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Cancer: Brain Cancers
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Total 371 results found since Jan 2013.
The combined association of depressive symptoms and C-reactive protein for incident disease risk up to 12 years later. Findings from the English Longitudinal of Ageing (ELSA).
CONCLUSION: A combination of depressive symptoms and CRP was implicated in the onset of CHD, stroke, diabetes/high blood glucose, and pulmonary disease up to 12 years later, reflecting the role of psychobiological processes across multiple disease states.
PMID: 31972338 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - January 19, 2020 Category: Neurology Authors: Poole L, Steptoe A Tags: Brain Behav Immun Source Type: research
A Single-Scan, Rapid Whole-Brain Protocol for Quantitative Water Content Mapping With Neurobiological Implications
Water concentration is tightly regulated in the healthy human brain and changes only slightly with age and gender in healthy subjects. Consequently, changes in water content are important for the characterization of disease. MRI can be used to measure changes in brain water content, but as these changes are usually in the low percentage range, highly accurate and precise methods are required for detection. The method proposed here is based on a long-TR (10 s) multiple-echo gradient-echo measurement with an acquisition time of 7:21 min. Using such a long TR ensures that there is no T1 weighting, meaning that the image inten...
Source: Frontiers in Neurology - December 19, 2019 Category: Neurology Source Type: research
New-onset refractory status epilepticus: a retrospective cohort study
Status epilepticus (SE) is a neurological emergency with more than 180 described causes; common causes include medication change or noncompliance in patients with known epilepsy, toxic-metabolic disturbances, sedative/hypnotic withdrawal, acute/remote stroke, and brain tumor [1]. The term new-onset refractory SE (NORSE) is applied to a patient without a prior diagnosis of epilepsy or other preexisting relevant neurological disorder, with new onset of refractory SE (RSE) that does not respond to first- and second-line antiseizure drugs and no clear acute or active structural, toxic, or metabolic cause.
Source: Seizure: European Journal of Epilepsy - December 2, 2019 Category: Neurology Authors: James J. Gugger, Khalil Husari, John C. Probasco, Mackenzie C. Cervenka Source Type: research
Case Report of a Novel Technique for Repair
of the Vertebral Artery During Cranial Surgery
AbstractSurgery of complex cranial base lesions carries a high risk of damage to
main vessels, often resulting in life-changing or even life-threatening injuries. We
describe a rapid, effective, and noninvasive application of a collagen-based
hemostatic patch to repair the vertebral artery during cranial surgery. A
61-year-old male patient underwent retrosigmoid craniotomy to remove a foramen
magnum meningioma that encased the vertebral artery. A linear incision was made
behind the ear and standard retrosigmoid craniotomy was performed with preservation
of the transverse and sigmoid sinuses. The dura was open...
Source: Neurology and Therapy - November 30, 2019 Category: Neurology Source Type: research
Pharmacological hypothermia induced neurovascular protection after severe stroke of transient middle cerebral artery occlusion in mice.
Abstract
Therapeutic hypothermia is a potential protective strategy after stroke. The present study evaluated the neurovascular protective potential of pharmacological hypothermia induced by the neurotensin receptor 1 agonist HPI-201 after severe ischemic stroke. Adult C57BL/6 mice were subjected to filament insertion-induced occlusion of the middle cerebral artery (60 min MCAO). HPI-201 was i.p. injected 120 min after the onset of MCAO to initiate and maintain the body temperature at 32-33°C for 6 hrs. The infarct volume, cell death, integrity of the blood brain barrier (BBB) and neurovascular unit (NVU), inflam...
Source: Experimental Neurology - November 22, 2019 Category: Neurology Authors: Zhao Y, Wei ZZ, Lee JH, Gu X, Sun J, Dix TA, Wei L, Yu SP Tags: Exp Neurol Source Type: research
GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury.
This study established a CI / R injury model in vivo and in vitro. The results showed that the expression of GAS5 was increased in CI / R rats, while miR-26b-5p expression was decreased. Besides, knockdown of GAS5 by siRNA (si-GAS5) reversed CI / R-induced apoptosis and inflammatory responses. Notably, bioinformatics analysis indicated that GAS5 competitively adsorbed miR-26b-5p, and the relationship was further confirmed by pull-down assay. In addition, miR-26b-5p overexpression reversed CI / R-induced apoptosis and inflammatory responses, whereas low expression of miR-26b-5p had the opposite effect. Moreover, TargetScan ...
Source: Behavioural Brain Research - November 17, 2019 Category: Neurology Authors: Shangguan Y, Han J, Su H Tags: Behav Brain Res Source Type: research
Effects of early postnatal exposure to fine particulate matter on emotional and cognitive development and structural synaptic plasticity in immature and mature rats
ConclusionsOur findings indicate that PM2.5 impairs emotional and cognitive development by disrupting structural synaptic plasticity, possibly via the CREB/BDNF signaling pathway.
Source: Brain and Behavior - November 10, 2019 Category: Neurology Authors: Jie Liu,
Chen Yang,
Jing Yang,
Xiaojie Song,
Wei Han,
Mingdan Xie,
Li Cheng,
Lingling Xie,
Hengsheng Chen,
Li Jiang Tags: ORIGINAL RESEARCH Source Type: research
“Accent issue”: foreign accent syndrome following ischemic stroke
In conclusion, FAS is a rare motor speech disorder, often related to cerebrovascular accidents involving critical regions in the dominant hemisphere. In addition, the present case adds further evidence to the role of the left primary motor cortex in modulation of prosody. In rare cases FAS can be the only sign of stroke or can appear after recovery from post-stroke aphasia.
