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Specialty: Neurology
Cancer: Brain Cancers
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Total 371 results found since Jan 2013.
From neurons to the neuro-glio-vascular unit: Seizures and brain homeostasis in networks
Rev Neurol (Paris). 2023 Feb 7:S0035-3787(23)00748-8. doi: 10.1016/j.neurol.2022.12.005. Online ahead of print.ABSTRACTWhile seizures are undoubtedly neuronal events, an ensemble of auxiliary brain cells profoundly shapes synaptic transmission in health and disease conditions. Endothelial-astrocyte-pericyte assemblies at the blood-brain barrier (BBB) and neuroglia within the neuro-glio-vascular unit (NGVU) finely tune brain parenchymal homeostasis, safeguarding the ionic and molecular compositions of the interstitial fluid. BBB permeability with neuroinflammation and the resulting loss of brain homeostatic control are unif...
Source: Revue Neurologique - February 9, 2023 Category: Neurology Authors: N Cresto A Janvier N Marchi Source Type: research
PHLDA1 knockdown alleviates mitochondrial dysfunction and endoplasmic reticulum stress-induced neuronal apoptosis via activating PPAR γ in cerebral ischemia-reperfusion injury
Brain Res Bull. 2023 Jan 18;194:23-34. doi: 10.1016/j.brainresbull.2023.01.007. Online ahead of print.ABSTRACTMitochondrial dysfunction and endoplasmic reticulum (ER) stress occur in ischemic stroke. The disruption of these two organelles can directly lead to cell death through various signaling pathways. Thus, investigation of the associated molecular mechanisms in cerebral ischemia is a prerequisite for stroke treatment. Pleckstrin homology-like domain family A member 1 (PHLDA1) is a multifunctional protein that can modulate mitochondrial function and ER stress in cardiomyocyte and cancer cells. This work studied the rol...
Source: Brain Research Bulletin - January 21, 2023 Category: Neurology Authors: Yushuang Liu Hanshu Zhao Nan Chen Yuelong Li Zeyang Zheng Zhiyu Sun Zhongling Zhang Source Type: research
α7 nicotinic acetylcholine receptor agonist improved brain injury and impaired glucose metabolism in a rat model of ischemic stroke
AbstractVagus nerve stimulation through the action of acetylcholine can modulate inflammatory responses and metabolism. α7 Nicotinic Acetylcholine Receptor (α7nAChR) is a key component in the biological functions of acetylcholine. To further explore the health benefits of vagus nerve stimulation, this study aimed to investigate whether α7nAChR agonists offer beneficial effects against poststroke inflammatory and m etabolic changes and to identify the underlying mechanisms in a rat model of stroke established by permanent cerebral ischemia. We found evidence showing that pretreatment with α7nAChR agonist, GTS-21, improv...
Source: Metabolic Brain Disease - January 20, 2023 Category: Neurology Source Type: research
Corrigendum: Case report: Cryptogenic giant brain abscess caused by Providencia rettgeri mimicking stroke and tumor in a patient with impaired immunity
Source: Frontiers in Neurology - January 9, 2023 Category: Neurology Source Type: research
β-hydroxybutyrate improves cognitive impairment caused by chronic cerebral hypoperfusion via amelioration of neuroinflammation and blood-brain barrier damage
CONCLUSION: BHB can improve the cognitive impairment caused by CCH. The potential mechanisms of BHB may be through reducing neuroinflammation and protecting BBB.PMID:36577190 | DOI:10.1016/j.brainresbull.2022.12.011
Source: Brain Research Bulletin - December 28, 2022 Category: Neurology Authors: Zhitian Wang Tian Li Miaoyu Du Lei Zhang Linling Xu Hao Song Junjian Zhang Source Type: research
Diindolylmethane Ameliorates Ischemic Stroke-Induced Brain Injury by Peripheral and Central Mechanisms
CONCLUSION: This inhibition of platelet aggregation, platelet mediated oxidative stress, and inflammation, improved blood flow, and reduced neurological deficits, brain infarction, BBB leakage, brain water content, and histopathological abnormalities indicate the preservation of brain structural integrity. Therefore, these findings conclude that DIM exhibits neuroprotection by inhibiting platelet aggregation. Thus, the present study provided preclinical evidence of DIM neuroprotection against ischemic stroke.PMID:36397630 | DOI:10.2174/1567202620666221116161128
Source: Current Neurovascular Research - November 18, 2022 Category: Neurology Authors: Ramakrishna Kakarla Sushil Kumar Singh Sairam Krishnamurthy Source Type: research
