Severity grading assessment classifications for both insulin resistance syndrome and status of pancreatic beta islet cells’ function in clinical practice using homeostasis model assessment method indices
This article aims to classify the severity grading assessments for both insulin resistance (IR) syndrome and status of pancreatic beta (β) islet cells’ function using the homeostasis model assessment method (that is; homeostasis model assessment-insulin resistance [HOMA-IR] and homeostasis model assessment-pancreatic beta (β) islet cells’ function [HOMA-B] indices) with the focus of disseminating this information rapidly for clinical use by physicians in their patients with dysfunctional regulation of glucose metabolism. It will also assist clinicians to prevent and screen for these individuals who ar...
Source: Canadian Journal of Diabetes - February 16, 2020 Category: Endocrinology Source Type: research

Renal outcome in patients with type 2 diabetes mellitus and diabetic kidney disease
Publication date: Available online 16 February 2020Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 16, 2020 Category: Endocrinology Source Type: research

Innovations in Providing Diabetes Care for Individuals Experiencing Homelessness: An Environmental Scan
The objective of this study is to document innovations in providing diabetes care for individuals experiencing homelessness.MethodsUsing directed snowball sampling, we recruited a sample of service providers (family physicians, nurses, social workers, endocrinologists, diabetes educators, and shelter workers) in 5 Canadian cities (Vancouver, Calgary, Edmonton, Toronto, Ottawa). Data was collected using detailed open-ended interviews. Transcripts and field notes were analyzed using thematic analysis.ResultsWe interviewed 96 program managers and providers representing 38 organizations. While many of the same challenges were ...
Source: Canadian Journal of Diabetes - February 15, 2020 Category: Endocrinology Source Type: research

Quality Gaps of Electronic Health Records in Diabetes Care
This study compared extracted structured EHR data with chart review from endocrinologists’ health-care records at a large, academic ambulatory hospital in Toronto, Ontario.MethodsConsecutive chart review for the first 10 patients with either type 1 or type 2 diabetes seen between January 1, 2015 and March 1, 2016 was sampled for each of the 10 endocrinologists within the diabetes program, and electronic data extraction was also completed for a core set of structured diabetes care elements. Fisher exact test was used to determine differences in data availability between extracted EHR data and chart review.ResultsOut o...
Source: Canadian Journal of Diabetes - February 14, 2020 Category: Endocrinology Source Type: research

Interplay Between Gut Microbiota and Gastrointestinal Peptides: Potential Outcomes on the Regulation of Glucose Control
Publication date: Available online 2 November 2019Source: Canadian Journal of DiabetesAuthor(s): Joseph Lupien-Meilleur, David E. Andrich, Samantha Quinn, Clément Micaelli-Baret, Roxane St-Amand, Denis Roy, David H. St-PierreAbstractA host of gastrointestinal (GI) peptides influence the regulation of vital functions, such as growth, appetite, stress, gut motility, energy expenditure, digestion and inflammation, as well as glucose and lipid homeostasis. Hence, impairments in the synthesis/secretion of glucagon-like peptide-1 (GLP-1), leptin, nesfatin-1, glucose-dependent insulinotropic peptide (GIP), ghrelin (acylate...
Source: Canadian Journal of Diabetes - February 11, 2020 Category: Endocrinology Source Type: research

Epidemiology of Diabetes in Pregnancy Among First Nations and Non-First Nations Women in Saskatchewan, 1980‒2013. Part 2: Predictors and Early Complications; Results From the Diabetes in Pregnancy: Outcomes and Ramification from a Retrospective Longitudinal Intra- Intergenerational Study in Saskatchewan Project
ConclusionsAlong with previously recognized predictors of GDM and pre-GDM, FN ethnicity was an independent determinant of DIP in Saskatchewan from 1980 to 2013. Early mother/child birth complications were increased in both FN and non-FN with DIP, but more so in FN. Effective DIP prevention strategies, and improvements in preconception, prenatal and perinatal care, are required to remove ethnicity-based disparities in DIP rates and outcomes.RésuméObjectifsCompte tenu des disparités dans l’incidence du diabète pendant la grossesse (DPG) entre les femmes des Premières Nations (PN) et l...
Source: Canadian Journal of Diabetes - February 5, 2020 Category: Endocrinology Source Type: research

