Prolactin-secreting tumors, dopamine agonists and pregnancy: a longitudinal experience of a tertiary neuroendocrine center
ConclusionFoetal exposure to DAs during the first weeks of embryogenesis is not associated with a greater risk of complications. The transient and mild developmental disorders recorded resolved spontaneously and the prevalence was substantially overlapping with that observed in the general population. (Source: Pituitary)
Source: Pituitary - March 18, 2024 Category: Endocrinology Source Type: research

Pituitary tumours without distinct lineage differentiation express stem cell marker SOX2
ConclusionsOur study is the first to biologically characterise pituitary tumours WDLD. We demonstrate that these tumours exhibit a higher expression of the stem cell marker SOX2 compared with other lineage-differentiated tumours, suggesting possible involvement of stem cells in their development. (Source: Pituitary)
Source: Pituitary - March 14, 2024 Category: Endocrinology Source Type: research

Correction: Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
(Source: Pituitary)
Source: Pituitary - March 13, 2024 Category: Endocrinology Source Type: research

Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test
ConclusionWe demonstrated that low insulin secretion is the main driver behind glucose intolerance in acromegaly. Compared to NGT and IGT controls with obesity, patients with NGT or IGT acromegaly had higher Si. Together, these findings suggest that impaired insulin secretion might be a specific mechanism for glucose intolerance in acromegaly. (Source: Pituitary)
Source: Pituitary - February 21, 2024 Category: Endocrinology Source Type: research

Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
ConclusionICDs with a broad range of psychiatric symptoms are common in individuals with DA-treated prolactinoma and NFPAs. Endocrinologists should be aware of this potential side effect, particularly in patients and those a personal history of psychiatric disorder. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research

Elevated risk of recurrence and retreatment for silent pituitary adenomas
ConclusionPatients undergoing resection of SPAs should be closely monitored for disease recurrence through more frequent clinical follow-up and diagnostic imaging than other adenomas, particularly among patients with STR and younger patients. Several patients can be observed after radiographic recurrence, and the decision to retreat should be individualized. Longitudinal clinical follow-up of SPAs, including an assessment of symptoms, endocrine function, and imaging remains critical. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research

Impulse control disorders in patients with dopamine agonist-treated pituitary adenomas: a cross-sectional multicenter study
ConclusionICDs with a broad range of psychiatric symptoms are common in individuals with DA-treated prolactinoma and NFPAs. Endocrinologists should be aware of this potential side effect, particularly in patients and those a personal history of psychiatric disorder. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research

Elevated risk of recurrence and retreatment for silent pituitary adenomas
ConclusionPatients undergoing resection of SPAs should be closely monitored for disease recurrence through more frequent clinical follow-up and diagnostic imaging than other adenomas, particularly among patients with STR and younger patients. Several patients can be observed after radiographic recurrence, and the decision to retreat should be individualized. Longitudinal clinical follow-up of SPAs, including an assessment of symptoms, endocrine function, and imaging remains critical. (Source: Pituitary)
Source: Pituitary - February 12, 2024 Category: Endocrinology Source Type: research

Different patient versus provider perspectives on living with Cushing ’s disease
ConclusionsCD patients experience long term symptoms and impaired QoL which may in part be due to a perception of lack of effective treatment options and little hope for improvement. Communicating experiences and care goals may improve long term outcomes for CD patients. (Source: Pituitary)
Source: Pituitary - February 5, 2024 Category: Endocrinology Source Type: research

Pituitary hypophysitis in granulomatosis with polyangiitis (GPA): a case series
We present three patients with GPA-related hy pophysitis highlighting the spectrum of pituitary involvement. All three patients were successfully treated with immunosuppressive regimens that included rituximab (RTX). Following remission induction with high-dose glucocorticoids, patients received 6 monthly RTX for remission maintenance. RTX was well tolerated without significant side effects. (Source: Pituitary)
Source: Pituitary - January 31, 2024 Category: Endocrinology Source Type: research

Diffusion-weighted imaging does not seem to be a predictor of consistency in pituitary adenomas
ConclusionOur results did not show usefulness of the DWI and T1WI for assessing the consistency of pituitary macroadenomas, nor as a predictor of the degree of surgical resection. (Source: Pituitary)
Source: Pituitary - January 25, 2024 Category: Endocrinology Source Type: research

Successful treatment of medically and surgically refractory lymphocytic hypophysitis with fractionated stereotactic radiotherapy: a single-center experience and systematic literature review
ConclusionsFocused radiation, including  FSRT, can play a role in symptomatic relief, effective mass shrinkage, and minimizing radiation exposure to critical surrounding structures in patients with refractory LH. However, further research efforts are necessary to better clarify its effects and optimal dose planning. (Source: Pituitary)
Source: Pituitary - January 25, 2024 Category: Endocrinology Source Type: research