Blocking of {alpha}4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice [Basic Sciences]

Conclusions—
Pharmacological inhibition of the VLA-4/vascular adhesion molecule-1 axis in experimental stroke was ineffective in our hands. Our results cast doubt on the effectiveness of anti-CD49d as a stroke treatment. Further translational studies should be performed before testing anti–VLA-4 antibodies in patients with stroke.

Source: Stroke - May 27, 2014 Category: Neurology Authors: Langhauser, F., Kraft, P., Gob, E., Leinweber, J., Schuhmann, M. K., Lorenz, K., Gelderblom, M., Bittner, S., Meuth, S. G., Wiendl, H., Magnus, T., Kleinschnitz, C. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Acute Cerebral Infarction Basic Sciences Source Type: research