Assessing Dysglycemia Risk among Younger Adults: a Validation of the Canadian Diabetes Risk Questionnaire
ConclusionsThe original CANRISK score performed well among young adults, even when compared with a young adult-specific model. We suggest that the cut point be lowered for young adults and the tool be permitted for use in this age group.RésuméObjectifsLa prévalence et l’incidence du diabète au Canada ont connu leur plus forte augmentation chez les jeunes adultes. Le questionnaire CANRISK (Canadian Diabetes Risk Questionnaire) a été créé pour évaluer le risque de dysglycémie chez les adultes ≥ 40 ans, mais n’a pas été valid&ea...
Source: Canadian Journal of Diabetes - February 5, 2020 Category: Endocrinology Source Type: research

At-Home Self-Applied Photobiomodulation Device for the Treatment of Diabetic Foot Ulcers in Adults with Type 2 Diabetes – Report of 4 Cases
Publication date: Available online 4 February 2020Source: Canadian Journal of DiabetesAuthor(s): Rose Raizman, Lilach GavishAbstractDiabetic foot ulcers (DFUs) incidence is increasing with the rising global prevalence of diabetes. In spite of following best practice standard of care, most DFU are slow to heal. Photobiomodulation (PBM), previously known as low-level laser therapy, has been shown to accelerate healing of acute or chronic wounds, and specifically diabetic foot ulcers. However, the frequent applications required, translates to frequent visits at the clinic which are difficult for patients with DFU. In the foll...
Source: Canadian Journal of Diabetes - February 5, 2020 Category: Endocrinology Source Type: research

Masthead
Publication date: February 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 1Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 3, 2020 Category: Endocrinology Source Type: research

Editorial Board
Publication date: February 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 1Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 3, 2020 Category: Endocrinology Source Type: research

Time to Rethink Reducing Cardiovascular Risk: Are We Ready?
Publication date: February 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 1Author(s): Alice Y.Y. Cheng, Thomas M.S. Wolever, G.B. John Mancini (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 3, 2020 Category: Endocrinology Source Type: research

Table of Contents
Publication date: February 2020Source: Canadian Journal of Diabetes, Volume 44, Issue 1Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 3, 2020 Category: Endocrinology Source Type: research

Assessment of the Risk Factors of Multidrug-Resistant Organism Infection in Adults With Type 1 or Type 2 Diabetes and Diabetic Foot Ulcer
ConclusionsOur meta-analysis indicated that ischemic ulcer, ulcer size, ulcer grade, osteomyelitis, previous antibiotic therapy and previous hospitalization were associated with MDRO infection in patients with diabetic foot ulcer.RésuméObjectifsÀ notre connaissance, c’est la première revue de littérature qui permet de déterminer les facteurs de risque d’infection liée à une bactérie multirésistante aux antibiotiques (BMR) chez les patients ayant un ulcère du pied diabétique. L’objectif de la présente étude &e...
Source: Canadian Journal of Diabetes - January 29, 2020 Category: Endocrinology Source Type: research

Diabetes in Long-term Care Homes: An Educational Intervention to Improve Diabetes Care
ConclusionAn educational intervention can improve knowledge and comfort of diabetes management of frontline LTC staff. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 29, 2020 Category: Endocrinology Source Type: research

Epidemiology of Diabetes in Pregnancy Among First Nations and Non-First Nations Women in Saskatchewan, 1980‒2013. Part 1: Populations, Methodology and Frequencies (1980‒2009); Results From the DIP: ORRIIGENSS Project
ConclusionsThe proportion of pregnancies complicated by DIP increased steadily among FN and non-FN women in Saskatchewan in 1980‒2009, but the incidence of GDM and pre-GDM is 2- to 3-fold higher among FN.RésuméObjectifsÉtant donné les conséquences immédiates et à long terme du diabète pendant la grossesse (DPG) chez la mère et l’enfant, nous avons comparé la fréquence du diabète gestationnel (DG) et du pré-DG entre les femmes des Premières Nations (PN) et les femmes non-PN de la Saskatchewan de 1980 à 2009.M&eac...
Source: Canadian Journal of Diabetes - January 25, 2020 Category: Endocrinology Source Type: research

