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Specialty: Endocrinology
Condition: Diabetes
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Total 1416 results found since Jan 2013.
GLP-1 Receptor Agonists and Risk of Adverse Cerebrovascular Outcomes in Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
CONCLUSION: GLP-1RAs, precisely longer acting formulations, reduced ischemic cerebrovascular events in T2DM. Observed benefits were significantly higher in patients with shorter T2DM duration and higher eGFR.PMID:36800286 | DOI:10.1210/clinem/dgad076
Source: The Journal of Clinical Endocrinology and Metabolism - February 17, 2023 Category: Endocrinology Authors: Mainak Banerjee Rimesh Pal Satinath Mukhopadhyay Kirthana Nair Source Type: research
Fasting Glucose Level and the Risk of Incident Atherosclerotic Cardiovascular Diseases.
CONCLUSIONSBoth low glucose level and impaired fasting glucose should be considered as predictors of risk for stroke and coronary heart disease. The fasting glucose level associated with the lowest cardiovascular risk may be in a narrow range.
PMID: 23404299 [PubMed - as supplied by publisher]
Source: Diabetes Care - February 12, 2013 Category: Endocrinology Authors: Park C, Guallar E, Linton JA, Lee DC, Jang Y, Son DK, Han EJ, Baek SJ, Yun YD, Jee SH, Samet JM Tags: Diabetes Care Source Type: research
External Validation of the UKPDS Risk Engine in Incident Type 2 Diabetes: a need for new risk type 2 diabetes-specific risk equations.
ConclusionsThe UKPDS stroke equations showed calibration ranging from poor to moderate; however, the CHD equations showed poor calibration and considerably overestimated CHD risk. There is a need for revised risk equations in type 2 diabetes.
PMID: 24089541 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 2, 2013 Category: Endocrinology Authors: Bannister CA, Poole CD, Jenkins-Jones S, Morgan CL, Elwyn G, Spasic I, Currie CJ Tags: Diabetes Care Source Type: research
Effects of fasting blood glucose levels and blood pressure and treatment of diabetes and hypertension on the incidence of cardiovascular disease: a study of 740 patients with incident Type 2 diabetes with up to 30 years’ follow‐up
ConclusionsThe cumulative incidence of cardiovascular disease and myocardial infarction increased with number of previous events and presence of hyperglycaemia and hypertension and decreased with pharmacological treatment of diabetes. A higher number of previous stroke events increased the cumulative incidence of stroke but no protective effect of pharmacological treatment was observed.This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - June 1, 2014 Category: Endocrinology Authors: S.P.O. Jansson, D.K.G. Andersson, K. Svärdsudd Tags: Research Article Source Type: research
Effects of glucose‐lowering and multifactorial interventions on cardiovascular and mortality outcomes: a meta‐analysis of randomized control trials
ConclusionsApart from non‐fatal MIs, there was no evidence that intensive glucose‐lowering and multifactorial interventions reduced or increased the risk of cardiovascular and mortality outcomes. Intensive glucose‐lowering and multifactorial interventions are likely to be beneficial in populations with a higher baseline incidence of CV mortality, but there was no evidence of an association with the mean duration of Type 2 diabetes. Multifactorial interventions had a much greater impact on non‐fatal MI and non‐fatal strokes. (PROSPERO registration no.: 42014013860)This article is protected by copyright. All rights reserved.
Source: Diabetic Medicine - August 18, 2015 Category: Endocrinology Authors: S. Seidu, F. A. Achana, L. J. Gray, M. J. Davies, K. Khunti Tags: Systematic Review or Meta‐analysis Source Type: research
Evaluating the impact of type 2 diabetes mellitus on cardiovascular risk in persons with metabolic syndrome using the UKPDS risk engine.
CONCLUSION: MS was more common in subjects with T2DM compared with controls (irrespective of the diagnostic criteria used) and MS appears to increase the risk of a coronary event in subjects with T2DM by threefold. Also from this study, MS did not appear to cause an additional increase in the risk of stroke in subjects with T2DM.
