Proportion of Brazilian diabetes patients that achieve treatment goals: implications for better quality of care.
CONCLUSIONS: The achievement of goals of good clinical practice varies among the parameters evaluated. Almost no patients achieved all targets. Many patients are overweight and do not achieve targets for HbA1c, lipid profile, or blood pressure control. PMID: 26672722 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - December 21, 2015 Category: Endocrinology Authors: Baptista DR, Thieme RD, Reis WC, Pontarolo R, Correr CJ Tags: Diabetol Metab Syndr Source Type: research

Diabetes Metab; +118 new citations
118 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Diabetes Metab These pubmed results were generated on 2015/12/17PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Diabetes Metab)
Source: Diabetes Metab - December 18, 2015 Category: Endocrinology Tags: Report Source Type: research

A case of severe ectopic ACTH syndrome from an occult primary - diagnostic and management dilemmas.
We present the case of a 66-year-old gentleman with ectopic ACTH syndrome from an occult primary tumour with multiple significant complications from hypercortisolaemia. Ectopic nature of his ACTH-dependent Cushing's syndrome was confirmed by non-suppression with high-dose dexamethasone suppression test and bilateral inferior petrosal sinus sampling. The primary ectopic source remained unidentified in spite of extensive anatomical and functional imaging studies, including CT scans and Dotatate-PET scan. Medical adrenolytic treatment at maximum tolerated doses failed to control his hypercortisolaemia, which led to recurrent ...
Source: Diabetes Metab - December 12, 2015 Category: Endocrinology Authors: Venugopal H, Griffin K, Amer S Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Erratum to: The association between periodontal disease and metabolic syndrome among outpatients with diabetes in Jordan.
Abstract [This corrects the article DOI: 10.1186/s40200-015-0192-8.]. PMID: 26649285 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 12, 2015 Category: Endocrinology Authors: Alhabashneh R, Khader Y, Herra Z, Asa'ad F Tags: J Diabetes Metab Disord Source Type: research

ACTH stimulation tests for the diagnosis of adrenal insufficiency: Systematic review and meta-analysis.
CONCLUSION: Both high and low dose ACTH stimulation tests had similar diagnostic accuracy. Both tests are adequate to rule in, but not rule out, primary and secondary adrenal insufficiency. Our confidence in these estimates is low to moderate due to the likely risk of bias, heterogeneity and imprecision. PMID: 26649617 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 9, 2015 Category: Endocrinology Authors: Ospina NS, Al Nofal A, Bancos I, Javed A, Khalid B, Kapoor E, Lteif AN, Natt N, Murad MH Tags: J Clin Endocrinol Metab Source Type: research

Beta cell glucose sensitivity is linked to insulin/glucagon bihormonal cells in non-diabetic humans.
CONCLUSIONS: Our data suggest that poor β-cell glucose sensitivity is linked to islet trans-differentiation, possibly from α cells to β cells, in an attempt to cope with higher demands for insulin secretion. Understanding the mechanism(s) that underlies the adaptive response of the islet cells to insulin resistance is a potential approach to design tools to enhance functional β-cell mass for diabetes therapy. PMID: 26649619 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 9, 2015 Category: Endocrinology Authors: Mezza T, Sorice GP, Conte C, Sun VA, Cefalo CM, Moffa S, Pontecorvi A, Mari A, Kulkarni RN, Giaccari A Tags: J Clin Endocrinol Metab Source Type: research

Cosyntropin-stimulated serum free cortisol in healthy, adrenally-insufficient, and mildly cirrhotic populations.
CONCLUSION: We provide normative data for SFF values in HV and AI during the CST. Normal CBG levels in mild cirrhosis did not affect interpretation of the CST. PMID: 26647150 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 8, 2015 Category: Endocrinology Authors: Rauschecker M, Abraham SB, Abel BS, Wesley R, Saverino E, Trivedi A, Heller T, Nieman LK Tags: J Clin Endocrinol Metab Source Type: research

Diurnal cortisol patterns, future diabetes and impaired glucose metabolism in the Whitehall II cohort study.
CONCLUSIONS: In this non-clinical population, alterations in diurnal cortisol patterns were predictive of future glucose disturbance. PMID: 26647151 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 8, 2015 Category: Endocrinology Authors: Hackett RA, Kivimäki M, Kumari M, Steptoe A Tags: J Clin Endocrinol Metab Source Type: research