An Intolerable Burden: Suicide, Intended Self-Injury and Diabetes
Publication date: Available online 25 January 2020Source: Canadian Journal of DiabetesAuthor(s): Katharine D. Barnard-Kelly, Diana Naranjo, Shideh Majidi, Halis K. Akturk, Marc Breton, Philippe Courtet, Emilie Olié, Rayhan A. Lal, Nicole Johnson, Mark Atkinson, Eric Renard (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 25, 2020 Category: Endocrinology Source Type: research

Lp(a) and Apo-lipoproteins as predictors for diabetic retinopathy and its severity in patients with type 2 diabetes: A case-cohort study
Publication date: Available online 23 January 2020Source: Canadian Journal of DiabetesAuthor(s): Fatemeh Moosaie, Reza Mohamadhosseinzadeh Davatgari, Fatemeh Dehghani Firouzabadi, Sadaf Esteghamati, Niloofar Deravi, Alipasha Meysamie, Pegah Khaloo, Manouchehr Nakhjavani, Alireza EsteghamatiAbstract:AimsTo measure the relationship between serum Lp(a) and apolipoproteins and the risk of developing diabetic retinopathy(DR)Methods1057 patients with type 2 diabetes were divided into three groups and followed for five years: 637 patients without DR, 162 patients with non-proliferative DR (NPDR), and 163 patients with proliferati...
Source: Canadian Journal of Diabetes - January 24, 2020 Category: Endocrinology Source Type: research

The role of estrogen in diabetes mellitus: a review of clinical and pre-clinical data
Publication date: Available online 12 January 2020Source: Canadian Journal of DiabetesAuthor(s): Monica De Paoli, Geoff H. WerstuckAbstractThe incidence and prevalence of diabetes mellitus, and the cardiovascular complications associated with this disease, are rapidly increasing worldwide. Individuals with diabetes have a higher mortality rate due to cardiovascular diseases and a reduced life expectancy compared to those without diabetes. This poses a significant economic burden on health care systems worldwide making the diabetes epidemic a global health crisis. Sex differences in the presentation and outcome of diabetes ...
Source: Canadian Journal of Diabetes - January 13, 2020 Category: Endocrinology Source Type: research

Outcomes of pregnancies affected by diabetes in a rural First Nations obstetrical program in northwest Ontario
ConclusionThis report illustrates a high prevalence of diabetes in this First Nations obstetrical population with associated adverse maternal and neonatal outcomes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 13, 2020 Category: Endocrinology Source Type: research

A systematic review and Delphi study to ascertain common risk factors for T2DM and dementia and brain-related complications of diabetes
ConclusionsResults revealed expert consensus and literature review agreement on a number of common modifiable risk factors for T2DM and dementia, as well as agreement on brain-related complications of diabetes. A number of other proposed shared risk factors did not reach consensus agreement suggesting a need for more high-quality studies to add to the evidence base. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 13, 2020 Category: Endocrinology Source Type: research

Participation in the Diabetes Empowerment Group Program (DEGP) Research Project: Patient Partners’ Perspectives
Publication date: Available online 12 January 2020Source: Canadian Journal of DiabetesAuthor(s): Justin Gagnon, Arlene Abramovich, Stephen Caminsky, Stewart Jack, Jennifer Reoch, Fanny Hersson Edery (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 13, 2020 Category: Endocrinology Source Type: research

Relationship between psychosocial factors and glucose control in patients with type 2 diabetes
Publication date: Available online 12 January 2020Source: Canadian Journal of DiabetesAuthor(s): Krishna Roy, Sahar Iqbal, Veeresh Gadag, Bill BavingtonAbstractObjectivesDespite significant advances in medical therapy and unrestricted access to health care, more than 50% patients with type 2 diabetes (T2D) cannot maintain their blood glucose to target. The present cross-sectional study investigates the association between psychosocial behaviour and diabetes management Newfoundland and Labrador where the prevalence of T2D is the highest in Canada.MethodsData was collected from 165 adult T2D patients. Four sets of self-admin...
Source: Canadian Journal of Diabetes - January 13, 2020 Category: Endocrinology Source Type: research

