Fixed Dose and Ratio Combination Therapies in Type 2 Diabetes
Publication date: Available online 18 May 2019Source: Canadian Journal of DiabetesAuthor(s): Robert SchlosserAbstractThe progressive natural history underlying type 2 diabetes often necessitates the use of multiple anti-hyperglycemic medications to achieve therapeutic goals and targets. The associated complexity of these regimens presents significant challenges to both physicians and patients. Fixed dose oral and fixed ratio injectable combination agents offer significant potential to simplify and consolidate therapy and lessen barriers to adherence. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 20, 2019 Category: Endocrinology Source Type: research

Culturally Tailored Self-Management Interventions for South Asians With Type 2 Diabetes: A Systematic Review
ConclusionFindings highlight the importance of rethinking the way in which South Asians are labelled as a homogenous group and accounting for such differences when adapting and designing culturally-tailored DSME and or DSMS interventions in clinical practice. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 18, 2019 Category: Endocrinology Source Type: research

Ethnicity and immigration status as risk factors for gestational diabetes mellitus, anaemia and pregnancy outcomes among food insecure women attending the Montreal Diet Dispensary program
ConclusionsAs disparities in maternal and infant outcomes were present, nutritional intervention(s) need to be targeted towards prevention of adverse pregnancy outcomes, prioritization of higher-risk groups and adaptation of the program to a multi-ethnic low-income population. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 17, 2019 Category: Endocrinology Source Type: research

A personalized care plan is positively associated with better clinical outcomes in the care of patients with type 2 diabetes: A cross-sectional real-life study
Publication date: Available online 15 May 2019Source: Canadian Journal of DiabetesAuthor(s): Ilona Mikkola, Maria Hagnäs, Jelena Hartsenko, Minna Kaila, Klas WinellAbstractAimsTo investigate whether the use of a personalized care plan is associated with clinical outcomes of type 2 diabetes (T2D) treatment in real-world.MethodsQuality of treatment was assessed using data from a yearly sample of patients with T2D visiting primary care health centres in 2012–2016. Patients were divided into three groups: 1) patient has a copy of their personalized care plan, 2) care plan exists in the patient record only or 3) pati...
Source: Canadian Journal of Diabetes - May 16, 2019 Category: Endocrinology Source Type: research

The Effects of Cannabis Use in Youth and Young Adults with Type 1 Diabetes: The Highs, the Lows, the Don’t Knows
Publication date: Available online 14 May 2019Source: Canadian Journal of DiabetesAuthor(s): Jill Pancer, Kaberi Dasgupta (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 14, 2019 Category: Endocrinology Source Type: research

Transient neonatal diabetes: An etiologic clue for the adult diabetologist
Publication date: Available online 11 May 2019Source: Canadian Journal of DiabetesAuthor(s): Anela Novak, Pamela Bowman, Ivana Kraljevic, Marija Tripolski, Jayne AL. Houghton, Elisa De Franco, Maggie H. Shepherd, Veselin Skrabic, Kashyap A. Patel (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 12, 2019 Category: Endocrinology Source Type: research

Gestational Glycemic Parameters and Future Cardiometabolic Risk at Medium-Term Follow Up
ConclusionsOur results suggest that there is no threshold of glycemic parameters for predicting future cardiometabolic status. Our data also suggest that the known association between gestational diabetes and cardiovascular disease is mediated, at least in part, by higher postpregnancy glycemia and worse lipid profiles, even though these metabolic parameters often remain within the normal range.RésuméObjectifsIl est connu que le diabète gestationnel est associé à un risque accru de maladies cardiovasculaires ultérieures chez la mère. Toutefois, on ne connaît pas les pa...
Source: Canadian Journal of Diabetes - May 11, 2019 Category: Endocrinology Source Type: research

Creative Arts Diabetes Initiative: Group Art Therapy and Peer Support for Youth and Young Adults Transitioning from Pediatric to Adult Diabetes Care in Manitoba
Publication date: Available online 9 May 2019Source: Canadian Journal of DiabetesAuthor(s): Catherine MacDonald, Sharlene Friedman, Seth MarksAbstractPsychosocial dysfunction is common in young adults of First Nations heritage living with type 2 diabetes in Manitoba. Improved psychosocial functioning may lead to better glycemic control, self-management and health outcomes. We offered 12 weeks of facilitated art therapy within a group/peer-support environment aiming to improve psychosocial functioning. A mixed methods study (n=12) with validated pre and post measures in diabetes related emotional distress (Problem Areas in ...
Source: Canadian Journal of Diabetes - May 11, 2019 Category: Endocrinology Source Type: research

