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Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes.
PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research
On RSS Readers, Divorce and Marriage
In just a few days, Google Reader will be history. I've used it to create over 18,000 Tweets, so yes, I will miss Google Reader. The end has pushed me into a divorce (or maybe it's just a separation?!) — from Google. I describe my Google divorce as kind of like when a married couple with children decide to separate … they still have to see their exes for the sake of the kids (and I still have my blogs with Google's Blogger, for now anyway), and it may be a cordial, but not quite blissful separation, but is still necessary.A number of my fellow diabetes blogging peers have already migrated from Google'...
Source: Scott's Web Log - June 28, 2013 Category: Diabetes Authors: Scott S Source Type: blogs
Identifying search terms
For any literature search, you will need to identify your search terms. What words or phrases are you going to search for? What thesaurus terms are you going to choose? If you are doing a detailed search for evidence for a systematic review, or doing a systematic search for some other reason, identification of search terms will include identification of synonyms, that is, alternative terms for the concept you are interested in.Here are some possible ways to identify thesaurus and free text terms, and synonyms. Scoping searchUse a PICO grid or similar to identify the search concepts, and search for those....
Source: Browsing - August 4, 2015 Category: Databases & Libraries Tags: literature searching systematic reviews Source Type: blogs
Translating search strategies (updated)
This is an update of a post from November 2015.If you are doing a systematic review, you will need to run the same search in more than one database.I use the term " translation " for the process of modifying a search so that it works in another database.It is important to run the same search in all databases.So, if you have a search that works in Ovid Medline, what do you need to change to make it work in another database like PsycINFO or Embase? Those other databases have different features or functionality.There are three areas where translation is necessary, once you have finalised your strategy:Search syntax – ...
Source: Browsing - August 22, 2017 Category: Databases & Libraries Source Type: blogs
The clinical characteristics and mutation search within monogenic diabetes genes in type 1 diabetes patients with long-term disease and preserved kidney function
CONCLUSIONS: Patients with long-term T1DM and well-preserved kidney function are characterized by good glycemic control, high HDL-cholesterol, low insulin requirements and near normal BMI. Monogenic diabetes mutations are not frequent among them.PMID:34825797 | DOI:10.20452/pamw.16143
Source: Molecular Medicine - November 26, 2021 Category: Molecular Biology Authors: Jerzy Hohendorff Magdalena Kwiatkowska Dorota Pisarczyk-Wiza Agnieszka Ludwig-S łomczyńska Magdalena Milcarek Przemys ław Kapusta Barbara Zapa ła Beata Kie ć-Wilk Iwona Trznadel-Morawska Magdalena Szopa Dorota Zozuli ńska-Ziółkiewicz Maciej T Ma ŠSource Type: research
Translating search strategies
Not sure if I borrowed this term, or invented it, but I mean modifying a search strategy for use in another database. For example, if you have a Medline strategy, what do you need to change to make it work in, say, PsycINFO or Embase? Other databases might have different features or functionality.There are two areas where translation is necessary, once you have finalised your strategy. I have assumed in what follows that you have a Medline strategy, and want to translate it for use in other databases.One area is search syntax (proximity operators, truncation, and so on), and the other is subject hea...
Source: Browsing - March 22, 2015 Category: Databases & Libraries Tags: literature searching Source Type: blogs
A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity
Eur J Med Chem. 2022 Mar 16;235:114240. doi: 10.1016/j.ejmech.2022.114240. Online ahead of print.ABSTRACTThe peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of the side-effects showed by the currently marketed PPARγ full agonists, is considered the major challenge for the pharmaceutical companies. Here we present a chemoinformatics search approach for new ligands that let us ident...
Source: European Journal of Medicinal Chemistry - March 24, 2022 Category: Chemistry Authors: Sabina Sblano Carmen Cerchia Antonio Laghezza Luca Piemontese Leonardo Brunetti Rosalba Leuci Federica Gilardi Aurelien Thomas Massimo Genovese Alice Santi Paolo Tortorella Paolo Paoli Antonio Lavecchia Fulvio Loiodice Source Type: research
Nutritional Factors and Preservation of C-Peptide in Youth With Recently Diagnosed Type 1 Diabetes: SEARCH Nutrition Ancillary Study.
CONCLUSIONS Increased intake of branched-chain amino acids and long-chain omega-3 fatty acids may support preservation of β-cell function. This represents a new direction for research to improve prognosis for type 1 diabetes.