A Population-Based Study of Diabetes Incidence by Ethnicity and Age: Support for the Development of Ethnic-Specific Prevention Strategies
ConclusionWe found a fifteen-year difference in age-equivalency of risk across ethnic groups. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - January 9, 2020 Category: Endocrinology Source Type: research

Maternal Diabetes Mellitus and Persistent Pulmonary Hypertension of the Newborn: Accumulated Evidence From Observational Studies
ConclusionsMaternal diabetes was associated with increased risk of PPHN. For babies with refractory hypoxemia, with mothers with diabetes, PPHN should be taken into consideration in clinical practice.RésuméObjectifsLe diabète sucré maternel (notamment le diabète sucré préexistant et le diabète sucré gestationnel) est lié à des issues défavorables chez le nourrisson. Toutefois, on ignore si le diabète maternel augmente le risque d’hypertension pulmonaire persistante du nouveau-né (HPPN). Par la présente, nous avons...
Source: Canadian Journal of Diabetes - January 3, 2020 Category: Endocrinology Source Type: research

Mechanisms by Which Glucagon-Like-Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors Reduce Cardiovascular Risk in Adults With Type 2 Diabetes Mellitus
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Abhinav Sharma, Subodh VermaAbstractThe growing global burden of type 2 diabetes mellitus confers significant morbidity and mortality in addition to significant cost to local health-care systems. In recent years, 2 classes of therapies have shown some promise in reducing the risk of adverse cardiovascular (CV) events: 1) glucagon-like-peptide-1 (GLP-1) receptor agonists and 2) sodium-glucose cotransporter-2 (SGLT-2) inhibitors. The mechanisms whereby these therapies reduce the risk of adverse CV outcomes are emerging. Both cl...
Source: Canadian Journal of Diabetes - December 25, 2019 Category: Endocrinology Source Type: research

Prevalence of Type 1 and Type 2 Diabetes-Related Complications and Their Association With Determinants Identified in Canada’s Survey on Living With Chronic Diseases—Diabetes Component
ConclusionsOur findings suggest that socioeconomic factors, including marital status, income and education, have a significant association with most types of complications. Our findings also confirm that low levels of physical activity and high levels of glycated hemoglobin were major determinants in many diabetes-related complications.RésuméObjectifsDans la présente étude, nous avons estimé la prévalence des complications du diabète et les facteurs qui y sont associés chez des patients canadiens diabétiques.MéthodesNous avons utilisé les donn&eac...
Source: Canadian Journal of Diabetes - December 21, 2019 Category: Endocrinology Source Type: research

Short-Term Dietary Oatmeal Interventions in Adults With Type 2 Diabetes: A Forgotten Tool
Publication date: Available online 25 September 2019Source: Canadian Journal of DiabetesAuthor(s): Maximilian Andreas Storz, Federica IraciAbstractDietary modifications play a central role in the treatment of diabetes. Educating and empowering individuals to make better dietary choices is a challenging task. In this context, 1 potential dietetic approach to achieve better glycemic control in type 2 diabetes is often overlooked: the use of short-term dietary oatmeal interventions. This concept was described more than 100 years ago by the German diabetologist Carl von Noorden. It is still applied in several German hospitals,...
Source: Canadian Journal of Diabetes - December 21, 2019 Category: Endocrinology Source Type: research

Talking Points for Helping Your Type 1 Diabetes Patient Decide About Hybrid Closed Loop
Publication date: Available online 26 October 2019Source: Canadian Journal of DiabetesAuthor(s): Bruce A. Perkins, Nancy Cardinez, Christine F. Opsteen (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - December 21, 2019 Category: Endocrinology Source Type: research

