Derivation and Validation of a Risk Prediction Tool for Hypoglycemia in Hospitalized Adults with Diabetes: the Hypoglycemia during Hospitalization (HyDHo) Score
ConclusionsA parsimonious risk prediction model that uses five key clinical variables predicts hypoglycemia during hospitalization at the time of admission. More than one-quarter of patients at low risk of hypoglycemia had a score below the threshold. They could be identified at the time of admission by applying the HyDHo Score, and may need less intensive glucose monitoring in hospital. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - August 11, 2018 Category: Endocrinology Source Type: research

Process Evaluation of the Canadian Diabetes Association Guidelines Dissemination Strategy Using the RE-AIM Framework
ConclusionsOur interactive tools were highly and repeatedly accessed, signifying its relevance to problems in clinical care. Our synthesized analyses indicate the guidelines website to be resource-intensive with a wide reach and a potential to change outcomes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - August 11, 2018 Category: Endocrinology Source Type: research

A Comparison of Structured Education Programs for Pediatric Type 1 Diabetes: Multiple Daily Injection (MDI) Therapy Delivered by Group Workshop Versus Self-Study Course
Publication date: Available online 9 August 2018Source: Canadian Journal of DiabetesAuthor(s): Karen Johnston, Gloria Johnston, Elizabeth Rosolowsky (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - August 9, 2018 Category: Endocrinology Source Type: research

Intercellular adhesion molecule-1 (ICAM-1) Lys469Glu polymorphism, systemic redox homeostasis and gestational diabetes mellitus
ConclusionAlthough no significant difference was observed between genotypes, oxidative damage observed in patients with GDM warrants earlier screening and management in the light of new evidence. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - August 2, 2018 Category: Endocrinology Source Type: research

Lived Experience as a Distinct Information Source: A Case Study to Improve E-Health Products for Adults With Type 1 or 2 Diabetes Starting Insulin
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Jennica Nichols, Stephanie Boutette, Krista Banasiak (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Masthead
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Table of Contents
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Editorial Board
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

In This Issue…
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Elizabeth Sellers (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Effects of Diabetes Mellitus on Cognitive Decline in Patients With Alzheimer Disease
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Tomoyuki Kawada (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