An idiographic investigation of diabetic alert dogs’ ability to learn from a small sample set
ConclusionsThe results suggest that some dogs can be trained to detect hypoglycemic breath of an individual with T1D but detection may not transfer to novel samples from other individuals. Results should be interpreted cautiously since the dogs were trained with a small number of breath samples before testing. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 11, 2019 Category: Endocrinology Source Type: research

Do cultural and psychosocial factors contribute to diabetes risk? A look into Vancouver’s South Asian community
ConclusionsNon-traditional factors such as cultural practices and emotional functioning are also important predictors of diabetes risk and should be considered when culturally tailoring diabetes prevention programs. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Developing a National Competency-Based Diabetes Curriculum in Undergraduate Medical Education: A Delphi Study
ConclusionA competency-based consensus curriculum for diabetes education for undergraduate medical students was developed using a modified Delphi method. The final consensus syllabus will be disseminated across the country. This curriculum serves as a step in the transition to competency-based UGME and in ensuring that future medical school graduates are proficient in diabetes care. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Is Age a Risk Factor for Cerebral Edema in Children with Diabetic Ketoacidosis? A Literature Review
Publication date: Available online 7 May 2019Source: Canadian Journal of DiabetesAuthor(s): S. Glackin, D.L. Metzger, R. Hanas, J.P. ChanoineAbstractCerebral edema (CE) is a rare but potentially fatal complication of diabetic ketoacidosis (DKA) in children with Type 1 diabetes (T1D). Cerebral edema is frequently mentioned as being more common in young children. The primary objective of this study was to review the evidence suggesting that younger age is a risk factor for the development of CE in DKA. The secondary objective was to assess if younger children are at higher risk of DKA and severe DKA. A literature review was ...
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Gestational Diabetes Mellitus Postpartum Follow Up Testing: Challenges and Solutions
Publication date: Available online 7 May 2019Source: Canadian Journal of DiabetesAuthor(s): B. Bhavadharini, R.M. Anjana, R. Pradeepa, M. Deepa, R. Uma, V. MohanAbstractOne in every four pregnancies is affected by hyperglycaemia, of which 90% is gestational diabetes mellitus (GDM). Women with GDM are at a high risk of developing both short-term and long-term complications. Various studies have shown the heightened risk of type 2 diabetes among women with GDM. Despite clear evidence from published literature about the substantial risk that GDM imposes on women after delivery, rates of postpartum follow up have been low in m...
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Capturing Patient Preferences towards Benefits and Risks of Second-line Antihyperglycemic Medications: A Discrete Choice Experiment
ConclusionAll eight characteristics were shown to significantly influence choice with cost and life expectancy carrying the most weight, and serious and minor side effects carrying the least weight. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

The role of the pharmacist certified diabetes educator along the type 2 diabetes care continuum
Publication date: Available online 7 May 2019Source: Canadian Journal of DiabetesAuthor(s): Michael Boivin (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Changes in the intestinal microbiota of type 2 diabetes mice in response to dietary supplementation with instant tea or matcha
ConclusionA competency-based consensus curriculum for diabetes education for undergraduate medical students was developed using a modified Delphi method. The final consensus syllabus will be disseminated across the country. This curriculum serves as a step in the transition to competency-based UGME and in ensuring that future medical school graduates are proficient in diabetes care. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Effect of hyperbaric oxygen therapy on the fatty acid composition and IGFBP-1 in insulin-dependent diabetes mellitus adult patients: a pilot study
Publication date: Available online 8 May 2019Source: Canadian Journal of DiabetesAuthor(s): Ivana Resanović, Zoran Gluvić, Božidarka Zarić, Emina Sudar-Milovanović, Vesna Vučić, Aleksandra Arsić, Olgica Nedić, Miloš Šunderić, Nikola Gligorijević, Davorka Milačić, Esma R. IsenovićAbstractBackgroundThe metabolic changes in insulin-dependent diabetes mellitus (IDDM) impair vasodilatation, and this leads to tissue hypoxia and microvascular pathology. Hyperbaric oxygen therapy (HBOT) can significantly improve the outcome of ischemic conditions in IDDM patients and reduce vascular complications.Object...
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