Diabetic Retinopathy and Vascular Endothelial Growth Factor Gene Insertion/Deletion Polymorphism
Publication date: Available online 25 August 2019Source: Canadian Journal of DiabetesAuthor(s): Sanam Zeib Khan, Nida Ajmal, Rozeena ShaikhAbstractDiabetic retinopathy (DR) is a microvascular complication of the retina of the eye and represents a major cause of blindness worldwide. It is a complex disorder characterized by both genetic and environmental factors. The vascular endothelial growth factor (VEGF) gene is among the main candidate genes for DR, as it is also involved in several other diseases, such as microvascular complications of diabetes mellitus and cancer. The VEGF gene is extremely polymorphic. The 18-bp fra...
Source: Canadian Journal of Diabetes - December 18, 2019 Category: Endocrinology Source Type: research

Cardiovascular Effects of Sodium-Glucose Cotransporter-2 Inhibitors in Adults With Type 2 Diabetes
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractAdults with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in adults with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other phase 3 cl...
Source: Canadian Journal of Diabetes - December 13, 2019 Category: Endocrinology Source Type: research

Time to Treatment Intensification in Newly Treated Adult Type 2 Diabetes Patients: Comparison of Canada and the United States
Publication date: Available online 25 September 2019Source: Canadian Journal of DiabetesAuthor(s): Tyler B. Dubois, Scot H. Simpson, Dean T. EurichAbstractObjectivesOur aim in this study was to determine whether differences exist in time to treatment intensification in newly treated type 2 diabetes patients in Canada and the United States (US).MethodsTwo separate retrospective cohorts of diabetes patients were used from Canada and the US. Time to treatment intensification (i.e. addition of a second antihyperglycemic agent after initial metformin use) was determined using multivariate Cox proportional hazard models.ResultsA...
Source: Canadian Journal of Diabetes - December 10, 2019 Category: Endocrinology Source Type: research

Assessing Allied Healthcare Professional Time in Type 1 Diabetes: Associations with Clinical Factors, Technology and Social Determinants
Publication date: Available online 10 December 2019Source: Canadian Journal of DiabetesAuthor(s): Antoine B.M. Clarke, Hanaa Ahsan, Jennifer Harrington, Farid H. MahmudAbstractBackgroundThe factors associated with allied healthcare professional (HCP) time spent face-to-face with patients in clinic have not been well described in type 1 diabetes (T1D) given the introduction of resource-intensive technologies and gaps in socioeconomic circumstances.ObjectiveTo evaluate clinical and social factors associated with non-physician HCP time in a pediatric T1D practice.MethodsNon-physician HCP workload data, including time spent in...
Source: Canadian Journal of Diabetes - December 10, 2019 Category: Endocrinology Source Type: research

Diabetic Peripheral Neuropathy Is Associated with Elevated Systolic Blood Pressure in non-hypertensive patients with type 2 diabetes and affect hypertensive management
Publication date: Available online 9 December 2019Source: Canadian Journal of DiabetesAuthor(s): Lingning Huang, Yongze Zhang, Yunmin Wang, Ximei Shen, Sunjie YanAbstractAimsInvestigate association between diabetic peripheral neuropathy (DPN)and above normal blood pressure in non-hypertensive patients with type 2 diabetes mellitus(T2DM). Compare the achievement of clinical target for DPN and non-DPN withT2DM .MethodsA retrospective survey was administered to 3810 patients with type 2 diabetes. Cases were grouped according to the Toronto Clinical Scoring System (TCSS): Non-DPN, Mild DPN, Moderate DPN and Severe DPN. 1835 pa...
Source: Canadian Journal of Diabetes - December 9, 2019 Category: Endocrinology Source Type: research

Improving Cultural Safety of Diabetes Care in Indigenous Populations of Canada, Australia, New Zealand and the USA: A Systematic Rapid Review
ConclusionsWhile based on a small number of studies, the review establishes moderate evidence that interventions to improve cultural safety can have positive effects on the treatment of diabetes in Indigenous populations. Further research with stronger study designs should be conducted to further validate the present conclusions. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - December 9, 2019 Category: Endocrinology Source Type: research

Effects of genistein supplementation on health in postmenopausal women with type 2 diabetes mellitus
Publication date: Available online 6 December 2019Source: Canadian Journal of DiabetesAuthor(s): Tomoyuki Kawada (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - December 7, 2019 Category: Endocrinology Source Type: research

