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Condition: Autoimmune Disease
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Total 293 results found since Jan 2013.

Differences in predictors of 5‐year survival over a 10‐year period in two cohorts of elderly nursing home residents in Sweden
ConclusionsThe present results indicate a trend that individuals are older and frailer when admitted to NH and that survival time after admission has been shortened. Hence, the need of daily support and care has increased, irrespective of housing. Also, predictors of survival, possible to influence, have changed.
Source: Scandinavian Journal of Caring Sciences - February 4, 2016 Category: Nursing Authors: Märta Sund Levander, Anna Milberg, Nils Rodhe, Pia Tingström, Ewa Grodzinsky Tags: Empirical Studies Source Type: research

Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research

Differences in predictors of 5 ‐year survival over a 10‐year period in two cohorts of elderly nursing home residents in Sweden
ConclusionsThe present results indicate a trend that individuals are older and frailer when admitted to NH and that survival time after admission has been shortened. Hence, the need of daily support and care has increased, irrespective of housing. Also, predictors of survival, possible to influence, have changed.
Source: Scandinavian Journal of Caring Sciences - February 3, 2016 Category: Nursing Authors: M ärta Sund Levander, Anna Milberg, Nils Rodhe, Pia Tingström, Ewa Grodzinsky Tags: Empirical Studies Source Type: research

Neurological diseases and bullous pemphigoid: A case & #8211;control study in Iranian patients
Conclusions: Neurological diseases in general, and stroke and dementia in particular, were significantly associated with bullous pemphigoid in our study.
Source: Indian Journal of Dermatology, Venereology and Leprology - February 2, 2017 Category: Dermatology Authors: Maryam Daneshpazhooh Javad Khorassani Kamran Balighi Narges Ghandi Hamidreza Mahmoudi Hamidreza Tohidinik Shahin Hamzelou Cheyda Chams-Davatchi Source Type: research

Fish Oil and Vitamin D Supplements May Not Help Prevent Heart Attacks and Cancer, Study Says
There’s good evidence that fish oil supplements may lower the risk of second heart events — like a heart attack or stroke — in people with heart disease, but few rigorous studies have investigated whether the supplement can help people to lower their risk of having a heart event in the first place. And while some data suggests that people with lower levels of vitamin D tend to have higher rates of heart disease and cancer, the evidence isn’t solid. Now, a new study published in the New England Journal of Medicine and presented at the annual meeting of the American Heart Association offers more findi...
Source: TIME: Health - November 10, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Drugs Source Type: news

Blood Cell-Bound C4d as a Marker of Complement Activation in Patients With the Antiphospholipid Syndrome
In conclusion the detection of complement activation products on circulating erythrocytes and platelets using a highly sensitive and specific assay further supports the view that APS is a complement-mediated disorder. Increased EC4d and PC4d percentages are associated with the active inflammatory disease in SLE. It is difficult to translate this finding to APS which is a non-acute inflammatory disorder. We failed to find an association with both the classification and non-classification criteria, including thrombocytopenia. However, we believe that this sensitive tool to evaluate complement activation may offer more inform...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Evidence That Increasing Serum 25(OH)D Concentrations to 30 ng/mL in the Kingdom of Saudi Arabia and the United Arab Emirates Could Greatly Improve Health Outcomes
Biomedicines. 2023 Mar 23;11(4):994. doi: 10.3390/biomedicines11040994.ABSTRACTAccumulating evidence supports the potential protective effects of vitamin D against chronic diseases such as Alzheimer's disease, autoimmune diseases, cancers, cardiovascular disease (ischaemic heart disease and stroke), type 2 diabetes, hypertension, chronic kidney disease, stroke, and infectious diseases such as acute respiratory tract diseases, COVID-19, influenza, and pneumonia, as well as adverse pregnancy outcomes. The respective evidence is based on ecological and observational studies, randomized controlled trials, mechanistic studies, ...
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: William B Grant Fatme Al Anouti Barbara J Boucher Hana M A Fakhoury Meis Moukayed Stefan Pilz Nasser M Al-Daghri Source Type: research

Cardiovascular events risk in patients with systemic autoimmune diseases: a prognostic systematic review and meta-analysis
CONCLUSION: Patients with SAD present an increased risk of CV morbidity and mortality, which should be considered when establishing therapeutic strategies. These findings support the role of systemic inflammation in the development of atherosclerosis-driven disease.PMID:37650912 | DOI:10.1007/s00392-023-02291-4
Source: Clin Med Res - August 31, 2023 Category: Research Authors: Claudia Asenjo-Lobos Leticia Gonz ález Juan Francisco Bulnes Marta Roque Paula Mu ñoz Venturelli Gonzalo Mart ínez Rodríguez Source Type: research

Mesenchymal Stem Cells: Potential in Treatment of Neurodegenerative Diseases.
Abstract Mesenchymal Stem Cells or Marrow Stromal Cells (MSCs) have long been viewed as a potent tool for regenerative cell therapy. MSCs are easily accessible from both healthy donor and patient tissue and expandable in vitro on a therapeutic scale without posing significant ethical or procedural problems. MSC based therapies have proven to be effective in preclinical studies for graft versus host disease, stroke, myocardial infarction, pulmonary fibrosis, autoimmune disorders and many other conditions and are currently undergoing clinical trials at a number of centers all over the world. MSCs are also being exte...
Source: Current Stem Cell Research and Therapy - September 22, 2014 Category: Stem Cells Authors: Tanna T, Sachan V Tags: Curr Stem Cell Res Ther Source Type: research

CADASIL and Autoimmunity: Coexistence in a Family with the R169C Mutation at Exon 4 of the NOTCH3 Gene
Conclusion: This is a rare description of the coexistence of autoimmunity in CADASIL patients with possible worsening clinical effects. The study extends the spectrum of atypical presentation of CADASIL. The coexistence of autoimmunity does not necessarily exclude CADASIL, but may cause an additional diagnostic and therapeutic challenge. This autoimmune disorder may have increased the severity of the disease and, additionally, may be related to the pathogenetic mechanisms of CADASIL. It is possible that the NOTCH3 mutation alone is not enough to trigger autoimmunity since, in the case of our family, the R169C mutation has ...
Source: Cerebrovascular Diseases - November 20, 2014 Category: Neurology Source Type: research

Anticardiolipin Antibodies in Children with Helicobacter pylori Infection
ConclusionsIn our particular experience, H. pylori can cause aCL antibody positivity in children and eradication of H. pylori provides the disappearance of these antibodies.
Source: Helicobacter - April 1, 2015 Category: Gastroenterology Authors: Serdar Umit Sarıcı, Orhan Gursel, Emin Kurekci, Vural Kesik, Avni Atay, Vedat Okutan, Ali Inal, Aysel Pekel, Mehmet Ali Ozguven, Okan Ozcan Tags: Original Article Source Type: research