Hepatitis C virus and neurological damage.

Hepatitis C virus and neurological damage. World J Hepatol. 2016 Apr 28;8(12):545-56 Authors: Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I Abstract Chronic hepatitis C virus (HCV) infection exhibits a wide range of extrahepatic complications, affecting various organs in the human body. Numerous HCV patients suffer neurological manifestations, ranging from cognitive impairment to peripheral neuropathy. Overexpression of the host immune response leads to the production of immune complexes, cryoglobulins, as well as autoantibodies, which is a major pathogenic mechanism responsible for nervous system dysfunction. Alternatively circulating inflammatory cytokines and chemokines and HCV replication in neurons is another factor that severely affects the nervous system. Furthermore, HCV infection causes both sensory and motor peripheral neuropathy in the mixed cryoglobulinemia as well as known as an important risk aspect for stroke. These extrahepatic manifestations are the reason behind underlying hepatic encephalopathy and chronic liver disease. The brain is an apt location for HCV replication, where the HCV virus may directly wield neurotoxicity. Other mechanisms that takes place by chronic HCV infection due the pathogenesis of neuropsychiatric disorders includes derangement of metabolic pathways of infected cells, autoimmune disorders, systemic or cerebral inflammation and alterations in neurotransmitter circuits. HCV and its pathogenic ...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research

Related Links:

CONCLUSIONS: The validity of self-reported disease was lower than expected, especially in those who reported having been diagnosed with MI. Proper consideration is needed when using these self-reported data in further studies. PMID: 31795614 [PubMed - in process]
Source: Journal of Preventive Medicine and Public Health - Category: International Medicine & Public Health Tags: J Prev Med Public Health Source Type: research
Contributors : Sandra Franco ; Daniela Buccione ; Raquel Pluvinet ; Beatriz Mothe ; Lidia Ruiz ; Maria Nevot ; Ana Jordan-Paiz ; Laia Ramos ; Susanna Auss ó ; Rosa M Morillas ; Lauro Sumoy ; Miguel A Martinez ; Cristina TuralSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensHuman immunodeficiency virus type 1 (HIV-1)-induced inflammation and/or long-term antiretroviral drug toxicity may contribute to the evolution of liver disease. We investigated circulating plasma microRNAs (miRNAs) as potential biomarkers of liver injury in patients mono-infected with HIV-1. We performed large...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
American Journal of Roentgenology, Ahead of Print.
Source: American Journal of Roentgenology - Category: Radiology Authors: Source Type: research
Publication date: Available online 4 December 2019Source: Interdisciplinary NeurosurgeryAuthor(s): Zhihui Deng, John DavisAbstractThere is evidence of disrupted cerebral blood flow in patients with a skull defect due to decompressive craniectomy though the pathophysiologic mechanism is yet to be established. Here we report on a patient who suffered one episode of transient ischemic attack (TIA) when developing early stage sinking skin flap syndrome (SSFS) post decompressive craniectomy due to a severe traumatic brain injury. This case report of TIA as a clinical presentation of SSFS indicating a potentially increased risk ...
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
Conclusions: This pilot study demonstrated the feasibility of a metacognitive occupation-based telerehabilitation intervention and its potential benefits in activity performance, participation, and QoL for older adults coping with long-term disability following ABI.Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03048708.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Our results suggest that in this community-dwelling population, a higher CAA score is related to cognitive impairment and a higher risk of stroke, dementia, and death. The composite CAA score can be used to practically quantify the severity of vascular brain injury.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
DiscussionThis overview will assess current evidence from systematic reviews for the association between cadmium exposure and risk of T2DM and other metabolic morbidities. This overview may be helpful for policy-makers and healthcare teams aiming to mitigate T2DM risk in populations at risk of cadmium exposure.Systematic review registrationPROSPERO CRD42019125956
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
DiscussionThis review will be the first to report and summarise the risk for and incidence of PPC in adult patients with MetS undergoing surgery across a range of surgical specialities. The results have the potential to inform the development of evidenced-based interventions to improve the management of PPC in the surgical patient with MetS. Findings from this systematic review and meta-analysis will inform a subsequent Delphi study on priorities and responses to PPC in patients with MetS. We will also disseminate our results through publication in scientific peer-reviewed journals, conference presentations and promotion t...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Publication date: Available online 4 December 2019Source: Sensors and Actuators A: PhysicalAuthor(s): Yanling Tian, Yue Ma, Fujun Wang, Kangkang Lu, Dawei ZhangAbstractThis paper presents the design, modeling, and experimental validation of a novel XYZ micro/nano positioner driven by piezoelectric actuator (PEA). To achieve a large motion stroke, compact structure and good decoupling performance, a novel displacement amplifier including L-shape levers and half-bridge (LSLHB) is proposed. By utilizing a concave input mechanism for location restriction between PEA and flexible mechanism, the motion coupling caused by the inc...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
CONCLUSIONS: Liraglutide could upregulate autophagy to decrease lipid over-accumulation via the AMPK/mTOR pathway. PMID: 31787541 [PubMed - as supplied by publisher]
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
More News: Autoimmune Disease | Brain | Gastroenterology | Hepatitis | Hepatitis C | Liver | Liver Disease | Neurology | Peripheral Neuropathy | Psychiatry | Stroke | Study | Urology & Nephrology | Virology