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Drug: Insulin
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Leptin and interleukin-1 β levels associated with osteoarthritis in Vietnamese patients: a cross-sectional analysis
This study aimed to investigate the levels of leptin and IL-1β in this patient population and explore their association with clinical parameters of MetS and OA. The study included 164 patients with primary knee OA, who were classified into two categories based on the presence of MetS, and 78 healthy controls. The plasma leptin and IL-1β levels were quantified by ELISA and correlated with clinical parameters. Leptin levels were higher in patients with OA (11.50±10.04 ng/mL) than in healthy controls (0.54±0.37 ng/mL) and increased in patients with MetS compared to those without MetS. IL-1β levels were also significantly...
Source: Braz J Med Biol Res - September 13, 2023 Category: Research Authors: N T T Mai N T Hang D H Hanh H Y Le N V Hinh N D Ky N M Tuan H V Tong D T Quan N L Toan Source Type: research
Prospective Nutraceutical Effects of Cinnamon Derivatives Against Insulin Resistance in Type II Diabetes Mellitus-Evidence From the Literature
Dose Response. 2023 Sep 10;21(3):15593258231200527. doi: 10.1177/15593258231200527. eCollection 2023 Jul-Sep.ABSTRACTApart from advances in pharmaceutical antidiabetic agents, efforts are being made toward hypoglycemic agents derived from natural sources. Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antidiabetic, and anti-hypertriglyceridemic agent. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and solvent extraction. These chemicals help in decreasing insulin resistance and can act against hyperglycemia and d...
Source: Dose Response - September 13, 2023 Category: Drugs & Pharmacology Authors: Saima Naz Mohsin Faiza Saleem Ayesha Humayun Afifa Tanweer Ambreen Muddassir Source Type: research
LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis
This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels in GDM mice were detected. The GDM mice were subjected to gain- and loss-of-function assays to examine the change of glucose metabolism indices (fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Yanli Xu Xiaodi Kang Huafang Liu Hongli Jiang Wenjing Wang Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis
Aging Cell. 2023 Sep 11. doi: 10.1111/acel.13975. Online ahead of print.ABSTRACTProteomic approaches have unique advantages in the identification of biological pathways that influence physical frailty, a multifactorial geriatric syndrome predictive of adverse health outcomes in older adults. To date, proteomic studies of frailty are scarce, and few evaluated prefrailty as a separate state or examined predictors of incident frailty. Using plasma proteins measured by 4955 SOMAmers in the Atherosclerosis Risk in Community study, we identified 134 and 179 proteins cross-sectionally associated with prefrailty and frailty, respe...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Fangyu Liu Thomas R Austin Jennifer A Schrack Jingsha Chen Jeremy Walston Rasika A Mathias Morgan Grams Michelle C Odden Anne Newman Bruce M Psaty Diego Ramonfaur Amil M Shah B Gwen Windham Josef Coresh Keenan A Walker Source Type: research
Long-term effects of a fat-directed FGF21 gene therapy in aged female mice
Gene Ther. 2023 Sep 12. doi: 10.1038/s41434-023-00422-0. Online ahead of print.ABSTRACTFibroblast growth factor 21 (FGF21) has been developed as a potential therapeutic agent for metabolic syndromes. Moreover, FGF21 is considered a pro-longevity hormone because transgenic mice overexpressing FGF21 display extended lifespan, raising the possibility of using FGF21 to promote healthy aging. We recently showed that visceral fat directed FGF21 gene therapy improves metabolic and immune health in insulin resistant BTBR mice. Here, we used a fat directed rAAV-FGF21 vector in 17-month-old female mice to investigate whether long-te...