REAL-World Health Outcomes of Insulin Glargine 300 U/mL versus Insulin Glargine 100 U/mL in Patients with TYpe 1 & Type 2 Diabetes in the Canadian LMC Diabetes Patient Registry: The REALITY Study
This study evaluated real-world clinical outcomes of patients with type 1 diabetes (T1D) and type 2 diabetes (T2D) initiating or transferring to insulin glargine 300 U/mL (Gla-300) vs insulin glargine 100 U/mL (Gla-100).MethodsThe REALITY study is a retrospective cohort study using data from the Canadian LMC Diabetes Registry. Four cohorts were analyzed: 1) Insulin naïve patients with T2D who initiated Gla-300 or Gla-100, 2) Patients with T2D who switched from NPH or detemir to Gla-300 or Gla-100, 3) Patients with T2D who switched from Gla-100 to Gla-300, and 4) Patients with T1D who switched from Gla-100, NPH or dete...
Source: Canadian Journal of Diabetes - May 8, 2019 Category: Endocrinology Source Type: research

Effectiveness of genistein supplementation on metabolic factors and antioxidant status in postmenopausal women with type-2 diabetes mellitus
Publication date: Available online 4 May 2019Source: Canadian Journal of DiabetesAuthor(s): Hassan Braxas, Maryam Rafraf, Saadat Karimi Hasanabad, Mohammad Asghari JafarabadiAbstractObjectivesThe risk of type 2 diabetes mellitus (T2DM) increases in women after menopause. Genistein is known to modulate metabolic pathways. The aim of this study was to investigate the effects of genistein supplementation on metabolic parameters, oxidative stress and obesity values in postmenopausal women with T2DM.MethodsThis randomized, double-blind, placebo-controlled clinical trial was conducted on 54 postmenopausal women aged 47-69 years ...
Source: Canadian Journal of Diabetes - May 5, 2019 Category: Endocrinology Source Type: research

Exploring Clinical Care among Adults with Diabetes Mellitus: Alignment with Recommended Statin and Sulfonylureas Treatment
ConclusionResults suggest that PCPs’ practice does not always align with current evidence-based guidelines or Choosing Wisely Canada recommendations for patients with DM. Some PCP’s characteristics were associated with lower implementation of recommended evidence-based care. This information can help guide future targeted medical education. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 27, 2019 Category: Endocrinology Source Type: research

Three Innovative Population Health Concepts for Patient Medical Homes to Improve Diabetes Care in Family Medicine
Publication date: Available online 19 April 2019Source: Canadian Journal of DiabetesAuthor(s): Daniel Ngui, Melissa Silva (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 20, 2019 Category: Endocrinology Source Type: research

Impact of Socioeconomic Status on Incidence of End-Stage Renal Disease and Mortality Following Dialysis in Adults with Diabetes
Publication date: Available online 17 April 2019Source: Canadian Journal of DiabetesAuthor(s): Calvin Ke, S.Joseph Kim, Baiju R. Shah, Arlene S. Bierman, Lorraine L. Lipscombe, Denice S. Feig, Gillian L. BoothAbstractAimsTo determine whether low socioeconomic status (SES), with or without universal drug coverage, predicts end-stage renal disease (ESRD) and survival after dialysis in patients with diabetes.MethodsWe conducted a population-based retrospective cohort study in Ontario, Canada. We used age ≥65 years as a surrogate for universal drug coverage. Adults with diabetes were followed from 31 March 1997 to 31 March ...
Source: Canadian Journal of Diabetes - April 18, 2019 Category: Endocrinology Source Type: research

The effect of acute aerobic exercise and rapamycin treatment on autophagy in peripheral blood mononuclear cells of adults with prediabetes
ConclusionsOur results indicate an impairment in autophagic flux in PBMCs from people with prediabetes when compared to controls in response to both exercise and RAPA treatment. Future methods of autophagic upregulation should be investigated to spare malfunctions in autophagy in people with prediabetes. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 17, 2019 Category: Endocrinology Source Type: research

