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A case series of atypical features of patients with biopsy-proven isolated IgG4-related hypophysitis and normal serum IgG4 levels
ConclusionsOur cases highlight the importance of considering IgG4-related hypophysitis in the differential diagnosis of solid and cystic sellar lesions presenting acutely with pituitary apoplexy symptoms. Existing diagnostic criteria may not be sufficiently precise to permit rapid and reliable identification, or avoidance of surgery in the acute setting. In contrast to other reports of the natural history of this condition, despite the severity of presenting features, the disease in our cases was pituitary-restricted with normal serum IgG4 levels. (Source: Pituitary)
Source: Pituitary - December 16, 2017 Category: Endocrinology Source Type: research

The dangers of the “Head Down” position in patients with untreated pituitary macroadenomas: case series and review of literature
ConclusionWe report a brief case series of acute cavernous sinus syndrome resulting from dependent positioning during non-cranial operations in patients with pituitary macroadenoma. Although rare, this highlights a potential danger of “head down” positioning in patients with intracranial pathology—particularly in or around the sella and cavernous sinus. Despite multiple cranial neuropathies upon presentation, both patients made complete recovery following surgical decompression of the cavernous sinuses. (Source: Pituitary)
Source: Pituitary - December 13, 2017 Category: Endocrinology Source Type: research

Discordance between mass spectrometry and immunometric IGF-1 assay in pituitary disease: a prospective study
ConclusionsIGF-1 results may differ after switching from an older immunoassay to a consensus-compliant assay such as LC-MS. Clinicians should consider the potential impact of assay switching before altering treatment due to discrepant results, particularly in patients monitored over time, such as those with acromegaly and GH deficiency. (Source: Pituitary)
Source: Pituitary - December 7, 2017 Category: Endocrinology Source Type: research

Bone histomorphometry in acromegaly patients with fragility vertebral fractures
ConclusionsThe apparent paradox of bone fragility in acromegaly patients with a normal BMD can be explained by increased cortical thickness and porosity and reduced trabecular thickness with increased trabecular separation. These structural and microarchitectural abnormalities persist in the controlled phase of acromegaly despite bone turnover normalization. The main determinant of bone disease after hormonal control is severe osteoblastic dysfunction. (Source: Pituitary)
Source: Pituitary - December 6, 2017 Category: Endocrinology Source Type: research

Consensus-driven in-hospital cortisol assessment after ACTH-secreting pituitary adenoma resection
AbstractPurposeRemission from Cushing disease (CD) after pituitary adenoma resection may be predicted by a postoperative reduction in serum cortisol level. A 2008 consensus statement recommends assessing morning cortisol levels during the first postoperative week, and replacing glucocorticoid (GC) if cortisol nadir of
Source: Pituitary - November 16, 2017 Category: Endocrinology Source Type: research

Excellence in the treatment of patients with pituitary tumors
(Source: Pituitary)
Source: Pituitary - November 9, 2017 Category: Endocrinology Source Type: research

Cardiovascular autonomic dysfunction in patients with idiopathic diabetes insipidus
AbstractIntroductionCentral diabetes insipidus (DI) is a rare disease characterized by the excretion of excessive volumes of dilute urine due to reduced levels of the antidiuretic hormone arginine vasopressin (AVP), caused by an acquired or genetic defect in the neurohypophysis. The aim of this study was to identify any autonomic dysfunction (AD) in patients with DI as a possible cofactor responsible for their reportedly higher mortality.MethodsThe study involved 12 patients (6 females) with central idiopathic DI and a well-controlled electrolyte balance, and 12 controls matched for age, sex and cardiovascular risk factors...
Source: Pituitary - October 28, 2017 Category: Endocrinology Source Type: research

A practical method for prevention of readmission for symptomatic hyponatremia following transsphenoidal surgery
ConclusionHyponatremia can be a life-threatening complication of TSS, and prevention of readmission for hyponatremia can help improve patient safety and decrease costs. Mandatory post-discharge fluid restriction is a simple and inexpensive intervention associated with decreased rates of readmission for hyponatremia and normal post-operative sodium levels. (Source: Pituitary)
Source: Pituitary - October 26, 2017 Category: Endocrinology Source Type: research