The Mountain of Health: The Perceptions and Perceived Expectations of Youth Living With Type 2 Diabetes in Winnipeg, Manitoba, Canada, Through a Grounded Theory Study
ConclusionFuture interventionists should be aware of the vast incongruence in patients' perceptions of health in type 2 diabetes and their perceptions of health-care providers' expectations during the development of interventions.RésuméObjectifL'objectif de la présente étude était d'examiner la perception des jeunes à l'égard de la prise en charge du diabète.MéthodesL'étude comptait 8 jeunes Manitobains atteints du diabète de type 2 (n=7 filles). Chaque jeune a participé à une entrevue semi-structurée en personne, par Skype ou...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Development of Perinatal Mental Illness in Women With Gestational Diabetes Mellitus: A Population-Based Cohort Study
ConclusionsIn this large population-based cohort of women in Alberta, GDM was not associated with an increased risk for developing new-onset mental illness during pregnancy or postpartum.RésuméObjectifsExaminer la relation entre le diabète sucré gestationnel (DSG) et le développement de la maladie mentale (troubles affectifs et anxieux) au cours de la grossesse et dans l'année qui suit l'accouchement.MéthodesNous avons relié les bases de données cliniques et administratives pour repérer les diagnostics de DSG et de maladie mentale chez les mères q...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Effect of Ruta chalepensis on Zinc, Lipid Profile and Antioxidant Levels in the Blood and Tissue of Streptozotocin-Induced Diabetes in Rats Fed Zinc-Deficient Diets
ConclusionsIt seems that R. chalepensis supplementation is a potent factor in reducing the oxidative severity of zinc deficiency in experimental diabetes through its hypoglycemic and antioxidant actions.RésuméObjectifsLors de diabète, le stress oxydatif et les anomalies lipidiques sont fréquents et prononcés, et représentent les facteurs importants qui participent à l'apparition des complications du diabète. La carence en zinc induit généralement un stress oxydatif. Lors de maladies métaboliques, l'antioxydant Ruta chalepensis estbien connu pour s...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Optimizing Glycemic Control in Adults With Type 1 or Type 2 Diabetes Attending a Multidisciplinary Foot Clinic
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Devin Betsch, Zhiwei Gao, Gerry Mugford, Susan McGrath-Terry, Gordon DowAbstractObjectivesTo determine the impact of a diabetes nurse educator (DNE) on glycemic control in a multidisciplinary diabetes foot (MDF) clinic.MethodsA prospective cohort trial to measure the impact of a DNE on glycemic control was conducted in an MDF clinic. Change in glycated hemoglobin (A1C) levels over time was measured against the percentage of patient visits (PPVs) accompanied by a glucose meter and/or diary.ResultsIncreasing PPVs were significantl...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Symptoms of Mental Illness and Their Impact on Managing Type 2 Diabetes in Adults
ConclusionsMultidimensional diabetes education programs that consider psychological, physical and social challenges are needed to address the needs of people with mental illnesses.RésuméObjectifsLes personnes atteintes de maladies mentales sont plus exposées aux complications du diabète susceptibles de réduire l'espérance de vie de 10 à 15 ans. Il est possible d'améliorer la prise en charge du diabète et les résultats cliniques lorsque les interventions sur le mode de vie portent sur des habitudes alimentaires saines et que l'activité physique uti...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Plasma Palmitoyl-Carnitine (AC16:0) Is a Marker of Increased Postprandial Nonesterified Incomplete Fatty Acid Oxidation Rate in Adults With Type 2 Diabetes
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Fatima-Zahra Bouchouirab, Mélanie Fortin, Christophe Noll, Jean Dubé, André C. CarpentierAbstractObjectivesEnhanced mitochondrial fatty acid utilization is known to increase radical oxidative stress and induce insulin resistance. An increased level of plasma acylcarnitine (AC) has been proposed to indicate mitochondrial energy substrate overload, a possible mechanism leading to insulin resistance. The aim of our study was to determine fasting and postprandial plasma acetyl-carnitine (AC2:0), palmitoyl-carnit...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

