The plasminogen activator system: involvement in central nervous system inflammation and a potential site for therapeutic intervention

Conclusions:
Cumulatively, our results suggest a role for uPA and uPAR in EAE pathogenesis, as exacerbation of disease was seen in their absence. Furthermore, the successful amelioration of EAE by PAI-1 treatment suggests that the PA system can be considered a potential site for therapeutic intervention in the treatment of neuroimmune diseases.

Source: Journal of Neuroinflammation - October 11, 2013 Category: Neurology Authors: Devorah Gur-WahnonTehila MizrachiFlorence-Yehudith Maaravi-PintoAthanasis LourbopoulosNikolaos GrigoriadisAbd HigaziTalma Brenner Source Type: research