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Total 102 results found since Jan 2013.

Cells to Society: Year of the Nurse / Global Impact
This study establishes baseline sociodemographic and clinical characteristics of hospitalized patients in Nepal who were experiencing heart failure.     Read more   Maternal Health ...
Source: Johns Hopkins University and Health Systems Archive - February 6, 2020 Category: Nursing Source Type: news

Molecules, Vol. 24, Pages 3274: Therapeutic Potential of Pien-Tze-Huang: A Review on Its Chemical Composition, Pharmacology, and Clinical Application
ingqing Huang Pien-Tze-Huang (PTH) is a famous and commonly used traditional Chinese medicine formula in China. It was first formulated by a royal physician of the Ming Dynasty (around 1555 AD). Recently, PTH has attracted attention worldwide due to its beneficial effects against various diseases, especially cancer. This paper systematically reviewed the up-to-date information on its chemical composition, pharmacology, and clinical application. A range of chemical compounds, mainly ginsenosides and bile acids, have been identified and quantified from PTH. Pharmacological studies indicated that PTH has beneficial effect...
Source: Molecules - September 8, 2019 Category: Chemistry Authors: Lili Huang Yiping Zhang Xiaoqin Zhang Xiuping Chen Yitao Wang Jinjian Lu Mingqing Huang Tags: Review Source Type: research

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 31208626 [PubMed - in process]
Source: Annals of Hepatology - June 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Vaccine safety in HIV-infected adults within the Vaccine Safety Datalink Project.
CONCLUSIONS: Routinely administered vaccines are generally safe for HIV-infected adults. PMID: 31064675 [PubMed - as supplied by publisher]
Source: Vaccine - May 3, 2019 Category: Allergy & Immunology Authors: Hechter RC, Qian L, Tartof SY, Sy LS, Klein NP, Weintraub E, Mercado C, Naleway A, McLean HQ, Jacobsen SJ Tags: Vaccine Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study
Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. Methods: Using the Veterans Aging Cohort Study Survey Cohort, insomnia symptoms were measured and dummy coded with the item, “Difficulty falling or staying asleep?” (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with the Department of Veterans Affairs (VA) and Medicare...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - April 9, 2019 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Stroke Characteristics, Risk Factors, and Outcomes in Transgender Adults: A Case Series
Conclusions: Understanding unique vulnerabilities of the transgender community for cerebrovascular events is essential to provide culturally appropriate counseling for harm reduction.
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.
Abstract Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Matrix metalloproteases act as an interface between host's...
Source: Gene - February 26, 2019 Category: Genetics & Stem Cells Authors: Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN Tags: Gene Source Type: research

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 30600298 [PubMed - in process]
Source: Annals of Hepatology - January 3, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Chronic Kidney Disease (CKD) in the U.S. Hemophilia Population: A Cohort Study
Conclusions: In this interim analysis of an ongoing national prospective cohort study, older men with moderate to severe hemophilia commonly report risk factors for CKD, including HTN (51.5%), DM, viral infection, and potential renal damaging medication use. Only 11.6% had CVD. Urological symptoms were also common, including hematuria and obstructive symptoms with urination.In our cohort, 11.4% met the definition of CKD, defined as the presence of either kidney damage or GFR < 60 ml/min/1.73 m2 for ≥ 3 months. The distribution of GFR values appeared similar to the general population. As with risk factors associated w...
Source: Blood - November 21, 2018 Category: Hematology Authors: Sood, S. L., Cheng, D., Shapiro, A., Kessler, C. M., Key, N. S., Quon, D., Eyster, M. E., Manco-Johnson, M. J., Kempton, C. L., Cuker, A., Ragni, M. V., Kuriakose, P., von Drygalski, A., Kouides, P. A., Escobar, M. A., Wheeler, A. P., Wang, T.-F., Leissin Tags: 322. Disorders of Coagulation or Fibrinolysis: Poster II Source Type: research

Rapid Decline in Kidney Function in Sickle Cell Disease
Conclusion:Rapid decline in eGFR is common in SCD. Use of ACE-I/ARB and history of stroke are associated with rapid decline in renal function. Rapid decline in eGFR is associated with an increased risk of death in SCD. Long-term studies are required to determine if therapies that may reduce loss of kidney function may decrease mortality in SCD.DisclosuresAtaga: Pfizer: Research Funding; Bioverativ: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis Pharmaceuticals: Honoraria; Modus Therapeutics: Honoraria; Global Blood Therapeutics: Honoraria, Membership on an entity's Board of Directo...
Source: Blood - November 21, 2018 Category: Hematology Authors: Derebail, V. K., Ciccone, E. J., Zhou, Q., Cai, J., Ataga, K. I. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster I Source Type: research

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil
CONCLUSIONS: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased ri sk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 8, 2018 Category: Tropical Medicine Source Type: research