The sodium-glucose cotransporter 2 inhibitor luseogliflozin improves glycaemic control assessed by continuous glucose monitoring even on a low-carbohydrate diet.
Abstract This randomized, double-blind, placebo-controlled, crossover study was the first to determine the effects of luseogliflozin in combination with a low-carbohydrate diet (LCD) on 24-h glucose variability assessed by continuous glucose monitoring (CGM). Eighteen Japanese patients with type 2 diabetes were randomized into two groups in which patients first received luseogliflozin 2.5 mg once-daily then placebo for 8 days each, or vice versa. Patients took luseogliflozin or placebo with a normal-carbohydrate diet (NCD) on Day 7 and with the LCD on Day 8. CGM was performed on both days. Luseogliflozin significa...
Source: Diabetes Metab - December 6, 2015 Category: Endocrinology Authors: Nishimura R, Omiya H, Sugio K, Ubukata M, Sakai S, Samukawa Y Tags: Diabetes Obes Metab Source Type: research

GLP-1 receptor agonist exenatide has no acute effect on MRI-measured exocrine pancreatic function in type 2 diabetes patients: a randomised trial.
CONCLUSIONS: Infusion of exenatide did not directly influence MRI-measured exocrine pancreatic excretion in patients with type 2 diabetes. Although long-term studies are warranted, these findings suggest that potential adverse pancreatic effects of GLP-1 receptor agonists are not mediated by changes in exocrine pancreatic secretion. (ClinicalTrials.gov:NCT01744236). PMID: 26640129 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 6, 2015 Category: Endocrinology Authors: Smits MM, Tonneijck L, Muskiet MH, Kramer MH, Diamant M, Pieters-van den Bos IC, van Raalte DH, Cahen DL Tags: Diabetes Obes Metab Source Type: research

The effect of transdermal nitroglycerin on pain control in diabetic patients with peripheral neuropathy.
CONCLUSIONS: It could be concluded that nitroglycerin plasters can effectively help alleviate pain in patients with diabetic neuropathy. TRIAL REGISTRATION: IRCT201308223213N1. PMID: 26629480 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 5, 2015 Category: Endocrinology Authors: Taheri A, Farbood A, Heshmat R, Samadi A, Khashayar P, Qorbani M, Ghorbani M, Ebrahimi Khaneqah G Tags: J Diabetes Metab Disord Source Type: research

Adiponectin, leptin and insulin levels at birth and in early postnatal life in neonates with hypoxic ischemic encephalopathy.
CONCLUSIONS: Neonates who are suffering from HIE had lower serum levels of adiponectin and higher serum levels of leptin and insulin than normal healthy neonates at birth and during the early postnatal period. The decline of leptin and increased the insulin levels after birth in all neonates may be important for the stimulation of feeding behavior and the acquisition of energy homeostasis during the early postnatal life. Positive significant correlations between adiponectin, leptin, body weight and body mass indices were present in normal healthy neonates but not in neonates with HIE reflecting the effect of hypoxia on the...
Source: Diabetes Metab - December 5, 2015 Category: Endocrinology Authors: El-Mazary AM, Nasif KA, Abdel-Hakeem GL, Sherif T, Farouk E, El-Gezawy EM Tags: J Diabetes Metab Disord Source Type: research

Uremic parkinsonism with atypical phenotypes and radiologic features.
Abstract Uremic encephalopathy with bilateral basal ganglia lesions has been reported as an acute neurometabolic disease which shows reversible clinical course and brain imaging features. The exact nature and pathophysiology have not been well established. We encountered two patients who showed a relapsing and aggravating course and an atypical phenotype including parkinsonism with paroxysmal dystonic head tremor and acute onset monoparesis of the lower extremity. They also showed unusual radiological findings which revealed combined lesions in the basal ganglia and cortex, persistent hemorrhagic transformation, a...
Source: Diabetes Metab - December 3, 2015 Category: Endocrinology Authors: Yoon JE, Kim JS, Park JH, Lee KB, Roh H, Park ST, Cho JW, Ahn MY Tags: Metab Brain Dis Source Type: research