Source: Neurological Sciences - October 28, 2019 Category: Neurology Source Type: research
Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease.
Authors: Román GC, Jackson RE, Gadhia R, Román AN, Reis J
Abstract
The mechanisms of action of the dietary components of the Mediterranean diet are reviewed in prevention of cardiovascular disease, stroke, age-associated cognitive decline and Alzheimer disease. A companion article provides a comprehensive review of extra-virgin olive oil. The benefits of consumption of long-chain ω-3 fatty acids are described. Fresh fish provides eicosapentaenoic acid while α-linolenic acid is found in canola and soybean oils, purslane and nuts. These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic...
Source: Revue Neurologique - September 16, 2019 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Stroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature
We report herein incidence and clinical features of hyperacute onset PCD, a vertebrobasilar stroke mimic. We performed a retrospective analysis of all suspected PCD cases referred to the Udine University Hospital between 2009 and 2017. Our center provides the only neuroimmunology laboratory for three provinces of the Friuli-Venezia Giulia region, Italy (983,190 people as of January 1, 2017). Inclusion criteria were (1) abrupt onset of neurological symptoms; (2) initial consideration of a vascular etiology; (3) final diagnosis of “definite PCD.” We also carried out a systematic review of the literature in order to ident...
Source: The Cerebellum - August 28, 2019 Category: Neurology Source Type: research
Neutrophil ‐to‐lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta‐analysis
ConclusionA high NLR can predict HT and 3 ‐month mortality in patients with AIS. Regardless of the country of origin and the sampling time, an NLR with a cutoff value of 7.5–11 was independently associated with HT in AIS patients.
Source: Brain and Behavior - August 19, 2019 Category: Neurology Authors: Ruirui Zhang,
Xiaodong Wu,
Wenjie Hu,
Li Zhao,
Shoucai Zhao,
Ji Zhang,
Zhaohu Chu,
Yang Xu Tags: ORIGINAL RESEARCH Source Type: research
Clematichinenoside Facilitates Recovery of Neurological and Motor Function in Rats after Cerebral Ischemic Injury through Inhibiting Notch/NF- κB Pathway
Purpose: The present study was to observe the therapeutic efficiency of Clematichinenoside (AR) on cerebral ischemic injury in rats, especially on neurological and motor function recovery and to explore the underlying mechanism. Methods: Following middle cerebral artery occlusion/reperfusion (MCAO/R) surgery, rats were treated orally with 32, 16, and 8 mg/kg AR respectively for 14 days during which cerebral injury was evaluated and proinflammatory factors tumor necrosis factor- α and interleukin-6 as well as neurotrophic factors brain-derived neurotrophic factor and Neurotrophin-3 levels were determined with ELISA kits.
Source: Journal of Stroke and Cerebrovascular Diseases - August 5, 2019 Category: Neurology Authors: Dan Xu, Nian Xia, Kai Hou, Fengyang Li, Shijie Chen, Yahui Hu, Weirong Fang, Yunman Li Source Type: research
Case Report of a Novel Technique for Repair of the Vertebral Artery During Cranial Surgery
We describe a rapid, effective, and noninvasive application of a collagen-based hemostatic patch to repair the vertebral artery during cranial surgery. A 61-year-old male patient underwent retrosigmoid craniotomy to remove a foramen magnum meningioma that encased the vertebral artery. A linear incision was made behind the ear and standard retrosigmoid craniotomy was performed with preservation of the transverse and sigmoid sinuses. The dura was opened in a Y-shaped fashion and the cerebellum was retracted with cerebrospinal fluid being released. Removing the exposed tumor from the artery resulted in a small arterial bleed....
Source: Neurology and Therapy - July 4, 2019 Category: Neurology Source Type: research
NDRG2 Protects the Brain from Excitotoxicity by Facilitating Interstitial Glutamate Uptake
AbstractGlutamate is a prominent neurotransmitter responsible for excitatory synaptic transmission and is taken up by sodium-dependent excitatory amino acid transporters (EAATs) on astrocytes to maintain synaptic homeostasis. Here, we report that N-myc downstream regulated gene 2 (NDRG2), a known tumor suppressor, is required to facilitate astroglial glutamate uptake and protect the brain from glutamate excitotoxicity after ischemia. NDRG2 knockout (Ndrg2−/−) mice exhibited an increase in cerebral interstitial glutamate and a reduction in glutamate uptake into astrocytes. The ability of NDRG2 to control EAAT-mediated g...
Source: Translational Stroke Research - June 26, 2019 Category: Neurology Source Type: research
Relationship between androgenic alopecia and white matter hyperintensities in apparently healthy subjects
AbstractA healthy brain is essential for living a longer and fuller life. Detecting asymptomatic white matter hyperintensities (WMHs) may be clinically important in terms of treatment and prognostic evaluation. WMHs in brain may reflect brain aging. Androgenic alopecia (AGA) is associated with significant cardiovascular risk factors that also have a negative impact on brain aging. The main purpose of present study was to know whether alopecia might provide predictive information of WMHs that may be considered as a surrogate marker of cerebral small vessel disease which is related to arteriolosclerosis and vascular risk fac...
Source: Brain Imaging and Behavior - June 26, 2019 Category: Neurology Source Type: research