Predictors of silent corticotroph adenoma recurrence; a large retrospective single center study and systematic literature review
AbstractPurposeSilent corticotroph adenomas (SCAs) are clinically silent and non-secreting, but exhibit positive adrenocorticotropic hormone (ACTH) immunostaining. We characterized a single center cohort of SCA patients, compared the SCAs to silent gonadotroph adenomas (SGAs), identified predictors of recurrence, and reviewed and compared the cohort to previously published SCAs cases.MethodsRetrospective review of SCA and SGA surgically resected patients over 10  years and 6 years, respectively. Definitions; SCA—no clinical or biochemical evidence of Cushing’s syndrome and ACTH positive immunostaining, and...
Source: Pituitary - October 14, 2017 Category: Endocrinology Source Type: research

Treatment of empty sella associated with visual impairment: a systematic review of chiasmapexy techniques
ConclusionsThe intradural chiasmapexy is indicated in treatment of SESS, instead the extradural approaches are suggested for surgical management of PESS. (Source: Pituitary)
Source: Pituitary - October 13, 2017 Category: Endocrinology Source Type: research

Guidelines versus real life practice: the case of colonoscopy in acromegaly
AbstractPurposeThe aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly.MethodsWe conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values.ResultsThe total number of colonoscopies performed in ACRO patients increased from 6 in the period 1990 –1994 to 57 in the period 2010–2014. Colonoscopy procedures were performed according to guideline...
Source: Pituitary - September 21, 2017 Category: Endocrinology Source Type: research

Preoperative risk factors for postoperative complications in endoscopic pituitary surgery: a systematic review
ConclusionBased on current literature, of low to medium quality, it is not possible to comprehensively quantify risk factors for complications. Nevertheless, older age and intraventricular extension were associated with increased postoperative complications. Future research should aim at prospective data collection, reporting of outcomes, and uniformity of definitions. Only then a proper risk analysis can be performed for endoscopic pituitary surgery. (Source: Pituitary)
Source: Pituitary - September 15, 2017 Category: Endocrinology Source Type: research

Association between FTO gene polymorphisms and HDL cholesterol concentration may cause higher risk of cardiovascular disease in patients with acromegaly
ConclusionThe risk-allele frequencies of studied polymorphisms in acromegaly were higher than in general European population. There is an association betweenFTO gene polymorphisms and HDL cholesterol concentration, suggestingFTO gene polymorphisms may be associated with higher CVD risk in patients with acromegaly. (Source: Pituitary)
Source: Pituitary - September 14, 2017 Category: Endocrinology Source Type: research

MGMT and MSH6 immunoexpression for functioning pituitary macroadenomas
AbstractPurposeKnowledge of biological behavior is crucial for clinical management of functioning pituitary macroadenomas. For recurrent cases unresponsive to standard treatment, temozolomide (TMZ) has been used as a therapeutic alternative. MGMT (O6-methyl-guanine-DNA methyltransferase) and MSH6 (mutS homolog 6) immunoexpression have been linked to the response to TMZ treatment and MGMT immunoexpression has been additionally linked to early recurrence of non-functioning pituitary adenomas. The aim of this study was to assess the prognostic value of MGMT and MSH6 immunoexpression for aggressive functioning pituitary adenom...
Source: Pituitary - September 12, 2017 Category: Endocrinology Source Type: research

Development of ACRODAT ® , a new software medical device to assess disease activity in patients with acromegaly
ConclusionThe validation study underlined IGF-I and tumor status for routine clinical decision-making, whereas patient-oriented outcome measures received less medical attention. An Acromegaly Disease Activity Tool (ACRODAT) is in development that might assist clinicians towards a more holistic approach to patient management in acromegaly. (Source: Pituitary)
Source: Pituitary - September 8, 2017 Category: Endocrinology Source Type: research

Criteria for the definition of Pituitary Tumor Centers of Excellence (PTCOE): A Pituitary Society Statement
ConclusionsAcknowledging that very few centers in the world, if any, likely fulfill the requirements here presented, the document may be a tool to guide improvements of care delivery to patients with pituitary disorders. All these criteria must be accommodated to the regulations and organization of Health of a given country. (Source: Pituitary)
Source: Pituitary - September 7, 2017 Category: Endocrinology Source Type: research