Polymorphisms in the P1 promoter of the IGF-1 gene in children with growth disorders.
CONCLUSIONS: This study demonstrated that SNP and (CA) n microsatellite repeat polymorphisms by themselves are not the primary regulatory elements of IGF-1 expression. However, our bioinformatics analysis has shown that the (CA) n microsatellite region in the P1 promoter of IGF-1 is able to form DNA loop structures which can modulate transcription. PMID: 26615580 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Broniarczyk JK, Kędzia A, Nowak W, Kościński Ł, Lewandowski M, Goździcka-Józefiak A Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Prevalence of chronic complications in patients with over 30-year history of type 1 diabetes depending on the age of onset of diabetes].
CONCLUSIONS: The diagnosis of type 1 diabetes before or after the age of 18 had no significant effect on the lack of chronic complications. Patients with diabetes diagnosed in childhood, after 30 years of disease, presented a higher incidence of diabetic kidney disease. PMID: 26615581 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Pisarczyk-Wiza D, Zozulińska-Ziółkiewicz D, Piłaciński S, Milcarek M, Wierusz-Wysocka B Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Sugar content in non-alcoholic beverages and dietary recemmendations for children and adolescents].
CONCLUSIONS: Significant monosaccharides and sucrose content in the tested non-alcohollic beverages tends to claim that their manufacturers should be obliged to place warnings on the labels addressed to patients suffering from disorders of carbohydrate metabolism. Educational programs for children and adolescents with diabetes should include information about the content of a large amount of sugars in fruit products: fruit juices, fruit drinks and fruit nectar. PMID: 26615582 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Bilek M, Rybakowa M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Insulin-like growth factor-1 (IGF-1) - structure and the role in the human body].
Abstract In the recent years, managed to broadly explore the structure and role of insulin-like growth factors type 1 and 2 (IGF1 I 2). They belong to the structure of polypeptide hormones homologous to proinsulin. They are characterized by a wide range of activities. IGF-1 is a key mediator of most tissue effects of growth hormone (GH). In addition to effects on growth processes of the body, is also an important factor for cell homeostasis, is subject to both endocrine and tissue-specific auto- and paracrine regulation. In this paper, the current, general knowledge on the structure, function and mechanism of biol...
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Filus A, Zdrojewicz Z Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

[Yeast-like fungi in the gastrointestinal tract in children and adolescents with diabetes type 1].
Abstract In recent years the frequency of fungal infections in human populations has increased considerably. The most common type offungus attacking the human organism is Candida albicans. Yeast-like fungi occur naturally in the oral cavity, intestines, vagina, or skin, however in amounts not dangerous to human health. The studies so far have shown that patients with diabetes type 1 (T1DM) to a large degree are exposed to complications related to fungal infections. A substantial growth of fungi observed in diabetic patients may unfavorably affect metabolic compensation, and lead to increased demand for insulin, as...
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Kowalewska B, Kawko M, Zorena K, Myśliwiec M Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Response to low dose indomethacin in two children with nephrogenic diabetes insipidus.
Abstract Two children with nephrogenic diabetes insipidus (NDI) were treated with oral indomethacin (0.75-1.2 mg/kg/day) three times a day for a mean duration of 3 yrs. Remission occurred in both patients in terms of achieving a normal fluid balance and body growth and the drug was withdrawn in one patient after 2 yrs. The treatment was well tolerated and no side effects were noted. The mean duration of follow-up was 6.5 yrs. These long-term observations of a favourable response to low dose indomethacin in 2 children with NDI need to be tested on larger number of patients. PMID: 26615585 [PubMed - in process]...
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Dayal D, Verma Attri S, Kumar Bhalla A, Kumar R Tags: Pediatr Endocrinol Diabetes Metab Source Type: research

Trends in mortality due to diabetes in Brazil, 1996-2011.
CONCLUSION: Mortality due to diabetes declined in Brazil from 1996 to 2011, minimally in men and considerably in women. The lesser declines in recent years may reflect the increasing prevalence of diabetes, and suggest that current efforts to prevent diabetes and minimize the impact of its complications need to be reinforced to ensure that declines will continue. PMID: 26617678 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 2, 2015 Category: Endocrinology Authors: Schmidt MI, Duncan BB, Ishitani L, da Conceição Franco G, de Abreu DM, Lana GC, França E Tags: Diabetol Metab Syndr Source Type: research

Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency.
CONCLUSIONS: Correction of vitamin D deficiency in type 2 diabetic patients decreases total cholesterol. Our results do not rule out reductions in LDL cholesterol, non-HDL cholesterol and triglycerides. PMID: 26623001 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 1, 2015 Category: Endocrinology Authors: Ramiro-Lozano JM, Calvo-Romero JM Tags: Ther Adv Endocrinol Metab Source Type: research