CANadian CAnagliflozin REgistry: Patient-Reported Outcomes of Canagliflozin in the Treatment of Type 2 Diabetes Mellitus in Canadian Clinical Practice
Publication date: Available online 16 April 2019Source: Canadian Journal of DiabetesAuthor(s): Vincent Woo, Alan Bell, Maureen Clement, Luis Noronha, Michael A. Tsoukas, Fernando Camacho, Shana Traina, Natasha Georgijev, Jennifer B. Rose, Delna Sorabji, Harpreet S. BajajAbstractObjectivesTo describe patient-reported outcomes (PROs) following initiation of treatment with canagliflozin (CANA) for type 2 diabetes mellitus (T2DM) in a real-world Canadian setting.MethodsCANadian CAnagliflozin REgistry (CanCARE) is a prospective, observational, single-arm, real-world Canadian study of the effectiveness and safety of CANA for the...
Source: Canadian Journal of Diabetes - April 17, 2019 Category: Endocrinology Source Type: research

Update in Cardiovascular Safety of Incretin-Based Therapy in Adults with Type 2 Diabetes Mellitus: A Meta-Analysis of Cardiovascular Outcome Trials
ConclusionThis meta-analysis demonstrated that GLP-1RAs were associated with a significant reduction in MACE, CV death, stroke, and death from any cause, while DPP-4 inhibitors were comparable to placebo for all CV outcomes, including hospitalizations for HF. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 14, 2019 Category: Endocrinology Source Type: research

Beginning a Diabetes Quality Improvement Project
Publication date: Available online 20 February 2019Source: Canadian Journal of DiabetesAuthor(s): Geetha Mukerji, Ilana Halperin, Phillip Segal, Lori Sutton, Rene Wong, Leigh Caplan, Dana Whitham, Julie A. GilmourAbstractThere is a large evidence-to-clinical practice gap in diabetes care. Application of quality improvement (QI) strategies can be used to improve gaps in care delivery. In this first of 3 articles in the diabetes QI primer series, we introduce the steps required to plan a QI project by using a case example for improving foot screening of people with diabetes. We review how to select an appropriate QI project,...
Source: Canadian Journal of Diabetes - April 10, 2019 Category: Endocrinology Source Type: research

Meta-analysis of Diagnostic Accuracy of Retinopathy for the Detection of Diabetic Kidney Disease in Type 2 Diabetes
ConclusionsDR may lack adequate evidences either to verify DKD or to exclude NDRD and the severity of DR may not parallel the presence of DKD. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - April 9, 2019 Category: Endocrinology Source Type: research

Enhancing Health Surveillance: Validation of a Novel Electronic Medical Records–Based Definition of Cases of Pediatric Type 1 and Type 2 Diabetes Mellitus
ConclusionsWe describe a novel method of calculating the prevalence of pediatric diabetes in a primary care population. This case definition will improve the surveillance of pediatric diabetes and enhance service planning and the development of strategies to support prevention and management.RésuméObjectifsComposer et valider une définition de cas basée sur les dossiers médicaux électroniques pour le diabète pédiatrique en soins primaires.MéthodesLes données des dossiers médicaux électroniques de 221 intervenants en soins primaires par...
Source: Canadian Journal of Diabetes - April 6, 2019 Category: Endocrinology Source Type: research

Implementing Change Ideas, Interpreting Data and Sustaining Change in a Quality Improvement Project
This article is the third and final installment in our diabetes quality improvement primer series. It summarizes how to interpret real-time data with run charts and highlights 4 key rules that can be applied to understand whether improvement is statistically significant. We also review the importance of outlining a family of measures, including outcome, process and balancing measures. Finally, we discuss strategies for sustaining change.RésuméCet article est le troisième et dernier volet de notre série d'abécédaires sur l'amélioration qualitative en matière de diab&eg...
Source: Canadian Journal of Diabetes - April 6, 2019 Category: Endocrinology Source Type: research

Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes
Publication date: Available online 23 January 2019Source: Canadian Journal of DiabetesAuthor(s): Vivek Krishna Pulakazhi Venu, Mahmoud El-Daly, Mahmoud Saifeddine, Simon A. Hirota, Hong Ding, Chris R. Triggle, Morley D. HollenbergAbstractThis overview deals with mechanisms whereby hyperglycemia-induced oxidative stress compromises vascular endothelial function and provides a background for a recently published study illustrating the beneficial impact of endothelial sodium-glucose cotransporter 2 (SGLT2) inhibitors in attenuating hyperglycemia-induced vascular dysfunction in vitro. The data provide new insight that can...
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Self-Monitoring of Blood Glucose: A Complementary Method Beyond the Oral Glucose Tolerance Test to Identify Hyperglycemia During Pregnancy
Publication date: Available online 18 February 2019Source: Canadian Journal of DiabetesAuthor(s): Amélie Ardilouze, Patricia Bouchard, Marie-France Hivert, Catherine Simard, Catherine Allard, Marie-Pierre Garant, Julie Ménard, Annie Ouellet, Ghislaine Houde, Marie-Hélène Pesant, Jean-Patrice Baillargeon, Jean-Luc ArdilouzeAbstractObjectivesTo compare: 1) 75 g oral glucose tolerance test (OGTT) and self-monitoring of blood glucose (SMBG) in identifying gestational diabetes mellitus (GDM) and other hyperglycemic statuses in pregnant women; 2) pregnancy outcomes according to glycemic status; a...
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Masthead
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Table of Contents
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Editorial Board
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Response to the Letter to the Editor From Dr. Boudreau et al, “Validation of a Stepwise Approach Using Glycated Hemoglobin Levels to Reduce the Number of Required Oral Glucose Tolerance Tests to Screen for Cystic Fibrosis–Related Diabetes in Adults”
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): Julie A. Gilmour (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Top 10 Reviewers for 2018
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Pharmacologic and Nonpharmacologic Therapies for the Gut Microbiota in Type 2 Diabetes
Publication date: April 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 3Author(s): Robert CaesarAbstractThe gut microbiota is an important regulator of host metabolism. Metagenome analyses have demonstrated that the gut microbiota differs between patients with type 2 diabetes and healthy subjects, and several studies have shown that impaired glucose metabolism is associated with decreased levels of butyrate-producing bacteria. Gut microbiota-produced metabolites, such as short-chain fatty acids, amino acid derivatives and secondary bile acids, participate in metabolic and immunologic processes and, hence, pose ...
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

The Role and Effectiveness of Telephone Peer Coaching for Adult Patients with Type 2 Diabetes
ConclusionsThis pilot found that a pragmatic low-cost telephone peer-coaching intervention assisted patients with type 2 diabetes to better self-manage their diabetes. Future replication and randomized trials are needed to validate these preliminary findings. Involving volunteer peers in the spectrum of diabetes care is a cost-effective way of providing additional support and continuity of care. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Gestational Glycaemic Parameters and Future Cardiometabolic Risk at Medium-Term Follow-Up
ConclusionsOur results suggest that there is no threshold of glycaemic parameters in predicting future cardiometabolic status. Our data also suggest that the known association between gestational diabetes and cardiovascular disease is mediated, at least in part, by higher post-pregnancy glycaemia and worse lipid profile even though these metabolic parameters often remain within the normal range. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Effects of Whole-Body Vibration in Older Adult Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
ConclusionWhole-body vibration could be a useful strategy in the management of symptoms and disability associated to T2DM, however it is necessary to perform further studies to reinforce the reported findings. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 29, 2019 Category: Endocrinology Source Type: research

Canada's New Healthy Eating Strategy: Implications for Healthcare Professionals and a Call to Action
Publication date: Available online 15 March 2019Source: Canadian Journal of DiabetesAuthor(s): Simon L. Bacon, Norm R.C. Campbell, Kim D. Raine, Ross Tsuyuki, Nadia A. Khan, Manuel Arango, Janusz Kaczorowski (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - March 16, 2019 Category: Endocrinology Source Type: research

