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Drug: Insulin
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Total 38796 results found since Jan 2013.
Association between different modalities of insulin administration and metabolic dysfunction-associated fatty liver disease in adults with type 1 diabetes mellitus
CONCLUSION: The lower prevalence of MAFLD with coexisting significant fibrosis we observed in adults with T1DM using CSII therapy, compared to those using MDI therapy, is primarily mediated by inter-group differences in age.PMID:37708990 | DOI:10.1016/j.diabet.2023.101477
Source: Diabetes and Metabolism - September 14, 2023 Category: Endocrinology Authors: Alessandro Csermely Alessandro Mantovani Mario Luca Morieri Luisa Palmisano Maria Masulli Efisio Cossu Marco Giorgio Baroni Katia Bonomo Flavia Agata Cimini Gisella Cavallo Raffaella Buzzetti Carmen Mignogna Frida Leonetti Simonetta Bacci Roberto Trevisan Source Type: research
Comparison of hyperoxia or normoxia resolution of intermittent hypoxia and intermittent hyperoxia episodes on liver histopathology, IGF-1, IGFBP-3, and GHBP in neonatal rats
CONCLUSIONS: Exposure to IH or intermittent hyperoxia during the first few weeks of life regardless of resolution in RA or hyperoxia is detrimental to the immature liver. These findings may suggest that interventions to prevent frequent fluctuations in oxygen saturation during early neonatal life remain a high priority.PMID:37708588 | DOI:10.1016/j.ghir.2023.101559
Source: Growth Hormone and IGF Research - September 14, 2023 Category: Endocrinology Authors: Charles L Cai Matthew Marcelino Jacob V Aranda Kay D Beharry Source Type: research
LncRNA XIST promotes insulin resistance in gestational diabetes mellitus via the microRNA-181b-5p/NDRG2 axis
This study was designed to unravel the regulatory mechanism of XIST on animal models of gestational diabetes mellitus (GDM) progression via the microRNA (miR)-181b-5p/N-myc downstream-regulated gene 2 (NDRG2) axis. XIST, miR-181b-5p, and NDRG2 expression levels in GDM mice were detected. The GDM mice were subjected to gain- and loss-of-function assays to examine the change of glucose metabolism indices (fasting blood glucose (FBG), fasting insulin (FINS) and homeostasis model assessment of insulin resistance (HOMA-IR)), serum oxidative stress factors (glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA)...
Source: General Physiology and Biophysics - September 13, 2023 Category: Physiology Authors: Yanli Xu Xiaodi Kang Huafang Liu Hongli Jiang Wenjing Wang Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: Am J Physiol Endocri... - September 13, 2023 Category: Endocrinology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Adipocyte STAT5 (signal transducer and activator of transcription 5) is not required for glucocorticoid-induced metabolic dysfunction
Conclusion: Adipocyte STAT5 is not necessary for GC-mediated progression of metabolic disease.PMID:37702737 | DOI:10.1152/ajpendo.00116.2023
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Innocence Harvey Allison J Richard Tamra M Mendoza Jacqueline M Stephens Source Type: research
Assessment of the incretin effect in healthy subjects: Concordance between clamp and OGTT methods
Am J Physiol Endocrinol Metab. 2023 Sep 13. doi: 10.1152/ajpendo.00104.2022. Online ahead of print.ABSTRACTThe incretin effect describes the insulin response to nutrient ingestion that exceeds the response to glycemia per se. It is mediated by gastrointestinal factors and is necessary to maintain postprandial glucose homeostasis. The incretin effect results in a more than 2-fold increase of the insulin response to a meal in healthy people and two different techniques have been used in the past to measure its magnitude. Most studies employ an OGTT on one day, followed by a matching glucose infusion on a separate day. Anothe...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 13, 2023 Category: Physiology Authors: Benedikt A Aulinger David A D'Alessio Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Neurochemical Research - September 13, 2023 Category: Neuroscience Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
Clinico-pathological characteristics of IGFR1 and VEGF-A co-expression in early and locally advanced-stage lung adenocarcinoma
CONCLUSIONS: These results suggest that IGFR1+&VEGF-A+ is expected to be a disadvantageous factor for prognosis in the subgroup of EGFR mutation in patients with early and locally advanced-stage lung adenocarcinoma. What's more, this study may provide the theoretical possibility to screen optimal population for a combination therapy with anti-VEGF and anti-IGFR1 in patients with early and locally advanced-stage lung adenocarcinoma.PMID:37702808 | DOI:10.1007/s00432-023-05371-0