Source: Cancer Control - September 12, 2023 Category: Cancer & Oncology Authors: Jacqueline M Anderson W David Arnold Wei Huang Alissa Ray Gregory Owendoff Lei Cao Source Type: research
Management of type 2 diabetes in the new era
CONCLUSION: Management of type 2 diabetes requires a holistic approach and recent breakthroughs are expected to improve the quality of care.PMID:37700155 | DOI:10.1007/s42000-023-00488-w
Source: Hormones - September 12, 2023 Category: Endocrinology Authors: Aris Liakos Thomas Karagiannis Ioannis Avgerinos Konstantinos Malandris Apostolos Tsapas Eleni Bekiari Source Type: research
HDAC3 inhibition protects against peripheral and central alterations in an animal model of obesity
CONCLUSION: Therefore, HDAC3 inhibition can represent a promising pharmacological target for the treatment of obesity.PMID:37698830 | DOI:10.1007/s43440-023-00528-7
Source: Pharmacological Reports - September 12, 2023 Category: Drugs & Pharmacology Authors: Franci éle Romero Machado Silvana Peterini Boeira Vandreza Cardoso Bortolotto St ífani Machado Araujo M árcia Rósula Poetini Cristini Escobar Viana Marina Prigol Leandro Cattelan Souza Marcelo Gomes de Gomes Source Type: research
Effect of fenofibrate and selective PPAR α modulator (SPPARMα), pemafibrate on KATP channel activity and insulin secretion
BMC Res Notes. 2023 Sep 11;16(1):202. doi: 10.1186/s13104-023-06489-7.ABSTRACTOBJECTIVE: Insulin secretion is regulated by ATP-sensitive potassium (KATP) channels in pancreatic beta-cells. Peroxisome proliferator-activated receptors (PPAR) α ligands are clinically used to treat dyslipidemia. A PPARα ligand, fenofibrate, and PPARγ ligands troglitazone and 15-deoxy-∆12,14-prostaglandin J2 are known to close KATP channels and induce insulin secretion. The recently developed PPARα ligand, pemafibrate, became a new entry for treating dyslipidemia. Because pemafibrate is reported to improve glucose intolerance in mice trea...
Source: Cell Research - September 12, 2023 Category: Cytology Authors: Shigeki Kitamura Naoya Murao Shoko Yokota Masaru Shimizu Tomoyuki Ono Yusuke Seino Atsushi Suzuki Yuko Maejima Kenju Shimomura Source Type: research
Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis
Aging Cell. 2023 Sep 11. doi: 10.1111/acel.13975. Online ahead of print.ABSTRACTProteomic approaches have unique advantages in the identification of biological pathways that influence physical frailty, a multifactorial geriatric syndrome predictive of adverse health outcomes in older adults. To date, proteomic studies of frailty are scarce, and few evaluated prefrailty as a separate state or examined predictors of incident frailty. Using plasma proteins measured by 4955 SOMAmers in the Atherosclerosis Risk in Community study, we identified 134 and 179 proteins cross-sectionally associated with prefrailty and frailty, respe...
Source: Atherosclerosis - September 12, 2023 Category: Cardiology Authors: Fangyu Liu Thomas R Austin Jennifer A Schrack Jingsha Chen Jeremy Walston Rasika A Mathias Morgan Grams Michelle C Odden Anne Newman Bruce M Psaty Diego Ramonfaur Amil M Shah B Gwen Windham Josef Coresh Keenan A Walker Source Type: research
Irisin deficiency exacerbates diet-induced insulin resistance and cardiac dysfunction in type II diabetes in mice
Am J Physiol Cell Physiol. 2023 Sep 11. doi: 10.1152/ajpcell.00232.2023. Online ahead of print.ABSTRACTMyokine Irisin is involved in the regulation of a variety of physiological conditions, metabolism, and survival. We and others have demonstrated that recombinant irisin contributes critically to modulation of insulin resistance and the improvement of cardiac function. However, whether deletion of irisin will regulates cardiac function and insulin sensitivity in type II diabetes remains unclear. We utilized the CRISPR/Cas-9 genome-editing system to delete irisin globally in mice and high fat diet (HFD)-induced type II diab...
Source: Am J Physiol Cell Ph... - September 11, 2023 Category: Cytology Authors: Jianguo Wang Yu Tina Zhao Ling Zhang Patrycja M Dubielecka Gangjian Qin Yueh Eugene Chin Adam C Gower Shougang Zhuang Paul Y Liu Ting C Zhao Source Type: research