PMID: 23801797 [PubMed - in process]
Source: Diabetes Care - July 1, 2013 Category: Endocrinology Authors: Mayer-Davis EJ, Dabelea D, Crandell JL, Crume T, D'Agostino RB, Dolan L, King IB, Lawrence JM, Norris JM, Pihoker C, The N Tags: Diabetes Care Source Type: research
Electromagnetic Interference From Electronic Devices Used in the Management of Type 1 Diabetes Can Impair the Performance of an Avalanche Transceiver in Search Mode
Conclusions Electromagnetic interference produced by some diabetes devices when held within 30 cm of a searching avalanche transceiver can impair the ability to locate a signal. Such interference could significantly compromise the outcome of a companion rescue scenario. Further investigation using other pumps and rtCGMS devices is required to evaluate all available diabetes electronics. Meantime, all electronic diabetes devices including rtCGMS and insulin pumps should not be used within 30 cm of an avalanche transceiver.
Source: Wilderness and Environmental Medicine - March 13, 2015 Category: Environmental Health Source Type: research
Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors.
Abstract
The incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) is constantly increasing. Despite this is apparently associated with the growing increase in obesity, insulin resistance and obesity-related metabolic disturbances their presence is not a necessary or sufficient condition to explain the accumulation of fat in the liver. Conversely, NAFLD is a predictor of other metabolic risks. NAFLD is currently the most frequent chronic liver disease but should not be considered benign or anecdotic because a considerable proportion of patients with NAFLD progress to cirrhosis and end-stage liver d...
Source: World Journal of Gastroenterology : WJG - March 14, 2015 Category: Gastroenterology Authors: Camps J, Joven J Tags: World J Gastroenterol Source Type: research
Comprehensive Search for GPCR Compounds which Can Enhance MafA and/or PDX-1 Expression Levels Using a Small Molecule Compound Library
In conclusion, fulvestrant and dexmedetomidine hydrochloride increased MafA, PDX-1, or insulin expression levels in MIN6 cells and islets from nondiabetic mice and obese type 2 diabetic db/db mice. To the best of our knowledge, this is the first report showing some molecule which can enhance MafA and/or PDX-1 expression levels. Therefore, although further extensive study is necessary, we think that the information in this study could be, at least in part, useful at some point such as in the development of new antidiabetes medicine based on the molecular mechanism of β-cell glucose toxicity in the future.PMID:37720599 | PM...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Hideaki Kaneto Atsushi Obata Masashi Shimoda Tomohiko Kimura Yoshiyuki Obata Tomoko Ikeda Saeko Moriuchi Shuhei Nakanishi Tomoatsu Mune Kohei Kaku Source Type: research
Albuminuria According to Status of Autoimmunity and Insulin Sensitivity Among Youth With Type 1 and Type 2 Diabetes.
CONCLUSIONSIn youth with diabetes, the DAA(-)/IR group had a greater UACR than all other groups, possibly because of the greater magnitude of insulin resistance. Further exploration of the relationships between severity of insulin resistance, autoimmunity, and albuminuria in youth with diabetes is warranted.
PMID: 23846811 [PubMed - as supplied by publisher]
Source: Diabetes Care - July 11, 2013 Category: Endocrinology Authors: Mottl AK, Lauer A, Dabelea D, Maahs DM, D'Agostino RB, Dolan LM, Gilliam LK, Lawrence JM, Rodriguez B, Marcovina SM, Imperatore G, Kanakatti Shankar R, Afkarian M, Reynolds K, Liese AD, Mauer M, Mayer-Davis EJ, For the SEARCH for Diabetes in Youth Study G Tags: Diabetes Care Source Type: research
Search for New Type of PPARγ Agonist-Like Anti-diabetic Compounds from Medicinal Plants.
Abstract
Potent ligands of peroxisome proliferator-activated receptor γ (PPARγ) such as thiazolidinediones (pioglitazone, troglitazone, etc.) improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Several constituents from medicinal plants were recently reported to show PPARγ agonist-like activity in 3T3-L1 cells, but did not show agonistic activity at the receptor site different from thiazolidinediones. Our recent studies on PPARγ agonist-like constituents, such as hydrangenol and hydrangeic acid from the processed...
Source: Biological and Pharmaceutical Bulletin - June 7, 2014 Category: Drugs & Pharmacology Authors: Matsuda H, Nakamura S, Yoshikawa M Tags: Biol Pharm Bull Source Type: research
In search of a surrogate: engineering human beta cell lines for therapy.
Abstract
Replacement of insulin-producing cells is a promising therapy for the restoration of the beta cell mass that is destroyed in patients with type 1 diabetes (T1D). However, the use of large amounts of islets per transplant, coupled with the scarcity of donor tissue, diminishes its feasibility. Here we briefly discuss current progress in developing ideal functional beta cells as well as the rationale for developing renewable sources of insulin-producing cells that can be transplanted.
PMID: 24958526 [PubMed - as supplied by publisher]
Source: Trends in Endocrinology and Metabolism: TEM - June 20, 2014 Category: Endocrinology Authors: Newby BN, Terada N, Mathews CE Tags: Trends Endocrinol Metab Source Type: research