Source: Clinical Lung Cancer - September 13, 2023 Category: Cancer & Oncology Authors: Wenting Liu Junling Xia Qingwu Du Jingya Wang Ting Mei Tingting Qin Source Type: research
EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events
In conclusion, these data highlight the importance of EHD2 for the integrity of the plasma membrane milieu, insulin receptor stability, and downstream insulin receptor signalling events, involved in glucose uptake and ultimately underscore its role in insulin resistance and obesity.PMID:37703099 | DOI:10.1091/mbc.E23-03-0078
Source: Mol Biol Cell - September 13, 2023 Category: Molecular Biology Authors: Mathis Neuhaus Claes Fryklund Holly Taylor Andrea Borreguero-Mu ñoz Franziska Kopietz Hamidreza Ardalani Oksana Rogova Laura Stirrat Shaun K Bremner Peter Sp égel Nia J Bryant Gwyn W Gould Karin G Stenkula Source Type: research
Ecdysone-induced microRNA miR-276a-3p controls developmental growth by targeting the insulin-like receptor in Drosophila
In this study, we found that fat body-specific expression of miR-276a, an ecdysone-responsive microRNA (miRNA), led to a decrease in the total mass of the larval fat body, resulting in significant growth reduction in Drosophila. Changes in miR-276a expression also affected the proliferation of Drosophila S2 cells. Furthermore, we found that the insulin-like receptor (InR) is a biologically relevant target gene regulated by miR-276a-3p. In addition, we found that miR-276a-3p is upregulated by the canonical ecdysone signalling pathway involving the ecdysone receptor and broad complex. A reduction in cell proliferation caused...
Source: Mol Biol Cell - September 13, 2023 Category: Molecular Biology Authors: Sojeong Lee Nayeon Kim Daegyu Jang Hee Kyung Kim Jongin Kim Ji Won Jeon Do-Hwan Lim Source Type: research
Low Density Lipoprotein Receptor-related Protein 2 Expression and Function in Cultured Astrocytes and Microglia
Neurochem Res. 2023 Sep 13. doi: 10.1007/s11064-023-04022-7. Online ahead of print.ABSTRACTActivation of glial cells, astrocytes and microglia, has been observed in neurodegenerative diseases including Alzheimer's disease (AD). Amyloid β (Aβ), which is aggregated and the aggregation is detected as characteristic pathology in AD brain, is known to be produced by neurons and to activate glial cells. Clearance of Aβ from the brain via active transport system is important to prevent the accumulation and aggregation. Low density lipoprotein receptor-related protein 2 (LRP2/megalin) is an Aβ transporter. However, expression ...
Source: Cell Research - September 13, 2023 Category: Cytology Authors: Katsura Takano-Kawabe Kazuyuki Matoba Yoichi Nakamura Mitsuaki Moriyama Source Type: research
Evaluation of Basal Plus Versus Sliding Scale Insulin Therapy on Glucose Variability in Critically Ill Patients Without Preexisting Diabetes
CONCLUSIONS AND RELEVANCE: The use of SSI compared with a BPI regimen may result in reduced glycemic variability in critically ill patients without preexisting diabetes. Future prospective studies, with a larger sample size, are warranted to confirm our exploratory findings and characterize clinically significant benefits.PMID:37700565 | DOI:10.1177/10600280231197255
Source: The Annals of Pharmacotherapy - September 13, 2023 Category: Drugs & Pharmacology Authors: Rachel E Webster Julie J Belfer Kyle J Schmidt Source Type: research
Molecular docking analysis of mefluhybenamine with lung cancer targets
Bioinformation. 2022 Dec 31;18(12):1186-1191. doi: 10.6026/973206300181186. eCollection 2022.ABSTRACTLung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. There...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Youssef S Alghamdi Source Type: research
Nrf2: Therapeutic target of islet function protection in diabetes and islet transplantation
Biomed Pharmacother. 2023 Sep 11;167:115463. doi: 10.1016/j.biopha.2023.115463. Online ahead of print.ABSTRACTNuclear factor-erythroid 2-related factor 2 (Nrf2) has been reported as a major intracellular regulator of antioxidant stress, notably in islet β cells with low antioxidant enzyme content. Nrf2 is capable of regulating antioxidant function, while it can also regulate insulin secretion, proliferation, and differentiation of β cells, ER stress, as well as mitochondrial function. Thus, Nrf2 pharmacological activators have been employed in the laboratory for the treatment of diabetic mice. Islet cells are exposed to ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 13, 2023 Category: Drugs & Pharmacology Authors: Butian Wei Xin Zhang Jiwei Qian Zhe Tang Bo Zhang Source Type: research
