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Drug: Insulin
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Effects of methylation and imprinting expression of Insulin-like growth factor 2 gene in gastric cancer
CONCLUSION: Our data suggest that IGF2 is involved in the occurrence and development of gastric cancer. Targeting IGF2 may be a potential therapeutic target for gastric cancer.PMID:37718779 | DOI:10.3233/CBM-230105
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Authors: Jiting Sun Jun Shu Duo Shi Wen Liu Yan Zhang Bing Luo Source Type: research
Signaling Circuits and the Apical Extracellular Matrix In Aging: Connections Identified in the Nematode < em > Caenorhabditis elegans < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00195.2023. Online ahead of print.ABSTRACTNumerous conserved signaling pathways play critical roles in aging, including insulin, TGF-β, Wnt, and autophagy pathways. Some of these pathways also play prominent roles in the formation and maintenance of the extracellular matrix. The nematode Caenorhabditis elegans has been an enduringly productive system for the identification of conserved mechanisms of biological aging. Recent studies in C. elegans highlight the regulatory circuits between conserved signaling pathways and the extracellular matrix, revealing a bidir...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Hannah Reich Cathy Savage-Dunn Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The three-dimensional structure of insulin and its receptor
Vitam Horm. 2023;123:151-185. doi: 10.1016/bs.vh.2022.12.001. Epub 2023 Jun 5.ABSTRACTInsulin is a peptide hormone essential for maintaining normal blood glucose levels. Individuals unable to secrete sufficient insulin or not able to respond properly to insulin develop diabetes. Since the discovery of insulin its structure and function has been intensively studied with the aim to develop effective diabetes treatments. The three-dimensional crystal structure of this 51 amino acid peptide paved the way for discoveries, outlined in this review, of determinants important for receptor binding and hormone stability that have bee...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Briony E Forbes Source Type: research
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Neurobiol Dis. 2023 Sep 15:106295. doi: 10.1016/j.nbd.2023.106295. Online ahead of print.ABSTRACTThe amyloid cascade hypothesis is widely accepted as an explanation for the neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. Using the 5xFAD mouse model of AD, we investigated various factors contributing to neuropathology, including genetic load (heterozygous (HTZ) versus homozygous (HZ) condition), behavioural phenotype, neuropathology markers, metabolic physiology, and gut microbiota composition at early (5 months of age) an...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Dina Medina-Vera Emma N Zambrana-Infantes Antonio J L ópez-Gambero Julia Verheul-Campos Luis J Sant ín Elena Baixeras Juan Suarez Francisco J Pavon Cristina Rosell-Valle Fernando Rodr íguez de Fonseca Source Type: research
A murine model of BSCL2-associated Celia's encephalopathy
Neurobiol Dis. 2023 Sep 15:106300. doi: 10.1016/j.nbd.2023.106300. Online ahead of print.ABSTRACTCelia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the c.985C > T variant in the BSCL2 gene, leading to the skipping of exon 7 and resulting in an aberrant seipin protein (Celia-seipin). To precisely define the temporal evolution and the mechanisms involved in neurodegeneration, lipodystrophy and fatty liver in Celia's encephalopathy, our group has generated the first global knock-in murine model for the...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Silvia Cobelo-G ómez Sof ía Sánchez-Iglesias Alberto R ábano Ana Senra Pablo Aguiar Noem í Gómez-Lado Lara Garc ía-Varela Iv án Burgueño-García Laura Lamp ón-Fernández Ant ía Fernández-Pombo Everardo Josu é Díaz-López Teresa Prado-Mora ñ Source Type: research
Transcending the amyloid-beta dominance paradigm in Alzheimer's disease: An exploration of behavioural, metabolic, and gut microbiota phenotypes in 5xFAD mice
Neurobiol Dis. 2023 Sep 15:106295. doi: 10.1016/j.nbd.2023.106295. Online ahead of print.ABSTRACTThe amyloid cascade hypothesis is widely accepted as an explanation for the neuropathological changes in Alzheimer's disease (AD). However, the role of amyloid-beta (Aβ) as the sole cause of these changes is being questioned. Using the 5xFAD mouse model of AD, we investigated various factors contributing to neuropathology, including genetic load (heterozygous (HTZ) versus homozygous (HZ) condition), behavioural phenotype, neuropathology markers, metabolic physiology, and gut microbiota composition at early (5 months of age) an...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Dina Medina-Vera Emma N Zambrana-Infantes Antonio J L ópez-Gambero Julia Verheul-Campos Luis J Sant ín Elena Baixeras Juan Suarez Francisco J Pavon Cristina Rosell-Valle Fernando Rodr íguez de Fonseca Source Type: research
A murine model of BSCL2-associated Celia's encephalopathy
Neurobiol Dis. 2023 Sep 15:106300. doi: 10.1016/j.nbd.2023.106300. Online ahead of print.ABSTRACTCelia's encephalopathy or progressive encephalopathy with/without lipodystrophy is a neurodegenerative disease with a fatal prognosis in childhood. It is generally caused by the c.985C > T variant in the BSCL2 gene, leading to the skipping of exon 7 and resulting in an aberrant seipin protein (Celia-seipin). To precisely define the temporal evolution and the mechanisms involved in neurodegeneration, lipodystrophy and fatty liver in Celia's encephalopathy, our group has generated the first global knock-in murine model for the...
Source: Neurobiology of Disease - September 17, 2023 Category: Neurology Authors: Silvia Cobelo-G ómez Sof ía Sánchez-Iglesias Alberto R ábano Ana Senra Pablo Aguiar Noem í Gómez-Lado Lara Garc ía-Varela Iv án Burgueño-García Laura Lamp ón-Fernández Ant ía Fernández-Pombo Everardo Josu é Díaz-López Teresa Prado-Mora ñ Source Type: research
Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2
Vitam Horm. 2023;123:187-230. doi: 10.1016/bs.vh.2023.01.010. Epub 2023 Mar 1.ABSTRACTElucidating how insulin and the related insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) bind to their cellular receptors (IR and IGF-1R) and how the receptors are activated has been the holy grail for generations of scientists. However, deciphering the 3D structure of tyrosine kinase receptors and their hormone-bound complexes has been complicated by the flexible and dimeric nature of the receptors and the dynamic nature of their interaction with hormones. Therefore, mutagenesis of hormones and kinetic studies first became an import...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Ji ří Jiráček Irena Selicharov á Lenka Žáková Source Type: research
The dual role of citrate in cancer
Biochim Biophys Acta Rev Cancer. 2023 Sep 15:188987. doi: 10.1016/j.bbcan.2023.188987. Online ahead of print.ABSTRACTCitrate is a key metabolite of the Krebs cycle that can also be exported in the cytosol, where it performs several functions. In normal cells, citrate sustains protein acetylation, lipid synthesis, gluconeogenesis, insulin secretion, bone tissues formation, spermatozoid mobility, and immune response. Dysregulation of citrate metabolism is implicated in several pathologies, including cancer. Here we discuss how cancer cells use citrate to sustain their proliferation, survival, and metastatic progression. Also...
Source: Biochimica et Biophysica Acta - September 17, 2023 Category: Biochemistry Authors: Philippe Icard Luca Simula Grit Zahn Marco Alifano Maria E Mycielska Source Type: research