Vitamin D as a risk factor for premature atherosclerosis in patients with type 2 diabetes.
CONCLUSIONS: Decreased vitamin D levels in patients with diabetes lead to increased CIMT. The absence of a statistically significance difference in lipid profile between increased and normal CIMT groups raises the possibility of underlying causes for atherosclerosis in patients with diabetes other than dyslipidemia. PMID: 26623002 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 1, 2015 Category: Endocrinology Authors: Hamdy Al-Said N, Abd El Ghaffar Mohamed N, Salam RF, Fawzy MW Tags: Ther Adv Endocrinol Metab Source Type: research

Comparison of conventional risk factors in middle-aged versus elderly diabetic and nondiabetic patients with myocardial infarction: prediction with decision-analytic model.
CONCLUSIONS: The CART model is capable of symbolizing interpretable clinical data for confirming and better prediction of MI occurrence in clinic or in hospital. Therefore, predictor variables in pattern could affect the outcome based on age group variable. Hyperglycemia, hypertension, hyperlipidemia and hyperuricemia were serious predictors for occurrence of MI in diabetics. PMID: 26623003 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - December 1, 2015 Category: Endocrinology Authors: Mahmoodi MR, Baneshi MR, Rastegari A Tags: Ther Adv Endocrinol Metab Source Type: research

Oral Presentation.
Authors: PMID: 26608948 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 29, 2015 Category: Endocrinology Tags: Diabetes Metab Res Rev Source Type: research

Infertility and Reproductive Function in Patients with Congenital Adrenal Hyperplasia: Pathophysiology, Advances in Management, and Recent Outcomes.
Abstract Individuals with congenital adrenal hyperplasia have reduced fertility. However, reproductive outcomes have improved over the years. This review provides an update on the multiple pathologic processes that contribute to reduced fertility in both sexes, from alterations of the hypothalamic-pituitary-gonadal axis to the direct effect on gonadal function by elevated circulating adrenal androgens. In addition, elevated serum progesterone concentrations may hinder ovulation and embryo implantation in women, whereas in men testicular adrenal rest tumors can be a major cause of infertility. Suppression of adrena...
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Lekarev O, Lin-Su K, Vogiatzi MG Tags: Endocrinol Metab Clin North Am Source Type: research

Reproductive Issues in Women with Turner Syndrome.
Abstract Turner syndrome is one of the most common chromosomal abnormalities affecting female infants. The severity of clinical manifestations varies and it affects multiple organ systems. Women with Turner syndrome have a 3-fold increase in mortality, which becomes even more pronounced in pregnancy. Reproductive options include adoption or surrogacy, assisted reproductive techniques, and in rare cases spontaneous pregnancy. Risks for women with Turner syndrome during pregnancy include aortic disorders, hepatic disease, thyroid disease, type 2 diabetes, and cesarean section delivery. Providers must be familiar wit...
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Folsom LJ, Fuqua JS Tags: Endocrinol Metab Clin North Am Source Type: research

Reproductive Endocrinology.
PMID: 26568499 [PubMed - in process] (Source: Diabetes Metab)
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: LeRoith D Tags: Endocrinol Metab Clin North Am Source Type: research

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies.
Abstract Obesity is gaining acceptance as a serious primary health burden that impairs the quality of life because of its associated complications, including diabetes, cardiovascular diseases, cancer, asthma, sleep disorders, hepatic dysfunction, renal dysfunction, and infertility. It is a complex metabolic disorder with a multifactorial origin. Growing evidence suggests that oxidative stress plays a role as the critical factor linking obesity with its associated complications. Obesity per se can induce systemic oxidative stress through various biochemical mechanisms, such as superoxide generation from NADPH oxida...
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Manna P, Jain SK Tags: Metab Syndr Relat Disord Source Type: research

Expression of REG Iα gene in type 2 diabetics in Pakistan.
CONCLUSION: REG Iα may be used as a marker/predictor of type 2 diabetes especially in the early stages of the disease. PMID: 26568772 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Uppal SS, Naveed AK, Baig S, Chaudhry B Tags: Diabetol Metab Syndr Source Type: research