A Canadian Cross-Sectional Survey on Psychosocial Supports for Adults Living With Type 1 or 2 Diabetes: Health-Care Providers' Awareness, Capacity and Motivation
ConclusionsMotivation to address psychosocial issues in diabetes was high, but capacity to do so and opportunity to learn how were both low. These findings can be used to develop a targeted strategy to help address this gap.RésuméObjectifsRésoudre les problèmes psychosociaux est essentiel à la prise en charge autonome du diabète. Ces travaux portent sur : 1) la perception des professionnels de la santé (PS) quant à la pertinence des divers problèmes psychosociaux dans la prise en charge du diabète; 2) la confiance qu'ont les PS de travailler sur ces prob...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Is YouTube Useful as a Source of Health Information for Adults With Type 2 Diabetes? A South Asian Perspective
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Amanda Y. Leong, Ravina Sanghera, Jaspreet Jhajj, Nandini Desai, Bikramjit Singh Jammu, Mark J. MakowskyAbstractObjectivesTo investigate the content, quality and popularity of information about type 2 diabetes available on YouTube.MethodsWe searched YouTube with the terms Diabetes, Diabetes type 2, Diabetes South Asians, Diabetes Punjabi and Diabetes Hindi to identify videos concerning type 2 diabetes. A team of health-care providers independently classified the first 20 videos from each search as useful, misleading, or personal...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Effect of Combined Exercise Versus Aerobic-Only Training on Skeletal Muscle Lipid Metabolism in a Rodent Model of Type 1 Diabetes
ConclusionsIntegration of aerobic and resistance exercise may exert a synergistic effect, producing adaptations characteristic of the “athlete's paradox,” including increased capacity to store and oxidize lipids.RésuméObjectifsL'anomalie du métabolisme lipidique des muscles squelettiques est associée à l'insulinorésistance chez les personnes atteintes du diabète de type 1. Bien que l'exercice aérobique restaure le métabolisme des lipides, cette modalité d'entraînement augmente le risque d'hypoglycémie après l'exercice. L'i...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Antioxidant Role of Vitamin D in Mice With Alloxan-Induced Diabetes
ConclusionsThe present work accounts for the ubiquitous roles of vitamin D in various diseases and highlights its role as a therapeutic intervention in diabetes mellitus.RésuméObjectifsLa découverte des récepteurs de la vitamine D a révolutionné la compréhension de la biologie de la vitamine D qui, croit-on désormais, influence un vaste éventail de voies cellulaires. L'action antihyperglycémiante de la vitamine D faisant appel au métabolisme du calcium a fait l'objet de bien des discussions, mais les études laissent désormais croire ...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Clinical Islet Transplantation for Adults With Type 1 Diabetes in Canada: Referral Patterns and Eligibility Assessment
ConclusionsMost referrals were received from people with diabetes, but acceptance rates were not significantly lower than for physician referrals. It will be important to increase awareness of severe hypoglycemia or glycemic lability as major indications for CIT among patients and physicians and to evaluate any impact this may have on the current acceptance rate of 19%.RésuméObjectifsEn raison de la disponibilité limitée des organes et des risques d'immunosuppression permanente, il est nécessaire de procéder à une sélection minutieuse au programme clinique de greffes ...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Comparison of Glycated Hemoglobin Results Based on At-Home and In-Lab Dried Blood Spot Sampling to Routine Venous Blood Sampling In-Lab in Adult Patients With Type 1 or Type 2 Diabetes
ConclusionsHome-blotter collection is an alternative to routine collection.RésuméObjectifsLa mesure régulière de l’hémoglobine glyquée (A1c) est astreignante sur le plan logistique. Le prélèvement sur papier buvard à domicile s’avère une solution de rechange. La présente étude permet de tester la viabilité des mesures de l’A1c sur papier buvard à domicile.MéthodesL’objectif était de comparer l’exactitude des prélèvements de l’A1c sur papier buvard à domicil...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Does Type 2 Diabetes Mellitus Affect the Healing of Bell's Palsy in Adults?
ConclusionsDiabetes does not affect the severity, recovery rate from or healing of BP.RésuméObjectifsLa paralysie de Bell (PB) se caractérise par une faiblesse faciale soudaine dont la cause est inconnue. Parmi les nombreux facteurs qui nuisent à la guérison de la PB, le facteur généralement jugé pertinent est la présence du diabète sucré de type 2. Notre objectif était d'examiner les répercussions du diabète sur la guérison de la PB.MéthodesNous avons suivi 60 patients atteints de PB durant 1 à 3 ans et l...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Emerging Role of Adipocytokines in Type 2 Diabetes as Mediators of Insulin Resistance and Cardiovascular Disease
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya DhanasekaranAbstractAdipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines play significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated b...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Gender-Related Differences in the Control of Cardiovascular Risk Factors in Primary Care for Elderly Patients With Type 2 Diabetes: A Cohort Study
Publication date: August 2018Source: Canadian Journal of Diabetes, Volume 42, Issue 4Author(s): Abdallah Al-Salameh, Sophie Bucher, Bernard Bauduceau, Linda Benattar-Zibi, Gilles Berrut, Philippe Bertin, Emmanuelle Corruble, Nicolas Danchin, Geneviève Derumeaux, Jean Doucet, Bruno Falissard, Françoise Forette, Olivier Hanon, Rissane Ourabah, Florence Pasquier, Michel Pinget, Virginie Ringa, Laurent BecquemontAbstractObjectiveThe aim of this study was to estimate the association between gender and control of diabetes and other cardiovascular risk factors in elderly patients with type 2 diabetes mellitus.Method...
Source: Canadian Journal of Diabetes - July 30, 2018 Category: Endocrinology Source Type: research

