candidate. To this end, using substrate-trapping and mass spectroscopy, we identified putative substrates of this phosphatase and investigated the actin cross-linking cytoskeletal protein alpha-actinin4. PTP1B and alpha-actinin4 co-localized in murine and human glomeruli and transiently transfected E11 podocyte cells. Additionally, podocyte PTP1B deficiency in vivo and culture was associated with elevated tyrosine phosphorylation of alpha-actinin4. Conversely, reconstitution of the knockdown cells with PTP1B attenuated alpha-actinin4 t...
Source: Biochimica et Biophysica Acta - September 20, 2023 Category: Biochemistry Authors: Ming-Fo Hsu Yoshihiro Ito Jai Prakash Singh Shu-Fang Hsu Alan Wells Kuang-Yu Jen Tzu-Ching Meng Fawaz G Haj Source Type: research
Role of the tripartite motif-containing (TRIM) family of proteins in insulin resistance and related disorders
Diabetes Obes Metab. 2023 Sep 19. doi: 10.1111/dom.15294. Online ahead of print.ABSTRACTEmerging evidence suggests that the ubiquitin-mediated degradation of insulin-signalling-related proteins may be involved in the development of insulin resistance and its related disorders. Tripartite motif-containing (TRIM) proteins, a superfamily belonging to the E3 ubiquitin ligases, are capable of controlling protein levels and function by ubiquitination, which is essential for the modulation of insulin sensitivity. Recent research has indicated that some of these TRIMs act as key regulatory factors of metabolic disorders such as ty...
Source: Atherosclerosis - September 20, 2023 Category: Cardiology Authors: Jianrong Chen Xianjie Feng Xu Zhou Yong Li Source Type: research
Construction and functional evaluation of oral long-acting insulin hydrogel microparticles based on physical and chemical double crosslinking
The objective of this study was to enhance the convenience and effectiveness of diabetes treatment by developing hydrogel microparticles as an oral insulin delivery system, aiming to reduce the necessity for frequent treatments. The hydrogel microparticles were prepared with polysaccharides through a combination of physical and chemical crosslinking method, they achieved good results in insulin loading efficiency (70 %), insulin release efficiency (98 %) and sustained release time (>20 h). The effective transmembrane transport was validated using an intestinal epithelial cell model, which demonstrated a continuous hypog...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: ShengQin Chen QingYa Miao Yang Liu Qiao Xiao YuKai Lin Yu Yang FengBiao Guo Source Type: research
Atractylodes macrocephala Koidz polysaccharide improves glycolipid metabolism disorders through activation of aryl hydrocarbon receptor by gut flora-produced tryptophan metabolites
In this study, a heterogeneous acidic heteropolysaccharide with high molecular weight mainly composed of fructose was isolated from Atractylodes macrocephala Koidz (AMP). Supplementation with AMP was shown to improve diet-induced GMD in a rat model, including decreasing the levels of serum triglycerides, total cholesterol, and glucose, and improving hepatic lipidosis and islet cells morphologies. AMP-treated rats also exhibited modified intestinal flora with enrichments of intestinal Lactobacillus and Rothia species, which was accompanied by increased tryptophan metabolites such as indole-3-propionic acid, indole, tryptami...
Source: International Journal of Biological Macromolecules - September 20, 2023 Category: Biochemistry Authors: Ziwen He Jingyan Guo Huiwen Zhang Jingjing Yu Yiqing Zhou Yajun Wang Ting Li Meiqiu Yan Bo Li Yigong Chen Suhong Chen Guiyuan Lv Jie Su Source Type: research
Macrophage-associated markers of metaflammation are linked to metabolic dysfunction in pediatric obesity
CONCLUSION: MAFLD and other metabolic disorders in pediatric patients with obesity are associated with an elevation of adipose tissue macrophage-related inflammation markers.PMID:37729736 | DOI:10.1016/j.cyto.2023.156372
Source: Cytokine - September 20, 2023 Category: Molecular Biology Authors: Julia Lischka Andrea Schanzer Charlotte de Gier Susanne Greber-Platzer Maximilian Zeyda Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 20, 2023 Category: Physiology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Diabetes Mellitus Drug Discovery: Insights into Targeting Feline and Human Amylin with Small Molecules
Vet Q. 2023 Sep 20:1-20. doi: 10.1080/01652176.2023.2260442. Online ahead of print.ABSTRACTType 2 diabetes (T2D) is a health concern for both humans and cats, with cases rising over the past decade. Around 70% of patients from either species exhibit pancreatic aggregates of islet amyloid polypeptide (IAPP), a protein that proves toxic upon misfolding. These misfolded protein aggregates congregate in the islets of Langerhans of the pancreas, diminishing the capability of β-cells to produce insulin and further perpetuating disease. Our team's drug discovery program is investigating newly synthesized compounds that could dim...