Endocrine abnormalities in ring chromosome 11: a case report and review of the literature.
Abstract Ring chromosomes (RCs) are uncommon cytogenetic findings, and RC11 has only been described in 19 cases in the literature. Endocrine abnormalities associated with RC11 were reported for two of these cases. The clinical features of RC11 can result from an alteration in the structure of the genetic material, ring instability, mosaicism, and various extents of genetic material loss. We herein describe a case of RC11 with clinical features of 11q-syndrome and endocrine abnormalities that have not yet been reported. A 20-year-old female patient had facial dysmorphism, short stature, psychomotor developmental de...
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Lange R, Von Linsingen C, Mata F, Moraes AB, Arruda M, Vieira Neto L Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study.
CONCLUSION: This is the first study reporting a gender-specific interaction between ABCA1/R230C variant and dietary carbohydrate and fat percentages affecting VAT/SAT ratio, GGT, ALP, adiponectin levels and HOMA index. Our study confirmed the previously reported gender-specific ABCA1-diet interaction affecting HDL-C levels observed in an independent study. Our results show how gene-environment interactions may help further understand how certain gene variants confer metabolic risk, and may provide information useful to design diet intervention studies. PMID: 26579206 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 20, 2015 Category: Endocrinology Authors: Jacobo-Albavera L, Posadas-Romero C, Vargas-Alarcón G, Romero-Hidalgo S, Posadas-Sánchez R, González-Salazar MD, Carnevale A, Canizales-Quinteros S, Medina-Urrutia A, Antúnez-Argüelles E, Villarreal-Molina T Tags: Nutr Metab (Lond) Source Type: research

Evaluation of Bone Mineral Density and Bone Biomarkers in Patients With Type 2 Diabetes Treated With Canagliflozin.
CONCLUSIONS: In older patients with T2DM, canagliflozin showed small but significant reductions in total hip BMD and increases in bone formation and resorption biomarkers, due at least in part to weight loss. PMID: 26580234 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Bilezikian JP, Watts NB, Usiskin K, Polidori D, Fung A, Sullivan D, Rosenthal N Tags: J Clin Endocrinol Metab Source Type: research

Link between increased satiety gut hormones and reduced food reward following gastric bypass surgery for obesity.
CONCLUSIONS: Enhanced satiety gut hormone responses after RYGB may be a causative mechanism by which anatomical alterations of the gut in obesity surgery modify behavioral and brain reward responses to food. PMID: 26580235 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Goldstone AP, Miras AD, Scholtz S, Jackson S, Neff KJ, Pénicaud L, Geoghegan J, Chhina N, Durighel G, Bell JD, Meillon S, le Roux CW Tags: J Clin Endocrinol Metab Source Type: research

Social Jetlag, Chronotype, and Cardiometabolic Risk.
CONCLUSION: Our findings suggest that a misalignment of sleep timing is associated with metabolic risk factors that predispose to diabetes and atherosclerotic cardiovascular disease. PMID: 26580236 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB Tags: J Clin Endocrinol Metab Source Type: research

Effects of Canagliflozin on Fracture Risk in Patients With Type 2 Diabetes Mellitus.
CONCLUSIONS: Fracture risk was increased with canagliflozin treatment, driven by CANVAS patients, who were older, with prior history/risk of cardiovascular disease, and with lower baseline eGFR and higher baseline diuretic use. The increase in fractures may be mediated by falls; however, the cause of increased fracture risk with canagliflozin is unknown. PMID: 26580237 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Watts NB, Bilezikian JP, Usiskin K, Edwards R, Desai M, Law G, Meininger G Tags: J Clin Endocrinol Metab Source Type: research

A case report: Nodule development from subcapsular aldosterone-producing cell clusters causes hyperaldosteronism.
CONCLUSION: A novel aldosterone-producing pathology, pAATL that causes unilateral PA, was detected in the adrenals of 2 patients. NGS analyses of the large pAATLs suggested that the introduction of APA-associated mutations in the ion channel/pump genes may be involved in the development of mAPA from existing APCCs. PMID: 26580238 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 18, 2015 Category: Endocrinology Authors: Nishimoto K, Seki T, Kurihara I, Yokota K, Omura M, Nishikawa T, Shibata H, Kosaka T, Oya M, Suematsu M, Mukai K Tags: J Clin Endocrinol Metab Source Type: research