Article 2 of 3: Diabetes QI Primer Series Determining Root Causes and Designing Change Ideas in a Quality Improvement Project
Publication date: Available online 12 March 2019Source: Canadian Journal of DiabetesAuthor(s): Ilana Halperin, Julie A. Gilmour, Phillip Segal, Lori Sutton, Rene Wong, Leigh Caplan, Dana Whitham, Geetha MukerjiAbstractIn this second article of our diabetes quality improvement (QI) primer series, readers will become familiar with various diagnostic tools used to understand the root causes of a quality problem. We will discuss change concepts, and specific change ideas will be developed to match the root causes. We will review the application of a plan-do-study-act (PDSA) cycle from the Model for Improvement QI framework to ...
Source: Canadian Journal of Diabetes - March 14, 2019 Category: Endocrinology Source Type: research

Heat-Shock Protein 70–Mediated Heat Preconditioning Attenuates Hepatic Carbohydrate and Oxidative Disturbances in Rats with Type 1 Diabetes
ConclusionsBased on our findings, heat preconditioning and HSP70 induction in rats with type 1 diabetes attenuates STZ-induced metabolic alterations in hepatic carbohydrate metabolism and oxidative states. These changes are more evident at 24 h recovery post-acute heat stress, based on the most evident accumulation of HSP70 in this time frame.RésuméObjectifsLe préconditionnement thermique et la synthèse des protéines de choc thermique (HSP pour heat-shock protein) ont des effets cytoprotecteurs importants contre le développement de lésions cellulaires causées par...
Source: Canadian Journal of Diabetes - March 9, 2019 Category: Endocrinology Source Type: research

Risk Factors for Recurrent Diabetic Ketoacidosis in Adults With Type 1 Diabetes
Publication date: Available online 28 January 2019Source: Canadian Journal of DiabetesAuthor(s): Sophie Del Degan, Frédérique Dubé, Claudia Gagnon, Geneviève BouletAbstractObjectivesIdentification of risk factors for recurrent diabetic ketoacidosis (DKA) in patients with type 1 diabetes could help target those at high risk so as to implement preventive measures. The main objective of this study was to identify factors associated with recurrent DKA in adult Canadian patients with type 1 diabetes.MethodsThis is a retrospective cohort study of adult patients who had a diagnosis of type 1 diabetes f...
Source: Canadian Journal of Diabetes - March 9, 2019 Category: Endocrinology Source Type: research

Risk Factors for Adverse Outcomes in Adult and Pediatric Patients With Hyperglycemia Presenting to the Emergency Department: A Systematic Review
Publication date: Available online 6 December 2018Source: Canadian Journal of DiabetesAuthor(s): Lubna Siddiqi, Kristine VanAarsen, Alla Iansavichene, Justin YanAbstractHyperglycemia is a significant cause of morbidity and mortality, often resulting in adverse outcomes. This review aimed to identify predictors of adverse outcomes, such as repeated hospital visits, hospitalization or death, in patients presenting to the emergency department (ED) with hyperglycemia.Electronic searches of Medline and EMBASE were conducted for studies in English of patients presenting to the ED with hyperglycemia. Both adult and pediatric popu...
Source: Canadian Journal of Diabetes - March 5, 2019 Category: Endocrinology Source Type: research

Article 3 of 3: Diabetes QI Primer Series Implementing Change Ideas, Interpreting Data, and Sustaining Change in a Quality Improvement Project
This article is the third and final installment in our diabetes quality improvement (QI) primer series. It summarizes how to interpret real-time data with run charts and highlights four key rules that can be applied to understand if improvement is statistically significant. We also review the importance of outlining a family of measures, including outcome, process, and balancing measures. Finally, we discuss strategies for sustaining and scaling change. (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 28, 2019 Category: Endocrinology Source Type: research

Masthead
Publication date: March 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 27, 2019 Category: Endocrinology Source Type: research

Table of Contents
Publication date: March 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 27, 2019 Category: Endocrinology Source Type: research

Editorial Board
Publication date: March 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 2Author(s): (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 27, 2019 Category: Endocrinology Source Type: research

Diabetes and Frailty: Revisiting the Converging Conditions
Publication date: March 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 2Author(s): Diana Sherifali (Source: Canadian Journal of Diabetes)
Source: Canadian Journal of Diabetes - February 27, 2019 Category: Endocrinology Source Type: research