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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.

Blocking of {alpha}4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice Basic Sciences
Conclusions— Pharmacological inhibition of the VLA-4/vascular adhesion molecule-1 axis in experimental stroke was ineffective in our hands. Our results cast doubt on the effectiveness of anti-CD49d as a stroke treatment. Further translational studies should be performed before testing anti–VLA-4 antibodies in patients with stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Langhauser, F., Kraft, P., Gob, E., Leinweber, J., Schuhmann, M. K., Lorenz, K., Gelderblom, M., Bittner, S., Meuth, S. G., Wiendl, H., Magnus, T., Kleinschnitz, C. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Acute Cerebral Infarction Basic Sciences Source Type: research

Autoimmune thyroiditis as a risk factor for stroke: A historical cohort study
Conclusion: Our results support the hypothesis of a slightly increased risk of stroke in patients with AIT. The higher effect size found soon after AIT diagnosis suggests an increased cardiovascular risk due to thyroid-hormone deficiency rather than a cumulative effect of autoimmune pathology. Better screening and early treatment of patients with asymptomatic hypothyroid AIT could help reduce excess risk of stroke in the first year after diagnosis.
Source: Neurology - May 5, 2014 Category: Neurology Authors: Karch, A., Thomas, S. L. Tags: Stroke prevention, Autoimmune diseases, All Cerebrovascular disease/Stroke, Cohort studies, Risk factors in epidemiology ARTICLE Source Type: research

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury Basic Sciences
Conclusions—Our findings suggest that brain ischemia activates and diversifies T-cell responses locally, which exacerbates ischemic brain injury.
Source: Stroke - May 25, 2018 Category: Neurology Authors: Wei-Na Jin, Rayna Gonzales, Yan Feng, Kristofer Wood, Zhi Chai, Jing-Fei Dong, Antonio La Cava, Fu-Dong Shi, Qiang Liu Tags: Ischemic Stroke Original Contributions Source Type: research

Comment: Does L-thyroxine prevent or cause stroke in hypothyroidism?
The association between overt hypothyroidism and atherosclerotic risk factors, especially hypertension and dyslipidemia, is clear. To date, only a few small and methodologically flawed epidemiologic studies have investigated the relationship between hypothyroidism and stroke, precluding definitive conclusions. In the current issue of Neurology®, Karch and Thomas1 present a large well-designed case-control study investigating this relationship. They compared 34,907 patients with autoimmune thyroiditis on treatment with l-thyroxine and 149,632 matched individuals without autoimmune thyroiditis from a UK primary care elec...
Source: Neurology - May 5, 2014 Category: Neurology Authors: Squizzato, A., Gerdes, V. E. A. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke
Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most pa...
Source: Frontiers in Neurology - April 23, 2019 Category: Neurology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064). Conflict of Interest Statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Supplementary Material The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research

Expression of Cytokines and Chemokines as Predictors of Stroke Outcomes in Acute Ischemic Stroke
Conclusions: Machine learning algorithms can be employed to develop prognostic predictive biomarkers for stroke outcomes in ischemic stroke patients, particularly in regard to identifying acute gene expression changes that occur during stroke.
Source: Frontiers in Neurology - January 14, 2020 Category: Neurology Source Type: research

Increased risk of ischaemic stroke among patients with multiple sclerosis
ConclusionsMultiple sclerosis is declared to be associated with an increased risk in developing stroke, which requires closer attention to this group of patients for stroke prevention, especially in the younger population.
Source: European Journal of Neurology - November 29, 2014 Category: Neurology Authors: C.‐H. Tseng, W.‐S. Huang, C.‐L. Lin, Y.‐J. Chang Tags: Original Article Source Type: research

Stroke In Young Adults: A 4-Year Retrospective Hospital-Based Study, First Report From United Arab Emirates (P1.020)
CONCLUSIONS: Stroke in young adults is prevalent in our region; main cause is unknown. The increased mortality in this age population is alarming requiring better risk-factor control measures. MR: Mortality rates, ICH: intracerebral hemorrhage, SAH: subarachnoid hemorrhageDisclosure: Dr. AlAmeri has nothing to disclose. Dr. AlNuaimi has nothing to disclose. Dr. Alsaadi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: AlAmeri, M., AlNuaimi, A., Alsaadi, T. Tags: Cerebrovascular Disease and Interventional Neurology I ePosters Source Type: research

Regulatory B cells in Experimental Stroke.
This article is protected by copyright. All rights reserved. PMID: 29313944 [PubMed - as supplied by publisher]
Source: Immunology - January 3, 2018 Category: Allergy & Immunology Authors: Seifert HA, Vandenbark AA, Offner H Tags: Immunology Source Type: research

Increased levels of antibodies against heat shock proteins in stroke patients.
In this study we determined the antibody levels against bacterial and human Hsp by ELISA in blood plasma obtained from stroke patients. Using ANOVA we analyzed levels of Hsp-antibodies in control and patient groups and correlate them with several stroke risk factors. The group of stroke patients had elevated levels of anti-Hsp antibodies compared to the control group. We also discovered an antibody level increase in patients that previously underwent another stroke. Our data provide evidence that autoimmunity could underlie formation of atherosclerosis plaque leading to stroke. PMID: 24904931 [PubMed - as supplied by publisher]
Source: Acta Biochim Pol - June 6, 2014 Category: Biochemistry Authors: Banecka-Majkutewicz Z, Grabowski M, Kadziński L, Papkov A, Węgrzyn A, Banecki B Tags: Acta Biochim Pol Source Type: research

Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
CONCLUSIONS: There is not enough evidence for or against NOACs or for high-intensity VKA compared to the standard VKA therapy in the secondary prevention of thrombosis in people with APS. There is some evidence of harm for high-intensity VKA regarding minor and any bleeding. The evidence was also not sufficient to show benefit or harm for VKA plus antiplatelet agent or dual antiplatelet therapy compared to a single antiplatelet drug. Future studies should be adequately powered, with proper adherence to treatment, in order to evaluate the effects of anticoagulants, antiplatelets, or both, for secondary thrombosis prevention...
Source: Cochrane Database of Systematic Reviews - October 2, 2017 Category: General Medicine Authors: Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A Tags: Cochrane Database Syst Rev Source Type: research

Stroke among Rheumatoid Arthritis Patients: Does Age Matter A Real-Life Study
Conclusion: RA is independently associated with stroke, especially among RA patients under 65 years, for whom cardiovascular risk factors were more prominent. Physicians should advise RA patients to manage their risk factors strictly.Neuroepidemiology 2017;49:99 –105
Source: Neuroepidemiology - November 14, 2017 Category: Epidemiology Source Type: research

Antiplatelet and anticoagulant agents for secondary prevention of stroke and other thromboembolic events in people with antiphospholipid syndrome.
CONCLUSIONS: The evidence identified indicates that NOACs compared with standard-dose VKAs may increase the risk of stroke and do not appear to alter the risk of other outcomes (moderate-certainty evidence). Using high-dose VKA versus standard-dose VKA did not alter the risk of any thromboembolic event or major bleeding but may increase the risk of any form of bleeding (low-certainty evidence). Standard-dose VKA combined with an AP agent compared with standard-dose VKA alone may increase the risk of any thromboembolic event and does not appear to alter the risk of major bleeding or other outcomes (low-certainty evidence). ...
Source: Cochrane Database of Systematic Reviews - October 12, 2020 Category: General Medicine Authors: Bala MM, Celinska-Lowenhoff M, Szot W, Padjas A, Kaczmarczyk M, Swierz MJ, Undas A Tags: Cochrane Database Syst Rev Source Type: research