Safe Use of Metformin in Adults With Type 2 Diabetes and Chronic Kidney Disease: Lower Dosages and Sick-Day Education Are Essential
Publication date: Available online 25 April 2018Source: Canadian Journal of DiabetesAuthor(s): Lori MacCallum, Peter A. SeniorAbstractMetformin, together with lifestyle intervention, is considered first-line treatment for glycemic management in people with type 2 diabetes. Despite this widespread use, one of the areas of longstanding debate has been whether metformin can be used safely in those with chronic kidney disease (CKD). The concern is the possibility of an increased risk for lactic acidosis resulting from metformin accumulation in those with renal impairment. Options in this patient population are limited, and man...
Source: Canadian Journal of Diabetes - July 28, 2018 Category: Endocrinology Source Type: research

Effect of Biochanin A on Retina Levels of Vascular Endothelial Growth Factor, Tumor Necrosis Factor-Alpha and Interleukin-1Beta in Rats with Streptozotocin-Induced Diabetes
Publication date: Available online 3 April 2018Source: Canadian Journal of DiabetesAuthor(s): Maryam Eskandari Mehrabadi, Zahra Salemi, Saeid Babaie, Mitra PanahiAbstractObjectivesWithout proper medication for the treatment of diabetic retinopathy, retinal cells become malnourished and degenerate, which results in damage to vision cells and can lead to blindness. Flavonoids such as biochanin A (BCA) can directly target various facets of angiogenesis. We assessed the effect of administrating BCA on angiogenic and inflammatory markers in the retina of rats with diabetes.MethodsWe randomly selected 2 groups from 30 male Wista...
Source: Canadian Journal of Diabetes - July 25, 2018 Category: Endocrinology Source Type: research

Factors Influencing Preferences of Adults with Type 2 Diabetes for Diabetes Self-Management Education Interventions
ConclusionsTo optimize the effectiveness of DSME interventions, health-care providers are encouraged to assess patients' preferences to inform the design of DSME interventions and tailor their implementation to fit the preferences of patients with a range of sociodemographic and clinical profiles.RésuméObjectifsLe but de cette étude était d'explorer les associations entre les facteurs liés aux patients et leurs préférences exprimées pour les différents types et les caractéristiques des interventions relatives à l'éducation à la gesti...
Source: Canadian Journal of Diabetes - July 24, 2018 Category: Endocrinology Source Type: research