Walter E. Dandy: his contributions to pituitary surgery in the context of the overall Johns Hopkins Hospital experience
AbstractBackgroundWalter E. Dandy (1886 –1946) was an outstanding neurosurgeon who spent his entire career at the Johns Hopkins Hospital. After graduating from medical school in 1910, he completed a research fellowship in the Hunterian laboratory with Harvey Cushing and then joined the Department of Surgery as resident, rising to the ra nk professor in 1931. Dandy made several contributions that helped building the neurosurgical specialty, most famously the introduction of pneumo-ventriculography to image brain lesions for which he received a Nobel prize nomination. He also performed many pituitary surgeries, althoug...
Source: Pituitary - September 4, 2017 Category: Endocrinology Source Type: research

Combined dexamethasone and desmopressin test in the differential diagnosis of ACTH-dependent Cushing ’s syndrome and pseudo-cushing’s states
(Source: Pituitary)
Source: Pituitary - September 4, 2017 Category: Endocrinology Source Type: research

Sphenoid sinus microbiota in pituitary apoplexy: a preliminary study
ConclusionsPA may be associated with an abnormal sphenoid sinus microbiota that is similar to that seen in patients with sphenoid sinusitis. (Source: Pituitary)
Source: Pituitary - August 29, 2017 Category: Endocrinology Source Type: research

Growth hormone-producing pituitary adenomas in childhood and young adulthood: clinical features and outcomes
ConclusionsGH-producing PAs in young patients are intriguing and difficult to treat due to their distinct tumor characteristics, including a lower incidence of the DG subtype and a higher incidence of SS3 adenomas and genetic abnormalities. Therefore, multi-modal therapies are essential to achieve optimal clinical outcomes. (Source: Pituitary)
Source: Pituitary - August 28, 2017 Category: Endocrinology Source Type: research

Pituitary apoplexy and rivaroxaban
We report the first case of PA with rivaroxaban which is one of the new oral anticoagulants: a 73 year-old patient presenting with severe headache and visual field deterioration. Surgery was performed. Radiotherapy treatment was decided three months after surgery because of tumor residue. (Source: Pituitary)
Source: Pituitary - August 22, 2017 Category: Endocrinology Source Type: research

The changing sella: internal carotid artery shift during transsphenoidal pituitary surgery
ConclusionsWe have demonstrated a uniform narrowing in ICD at different levels of the ICA during and after TSS adenoma resection. Surgeons should be aware of this change since it determines the width of the surgical corridor and can thus influence the ease of surgery. (Source: Pituitary)
Source: Pituitary - August 21, 2017 Category: Endocrinology Source Type: research

Vasculogenic hyperprolactinemia: severe prolactin excess in association with internal carotid artery aneurysms
Conclusions We propose the term ‘vasculogenic hyperprolactinemia’ to encompass the hyperprolactinemia associated with ICA aneurysms. This may be mediated by an endothelial factor capable of paracrine stimulation of lactotrophs; however, angiotensin II, substance P, histamine and PRLH appear unlikely to be causative. (Source: Pituitary)
Source: Pituitary - August 21, 2017 Category: Endocrinology Source Type: research

Surgical debulking of pituitary adenomas improves responsiveness to octreotide lar in the treatment of acromegaly
AbstractBackgroundStudies comparing primary medical treatment of acromegaly with surgery are often non-randomized, and not stratified by illness severity. We prospectively compared primary medical therapy with pituitary surgery in patients with acromegaly. All patients had macroadenomas, at least one random human growth hormone (GH) level  ≥12.5 ng/mL, elevated IGF-I levels and failure to suppress GH to
Source: Pituitary - August 19, 2017 Category: Endocrinology Source Type: research

Evidence of dysexecutive syndrome in patients with acromegaly
ConclusionsAcromegalic patients were severely impaired in semantic inhibition, executive processing, working memory and executive inhibition, and they have realized a portion of these deficits. A high level of IGF-1, disease duration may contribute to the impairment of specific aspects of executive function. (Source: Pituitary)
Source: Pituitary - August 19, 2017 Category: Endocrinology Source Type: research

The prevalence of growth hormone deficiency in survivors of subarachnoid haemorrhage: results from a large single centre study
We report on the prevalence of GHD in a large cohort of patients following SAH, when dynamic and confirmatory pituitary hormone testing methods are systematically employed.DesignIn this cross-sectional study, pituitary function was assessed in 100 patients following SAH. Baseline pituitary hormonal profile measurement and glucagon stimulation testing (GST) was carried out in all patients. Isolated GHD was confirmed with an Arginine stimulation test and ACTH deficiency was confirmed with a short synacthen test.ResultsThe prevalence of hypopituitarism in our cohort was 19% and the prevalence of GHD was 14%. There was no asso...
Source: Pituitary - August 18, 2017 Category: Endocrinology Source Type: research

