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Specialty: Endocrinology
Condition: Diabetes

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Total 1416 results found since Jan 2013.

SGLT2 inhibitors: Effect on myocardial infarction and stroke in type 2 diabetes
J Clin Endocrinol Metab. 2023 Feb 28:dgad113. doi: 10.1210/clinem/dgad113. Online ahead of print.ABSTRACTBACKGROUND: SGLT2 inhibitors (sodium-glucose cotransporter-2 inhibitors) have recently been recommended as preferred agents for management of hyperglycemia in type 2 diabetes, primarily based on their ability to reduce a composite of major cardiovascular adverse events (3P MACE), predominantly by reducing cardiovascular death. However reduction of the individual components, myocardial infarction (MI) or stroke (fatal and non-fatal) events have not been well explored.METHODS: In this meta-analysis, we included data avail...
Source: The Journal of Clinical Endocrinology and Metabolism - March 1, 2023 Category: Endocrinology Authors: Pradip Mukhopadhyay Debmalya Sanyal Purushottam Chatterjee Kaushik Pandit Sujoy Ghosh Source Type: research

Incidence of Stroke in People With Diabetes Compared to Those Without Diabetes: A Systematic Review
Conclusion The considerable differences between results can partly be explained by differences in study designs, statistical methods, definitions of stroke, and methods used to identify patients with diabetes. The lack of evidence arising from these differences ought to be rectified by new studies. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Experimental and Clinical Endocrinology and Diabetes - July 17, 2023 Category: Endocrinology Authors: Kvitkina, Tatjana Narres, Maria Claessen, Heiner Metzendorf, Maria-Inti Richter, Bernd Icks, Andrea Tags: Review Source Type: research

Activation of hepatic inflammatory pathways by catecholamines is associated with hepatic insulin resistance in male ischemic stroke rats.
Abstract Patients who experience acute ischemic stroke may develop hyperglycemia, even in the absence of diabetes. In the current study we determined the effects of acute stroke on hepatic insulin signaling, tumor necrosis factor α (TNF-α) expression, endoplasmic reticulum (ER) stress, the activities of c-Jun N-terminal kinase (JNK), inhibitor κB kinase β (IKK-β), and nuclear factor-κB (NF-κB) pathways. Rats with cerebral ischemia developed higher blood glucose, and insulin levels, and insulin resistance index, as well as hepatic gluconeogenic enzyme expression compared to the sham-treated group. The hepati...
Source: Endocrinology - January 17, 2014 Category: Endocrinology Authors: Wang YY, Lin SY, Chuang YH, Sheu WH, Tung KC, Chen CJ Tags: Endocrinology Source Type: research

Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study.
CONCLUSIONS: In this study of patients with diabetes, the use of low-dose aspirin showed an increased risk of hospitalization for ischemic stroke. These results suggest that low-dose aspirin use for the primary prevention of ischemic stroke should be reconsidered in patients with diabetes. PMID: 25733983 [PubMed]
Source: Diabetes Metab - March 6, 2015 Category: Endocrinology Authors: Kim YJ, Choi NK, Kim MS, Lee J, Chang Y, Seong JM, Jung SY, Shin JY, Park JE, Park BJ Tags: Diabetol Metab Syndr Source Type: research

Temporal Trends in Ischemic Stroke and Anticoagulation Therapy for Nonvalvular Atrial Fibrillation: Impact of Diabetes
ConclusionsIschemic stroke declined and warfarin use increased similarly in Medicare patients with and without diabetes. Ischemic stroke rates were consistently higher in diabetes patients, validating the inclusion of diabetes in risk calculators. The population of Medicare patients with diabetes who did not receive warfarin deserves future attention. This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes - February 29, 2016 Category: Endocrinology Authors: Gautam R. SHROFF, Craig A. SOLID, Zachary BLOOMGARDEN, Jonathan L. HALPERIN, Charles A. HERZOG Tags: Original Article Source Type: research

Temporal trends in ischemic stroke and anticoagulation therapy for non‐valvular atrial fibrillation: effect of diabetes
ConclusionsIschemic stroke declined and warfarin use increased similarly in Medicare patients with and without diabetes. Ischemic stroke rates were consistently higher in diabetes patients, validating the inclusion of diabetes in risk calculators. The population of Medicare patients with diabetes who did not receive warfarin deserves future attention.
Source: Journal of Diabetes - April 12, 2016 Category: Endocrinology Authors: Gautam R. Shroff, Craig A. Solid, Zachary Bloomgarden, Jonathan L. Halperin, Charles A. Herzog Tags: Original Article Source Type: research

Sex Differences in the Impact of Shift Work Schedules on Pathological Outcomes in an Animal Model of Ischemic Stroke.
Abstract Circadian clock desynchronization has been implicated in the pathophysiology of cardiovascular disease and related risk factors (e.g., obesity, diabetes). Thus, we examined the extent to which circadian desynchronization exacerbates ischemic stroke outcomes and whether its detrimental effects on stroke severity and functional impairments are further modified by biological sex. Circadian entrainment of activity rhythms in all male and female rats was observed during exposure to a fixed light:dark (LD) 12:12 cycle but was severely disrupted when this LD cycle was routinely shifted (12hr advance/5d) for ≈ ...
Source: Endocrinology - June 1, 2016 Category: Endocrinology Authors: Earnest DJ, Neuendorff N, Coffman J, Selvamani A, Sohrabji F Tags: Endocrinology Source Type: research