Perceptions by Adult Patients with Type 1 and 2 Diabetes of Current and Advanced Technologies of Blood Glucose Monitoring: A Prospective Study
ConclusionsThe favoured advanced technology, selected by 49.7% (n=97/195) of participants, was the wristband. Statistical significance was seen between the type of diabetes and the device selected; patients with type 1 diabetes preferred contact lenses (p
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Copeptin and Estimated Insulin Sensitivity in Adults With and Without Type 1 Diabetes: The CACTI Study
ConclusionsCopeptin does not correlate with markers of IR in type 1 diabetes but strongly correlates in non-type 1 diabetes. Thus, elevated vasopressin activity and IR appear to be independent risk factors for vascular complications in type 1 diabetes.RésuméObjectifsLa copeptine, un marqueur de substitution de la vasopressine, est élevée chez les individus présentant une insulino-résistance (IR) et un diabète de type 2. Alors que les adultes atteints de diabète de type 1 présentent également des concentrations élevées de copeptine et une IR...
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Association Between Elevated C-Reactive Protein Levels and Prediabetes in Adults, Particularly Impaired Glucose Tolerance
ConclusionsElevated serum CRP levels are associated with prediabetes, particularly impaired glucose tolerance.RésuméObjectifsLe prédiabète est un état précurseur du diabète et augmente le risque de maladie cardiovasculaire. Un niveau élevé de protéine C réactive (CRP) est un facteur de risque pour le développement du diabète, et les individus avec un prédiabète ont des niveaux plus élevés de CRP que ceux ayant une tolérance normale au glucose. En outre, l'inflammation systémique peut jouer un...
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Improving Glycemic Control in Adults and Children With Type 1 Diabetes With the Use of Smartphone-Based Mobile Applications: A Systematic Review
The objectives of this study were to examine the literature evaluating the use of mobile apps (stand-alone and text messaging/feedback) in type 1 diabetes and to review top-rated mobile apps applicable to type 1 diabetes.MethodsMedline, Cochrane and Embase databases were systematically searched to identify studies published from inception to February 2018. Top-rated relevant apps from Google Play Store and Apple App Store were reviewed in July 2017.ResultsThe literature search yielded 3,462 studies. Of these studies, 9 evaluated the stand-alone apps; 3 showed significant improvement in glycated hemoglobin (A1C) levels (0.5%, p
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Assessing the Levels of L-Carnitine and Total Antioxidant Capacity in Adults With Newly Diagnosed and Long-Standing Type 2 Diabetes
This study is essentially a correlative study that examines the potential of reduced levels of L-carnitine (LC) when combined with the pathophysiology of type 2 diabetes. The aim of the study was to assess the levels of LC, total antioxidant capacity (TAOC), fasting blood sugar (FBS), triglycerides and cholesterol in people with newly diagnosed and long-standing type 2 diabetes and in healthy controls.MethodsThe study was done in 90 adult subjects, including 30 with newly diagnosed diabetes, 30 with long-standing type 2 diabetes and 30 healthy controls. Plasma samples were used to assay the biochemical parameters.ResultsIn...
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Population-Level Outcomes With a 2-Step Approach for Gestational Diabetes Screening and Diagnosis: Response to the Letter to the Editor From Dr. Kong
Publication date: Available online 13 April 2018Source: Canadian Journal of DiabetesAuthor(s): Lois Donovan, Alun Edwards, Anamaria Savu, Sonia Butalia, Edmond Ryan, Jeffrey Johnson, Padma Kaul (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Evaluation of rs3088442 G>A SLC22A3 Gene Polymorphism and Role of microRNA 147 in T2DM Groups of Adult Pakistani Population in Response to Metformin
ConclusionsThese results suggested that the SLC22A3 rs3088442 2282 A allele may confer metformin clinical response in T2DM among Pakistani population. Over expression of microRNA 147 is associated with the down expression of the SLC22A3 gene in T2DM patients. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Celastrol Reverses Palmitic Acid-Induced Insulin Resistance in HepG2 Cells via Restoring the miR-223 and GLUT4 pathway.
In this study, we investigated how celastrol regulates IR. The HepG2 cellular IR model was initially established with palmitic acid (PA). The expression and activity of glucose transporter 4 (GLUT4), insulin receptor substrate-1 (IRS1), and 9 microRNAs (miRNAs) (miR-7, -34a, -96, -113, -126, -145, -150, -223, and -370) were detected before and after celastrol treatment using the PA-induced HepG2 IR model. The results showed that 250 μM PA for ≥ 2 d was optimal for inducing IR in HepG2 cells; 600 nM celastrol significantly attenuated the PA-induced IR in HepG2 cells. The PA-induced GLUT4 and IRS1 down-regulation and S...
Source: Canadian Journal of Diabetes - July 18, 2018 Category: Endocrinology Source Type: research

Optimal Glycated Hemoglobin Cutoff Point for Diagnosis of Type 2 Diabetes in Iranian Adults
Publication date: Available online 12 March 2018Source: Canadian Journal of DiabetesAuthor(s): Farideh Razi, Patricia Khashayar, Robabeh Ghodssi-Ghassemabadi, Mohsen Mehrabzadeh, Maryam Peimani, Fatemeh Bandarian, Ensieh Nasli-EsfahaniAbstractObjectivesThe aim of this study was to evaluate the capability of glycated hemoglobin (A1C) levels to be a tool for identifying Iranian adults with diabetes and prediabetes.MethodsIn a cross-sectional population-based study, 1,813 adults, men and women 35 to 75 years of age and without a history of diabetes and hemoglobinopathies, were included. Fasting blood glucose and A1C levels we...
Source: Canadian Journal of Diabetes - July 11, 2018 Category: Endocrinology Source Type: research

