Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke

Conclusions: We developed an index to measure gut microbiota dysbiosis in stroke patients; this index was significantly correlated with patients' outcome and was causally related to outcome in a mouse model of stroke. Our model facilitates the potential clinical application of gut microbiota data in stroke and adds quantitative evidence linking the gut microbiota to stroke. Introduction Ischemic stroke imposes a heavy burden on society, with 24.9 million cases worldwide (1). Although intravenous thrombolysis and endovascular treatment greatly improve some patients' prognosis, the prognosis for most patients with acute ischemic stroke is still poor. Therefore, identifying potential risk factors associated with stroke prognosis is important in clinical management. In current clinical studies, stroke patients often display significant changes in microbial diversity and bacterial counts in fecal samples independent of certain comorbidities (hypertension, age and type 2 diabetes) (2–4). In a relatively large sample size, our previous study found that, compared to asymptomatic controls, patients with acute atherosclerosis stroke showed significant dysbiosis in the gut microbiota, with increases in opportunistic pathogens and decreases in beneficial genera, and such changes were especially pronounced in severe stroke patients (3). However, clinical studies remain limited in their ability to delineate the potential link between gut microbiome and stroke...
Source: Frontiers in Neurology - Category: Neurology Source Type: research