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Specialty: Endocrinology
Condition: Diabetes

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Total 1416 results found since Jan 2013.

Is diabetes an independent risk factor for in‐hospital complications after a stroke? 糖尿病是卒中后发生院内并发症的一个独立危险因素吗？
ConclusionsAlthough IS patients with DM more often suffered IHCs, previous diagnosis of DM is not per se associated with the risk of IHCs. Stroke severity and on‐admission glycemia ≥155 mg/dL were the most significant predictors for the development of IHCs. 摘要 背景：与没有糖尿病（DM）的患者相比，DM患者更有可能发生院内并发症（in‐hospital complications，IHCs）。另外，他们发生缺血性卒中（ischemic stroke，IS）后的预后更差。我们的目的是评估IS患者发生IHCs的风险增加是否是因为DM本身，还是因为DM导致的代谢指标控制不佳或是...
Source: Journal of Diabetes - December 1, 2014 Category: Endocrinology Authors: Andrés Cruz‐Herranz, Blanca Fuentes, Patricia Martínez‐Sánchez, Gerardo Ruiz‐Ares, Manuel Lara‐Lara, Borja Sanz‐Cuesta, Exuperio Díez‐Tejedor Tags: Original Article Source Type: research

Potentials of incretin‐based therapies in dementia and stroke in type 2 diabetes mellitus
In conclusion, experimental studies show promising results of incretin‐based therapies at improving the outcome of Alzheimer's disease and stroke through glucose‐independent pleiotropic effects on the brain. If these findings would indeed be confirmed in large clinical randomized controlled trials, this would have substantial impact. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - August 24, 2015 Category: Endocrinology Authors: Onno. N. Groeneveld, L. Jaap. Kappelle, Geert Jan Biessels Tags: Review Source Type: research

Is diabetes an independent risk factor for in‐hospital complications after a stroke? / 糖尿病是卒中后发生院内并发症的一个独立危险因素吗？
ConclusionsAlthough IS patients with DM more often suffered IHCs, previous diagnosis of DM is not per se associated with the risk of IHCs. Stroke severity and on‐admission glycemia ≥155 mg/dL were the most significant predictors for the development of IHCs. 摘要 背景：与没有糖尿病（DM）的患者相比，DM患者更有可能发生院内并发症（in‐hospital complications，IHCs）。另外，他们发生缺血性卒中（ischemic stroke，IS）后的预后更差。我们的目的是评估IS患者发生IHCs的风险增加是否是因为DM本身，还是因为DM导致的代谢指标控制不佳或是...
Source: Journal of Diabetes - December 1, 2014 Category: Endocrinology Authors: Andrés Cruz‐Herranz, Blanca Fuentes, Patricia Martínez‐Sánchez, Gerardo Ruiz‐Ares, Manuel Lara‐Lara, Borja Sanz‐Cuesta, Exuperio Díez‐Tejedor Tags: Original Article Source Type: research

Prior treatment with dipeptidyl peptidase 4 inhibitors is associated with better functional outcome and lower in-hospital mortality in patients with type 2 diabetes mellitus admitted with acute ischaemic stroke
In conclusion, prior treatment with dipeptidyl peptidase 4 inhibitors in patients with acute ischaemic stroke appears to be associated with better functional outcome and lower mortality risk.
Source: Diabetes and Vascular Disease Research - October 22, 2015 Category: Endocrinology Authors: Tziomalos, K., Bouziana, S. D., Spanou, M., Kostaki, S., Papadopoulou, M., Giampatzis, V., Dourliou, V., Kostourou, D.-T., Savopoulos, C., Hatzitolios, A. I. Tags: Brief Reports Source Type: research

Gliptin‐mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon‐like peptide‐1 receptor
Gliptins are anti‐type 2 diabetes (T2D) drugs that regulate glycaemia by preventing endogenous glucagon‐like peptide‐1 (GLP‐1) degradation. Chronically administered gliptins before experimental stroke can also induce neuroprotection, and this effect is potentially relevant for reducing brain damage in patients with T2D and high risk of stroke. It is not known, however, whether acute gliptin treatment after stroke (mimicking a post‐hospitalization treatment) is neuroprotective or whether gliptin‐mediated neuroprotection occurs via GLP‐1‐receptor (GLP‐1R) activation. To answer these two questions, wild‐ty...
Source: Diabetes, Obesity and Metabolism - March 17, 2016 Category: Endocrinology Authors: V. Darsalia, M. Larsson, G. Lietzau, D. Nathanson, T. Nyström, T. Klein, C. Patrone Tags: RESEARCH LETTER Source Type: research

Illuminating the Effects of Stroke on the Diabetic Brain: Insights From Imaging Neural and Vascular Networks in Experimental Animal Models
Type 1 diabetes is known to cause circulatory problems in the eyes, heart, and limbs, and the brain is no exception. Because of the insidious effects of diabetes on brain circulation, patients with diabetes are two to four times more likely to have an ischemic stroke and are less likely to regain functions that are lost. To provide a more mechanistic understanding of this clinically significant problem, imaging studies have focused on how stroke affects neural and vascular networks in experimental models of type 1 diabetes. The emerging picture is that diabetes leads to maladaptive changes in the cerebrovascular system tha...
Source: Diabetes - June 20, 2016 Category: Endocrinology Authors: Reeson, P.; Jeffery, A.; Brown, C. E. Tags: Perspectives in Diabetes Source Type: research