A Randomised Crossover Trial: The Effect of Inulin on Glucose Homeostasis in Subtypes of Prediabetes.
CONCLUSION: The FCHO, inulin, may have unique metabolic effects that are of particular benefit to people at risk of diabetes, which warrant further investigation. PMID: 26571012 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Guess ND, Dornhorst A, Oliver N, Frost GS Tags: Ann Nutr Metab Source Type: research

White matter microstructure and cognitive function in young women with polycystic ovary syndrome.
CONCLUSIONS: White matter microstructure is altered, and cognitive performance is compromised, in young adults with PCOS. These alterations in brain structure and function are independent of age, education and body mass index. If reversible, these changes represent a potential target for treatment. PMID: 26574952 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Rees DA, Udiawar M, Berlot R, Jones DK, O'Sullivan MJ Tags: J Clin Endocrinol Metab Source Type: research

Dual 5-alpha reductase inhibition promotes hepatic lipid accumulation in man.
CONCLUSIONS: Dual SRD5A inhibition with Dutasteride is associated with increased intrahepatic lipid accumulation. PMID: 26574953 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Hazlehurst JM, Oprescu AI, Nikolaou N, Di Guida R, Grinbergs AE, Davies NP, Flintham RB, Armstrong MJ, Taylor AE, Hughes BA, Yu J, Hodson L, Dunn WB, Tomlinson JW Tags: J Clin Endocrinol Metab Source Type: research

Obesity is associated with low NAD(+)/SIRT pathway expression in adipose tissue of BMI-discordant monozygotic twins.
CONCLUSIONS: Our data highlight a strong relationship of reduced NAD(+)/SIRT pathway expression with acquired obesity, inflammation, insulin resistance, and impaired mitochondrial protein homeostasis in SAT. PMID: 26574954 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Jukarainen S, Heinonen S, Rämö JT, Rinnankoski-Tuikka R, Rappou E, Tummers M, Muniandy M, Hakkarainen A, Lundbom J, Lundbom N, Kaprio J, Rissanen A, Pirinen E, Pietiläinen KH Tags: J Clin Endocrinol Metab Source Type: research

Biomarkers of ectopic fat deposition: the next frontier in serum lipidomics.
CONCLUSIONS: Different serum lipids predict intramuscular TAG accumulation in obese people vs. athletes. The ability of serum lipidomics to predict intramuscular DAG and ceramide in insulin-resistant humans may prove a new biomarker to determine risk for diabetes. PMID: 26574956 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Perreault L, Starling AP, Glueck D, Brozinick JT, Sanders P, Siddall P, Kuo MS, Dabelea D, Bergman BC Tags: J Clin Endocrinol Metab Source Type: research

Female Physicians and the Future of Endocrinology.
CONCLUSIONS: Endocrinology is predicted to become the most female-predominant subspecialty of internal medicine. The specialty of endocrinology should take a lead role in advocating for changes that support the success of female physicians. Strengthening and supporting the physician workforce can only serve to attract talented physicians of both genders to the specialty, which will be key to meeting the needs of the increasing numbers of patients with endocrine disorders. PMID: 26574957 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Pelley E, Danoff A, Cooper DS, Becker C Tags: J Clin Endocrinol Metab Source Type: research

Cerebrovascular Complications of Diabetes: Alpha Glucosidase Inhibitor as Potential Therapy.
Abstract Increased risk of cerebrovascular accident in diabetes cannot be fully explained by traditional risk factors. Epidemiological studies show that postprandial hyperglycemia is strongly associated with cerebrovascular events and cerebrovascular-associated mortality. Postprandial hyperglycemia contributes to vascular damage by several mechanisms such as endothelial dysfunction, arthrosclerosis, oxidative stress, inflammation, and hypercoagulability. Hyperglycemia has deleterious effects on the vascular endothelium and leads to the development of cerebrovascular disease. Thus, an important strategy to reduce c...
Source: Diabetes Metab - November 17, 2015 Category: Endocrinology Authors: Patel SS Tags: Horm Metab Res Source Type: research

Serum Levels of sRAGE Are Associated with Body Measurements, but Not Glycemic Parameters in Patients with Prediabetes.
CONCLUSIONS: In contrast to glycemic parameters, serum levels of sRAGE were negatively correlated with body measurements indicative of obesity in the prediabetic state. In addition, the negative correlation with LDL cholesterol levels suggests that sRAGE has a more robust association with metabolic syndrome than with prediabetes. PMID: 26569122 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 16, 2015 Category: Endocrinology Authors: Guclu M, Ali A, Eroglu DU, Büyükuysal SO, Cander S, Ocak N Tags: Metab Syndr Relat Disord Source Type: research

