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Drug: Insulin
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Total 38796 results found since Jan 2013.
Molecular docking analysis of mefluhybenamine with lung cancer targets
Bioinformation. 2022 Dec 31;18(12):1186-1191. doi: 10.6026/973206300181186. eCollection 2022.ABSTRACTLung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. There...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Youssef S Alghamdi Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Leptin and interleukin-1 β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis
This study aimed to investigate the levels of leptin and IL-1β in this patient population and explore their association with clinical parameters of MetS and OA. The study included 164 patients with primary knee OA, who were classified into two categories based on the presence of MetS, and 78 healthy controls. The plasma leptin and IL-1β levels were quantified by ELISA and correlated with clinical parameters. Leptin levels were higher in patients with OA (11.50±10.04 ng/mL) than in healthy controls (0.54±0.37 ng/mL) and increased in patients with MetS compared to those without MetS. IL-1β levels were also significantly...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: N T T Mai N T Hang D H Hanh H Y Le N V Hinh N D Ky N M Tuan H V Tong D T Quan N L Toan Source Type: research
LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis
This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels in GDM mice were detected. The GDM mice were subjected to gain- and loss-of-function assays to examine the change of glucose metabolism indices (fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Yanli Xu Xiaodi Kang Huafang Liu Hongli Jiang Wenjing Wang Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Leptin and interleukin-1 β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis
This study aimed to investigate the levels of leptin and IL-1β in this patient population and explore their association with clinical parameters of MetS and OA. The study included 164 patients with primary knee OA, who were classified into two categories based on the presence of MetS, and 78 healthy controls. The plasma leptin and IL-1β levels were quantified by ELISA and correlated with clinical parameters. Leptin levels were higher in patients with OA (11.50±10.04 ng/mL) than in healthy controls (0.54±0.37 ng/mL) and increased in patients with MetS compared to those without MetS. IL-1β levels were also significantly...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: N T T Mai N T Hang D H Hanh H Y Le N V Hinh N D Ky N M Tuan H V Tong D T Quan N L Toan Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus-Evidence From the Literature
Dose Response. 2023 Sep 10;21(3):15593258231200527. doi: 10.1177/15593258231200527. eCollection 2023 Jul-Sep.ABSTRACTApart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and d...
Source: Dose Response - September 13, 2023 Category: Drugs & Pharmacology Authors: Saima Naz Mohsin Faiza Saleem Ayesha Humayun Afifa Tanweer Ambreen Muddassir Source Type: research