Incidence of myocardial infarction and stroke in acromegaly patients: results from the German Acromegaly Registry
In this study, we examine if the incidence of myocardial infarction (MI) and stroke differ from that of the general population.MethodsData from the German Acromegaly Registry in seven specialized endocrine centres were analysed (n  = 479, 56% female, 46 years old at diagnosis, 5549 person-years from diagnosis). Standardized incidence ratios (SIR) were calculated as compared to the general population.ResultsMI and stroke incidences were very close to those of the general population with an SIR (95% CI) of 0.89 (0.47 –1.52, p = 0.80) for MI and 1.17 (0.66–1.93, p =&thi...
Source: Pituitary - August 14, 2017 Category: Endocrinology Source Type: research

Double pituitary adenomas are most commonly associated with GH- and ACTH-secreting tumors: systematic review of the literature
ConclusionDouble pituitary adenomas are rare but most commonly found with GH- or ACTH-producing tumors. It is critical to remove all identified possible adenomas to achieve biochemical cure and clinicians should have heightened sensitivity in patients with acromegaly or Cushing ’s Disease. (Source: Pituitary)
Source: Pituitary - August 1, 2017 Category: Endocrinology Source Type: research

A multicenter, observational study of lanreotide depot/autogel (LAN) in patients with acromegaly in the United States: 2-year experience from the SODA registry
AbstractPurposeThis analysis evaluates the 2-year effectiveness and safety of lanreotide depot/autogel (LAN), as well as treatment convenience and acromegaly symptom relief, from the Somatuline® Depot for Acromegaly (SODA) registry, a post-marketing, open-label, observational, multicenter, United States registry study.MethodsPatients with acromegaly treated with LAN were eligible for enrollment. Demographics, LAN dose, extended dosing interval (EDI) (interval of injections ≥42 days), insulin-like growth factor 1 (IGF-1), growth hormone (GH), glycated hemoglobin, adverse events (AEs), injection convenience, and sympt...
Source: Pituitary - July 24, 2017 Category: Endocrinology Source Type: research

Late-onset X-linked adrenal hypoplasia (DAX-1, NR0B1 ): two new adult-onset cases from a single center
ConclusionsWe describe two missense mutations within the putative carboxyl-terminal ligand binding domain of DAX-1, presenting with AHC and HH in adulthood, from a single center. DAX-1 mutations may be more frequent in adults than previously recognized. We recommend testing for DAX-1 mutations in all adults with primary AI and HH or impaired fertility where the etiology is unclear. (Source: Pituitary)
Source: Pituitary - July 24, 2017 Category: Endocrinology Source Type: research

Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients
AbstractPurposeWhether the renin –angiotensin–aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown. The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acr omegaly.MethodsThe study included one hundred and seventeen acromegalic patients (62  F/55 M, age: 50.2 ± 12.3 years) and 106 healthy controls (92 F/14 M, age: 41.4 ± 11.3 years). PCR method was used to evaluate the prevalence...
Source: Pituitary - July 15, 2017 Category: Endocrinology Source Type: research

Best candidates for dopamine agonist withdrawal in patients with prolactinomas
ConclusionsPatients who have no tumor visible on MRI, have a nadir PRL level6 years may be the best candidates for DA withdrawal. (Source: Pituitary)
Source: Pituitary - July 14, 2017 Category: Endocrinology Source Type: research

The extended, transnasal, transsphenoidal approach for anterior skull base meningioma: considerations in patient selection
ConclusionsAlthough more commonly treated transcranially, anterior skull base meningiomas are sometimes amenable to resection transphenoidally. Patient selection is critical, and multiple factors, including tumor size, consistency, and location, patient and surgeon preference, and presenting symptoms each affect the optimum surgical approach. We have developed criteria for patient selection so that transsphenoidal surgery can be used to resect or debulk anterior skull base meningiomas safely and with favorable outcomes. (Source: Pituitary)
Source: Pituitary - July 8, 2017 Category: Endocrinology Source Type: research