Knowledge Translation to Optimize Adult Inpatient Glycemic Management with Basal Bolus Insulin Therapy and Improve Patient Outcomes
This study was conducted in 2 phases and focused on the hospitalist provider group across 4 acute care facilities in Calgary. Phase 1 involved a qualitative evaluation of provider and site specific barriers and facilitators, which were mapped to validated interventions using behaviour change theory. This informed the co-development and optimization of the BBIT Knowledge Translation toolkit, with each tool targeting a specific barrier to improved diabetes care practice, including BBIT ordering. In Phase 2, the BBIT Knowledge Translation toolkit was implemented and evaluated, focusing on BBIT ordering frequency, as well as s...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

The Effect of Omega-3 on Circulating Adiponectin in Adults with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
The objective of this study was to evaluate the effect of omega-3 (food or supplement) on circulating adiponectin in patients with type 2 diabetes through a systematic review of meta-analyses of randomized controlled trials.PubMed, Scopus and Web of Science were searched for relevant studies through May 2016. Two researchers screened and abstracted the literature independently. Pooled estimates were obtained using the random-effects models.Overall, omega-3 increased adiponectin by 0.57 µg/mL (95% confidence interval [CI] 0.15 to 1.31; p=0.01, I-square=74.2% p for heterogeneity
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

The Association Between Taste Impairment and Serum Zinc Concentration in Adult Patients with Type 2 Diabetes
In this study, we aimed to elucidate the association between taste acuity and serum zinc concentration in patients with type 2 diabetes.MethodsWe enrolled 29 patients who were hospitalized and asked them to attend a 2-week diabetes education program. Fasting blood samples were obtained on the morning of the first day and 2 weeks after hospitalization. The acuity of sweet, salty, sour or bitter taste was evaluated by a filter-paper disc method. Correlations among taste acuity, glycemic control and serum zinc concentration were analyzed using the Spearman rank correlation coefficient.ResultsThe following parameters (mean &pl...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Accumulation of Advanced Glycation Endproducts and Subclinical Inflammation in Deep Tissues of Adult Patients With and Without Diabetes
ConclusionsAGE contents were strongly correlated with each other and were accompanied by inflammatory cells. Skin AF measurement could provide information about the systemic accumulation of AGEs.RésuméObjectifsLes produits terminaux de la glycation avancée (PTGA) jouent un rôle essentiel dans le développement des complications du pied chez les personnes diabétiques. L'autofluorescence (AF) cutanée déterminerait de manière non effractive l'accumulation tissulaire des PTGA. La présente étude a permis d'évaluer l'association entre l'AF cutan&ea...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Activated Mast Cells Mediate Low-Grade Inflammation in Type 2 Diabetes: Interleukin-37 Could be Beneficial
Publication date: Available online 31 January 2018Source: Canadian Journal of DiabetesAuthor(s): Pio Conti, Gianpaolo Ronconi, Spyridon K. Kritas, Alessandro Caraffa, Theoharis C. TheoharidesAbstractMast cells (MCs) promote guest immune responses to parasites and play a critical role in allergic and inflammatory reactions. Once they have been activated, MCs release highly inflammatory compounds that can provoke serious pathologic signs that can lead to death. MCs generate a number of preformed, de novo synthesized compounds and inflammatory cytokine/chemokine synthesis in response to the high-affinity (Kd=10–10 M) im...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Diabetes Risk in Childhood Cancer Survivors: A Population-Based Study
ConclusionsOur study supports evidence of an increased risk for diabetes in survivors of childhood cancer. Future research is warranted for better identification of treatment-related risk factors for diabetes in this population.RésuméObjectifsGrâce à l'amélioration constante de la survie après un cancer chez l'enfant, les conséquences à long terme des traitements contre le cancer sur la santé retiennent de plus en plus l'attention. Le diabète apparaît comme une conséquence tardive potentielle de la thérapie contre le cancer. Toutefois,...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Direct Health-Care Costs and Productivity Costs Associated With Hypoglycemia in Adults With Type 1 and Type 2 Diabetes Mellitus That Participated in the Canadian Hypoglycemia Assessment Tool Program
ConclusionsThe impact of hypoglycemia events on health-care resource utilization and work productivity leads to substantial direct and indirect costs in Canadian patients with diabetes.RésuméObjectifsIl existe peu de données sur le coût des épisodes d'hypoglycémie chez les Canadiens atteints du diabète de type 1 ou de type 2. L'objectif de la présente étude était d'estimer les coûts directs et indirects des soins de santé associés à l'hypoglycémie en s'appuyant sur une cohorte de 498 patients canadiens de l'étude m...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

