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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.
An Overview of Quadrivalent Human Papillomavirus Vaccine Safety: 2006 to 2015
Conclusions: These results, along with the safety data from the prelicensure clinical trials, confirm that the HPV4 vaccine has a favorable safety profile. Key policy, medical and regulatory organizations around the world have independently reviewed these data and continue to recommend routine HPV vaccination.
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Bullous pemphigoid and neurodegenerative diseases: a study in a setting of a Central European university dermatology department.
Abstract
Bullous pemphigoid (BP) is an autoimmune blistering dermatosis of the elderly mediated by IgG and IgE antibodies to skin hemidesmosomal proteins, BP180 and/or BP230, that occur physiologically also in neuronal tissue. It was reported that BP is associated with neurodegenerative diseases (ND). We performed a retrospective study in a setting of a Central European university dermatology department on prevalence of ND in 94 BP patients. 26 out of 94 BP patients had at least one ND. ND included: Parkinson's disease, dementia, stroke, hear loss, tinnitus, blindness, vertigo, neurosyphilis, systemic sclerosis, a...
Source: Aging Clinical and Experimental Research - September 29, 2015 Category: Geriatrics Authors: Pietkiewicz P, Gornowicz-Porowska J, Bowszyc-Dmochowska M, Bartkiewicz P, Dmochowski M Tags: Aging Clin Exp Res Source Type: research
Depression as a Microglial Disease.
Abstract
Despite decades of intensive research, the biological mechanisms that causally underlie depression are still unclear, and therefore the development of novel effective antidepressant treatments is hindered. Recent studies indicate that impairment of the normal structure and function of microglia, caused by either intense inflammatory activation (e.g., following infections, trauma, stroke, short-term stress, autoimmune or neurodegenerative diseases) or by decline and senescence of these cells (e.g., during aging, Alzheimer's disease, or chronic unpredictable stress exposure), can lead to depression and asso...
Source: Trends in Neurosciences - October 1, 2015 Category: Neuroscience Authors: Yirmiya R, Rimmerman N, Reshef R Tags: Trends Neurosci Source Type: research
Study of the lipidemic profile of diabetic patients. Negative correlation of cholesterol levels of diabetes type I patients with serum amylase concentration.
Authors: Eleftheriou P, Tseka E, Varaga E, Nasiou M, Sampanis C, Zografou I, Oulorgia J, Damontsidou K, Zaimi T, Markou HI, Varsamidis K, Petrou C, Limberaki E, Ganou CJ
Abstract
Diabetes Mellitus type I (DM1) and II (DM2) share the common characteristic of high blood glucose concentration and the health complications resulting from uncontrolled hyperglycemia such as hyperlipidemia, cardiovascular problems, stroke, ketoacidosis, kidney failure and blindness but have different etiology. DM1 is practically an autoimmune disease. Genetic susceptibility together with environmental factors leads to disease development. ...
Source: Hellenic Journal of Nuclear Medicine - November 18, 2015 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Statistical methods for studying disease subtype heterogeneity
A fundamental goal of epidemiologic research is to investigate the relationship between exposures and disease risk. Cases of the disease are often considered a single outcome and assumed to share a common etiology. However, evidence indicates that many human diseases arise and evolve through a range of heterogeneous molecular pathologic processes, influenced by diverse exposures. Pathogenic heterogeneity has been considered in various neoplasms such as colorectal, lung, prostate, and breast cancers, leukemia and lymphoma, and non‐neoplastic diseases, including obesity, type II diabetes, glaucoma, stroke, cardiovascular d...
Source: Statistics in Medicine - December 1, 2015 Category: Statistics Authors: Molin Wang, Donna Spiegelman, Aya Kuchiba, Paul Lochhead, Sehee Kim, Andrew T. Chan, Elizabeth M. Poole, Rulla Tamimi, Shelley S. Tworoger, Edward Giovannucci, Bernard Rosner, Shuji Ogino Tags: Tutorial in Biostatistics Source Type: research
Sjogren's syndrome with acute cerebellar ataxia and massive lymphadenopathy : a case report.
DISCUSSION: For patients with acute acquired cerebellar ataxia, immune-mediated cerebellar ataxia should be an important differential diagnosis aside from the more common causes like stroke or drugs.
PMID: 24030041 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Multiple cerebral and cerebellar infarcts as the first clinical manifestation in a patient with Churg-Strauss syndrome: case report and literature review.
CONCLUSION: Symptoms and signs of central nervous system can be the initial neurological manifestation of CSS patients. CSS should be considered while patients have stroke and hypereosinophilia. In our patient, there is a good response to timely steroid, immunosuppressant and anticoagulant therapies.