Temporal trends in ischemic stroke and anticoagulation therapy for non ‐valvular atrial fibrillation: effect of diabetes
ConclusionsIschemic stroke declined and warfarin use increased similarly in Medicare patients with and without diabetes. Ischemic stroke rates were consistently higher in diabetes patients, validating the inclusion of diabetes in risk calculators. The population of Medicare patients with diabetes who did not receive warfarin deserves future attention.
Source: Journal of Diabetes - April 12, 2016 Category: Endocrinology Authors: Gautam R. Shroff, Craig A. Solid, Zachary Bloomgarden, Jonathan L. Halperin, Charles A. Herzog Tags: Original Article Source Type: research

Lower Extremity Peripheral Arterial Disease Is an Independent Predictor of Coronary Heart Disease and Stroke Risks in Patients with Type 2 Diabetes Mellitus in China.
In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM. PMID: 28607554 [PubMed - in process]
Source: International Journal of Endocrinology - June 14, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Relation of Carotid Artery Plaque to Coronary Heart Disease and Stroke in Chinese Patients: Does Hyperglycemia Status Matter?
Conclusions The incident coronary heart disease and stroke events in patients with plaque were higher than those without plaque, and this difference was more pronounced for patients with hyperglycemia vs. those without hyperglycemia. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Experimental and Clinical Endocrinology and Diabetes - November 28, 2017 Category: Endocrinology Authors: Zhou, Huanhuan Wang, Xiaoyun Zhu, Junya Fish, Anne Kong, Weimin Li, Fan Liu, Lin Yuan, Xiaodan Gao, Xin Lou, Qingqing Tags: Article Source Type: research

Association between hemoglobin A1c and acute ischemic stroke among patients with type-2 diabetes: a case-control study
ConclusionsOngoing surveillance of HbA1c among PTDs should be conducted alongside knowledge sharing of glycemic control and stroke prevention as an essential measure to prevent developing AIS risk.
Source: International Journal of Diabetes in Developing Countries - March 2, 2020 Category: Endocrinology Source Type: research

Triglyceride-Glucose Index and the Risk of Stroke: A Systematic Review and Dose-Response Meta-Analysis
In conclusion, elevated TyG index is the independent risk factor for incident strokes (especially ischemic stroke). [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Hormone and Metabolic Research - March 11, 2022 Category: Endocrinology Authors: Feng, Xiao Yao, Yao Wu, Lingshan Cheng, Chang Tang, Qiaoqiao Xu, Shabei Tags: Endocrine Care Source Type: research

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride.
Abstract Type 2 diabetes is a strong risk factor for stroke. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor in clinical use against type 2 diabetes. The aim of this study was to determine the potential antistroke efficacy of linagliptin in type 2 diabetic mice. To understand whether efficacy was mediated by glycemia regulation, a comparison with the sulfonylurea glimepiride was done. To determine whether linagliptin-mediated efficacy was dependent on a diabetic background, experiments in nondiabetic mice were performed. Type 2 diabetes was induced by feeding the mice a high-fat diet for 32 weeks. Mice w...
Source: Diabetes - December 17, 2012 Category: Endocrinology Authors: Darsalia V, Ortsäter H, Olverling A, Darlöf E, Wolbert P, Nyström T, Klein T, Sjöholm A, Patrone C Tags: Diabetes Source Type: research

Is Diabetes an Independent Risk Factor for In‐Hospital Complications after a Stroke?
ConclusionsAlthough IS patients with DM more often suffered IHCs, previous diagnosis of DM is not per se associated with the risk of IHCs. Stroke severity and on‐admission glycemia ≥155 mg/dl were the most significant predictors for the development of IHCs.
Source: Journal of Diabetes - September 30, 2014 Category: Endocrinology Authors: Andrés Cruz‐Herranz, Blanca Fuentes, Patricia Martínez‐Sánchez, Gerardo Ruiz‐Ares, Manuel Lara‐Lara, Borja Sanz‐Cuesta, Exuperio Díez‐Tejedor Tags: Original Article Source Type: research

Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
Conclusions: In this study of patients with diabetes, the use of low-dose aspirin showed an increased risk of hospitalization for ischemic stroke. These results suggest that low-dose aspirin use for the primary prevention of ischemic stroke should be reconsidered in patients with diabetes.
Source: Diabetology and Metabolic Syndrome - February 15, 2015 Category: Endocrinology Authors: Ye-Jee KimNam-Kyong ChoiMi-Sook KimJoongyub LeeYoosoo ChangJong-Mi SeongSun-Young JungJu-Young ShinJi-Eun ParkByung-Joo Park Source Type: research