What Can We Learn From Diabetes-Related YouTube Videos?
Publication date: Available online 31 January 2018Source: Canadian Journal of DiabetesAuthor(s): Benjamin K.P. Woo (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Evaluation of a Diabetes Coach Program Aimed to Improve the Care of Children and Youth With Type 1 Diabetes and With Compromised Control
ConclusionsParticipation in the DCP decreased A1C values in pediatric patients; however, the levels were not sustained after visits stopped. Pediatric health coaches may play an important role in the management of type 1 diabetes, but further research is needed to explore their benefits and how positive effects can be sustained.RésuméObjectifsÉvaluer les répercussions du Diabetes Coach Program (DCP) sur les concentrations de l'hémoglobine glyquée (A1c) chez les jeunes atteints du diabète de type 1. Les jeunes ont été orientés vers le DCP et y ont partici...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Qualitative Evaluation of the Barriers and Facilitators Influencing the Use of an Electronic Basal Bolus Insulin Therapy Protocol to Improve the Care of Adult Inpatients With Diabetes
ConclusionsThe outcomes highlight the complex interplay between educational, organizational and technical themes and the significance of employing a systemic approach to support the implementation of electronic inpatient glycemic-management protocols within complex social organizations.RésuméObjectifsUne évaluation qualitative des répercussions perçues d'un nouveau modèle d'ordonnances électroniques relatif aux schémas insuliniques de type basal-bolus qui est fondé sur des données probantes sur le flux de travail et la pratique cliniques, et une explorat...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, Improves Trabecular Bone Mineral Density and Microstructure in Obese, Insulin-Resistant, Pre-diabetic Rats
ConclusionsVildagliptin had a beneficial effect on the bone of obese insulin-resistant rats with prediabetes, particularly at the trabecular site. Such benefit probably results from enhanced bone formation rather than from suppressed bone resorption.RésuméObjectifL'insulinorésistance associée à l'obésité et le diabète de type 2 détériorent énormément les propriétés mécaniques et la qualité de l'os. Toutefois, puisque plusieurs médicaments contre le diabète, particulièrement les thiazolidinedi...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Understanding the Experiences of East African Immigrant Women with Gestational Diabetes Mellitus
ConclusionsStudy findings point to the need for more context-specific and culturally appropriate support and care. Diagnoses of GDM extended beyond the individuals affected and impacted their families culturally, psychologically and financially. Addressing the emergent themes during pregnancy is imperative to improving care providers' engagement with EA immigrant women in postpartum diabetes screening activities and beyond. The findings of this study contain elements transferable to other immigrant groups in similar socioecologic contexts.RésuméObjectifsLes femmes de l'Afrique orientale (AO) représente...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research

Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity and Metformin Treatment in Adult Patients With Type 2 Diabetes Mellitus
ConclusionsOur results suggest that BDNF may be associated with lipid metabolism and that increased production of BDNF may be related to metformin treatment. Moreover, we showed an association between BDNF levels and platelet reactivity; we found that serum BDNF levels in patients with type 2 diabetes who had high platelet reactivity were higher than in subjects with normal platelet reactivity despite antiplatelet therapy.RésuméObjectifsL'objectif de la présente étude était d'examiner l'association des concentrations sériques du facteur neurotrophique dérivé du cervea...
Source: Canadian Journal of Diabetes - July 10, 2018 Category: Endocrinology Source Type: research