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Specialty: Endocrinology
Condition: Diabetes

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Total 1416 results found since Jan 2013.

Three-question set from Michigan Neuropathy Screening Instrument adds independent prognostic information on cardiovascular outcomes: analysis of ALTITUDE trial
Conclusions/interpretationWe identified three questions from the MNSI that provide additional prognostic information for individuals with type 2 diabetes and CKD and/or CVD. If externally validated, these questions may be integrated into the clinical history to augment prediction of CV events in high-risk individuals with type 2 diabetes.
Source: Diabetologia - November 3, 2017 Category: Endocrinology Source Type: research

Cardiovascular outcomes with glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes: a meta-analysis
Publication date: Available online 6 December 2017 Source:The Lancet Diabetes & Endocrinology Author(s): M Angelyn Bethel, Rishi A Patel, Peter Merrill, Yuliya Lokhnygina, John B Buse, Robert J Mentz, Neha J Pagidipati, Juliana C Chan, Stephanie M Gustavson, Nayyar Iqbal, Aldo P Maggioni, Peter Öhman, Neil R Poulter, Ambady Ramachandran, Bernard Zinman, Adrian F Hernandez, Rury R Holman Background Glucagon-like peptide-1 (GLP-1) receptor agonists are effective glucose-lowering drugs. Findings from cardiovascular outcome trials showed cardiovascular safety of GLP-1 receptor agonists, but results for cardiovascular...
Source: The Lancet Diabetes and Endocrinology - December 6, 2017 Category: Endocrinology Source Type: research

Clinical Impact of 5  Years of Liraglutide Treatment on Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus in a Real-Life Setting in Italy: An Observational Study
ConclusionIn patients prolonging treatment with liraglutide for 5  years, the benefits in relation to metabolic control and CV risk factors are maintained. The UKPDS risk scores suggest that liraglutide is associated with a reduced CHD risk, but not with a reduced stroke risk.
Source: Diabetes Therapy - September 20, 2018 Category: Endocrinology Source Type: research

Polyvascular disease, type 2 diabetes, and long-term vascular risk: a secondary analysis of the IMPROVE-IT trial
Publication date: Available online 2 November 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Marc P Bonaca, J Antonio Gutierrez, Christopher Cannon, Robert Giugliano, Michael Blazing, Jeong-Gun Park, Jennifer White, Andrew Tershakovec, Eugene BraunwaldSummaryBackgroundPolyvascular disease and type 2 diabetes are each associated with increased cardiovascular risk, but whether these risks are additive is unknown. In this exploratory analysis of a randomised trial, we explored the long-term cardiovascular risk associated with polyvascular disease, type 2 diabetes, and their combination in patients with acute corona...
Source: The Lancet Diabetes and Endocrinology - November 3, 2018 Category: Endocrinology Source Type: research

Cardiovascular and mortality events in type 2 diabetes cardiovascular outcomes trials: a systematic review with trend analysis
ConclusionsIn contrast to real-world data, there was no evidence of an improvement in all-cause and cardiovascular mortality in type 2 diabetes participants included in control arms of randomised clinical trials across 5 decades. Further studies should investigate whether and how dissimilarities in populations, procedures, and assessments of exposures and outcomes explain the differences between real-world setting and clinical trials.
Source: Acta Diabetologica - November 19, 2018 Category: Endocrinology Source Type: research

Behavioral Strategies to Lower Postprandial Glucose in Those with Type 2 Diabetes May Also Lower Risk of Coronary Heart Disease
ConclusionThese secondary analyses suggest that broad-spectrum lifestyle interventions that focus on lowering PPG may lower the risk of future CHD, which could guide future research.Trial RegistrationClinicalTrials.gov ID: NCT02432391.
Source: Diabetes Therapy - December 18, 2018 Category: Endocrinology Source Type: research

Update in Cardiovascular Safety of Incretin-Based Therapy in Adults with Type 2 Diabetes Mellitus: A Meta-Analysis of Cardiovascular Outcome Trials
ConclusionThis meta-analysis demonstrated that GLP-1RAs were associated with a significant reduction in MACE, CV death, stroke, and death from any cause, while DPP-4 inhibitors were comparable to placebo for all CV outcomes, including hospitalizations for HF.
Source: Canadian Journal of Diabetes - April 14, 2019 Category: Endocrinology Source Type: research

