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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.

Serum vitamin D deficiency and its association with systemic disease in exfoliation syndrome.
Conclusions: Although vitamin D levels were similar between XFS and control subjects, the levels were found to be decreased in both groups. Patients with XFS had a significantly higher prevalence of cerebrovascular and cardiovascular disease as compared to controls independent of their 
serum 25(OH) D levels. Low vitamin D level does not appear to be linked to XFS in the studied population. PMID: 23564611 [PubMed - as supplied by publisher]
Source: European Journal of Ophthalmology - April 8, 2013 Category: Opthalmology Authors: Kocabeyoglu S, Mocan MC, Irkec M, Pinar A, Bozkurt B, Orhan M Tags: Eur J Ophthalmol Source Type: research

Moyamoya Disease in a Primarily White, Midwestern US Population: Increased Prevalence of Autoimmune Disease Brief Reports
Conclusions— This study of a unique, primarily white, Midwestern population of moyamoya patients demonstrates a significantly higher prevalence of autoimmune disease than in the general population. This supports a possible autoimmune component to the pathogenesis of moyamoya disease.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Bower, R. S., Mallory, G. W., Nwojo, M., Kudva, Y. C., Flemming, K. D., Meyer, F. B. Tags: Type 1 diabetes, Epidemiology, Other Vascular biology Brief Reports Source Type: research

Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4
by Harinder Manku, Carl D. Langefeld, Sandra G. Guerra, Talat H. Malik, Marta Alarcon-Riquelme, Juan-Manuel Anaya, Sang-Cheol Bae, Susan A. Boackle, Elizabeth E. Brown, Lindsey A. Criswell, Barry I. Freedman, Patrick M. Gaffney, Peter A. Gregersen, Joel M. Guthridge, Sang-Hoon Han, John B. Harley, Chaim O. Jacob, Judith A. James, Diane L. Kamen, Kenneth M. Kaufman, Jennifer A. Kelly, Javier Martin, Joan T. Merrill, Kathy L. Moser, Timothy B. Niewold, So-Yeon Park, Bernardo A. Pons-Estel, Amr H. Sawalha, R. Hal Scofield, Nan Shen, Anne M. Stevens, Celi Sun, Gary S. Gilkeson, Jeff C. Edberg, Robert P. Kimberly, Swapan K. Nat...
Source: PLoS Genetics - July 18, 2013 Category: Genetics & Stem Cells Authors: Harinder Manku et al. Source Type: research

Autoimmune gabab antibody encephalitis associated with non-malignant lung lesion
GABAb receptor autoimmune encephalitis is a potentially treatable disorder characterised by seizures, memory deficits, increased anxiety and mood dysregulation. In some patients it is associated with small–cell lung cancer and with other autoantibodies. We are presenting a case of GABAb receptor autoimmune encephalitis which was associated with non–malignant lung lesion, likely inflammatory in nature. A 62 year old woman presented with recent onset depression and tonic–clonic seizures. CT head showed patchy white matter changes particularly in the left frontal lobe. Initial treatment for suspected infecti...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Wysota, B., Teare, L., Karim, A., Jacob, S. Tags: Immunology (including allergy), Epilepsy and seizures, Infection (neurology), Stroke, Drugs: psychiatry, Memory disorders (psychiatry), Radiology, Drugs: musculoskeletal and joint diseases, Radiology (diagnostics) Association of British Neurologists (AB Source Type: research

The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention
Conclusions: Cumulatively, our results suggest a role for uPA and uPAR in EAE pathogenesis, as exacerbation of disease was seen in their absence. Furthermore, the successful amelioration of EAE by PAI-1 treatment suggests that the PA system can be considered a potential site for therapeutic intervention in the treatment of neuroimmune diseases.
Source: Journal of Neuroinflammation - October 11, 2013 Category: Neurology Authors: Devorah Gur-WahnonTehila MizrachiFlorence-Yehudith Maaravi-PintoAthanasis LourbopoulosNikolaos GrigoriadisAbd HigaziTalma Brenner Source Type: research

Risk of subarachnoid haemorrhage in people admitted to hospital with selected immune-mediated diseases: record-linkage studies
Conclusions: Our findings strongly support the suggestion that patients with some immune-mediated diseases have an increased risk of SAH. Further studies of the mechanisms behind this association are warranted.
Source: BMC Neurology - November 14, 2013 Category: Neurology Authors: Sreeram RamagopalanJulia PakpoorOlena SeminogRaph GoldacreLee GrahamMichael Goldacre Source Type: research

Fitting and flailing: recognition of paediatric antiphospholipid syndrome
We present two cases of paediatric APS, who presented with primary neurological events, and discuss approaches to diagnosis, interpretation of screening investigations, including antinuclear antibodies (ANA), anti-extractable nuclear antigen (ENA) antibodies and lupus anticoagulant. Possible approaches to the management of paediatric APS are discussed.
Source: Archives of Disease in Childhood - Education and Practice - January 13, 2014 Category: Pediatrics Authors: Freeman, H., Patel, J., Fernandez, D., Sharples, P., Ramanan, A. V. Tags: Immunology (including allergy), Drugs: cardiovascular system, Stroke, Screening (epidemiology), Screening (public health) Problem solving in clinical practice Source Type: research