Development and comparison of a young adult-specific dysglycemia risk score to the published CANRISK: A cross-sectional analysis of pooled Canadian data from 2007–11 and 2013–15
ConclusionsThe original CANRISK score performed well among young adults, even when compared to a young adult-specific model. We suggest that the cut-point be lowered for young adults and the tool be permitted for use in this age group. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - December 6, 2019 Category: Endocrinology Source Type: research

Clinical considerations in patients with comorbid Type 2 Diabetes and Depressive Symptoms associated with severe hypoglycemia
Publication date: Available online 29 November 2019Source: Canadian Journal of DiabetesAuthor(s): Karo Gyurjian, Benjamin K.P. Woo (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

A Randomized Trial of the Close Reading and Creative Writing Program: An Alternative Educational Method for Group Care Intervention in Type 2 Diabetes Management
ConclusionsThis is the first randomized trial designed to evaluate a group care intervention to manage type 2 diabetes using narrative techniques. The results suggest that this may be a useful model for more highly schooled individuals, and may represent an alternative for the educational process.RésuméObjectifsLes soins de groupe aux individus diabétiques constituent une pratique pédagogique reconnue, mais les techniques issues de la médecine narrative qui ont recours aux œuvres littéraires n'ont jamais été intégrées dans ces programmes. Nous avon...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

MicroRNA-15a Inhibits Glucose Transporter 4 Translocation and Impairs Glucose Metabolism in L6 Skeletal Muscle Via Targeting of Vesicle-Associated Membrane Protein-Associated Protein A
ConclusionsThese findings reveal the following: 1) VAP-A is a marker of skeletal muscle glucose disposal and 2) a novel mechanism for GLUT4 translocation by miR-15a.RésuméObjectifsOn rapporte que les microARN participent à de nombreux processus biologiques cellulaires importants comme le métabolisme glucidique. L'objectif de la présente étude était d'examiner les rôles du microARN-15a (miARN-15a) dans la régulation de la l'insulinosensibilité.MéthodesDans les cellules musculaires squelettiques des rats L6, nous avons observé l'effet du miARN...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Response to the Letter to the Editor From Dr Kawada, “Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors for the Treatment of Hypertensive Patients With Type 2 Diabetes Mellitus”
Publication date: Available online 15 August 2019Source: Canadian Journal of DiabetesAuthor(s): Thomas A. Mavrakanas, Mark L. Lipman (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Weighing Coronary Revascularization Options in Patients With Type 2 Diabetes Mellitus
In this study, we review the current literature in the management of patients with DM and coronary artery disease undergoing a revascularization procedure.RésuméLes patients atteints de diabète sucré (DS) sont exposés à un risque accru de coronaropathie. Le choix d'une stratégie de revascularisation optimale telle que le pontage aortocoronarien ou l'intervention coronarienne percutanée (ICP) peut être difficile pour cette population. De nombreuses données probantes montrent que chez les patients atteints de DS et d'une cardiopathie ischémique multi...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Relation Between Oxidative Stress and Hematologic Abnormalities in Children With Type 1 Diabetes
ConclusionsThe data demonstrated that the hematologic profile showed noticeable alterations in children with T1DM, and the inflammation and oxidative stress markers were contributed to the hematologic abnormalities. The results revealed that some hematologic indices can be used in the early detection of children with T1DM at risk for diabetic complications.RésuméObjectifsUn grand nombre d’études récentes ont permis d'attirer de nouveau l'attention sur le profil hématologique dans le dépistage précoce de l'inflammation et des complications liées au diabète...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Twice-Daily vs 4-Times-Daily Glucose Testing in Women With Gestational Diabetes Mellitus: A Pilot Study
ConclusionsTwice-daily BG testing appears to generate 14-day average values similar to 4-times-daily BG testing. In women with GDM, whose BG is in target range, twice-daily BG monitoring may reduce inconvenience and cost.RÉSUMÉObjectifsChez les femmes atteintes de diabète sucré gestationnel (DSG), le contrôle de la glycémie est généralement évalué par l'auto-surveillance de la glycémie capillaire (GC). Actuellement, la méthode standard de surveillance est l'auto-évaluation 4 fois par jour. Le but de notre étude était de ...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Sex-Related Differences in Blood Glucose Responses to Resistance Exercise in Adults With Type 1 Diabetes: A Secondary Data Analysis
In this study, we explored whether sex-related differences may exist in BG responses to RE in individuals with type 1 diabetes.MethodsA secondary data analysis was conducted on pooled data from 2 studies with identical RE protocols for individuals with type 1 diabetes (13 males, age range 16 to 63 years; 10 females, age range 19 to 45 years). The RE session consisted of 7 resistance-based exercises performed at 5 pm. Plasma glucose samples were collected before, immediately after and 1 h after exercise. Interstitial glucose levels were recorded through blinded continuous glucose monitoring 24 h before, ...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Glucagon-Like Peptide-1 Receptor Agonists in Adult Patients With Type 2 Diabetes: Review of Cardiovascular Outcome Trials
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Elodie M. Varin, Brent A. McLean, Julie A. LovshinAbstractPeople with type 2 diabetes are at heightened risk for developing cardiovascular (CV) events. CV disease is the leading cause of premature death among adults with type 2 diabetes. Unfortunately, historically, some antidiabetes agents were implicated in worsening CV function, despite improving glycemic and metabolic control. Accordingly, over a decade ago, health regulatory bodies modified approval requirements for novel antidiabetes pharmacotherapies, requiring prospectiv...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Role of Sodium-Glucose Cotransporter-2 Inhibition in the Treatment of Adults With Heart Failure
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Abhinav Sharma, Justin A. EzekowitzABSTRACTDiabetes and heart failure (HF) independently contribute to significant cardiovascular (CV) morbidity and mortality. Both are tremendous burdens to health-care systems. Among patients with established HF, diabetes mellitus is one of the most common comorbidities, present in up to 45% of all patients. Although atherosclerotic CV disease outcomes are thought to be the major cause of morbidity and mortality among patients with diabetes, HF death and hospitalization has been recognized as b...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Screening for Atherosclerotic Cardiovascular Disease in Patients With Type 2 Diabetes Mellitus: Controversies and Guidelines
Publication date: Available online 23 August 2019Source: Canadian Journal of DiabetesAuthor(s): Paolo RaggiAbstractIf a disease state is highly prevalent and its consequences are severe, it may be appropriate to seek methods to identify it early to forestall its development and complications. Diabetes mellitus is a proven risk factor for the development of atherosclerosis, although its face and outcome are changing, as shown in contemporary clinical trials. In fact, decompensated heart failure seems to drive the hospitalization rate in patients with diabetes, and mortality from heart failure is reduced with modern hypoglyc...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