Use of plasma metanephrine to aid adrenal venous sampling in combined aldosterone and cortisol over-secretion.
We describe a case where metanephrine was measured during AVS to successfully circumvent this problem. A 55-year-old hypertensive male had raised plasma aldosterone/renin ratios and PA confirmed by fludrocortisone suppression testing. Failure of plasma cortisol to suppress overnight following dexamethasone and persistently suppressed corticotrophin were consistent with adrenal hypercortisolism. On AVS, comparison of adrenal and peripheral A/F ratios (left 5.7 vs peripheral 1.0; right 1.7 vs peripheral 1.1) suggested bilateral aldosterone production, with the left gland dominant but without contralateral suppression. Howeve...
Source: Diabetes Metab - November 15, 2015 Category: Endocrinology Authors: Goupil R, Wolley M, Ungerer J, McWhinney B, Mukai K, Naruse M, Gordon RD, Stowasser M Tags: Endocrinol Diabetes Metab Case Rep Source Type: research

Effect of metabolic control on oxidative stress, subclinical atherosclerosis and peripheral artery disease in diabetic patients.
CONCLUSIONS: Our study showed poor glycemic control leads to worse CIMT by increasing age and duration of diabetes. However we did not find a significan correlation between glycemic status and TAS levels. We suggest CIMT measurement along with other SA markers in poor glycemic diabetics, especially in older patients with longer duration of diabetes, to identify high risk CVD patients. PMID: 26561542 [PubMed] (Source: Diabetes Metab)
Source: Diabetes Metab - November 15, 2015 Category: Endocrinology Authors: Tabatabaei-Malazy O, Fakhrzadeh H, Sharifi F, Mirarefin M, Arzaghi SM, Badamchizadeh Z, Alizadeh Khoee M, Larijani B Tags: J Diabetes Metab Disord Source Type: research

Reduced frequency and severity of ketoacidosis at diagnosis of childhood type 1 diabetes in Northwest Saudi Arabia.
CONCLUSIONS: In NWSA, the frequency and severity of DKA at onset of childhood T1D were reduced following 4 years awareness campaign; but the rate is still high. Maintaining the campaign may result in further improvement following a longer period of observation. PMID: 26565539 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 13, 2015 Category: Endocrinology Authors: Ahmed AM, Al-Maghamsi M, Al-Harbi AM, Eid IM, Baghdadi HH, Habeb AM Tags: J Pediatr Endocrinol Metab Source Type: research

Anxiety, depression and self-esteem levels in obese children: a case-control study.
CONCLUSIONS: Our results indicate that obese children may experience psychiatric disorders more than normal-weight peers. PMID: 26565543 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 13, 2015 Category: Endocrinology Authors: Topçu S, Orhon FŞ, Tayfun M, Uçaktürk SA, Demirel F Tags: J Pediatr Endocrinol Metab Source Type: research

Cardiorespiratory Fitness and Light-Intensity Physical Activity Are Independently Associated with Reduced Cardiovascular Disease Risk in Urban Black South African Women: A Cross-Sectional Study.
CONCLUSION: Both physical activity and cardiorespiratory fitness were associated with reduced total and central fat mass, VAT, and reduced cardiometabolic risk for CVD and T2D. Longitudinal studies are required to confirm whether the promotion of increasing light physical activity, while reducing sedentary time and increasing cardiorespiratory fitness, reduces the risk for obesity, CVD and T2D. PMID: 26565756 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 13, 2015 Category: Endocrinology Authors: Dickie K, Micklesfield LK, Chantler S, Lambert EV, Goedecke JH Tags: Metab Syndr Relat Disord Source Type: research

Endocrine manifestations in a monocentric cohort of 64 patients with Erdheim-Chester disease.
CONCLUSION: Endocrine involvement is very frequent in ECD and should carefully be evaluated at diagnosis and during follow-up. PMID: 26565949 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - November 13, 2015 Category: Endocrinology Authors: Courtillot C, Laugier Robiolle S, Cohen Aubart F, Leban M, Renard Penna R, Drier A, Charlotte F, Amoura Z, Touraine P, Haroche J Tags: J Clin Endocrinol Metab Source Type: research