Insulin resistance and elevated c-reactive protein among first-degree relatives of ischemic stroke patients
Conclusion First-degree relatives of ischemic stroke patients exhibited hyperinsulinemia, Insulin resistance and dyslipidemia. Insulin resistance, a low grade inflammatory state that leads to increased C-reactive protein which triggers the development of atherosclerosis. So screening for insulin resistance and dyslipidemia in first-degree relatives of ischemic stroke patients may help in preventing adverse vascular events.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 4, 2017 Category: Endocrinology Source Type: research

Incidence of myocardial infarction and stroke in acromegaly patients: results from the German Acromegaly Registry
ConclusionsFor acromegaly patients being treated at specialized centres, the incidence of MIs and strokes does not seem to differ from the general population. Certainty regarding such statements requires large, prospective studies however.
Source: Pituitary - August 14, 2017 Category: Endocrinology Source Type: research

Post-stroke Cognitive Impairment and Malnutrition in the Elderly (PCIME): study design and protocol
ConclusionPCIME will enable us to assess the role of malnutrition in development of post stroke dementia. This study will help clinicians and researchers develop preventive measures to reduce the burden of stroke and dementia.
Source: Journal of Diabetes and Metabolic Disorders - July 13, 2021 Category: Endocrinology Source Type: research

Risk of stroke and retinopathy during GLP-1 receptor agonist cardiovascular outcome trials: An eight RCTs meta-analysis
ConclusionGLP-1RA significantly reduces the risk of ischemic stroke in type 2 diabetics with cardiovascular risk factors.
Source: Frontiers in Endocrinology - December 5, 2022 Category: Endocrinology Source Type: research

Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
The pathological condition of insulin resistance prevents the neuroprotective effects of insulin. Numerous studies have demonstrated that insulin resistance, as an independent risk factor for ischemic stroke, accelerates the formation of thrombosis and promotes the development of atherosclerosis, both of which are major mechanisms of ischemic stroke. Additionally, insulin resistance negatively affects the prognosis of patients with ischemic stroke regardless of whether the patient has diabetes, but the mechanisms are not well studied. We explored the association between insulin resistance and the primary mechanisms of brai...
Source: Frontiers in Endocrinology - December 15, 2022 Category: Endocrinology Source Type: research

Cerebral neovascularization in diabetes: implications for stroke recovery and beyond.
Abstract Neovascularization is an innate physiologic response by which tissues respond to various stimuli through collateral remodeling (arteriogenesis) and new vessel formation from existing vessels (angiogenesis) or from endothelial progenitor cells (vasculogenesis). Diabetes has a major impact on the neovascularization process but the response varies between different organ systems. While excessive angiogenesis complicates diabetic retinopathy, impaired neovascularization contributes to coronary and peripheral complications of diabetes. How diabetes influences cerebral neovascularization remained unresolved unt...
Source: Diabetes Metab - February 5, 2014 Category: Endocrinology Authors: Ergul A, Abdelsaid M, Fouda AY, Fagan SC Tags: J Cereb Blood Flow Metab Source Type: research

Metformin Treatment in Post-stroke Period Prevents Nitrative Stress and Restores Angiogenic Signaling in the Brain in Diabetes.
Abstract We have shown that diabetes impedes vascular repair and causes vasoregression in the brain after stroke but mechanisms underlying this response are still unclear. We hypothesized that excess peroxynitrite formation in diabetic ischemia/reperfusion injury (I/R) inactivates the p85 subunit of PI3K by nitration and diverts the PI3K-Akt-survival signal to the p38MAPkinase-apoptosis pathway. Nitrotyrosine (NY), Akt and p38 activity, p85 nitration and caspase-3 cleavage were measured in brains from control, diabetic (GK) or GK rats treated with metformin subjected to sham or stroke surgery and in brain microvas...
Source: Diabetes - December 18, 2014 Category: Endocrinology Authors: Abdelsaid M, Prakash R, Li W, Coucha M, Hafez S, Johnson MH, Fagan SC, Ergul A Tags: Diabetes Source Type: research

The association of atopy with incidence of ischemic heart disease, stroke, and diabetes
Abstract Allergy is a systemic inflammatory disease that could theoretically affect the risk of cardiovascular disease (CVD) and diabetes through inflammatory pathways or mast cell-induced coronary spasm. Whether allergy is associated with an increased risk of CVD and diabetes is largely unknown. We investigated the association between atopy as assessed by IgE sensitization, a well-accepted biomarker of allergy, and incidence of ischemic heart disease, stroke, and diabetes in five Danish population-based cohorts. A total of 14,849 participants were included in the study. Atopy was defined as serum-specific IgE po...
Source: Endocrine - March 1, 2015 Category: Endocrinology Source Type: research

Circulating Insulin-like Growth Factor Binding Protein-3 Predicts One-year Outcome after Ischemic Stroke
Conclusion: IGFBP-3 levels after ischemic stroke may independently predict functional outcome after one year.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - June 11, 2015 Category: Endocrinology Authors: Ebinger, M.Ipsen, N.Leonards, C. O.Empl, L.Hanne, L.Liman, T.Mai, K.Strasburger, C. J.Spranger, J.Endres, M. Tags: Article Source Type: research