PMID: 26396537 [PubMed]
Source: Diabetes Metab - September 26, 2015 Category: Endocrinology Authors: Ogedengbe OS, Ezeani IU, Chukwuonye II, Anyabolu EN, Ozor II, Eregie A Tags: Diabetes Metab Syndr Obes Source Type: research
Evaluating the impact of type 2 diabetes mellitus on cardiovascular risk in persons with metabolic syndrome using the UKPDS risk engine
Conclusion: MS was more common in subjects with T2DM compared with controls (irrespective of the diagnostic criteria used) and MS appears to increase the risk of a coronary event in subjects with T2DM by threefold. Also from this study, MS did not appear to cause an additional increase in the risk of stroke in subjects with T2DM.Keywords: diabetes mellitus, metabolic syndrome, coronary heart disease, cardiovascular disease, UKPDS risk engine
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - September 15, 2015 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Pathogenesis and neuroimaging of cerebral large and small vessel disease in type 2 diabetes: A possible link between cerebral and retinal microvascular abnormalities
This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - April 30, 2016 Category: Endocrinology Authors: Toshitaka Umemura, Takahiko Kawamura, Nigishi Hotta Tags: Review Source Type: research
Pioglitazone Prevents Diabetes in Patients With Insulin Resistance and Cerebrovascular Disease
CONCLUSIONS
Among patients with insulin resistance but without diabetes who had had a recent ischemic stroke or TIA, pioglitazone decreased the risk of diabetes while also reducing the risk of subsequent ischemic events. Pioglitazone is the first medication shown to prevent both progression to diabetes and major cardiovascular events as prespecified outcomes in a single trial.
Source: Diabetes Care - September 21, 2016 Category: Endocrinology Authors: Inzucchi, S. E.; Viscoli, C. M.; Young, L. H.; Furie, K. L.; Gorman, M.; Lovejoy, A. M.; Dagogo-Jack, S.; Ismail-Beigi, F.; Korytkowski, M. T.; Pratley, R. E.; Schwartz, G. G.; Kernan, W. N.; for the IRIS Trial Investigators Tags: Clinical Care/Education/Nutrition/Psychosocial Research Source Type: research
No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase 4 inhibitors versus therapeutic alternatives
ConclusionThough limited by the short treatment duration, our study suggests no increased short‐term risk of MI stroke or HF with DPP‐4i versus SU/TZD.
Source: Diabetes, Obesity and Metabolism - January 31, 2017 Category: Endocrinology Authors: Mugdha Gokhale, John B. Buse, Michele Jonsson Funk, Jennifer Lund, Virginia Pate, Ross J Simpson, Til St ürmer Tags: ORIGINAL ARTICLE Source Type: research
No increased risk of cardiovascular events in older adults initiating dipeptidyl peptidase ‐4 inhibitors vs therapeutic alternatives
ConclusionAlthough limited by the short treatment period, the present study suggests there is no increased short‐term risk of MI, stroke or HF with DPP‐4 inhibitors vs SUs/TZDs.
Source: Diabetes, Obesity and Metabolism - March 16, 2017 Category: Endocrinology Authors: Mugdha Gokhale, John B. Buse, Michele Jonsson Funk, Jennifer Lund, Virginia Pate, Ross J. Simpson, Til St ürmer Tags: ORIGINAL ARTICLE Source Type: research
A Prospective Cohort Study of Prenatal Diethylstilbestrol Exposure and Cardiovascular Disease Risk.
Conclusions: These data demonstrate associations in women of prenatal DES exposure with CAD and MI, but not stroke, that appear independent of established CVD risk factors.
PMID: 29069384 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 20, 2017 Category: Endocrinology Authors: Troisi R, Titus L, Hatch EE, Palmer JR, Huo D, Strohsnitter WC, Adam E, Ricker W, Hyer M, Hoover RN Tags: J Clin Endocrinol Metab Source Type: research
The Repeatedly Elevated Fatty Liver Index Is Associated With Increased Mortality: A Population-Based Cohort Study
ConclusionRepeated evaluations of NAFLD status based on FLI measurements could help physicians identify higher-risk groups in terms of mortality, MI, and stroke. The association between FLI worsening or improvement and outcomes also suggests clinical benefits of the prevention and treatment of NAFLD.
Source: Frontiers in Endocrinology - March 12, 2021 Category: Endocrinology Source Type: research
Retinal arteriolar tortuosity and fractal dimension are associated with long-term cardiovascular outcomes in people with type 2 diabetes
Conclusions/interpretationArteriolar tortuosity and fractal dimension were associated with incident cerebrovascular events, independent of a wide range of traditional cardiovascular risk factors including diabetic retinopathy. These findings suggest potential for measurements of early retinal vasculature change to aid in the identification of people with type 2 diabetes who are at increased risk from stroke.Graphical abstract
Source: Diabetologia - September 8, 2021 Category: Endocrinology Source Type: research