PMID: 23329548 [PubMed - indexed for MEDLINE]
Source: Acta Neurologica Taiwanica - December 12, 2015 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
Low prevalence of patients with mitochondrial disease in the German/Austrian DPV diabetes registry
Conclusion: Primary mitochondrial disorders are a rare cause of juvenile diabetes and likely to be underdiagnosed. As there is clinical overlap with T1D and T2D, dyslipidemia and low body weight may help to identify further DMO cases.
What is Known:
• In adults diabetes of mitochondrial origin (DMO) is a rare cause of non-autoimmune diabetes, affecting about 0.8 % of diabetes cases.
• Common features are a maternal family history of diabetes, hearing loss and neurological abnorma...
Source: European Journal of Pediatrics - December 15, 2015 Category: Pediatrics Source Type: research
Salt and miscarriage: is there a link?
Salt is a major mineral element that plays fundamental roles in health and disease. Excessive salt intake is a major cause of hypertension, cardiovascular disease and stroke. Miscarriage and preeclampsia are the most common pregnancy complications with multiple etiological factors, including inflammatory and autoimmune conditions. More recently, different studies indicated that excessive salt intake is involved in the development of inflammatory processes through induction of T helper-17 pathway and their inflammatory cytokines.
Source: Medical Hypotheses - February 9, 2016 Category: Biomedical Science Authors: Amir Abdoli Source Type: research
Obstructive Sleep Apnea in Patients with Branch Retinal Vein Occlusion: A Preliminary Study.
CONCLUSIONS: We found a higher than expected rate of OSA in BRVO patients lacking concomitant diseases typically associated with OSA. Our findings suggest that OSA could be an additional risk factor in the pathogenesis of BRVO or at least a frequently associated condition that could function as a triggering factor.
PMID: 27051260 [PubMed - as supplied by publisher]
Source: Korean Journal of Ophthalmology : KJO - April 7, 2016 Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
Hepatitis C virus and neurological damage.
Authors: Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I
Abstract
Chronic hepatitis C virus (HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and...
Source: World Journal of Hepatology - May 4, 2016 Category: Gastroenterology Tags: World J Hepatol Source Type: research
Phytocannabinoids and cannabimimetic drugs: recent patents in central nervous system disorders.
CONCLUSIONS: Finally, although the study of the mechanisms of action of these compounds is still unsolved, many reports and patents strongly suggest therapeutic potential of these compounds in neurological diseases.
PMID: 27184693 [PubMed - as supplied by publisher]
Source: Recent Patents on CNS Drug Discovery - May 18, 2016 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research
Vitamin D Deficiency Is As Dangerous As Smoking
The advice you’re getting from your doctor, the TV and even the Surgeon General is so wrong, it’s scary.
They’re all busy telling you to stay out of the sun.
But Swedish researchers recently discovered that nonsmokers who avoid the sun have a life expectancy similar to smokers who spend a lot of time in the sun.
Staying out of the sun is as dangerous as smoking.1
It doesn’t surprise me. I tell all my patients sunlight exposure is essential to our health because it is the best source of vitamin D… possibly the most important nutrient we know of.
Mainstream medicine still doesn’t recognize th...
Source: Al Sears, MD Natural Remedies - May 19, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news
Turmeric: Bali’s Anti-Cancer Tonic
I’m always happy to find things in my travels to bring back to you. Today I want to tell you about a miracle of nature called turmeric.
Turmeric has been used to treat a wide variety of conditions.
You can read about it in-depth in my latest book, Healing Herbs of Paradise.
The roots of this exotic leafy plant contain curcumin, a very powerful antioxidant that also has remarkable anti-inflammatory properties.1,2,3
What Does Curcumin Do?
Curcumin neutralizes free radicals… those nasty little chemicals that travel through your body and cause damage to healthy cells and cell membranes.
Which means curcumin effectivel...
Source: Al Sears, MD Natural Remedies - May 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Cancer Source Type: news
Pituitary aspergillus infection
We report a case of Aspergillus infection involving the pituitary gland and sellar region discovered in a 74-year-old man. The patient had a history of hypertension, chronic renal disease, autoimmune hemolytic anemia and presented with right eye pain, headaches and worsening hemiparesis. Imaging studies revealed a right internal carotid artery occlusion and an acute right pontine stroke along with smaller infarcts in the right middle cerebral artery distribution. Clinically, the patient was thought to have vasculitis. An infectious etiology was not identified. He developed respiratory distress and died. At autopsy, necroti...
Source: Journal of Clinical Neuroscience - May 29, 2016 Category: Neuroscience Source Type: research