Erratum to: Acromegaly: surgical results in 548 patients
(Source: Pituitary)
Source: Pituitary - July 5, 2017 Category: Endocrinology Source Type: research

Ovarian hyperstimulation syndrome due to follicle-stimulating hormone-secreting pituitary adenomas
ConclusionsFrequency of OHSS due to a gonadotroph adenoma is not negligible. Increased awareness of the characteristic clinical and hormonal picture should permit an early detection of this condition in premenopausal women with a pituitary adenoma. (Source: Pituitary)
Source: Pituitary - July 4, 2017 Category: Endocrinology Source Type: research

Visual outcomes after endoscopic endonasal pituitary adenoma resection: a systematic review and meta-analysis
ConclusionWhile visual deficits improved after EETS in the majority of patients, complete recovery was only achieved in less than half of the patients and some patients even suffered from visual deterioration. (Source: Pituitary)
Source: Pituitary - June 22, 2017 Category: Endocrinology Source Type: research

Contribution of sellar dura integrity to symptom manifestation in pituitary adenomas with intratumoral hemorrhage
ConclusionRapid volume expansion of a hematoma and lack of extension or unidirectional extension might lead to significant compression of the sellar and surrounding structures. Of note, the integrity of the sellar dura might contribute to the acute onset of symptom manifestations caused by hemorrhage in pituitary adenomas. (Source: Pituitary)
Source: Pituitary - June 14, 2017 Category: Endocrinology Source Type: research

Genetic analysis of IRF6 , a gene involved in craniofacial midline formation, in relation to pituitary and facial morphology of patients with idiopathic growth hormone deficiency
ConclusionThis is the first report ofIRF6 analysis in an IGHD cohort. We found one new mutation which, based on in silico analysis, could be of functional relevance. However, we did not find any mutations in the other patients. Therefore, we conclude thatIRF6 defects are rare in IGHD patients and further research should focus on new candidate genes. (Source: Pituitary)
Source: Pituitary - June 7, 2017 Category: Endocrinology Source Type: research

Acromegaly: surgical results in 548 patients
ConclusionsSurgery remains the first line of therapy for a majority of acromegalic patients. This series proves to be very valuable in circumscribed adenomas but also in invasive tumours. Levels of GH and IGF-I were decreased in almost all the patients without remission. (Source: Pituitary)
Source: Pituitary - June 6, 2017 Category: Endocrinology Source Type: research

Impairment of osmotic challenge-induced neurohypophyseal hormones secretion in sepsis survivor rats
ConclusionThe results suggest that the inflammatory components mediated a persistent impairment in the component of the osmoregulatory reflex affecting the secretion of neurohypophyseal hormones in sepsis survivor animals. (Source: Pituitary)
Source: Pituitary - June 6, 2017 Category: Endocrinology Source Type: research

Pituitary dysfunction in granulomatosis with polyangiitis
ConclusionGPA should be carefully considered in patients with a sellar mass and unusual clinical presentation with DI and systemic disease. Although conventional induction-remission treatment improves systemic symptoms and radiological pituitary abnormalities, hormonal deficiencies persist in most of the patients. Therefore, follow-up should include both imaging and pituitary function assessment. (Source: Pituitary)
Source: Pituitary - May 24, 2017 Category: Endocrinology Source Type: research

Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience
AbstractPurposeAcromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported thatGNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.MethodsThirty consec...
Source: Pituitary - May 24, 2017 Category: Endocrinology Source Type: research

Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas
This study investigates the hypothalamic pituitary adrenal axis (HPA) characteristics after adenomectomy in patients with SCAs.MethodsBiochemical parameters of HPA function were monitored frequently after surgical resection of non-functioning macroadenomas. Levels of ACTH, cortisol, DHEA and DHEA-S were measured frequently for 48  h after adenomectomy. HPA data of patients with SCAs (n = 38) were compared to others (Controls) with non-secreting, ACTH-negative immunostaining adenomas of similar age and gender distribution (n = 182) who had adenomectomy.ResultPlasma ACTH increased (P  
Source: Pituitary - May 20, 2017 Category: Endocrinology Source Type: research

