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Specialty: Endocrinology
Condition: Diabetes

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Total 1416 results found since Jan 2013.

Diabetic Microangiopathy: Impact of Impaired Cerebral Vasoreactivity and Delayed Angiogenesis After Permanent Middle Cerebral Artery Occlusion on Stroke Damage and Cerebral Repair in Mice
Diabetes increases the risk of stroke by three, increases related mortality, and delays recovery. We aimed to characterize functional and structural alterations in cerebral microvasculature before and after experimental cerebral ischemia in a mouse model of type 1 diabetes. We hypothesized that preexisting brain microvascular disease in patients with diabetes might partly explain increased stroke severity and impact on outcome. Diabetes was induced in 4-week-old C57Bl/6J mice by intraperitoneal injections of streptozotocin (60 mg/kg). After 8 weeks of diabetes, the vasoreactivity of the neurovascular network to CO2 was abo...
Source: Diabetes - February 24, 2015 Category: Endocrinology Authors: Poittevin, M.; Bonnin, P.; Pimpie, C.; Riviere, L.; Sebrie, C.; Dohan, A.; Pocard, M.; Charriaut-Marlangue, C.; Kubis, N. Tags: Pathophysiology Source Type: research

Diabetes, hypertension and stroke - does Alzheimer protect you?
CONCLUSIONS: Overall, in addition to the above novel findings, our study expands the data base on risk factors that could be used in near future when testing for the genetic risk of Alzheimer's disease. PMID: 25702297 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Consequences of Comorbidity of Elevated Stress and/or Depressive Symptoms and Incident Cardiovascular Outcomes in Diabetes: Results From the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
CONCLUSIONS Comorbid stress and/or depressive symptoms are common in individuals with diabetes and together are associated with progressively increased risks for adverse CV outcomes.
Source: Diabetes Care - December 22, 2015 Category: Endocrinology Authors: Cummings, D. M.; Kirian, K.; Howard, G.; Howard, V.; Yuan, Y.; Muntner, P.; Kissela, B.; Redmond, N.; Judd, S. E.; Safford, M. M. Tags: Epidemiology/Health Services Research Source Type: research

Cerebrovascular Safety of Sulfonylureas: The Role of KATP Channels in Neuroprotection and the Risk of Stroke in Patients With Type 2 Diabetes
Sulfonylureas are ATP-sensitive potassium (KATP) channel blockers commonly used in the treatment of type 2 diabetes mellitus (T2DM). Activation of KATP channels plays a neuroprotective role in ischemia; thus, whether sulfonylureas affect the outcomes of stroke in patients with T2DM needs to be further studied. In our study, streptozotocin (STZ)-induced diabetic mice subjected to transient middle cerebral artery occlusion (MCAO) showed larger areas of brain damage and poorer behavioral outcomes. Blocking the KATP channel by tolbutamide increased neuronal injury induced by oxygen-glucose deprivation (OGD) in vitro and perman...
Source: Diabetes - August 22, 2016 Category: Endocrinology Authors: Liu, R.; Wang, H.; Xu, B.; Chen, W.; Turlova, E.; Dong, N.; Sun, C. L. F.; Lu, Y.; Fu, H.; Shi, R.; Barszczyk, A.; Yang, D.; Jin, T.; Mannucci, E.; Feng, Z.-P.; Sun, H.-S. Tags: Pharmacology and Therapeutics Source Type: research

Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 diabetes
Conclusions/interpretationUrinary L-FABP is an independent predictor of stroke and mortality in individuals with type 1 diabetes.
Source: Diabetologia - August 10, 2017 Category: Endocrinology Source Type: research

Effects of glycemic variability and hyperglycemia in acute ischemic stroke on post-stroke cognitive impairments
We aimed to investigate the effect of glycemic variability in the acute stage of stroke on the development of post-stroke cognitive impairment (PSCI).
Source: Journal of Diabetes and Its Complications - March 28, 2018 Category: Endocrinology Authors: Jae-Sung Lim, Chulho Kim, Mi Sun Oh, Ju-Hun Lee, San Jung, Min Uk Jang, Sang-Hwa Lee, Yeo Jin Kim, Yerim Kim, Sang Won Suh, Byung-Chul Lee, Kyung-Ho Yu Source Type: research

Meta-analyses of the effects of Dpp-4 inhibitors, SGLT2 inhibitors and GLP1 receptor analogues on cardiovascular death, myocardial infarction, stroke and hospitalization for heart failure
To assess the effects DPP- 4i; SGLT2-i& GLP1-RA on CV death, MI, stroke and hHF . This is probably the first meta-analysis to assess the effects of these drugs on MI and stroke in totality, including non-fatal& fatal MI and stroke.
Source: Diabetes Research and Clinical Practice - February 19, 2019 Category: Endocrinology Authors: Binayak Sinha, Samit Ghosal Source Type: research

Effect of Ramadan fasting on incidence of Cerebrovascular stroke in Egyptian patients with Type 2 Diabetes Mellitus
Diabetes is an independent risk factor for stroke disease. Fasting during Ramadan, Muslims must abstain from eating, drinking, taking oral medications, and smoking from the exact time of dawn until time of sunset; in this study we investigated if there is impact of Ramadan Fasting on incidence of Cerebrovascular stroke among Patients with Type 2 Diabetes Mellitus. This cross sectional study was conducted in medical ICU of Zagazig University Hospitals, in months of Sha ’ban, Ramadan and Shawwal, in 1436; total numbers of 220 patients diagnosed as cerebrovascular stroke were enrolled in.
Source: Diabetes Research and Clinical Practice - March 18, 2019 Category: Endocrinology Authors: Mohamed H. Asy, Mohamed Awd, Arafa M. Elshabrawy, Mahmoud Gharieb Source Type: research

The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials
ConclusionsThis meta-analysis suggested the beneficial impacts of ALA supplementation in improving fasting glucose of patients diagnosed with stroke.
Source: Journal of Diabetes and Metabolic Disorders - July 28, 2019 Category: Endocrinology Source Type: research

Stroke in the patient with diabetes (Part 2) -Prevention and the effects of glucose lowering therapies
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. Stroke primary prevention can be achieved by controlling atrial fibrillation and hypertension, and the utilization of statins and anticoagulant therapies. Utilizing pioglitazone and GLP-1 receptor agonists reduce the risk of stroke while the utilization of metformin, α-glucosidase inhibitors, DPP-4 and SGLT-2 inhibitors have no effect.
Source: Diabetes Research and Clinical Practice - May 11, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (Part 1) - Epidemiology, etiology, therapy and prognosis
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the...
Source: Diabetes Research and Clinical Practice - May 18, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (part 1) – Epidemiology, etiology, therapy and prognosis
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the...
Source: Diabetes Research and Clinical Practice - May 18, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Stroke in the patient with diabetes (Part 2) – Prevention and the effects of glucose lowering therapies
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. Stroke primary prevention can be achieved by controlling atrial fibrillation and hypertension, and the utilization of statins and anticoagulant therapies. Utilizing pioglitazone and GLP-1 receptor agonists reduce the risk of stroke while the utilization of metformin, α-glucosidase inhibitors, DPP-4 and SGLT-2 inhibitors have no effect.
Source: Diabetes Research and Clinical Practice - May 11, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Establishment of Clinical Prediction Model Based on the Study of Risk Factors of Stroke in Patients With Type 2 Diabetes Mellitus
Conclusion: This study established a model predicting risk of stroke for T2DM patients through a community-based survey.
Source: Frontiers in Endocrinology - August 24, 2020 Category: Endocrinology Source Type: research