Update on Cardiovascular Safety of Incretin-Based Therapy in Adults With Type 2 Diabetes Mellitus: A Meta-Analysis of Cardiovascular Outcome Trials
ConclusionsThis meta-analysis demonstrated that GLP-1RAs were associated with a significant reduction in major adverse CV events, CV death, stroke and death from any cause, while DPP-4 inhibitors were comparable to placebo for all CV outcomes, including hospitalizations for heart failure.RésuméObjectifsLes auteurs de deux grands essais randomisés ont récemment publié leurs conclusions concernant les effets d'un agoniste du récepteur au glucagon-like peptide-1 (A-GLP-1R) (essai HARMONY) et d'un inhibiteur de la dipeptidyl peptidase 4 (DPP-4) (essai CARMELINA) sur les bénéfices cardiovasculaires (CV) chez les patie...
Source: Canadian Journal of Diabetes - June 5, 2019 Category: Endocrinology Source Type: research

Higher triglyceride to high density lipoprotein cholesterol ratio increases cardiovascular risk: 10 ‐year prospective study in a cohort of Chinese adults
ConclusionsAmong Chinese population, higher TG/HDL ‐C ratio has a correlation with increased major CV event risks.This article is protected by copyright. All rights reserved.
Source: Journal of Diabetes Investigation - July 19, 2019 Category: Endocrinology Authors: Zekai Chen, Guanzhi Chen, Hailun Qin, Zefeng Cai, Jianhuan Huang, Haojia Chen, Weiqiang Wu, Zhichao Chen, Shouling Wu, Youren Chen Tags: Original Article Source Type: research

Comparison of prevalence of life style risk factors and 10 year risk of CVD event among rural and tribal population of Kollegal Taluk, Chamrajanagar district, South India
ConclusionsHigh prevalence of tobacco consumption among tribal and high prevalence of hypertension and diabetes among rural predisposes 10% of population to moderate to high risk of stroke/MI within 10 years.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - August 2, 2019 Category: Endocrinology Source Type: research

Higher triglyceride to high ‐density lipoprotein cholesterol ratio increases cardiovascular risk: 10‐year prospective study in a cohort of Chinese adults
ConclusionsAmong the Chinese population, a higher TG/HDL ‐C ratio is correlated with an increased risk of major CV events.
Source: Journal of Diabetes Investigation - August 2, 2019 Category: Endocrinology Authors: Zekai Chen, Guanzhi Chen, Hailun Qin, Zefeng Cai, Jianhuan Huang, Haojia Chen, Weiqiang Wu, Zhichao Chen, Shouling Wu, Youren Chen Tags: Original Article Source Type: research

The Association of Hypoglycemia Assessed by Continuous Glucose Monitoring With Cardiovascular Outcomes and Mortality in Patients With Type 2 Diabetes
Conclusions: CGM is effective to detect asymptomatic and nocturnal hypoglycemia. Hypoglycemia is associated with an increased risk of non-fatal stroke, cardiovascular related death and total mortality. The cardiovascular mortality is dose-dependent on the severity of hypoglycemia.
Source: Frontiers in Endocrinology - August 5, 2019 Category: Endocrinology Source Type: research

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes
Conclusions/interpretationHigher omentin concentrations are associated with an increased risk for cardiovascular events in individuals with diabetes after adjustment for multiple cardiovascular risk factors. Given data from preclinical studies, it appears possible that this association reflects a compensatory, but insufficient upregulation of omentin concentrations as a response to stimuli that increase cardiovascular risk.
Source: Diabetologia - November 8, 2019 Category: Endocrinology Source Type: research

Higher triglyceride to high ‐density lipoprotein cholesterol ratio increases cardiovascular risk: 10‐year prospective study in a cohort of Chinese adults
ConclusionsAmong the Chinese population, a higher TG/HDL ‐C ratio is correlated with an increased risk of major CV events.
Source: Journal of Diabetes Investigation - August 2, 2019 Category: Endocrinology Authors: Zekai Chen, Guanzhi Chen, Hailun Qin, Zefeng Cai, Jianhuan Huang, Haojia Chen, Weiqiang Wu, Zhichao Chen, Shouling Wu, Youren Chen Tags: Original Article Source Type: research

Association Between Obesity Type and Common Vascular and Metabolic Diseases: A Cross-Sectional Study
Conclusions: Central obesity alone and compound obesity are associated with the risk of hypertension, hyperlipidemia, and diabetes mellitus. Compound obesity but not central obesity alone is associated with the risk of coronary heart disease, but further research is needed to confirm it. There are no significant relationship between stroke and central obesity alone or compound obesity.
Source: Frontiers in Endocrinology - January 8, 2020 Category: Endocrinology Source Type: research