Mortality of bullous pemphigoid in Singapore: risk factors and causes of death in 359 patients seen at the National Skin Centre.
CONCLUSION: This study confirmed an increased 3-year mortality rate for BP patients in Singapore. Risk factors for increased mortality include medical co-morbidities, especially neurological, cardiac and renal diseases. Treatment with combination therapy, including the use of low to moderate dose corticosteroid, appeared to decrease mortality risk in BP patients. This article is protected by copyright. All rights reserved. PMID: 24372558 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - December 24, 2013 Category: Dermatology Authors: Cai SC, Allen JC, Lim YL, Chua SH, Tan SH, Tang MB Tags: Br J Dermatol Source Type: research

A16: Long‐term follow‐up of 36 Pediatric Antiphospholipid Syndrome Patients: A Retrospective Study
Conclusion:Despite of prophylaxis with anticoagulants, new thrombotic events occurred in 25% of the patients and reaching the ideal prothrombin time to prevent thrombotic episodes was the major challenge, as nearly half of the patients had hemorrhagic events. Studies are necessary to identify ideal parameters for treating and monitoring children with antiphospholipid syndrome.
Source: Arthritis and Rheumatism - March 27, 2014 Category: Rheumatology Authors: Francisco Hugo Gomes, Luciana Carvalho, Paola Pinheiro, Tamara Resende, Virgínia Ferriani Tags: Poster Presentations Source Type: research

Celiac disease linked to increased risk of coronary artery disease
People with celiac disease may have a near two-fold increased risk of coronary artery disease compared with the general population, according to research. The study is the first to look at the association between celiac disease and coronary artery disease and adds to the evolving understanding of how systemic inflammation and autoimmune processes might influence cardiovascular disease development. Data also showed a slightly higher risk of stroke among people with celiac disease compared to controls.
Source: ScienceDaily Headlines - March 29, 2014 Category: Science Source Type: news

Voltage Gated Calcium Channels Antibody-Associated Autoimmune Encephalitis (P5.228)
ConclusionThis case demonstrates a correlation between a high titer of VGCC antibodies and autoimmune encephalitis. Our patient's initial improvement with steroids and plasma exchange in the face of a negative CT and PET suggests a primary autoimmune process rather than a paraneoplastic etiology, though we admit that it is premature to rule out remission and we will continue to follow herDisclosure: Dr. Alwaki has nothing to disclose. Dr. Lugo has nothing to disclose. Dr. Goshgarian has nothing to disclose. Dr. Ahmad has nothing to disclose. Dr. Hefzy has nothing to disclose. Dr. Mitsias has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alwaki, A., Lugo, A., Goshgarian, C., Ahmad, O., Hefzy, H., Mitsias, P. Tags: Aging, Dementia, and Cognitive and Behavioral Neurology: Creutzfeldt-Jakob Disease and Subacute Encephalopathies Source Type: research

Bullous pemphigoid and comorbidities: a case-control study in Portuguese patients
CONCLUSIONS: The results of this study substantiate the association between BP and neurological diseases. In addition, they highlight the potential complications associated with the treatment of BP.
Source: Anais Brasileiros de Dermatologia - April 25, 2014 Category: Dermatology Source Type: research

Agent Orange exposure and disease prevalence in Korean Vietnam veterans: The Korean veterans health study.
In conclusion, Agent Orange exposure increased the prevalence of endocrine disorders, especially in the thyroid and pituitary gland; various neurologic diseases; COPD; and liver cirrhosis. Overall, this study suggests that Agent Orange/2,4-D/TCDD exposure several decades earlier may increase morbidity from various diseases, some of which have rarely been explored in previous epidemiologic studies. PMID: 24906069 [PubMed - as supplied by publisher]
Source: Environmental Research - June 3, 2014 Category: Environmental Health Authors: Yi SW, Hong JS, Ohrr H, Yi JJ Tags: Environ Res Source Type: research

Mice with experimental antiphospholipid syndrome display hippocampal dysfunction and a reduction of dendritic complexity in hippocampal CA1 neurons
ConclusionReduction of hippocampal dendritic complexity may represent the structural basis for the behavioral and cognitive abnormalities of eAPS mice.
Source: Neuropathology and Applied Neurobiology - September 9, 2014 Category: Neurology Authors: Katrin Frauenknecht, Aviva Katzav, Ronen Weiss Lavi, Avishag Sabag, Susanne Otten, Joab Chapman, Clemens J. Sommer Tags: Original Article Source Type: research

Renal "hyperfiltrators" are at elevated risk of death and chronic diseases
Conclusion: Renal "hyperfiltrators" represent individuals with autoimmune activation (involving serum creatinine, partly escaping assay), are misclassified into optimal renal function and actually are at significantly higher risk of death, HF or cardiopulmonary events. Low serum creatinine levels may represent a clue to the existence of autoimmune activation.
Source: BMC Nephrology - October 2, 2014 Category: Urology & Nephrology Authors: Servet AltayAltan OnatFatma Özpamuk-KaradenizYusuf KaradenizTu¿ba Kemalo¿lu-ÖzGünay Can Source Type: research