A Longitudinal Study on the Association Between Diabetic Foot Disease and Health-Related Quality of Life in Adults With Type 2 Diabetes
ConclusionsAlthough participants with diabetic foot disease reported lower HRQOL at baseline, they had similar changes compared to those without diabetic foot disease during the 2-year follow up. Efforts to maintain general health and early intervention to prevent diabetic foot disease may help to avoid initial deterioration of physical health and HRQOL.RÉSUMÉObjectifsLe but de cette étude était d'évaluer l'association entre une condition de pied diabétique et la qualité de vie liée à la santé (QVLS) au cours d'un suivi de deux ans chez les personnes att...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

Mechanisms by which GLP-1 receptor agonists and SGLT-2 inhibitors reduce cardiovascular risk
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Abhinav Sharma, Subodh Verma (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research

The Cardiovascular Effects of SGLT2 Inhibitors
Publication date: Available online 24 September 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent C. WooAbstractIndividuals with type 2 diabetes mellitus can benefit from pharmacotherapies that lower their risk for cardiovascular disease. This review describes the salient findings from sodium-glucose cotransporter-2 (SGLT2) inhibitor cardiovascular outcome trials that serendipitously revealed the cardiorenal benefits of SGLT2 inhibitors in individuals with type 2 diabetes mellitus who either have established cardiovascular disease or multiple cardiovascular risk factors. It also summarizes the findings from other ...
Source: Canadian Journal of Diabetes - November 29, 2019 Category: Endocrinology Source Type: research