Source: Veterinary Quarterly - September 20, 2023 Category: Veterinary Research Authors: Kendall B E Moore Natalie G Horgan Brooke Lenters Jessica S Fortin Source Type: research
Endoplasmic Reticulum Stress in Pancreatic β-Cells Induces Incretin Desensitization and β-Cell Dysfunction via ATF4-Mediated PDE4D Expression
Am J Physiol Endocrinol Metab. 2023 Sep 20. doi: 10.1152/ajpendo.00156.2023. Online ahead of print.ABSTRACTPancreatic β-cell dysfunction and eventual loss are key steps in the progression of type 2 diabetes (T2D). Endoplasmic reticulum (ER) stress responses, especially those mediated by the PERK-ATF4 pathway, have been implicated in promoting these β-cell pathologies. However, the exact molecular events surrounding the role of the PERK-ATF4 pathway in β-cell dysfunction remain unknown. Here, we report our discovery that ATF4 promotes the expression of PDE4D, which disrupts β-cell function via a downregulation of cAMP s...
Source: Am J Physiol Endocri... - September 20, 2023 Category: Endocrinology Authors: Ji-Hye Lee Hanguk Ryu Hyejin Lee Hye Ram Yu Yurong Gao Kyeong-Min Lee Young-Joon Kim Jaemin Lee Source Type: research
Cancers, Vol. 15, Pages 4651: Is Insulin Receptor Substrate4 (IRS4) a Platform Involved in the Activation of Several Oncogenes?
Miguel A. Ortega
The IRS (insulin receptor substrate) family of scaffold proteins includes insulin receptor substrate-4 (IRS4), which is expressed only in a few cell lines, including human kidney, brain, liver, and thymus and some cell lines. Its N-terminus carries a phosphotyrosine-binding (PTB) domain and a pleckstrin homology domain (PH), which distinguishes it as a member of this family. In this paper, we collected data about the molecular mechanisms that explain the relevance of IRS4 in the development of cancer and identify IRS4 differences that distinguish it from IRS1 and IRS2. Search engines and different dat...
Source: Cancers - September 20, 2023 Category: Cancer & Oncology Authors: Luis G. Guijarro Francisco Javier Justo Bermejo Diego Liviu Boaru Patricia De Castro-Martinez Diego De Leon-Oliva Oscar Fraile-Mart ínez Cielo Garcia-Montero Melchor Alvarez-Mon Mar ía del Val Toledo-Lobo Miguel A. Ortega Tags: Review Source Type: research
Chronic periodontitis induces the proliferation of pancreatic β-cells to cause hyperinsulinemia in a rat model
CONCLUSION: Our study results link CP-induced hyperinsulinemia with changes in islets, such as islet hyperplasia and compensatory β-cell proliferation, by using a CP rat model.PMID:37723987 | DOI:10.1111/jre.13185
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Leilei Ye Yingtao Lv Qianqi Wu Yiyan Chen Xueyang Zhang Yuan Su Source Type: research
Osteopontin-driven T-cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD
CONCLUSIONS: Current findings highlight a critical role of SPP1 in the initiation of obesity-driven chronic inflammation by regulating accumulation and/or polarization of T cells. Early targeting of SPP1 could be beneficial for IR and MAFLD treatment.PMID:37724058 | DOI:10.1002/oby.23868
Source: Obesity - September 19, 2023 Category: Eating Disorders & Weight Management Authors: Fr édéric Soysouvanh D éborah Rousseau St éphanie Bonnafous Manon Bourinet Axelle Strazzulla St éphanie Patouraux Jean Machowiak Marwin A Farrugia Antonio Iannelli Albert Tran Rodolphe Anty Carmelo Luci Philippe Gual Source Type: research