‘Ectopic’ suprasellar type IIa PRL-secreting pituitary adenoma
ConclusionEctopic suprasellar pituitary adenomas (ESPAs) are extremely rare intracranial extracerebral tumors. SPAs can be classified into three types according to their origin and their relationship with surrounding tissue. Only type III is theoretically a true ectopic, based on previous reports. Thus, ESPAs are uncommon compared to other EPAs. Our case is the first reported case of a type IIa ‘E’SPA and the first description of this subtype classification until now. The pars tuberalis may be different from the pars distalis, and each subtype of adenohypophyseal cells may have different migration characteristi...
Source: Pituitary - May 19, 2017 Category: Endocrinology Source Type: research

Prolactinoma management: predictors of remission and recurrence after dopamine agonists withdrawal
AbstractObjectiveProlactinomas are the most common functional pituitary tumour. Dopamine agonists (DA) are its principal treatment. The criteria that should guide therapy withdrawal and the factors that influence disease remission or relapse are not yet fully established. Our purpose is to evaluate the proportion of patients who attempted DA withdrawal, and to identify the factors that influence clinicians to try it. In addition, we aim to study the factors that are involved in prolactinoma remission/relapse after therapy withdrawal.MethodsWe retrospectively evaluated 142 patients with prolactinoma diagnosis who had been t...
Source: Pituitary - May 18, 2017 Category: Endocrinology Source Type: research

Increased expression of the microRNA 106b~25 cluster and its host gene MCM7 in corticotroph pituitary adenomas is associated with tumor invasion and Crooke ’s cell morphology
ConclusionsmiR-106b~25 and its host gene MCM7 are potential novel biomarkers for invasive ACTH-immunopositive pituitary adenomas. Additionally, they are both significantly upregulated in rare Crooke ’s cell adenomas and might therefore contribute to their aggressive phenotype. (Source: Pituitary)
Source: Pituitary - April 21, 2017 Category: Endocrinology Source Type: research

Sphenoid sinus mucosal thickening in the acute phase of pituitary apoplexy
AbstractPurposeIn pituitary apoplexy (PA), there are preliminary reports on the appearance of sphenoid sinus mucosal thickening (SSMT). SSMT is otherwise uncommon with an incidence of up to 7% in asymptomatic individuals. The aim of this study was to evaluate the incidence and clinical significance of SSMT in patients with PA and a control group of surgically treated non-functioning pituitary adenomas (NFPAs).MethodsRetrospective review of clinical and imaging variables in PA and NFPA patients. Sphenoid sinus mucosal thickness was measured on the presenting MRI scan by a blinded neuroradiologist. Pathological SSMT was defi...
Source: Pituitary - April 18, 2017 Category: Endocrinology Source Type: research

Expression of cell cycle regulators and biomarkers of proliferation and regrowth in human pituitary adenomas
ConclusionsInteresting and novel observations on the differences in expression of tumour markers studied are reported. Correlation between Ki-67 expression, PTTG nuclear expression and recurrence/regrowth of PAs, emphasizes the role that Ki-67 and PTTG expression have as markers of increased proliferation. c-MYC and PTTG nuclear expression levels were correlated providing evidence that PTTG induces c-MYC expression in PAs and we propose that c-MYC might principally have a role in early pituitary tumorigenesis. Evidence is shown that the anti-proliferative effect of somatostatin analogue treatment in vivo occurs through reg...
Source: Pituitary - March 24, 2017 Category: Endocrinology Source Type: research

White matter involvement on DTI-MRI in Cushing ’s syndrome relates to mood disturbances and processing speed: a case-control study
AbstractPurposeCushing ’s syndrome (CS) is an endocrine disorder due to prolonged exposure to cortisol. Recently, microstructural white matter (WM) alterations detected by diffusion tensor imaging (DTI) have been reported in CS patients, and related to depression, but other functional significances. remain otherwise unc lear. We aimed at investigating in more depth mood symptoms in CS patients, and how these relate to cognition (information processing speed), and to WM alterations on DTI.MethodsThe sample comprised 35 CS patients and 35 healthy controls. Beck Depression Inventory-II (BDI-II) was used to measure depre...
Source: Pituitary - March 22, 2017 Category: Endocrinology Source Type: research

Follow-up intervals in patients with Cushing ’s disease: recommendations from a panel of experienced pituitary clinicians
ConclusionsWith a high level of consensus using the Delphi process, panelists recommended regular follow-up in most patient scenarios for this chronic condition. These recommendations may be useful for assessment of CD care both in research and clinical practice. (Source: Pituitary)
Source: Pituitary - March 8, 2017 Category: Endocrinology Source Type: research