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What Causes Ataxia?
Discussion Coordination and balance problems are caused by various problems affecting the central and peripheral nervous system. Normal development of a child or weakness of a child are commonly mistaken for true ataxia. Ataxia specifically refers to “…impairment of the coordination of movement without loss of muscle strength.” If it is purely due to abnormalities of the cerebellum then there should be no changes in mental status, sensation or weakness. Sometimes it is difficult to determine if there are abnormalities in other areas. For example, Guillian-Barre often presents with difficulty or clumsy wal...
Source: PediatricEducation.org - March 31, 2014 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Table of Contents
Abstract Long QT syndrome more likely in patients with HIV, hepatitis C Long‐term treatments for obesity yield results with lifestyle changes Interaction of valproic acid with two drugs Topiramate study signals possible treatment for cocaine dependence Adjunctive modafinil improves depression, lessens fatigue D‐cycloserine, exposure therapy promising for treating PTSD Gabapentin results bode well for alcohol treatment by MDs Vortioxetine shows efficacy in treating major depression Better trials needed for SSRIs in stroke recovery Drug Safety Communication
Source: The Brown University Psychopharmacology Update - February 12, 2014 Category: Psychiatry Source Type: research

Antivirals for HCV improve kidney and cardiovascular diseases in diabetic patients
(Wiley) Researchers from Taiwan reveal that antiviral therapy for hepatitis C virus (HCV) improves kidney and cardiovascular outcomes for patients with diabetes. Results of the study published in Hepatology, a journal of the American Association for the Study of Liver Diseases, show that incidences of kidney disease, stroke, and heart attack were lower in patients treated with pegylated interferon and ribavirin compared to HCV patients not treated with antivirals or diabetic patients not infected with the virus.
Source: EurekAlert! - Infectious and Emerging Diseases - December 11, 2013 Category: Infectious Diseases Source Type: news

Platelet-Secreted MicroRNA-223 Promotes Endothelial Cell Apoptosis Induced by Advanced Glycation End Products via Targeting the Insulin-like Growth Factor 1 Receptor.
In conclusion, our study presents the first evidence, to our knowledge, that platelet-released miR-223 promotes advanced glycation end product-induced vascular endothelial cell apoptosis via targeting insulin-like growth factor 1 receptor. PMID: 24307738 [PubMed - as supplied by publisher]
Source: Journal of Immunology - December 4, 2013 Category: Allergy & Immunology Authors: Pan Y, Liang H, Liu H, Li D, Chen X, Li L, Zhang CY, Zen K Tags: J Immunol Source Type: research

Impact of virus clearance for the development of hemorrhagic stroke in chronic hepatitis C
In conclusion, HCV clearance reduced the development of intracerebral hemorrhagic stroke. In particular, HCV clearance reduced intracerebral hemorrhagic stroke to about one‐fourth in cirrhotic patients. J. Med. Virol. © 2013 Wiley Periodicals, Inc.
Source: Journal of Medical Virology - October 24, 2013 Category: Virology Authors: Yasuji Arase, Mariko Kobayashi, Yusuke Kawamura, Fumitaka Suzuki, Yoshiyuki Suzuki, Norio Akuta, Masahiro Kobayashi, Hitomi Sezaki, Satoshi Saito, Tetsuya Hosaka, Kenji Ikeda, Hiromitsu Kumada, Tetsuro Kobayashi Tags: Research Article Source Type: research

Antiviral treatment for hepatitis C virus infection is associated with improved renal and cardiovascular outcomes in diabetic patients
Conclusions: Antiviral treatment for HCV infection is associated with improved renal and cardiovascular outcomes in diabetic patients. (Hepatology 2013;)
Source: Hepatology - October 12, 2013 Category: Internal Medicine Authors: Yao‐Chun Hsu, Jaw‐Town Lin, Hsiu J. Ho, Yu‐Hsi Kao, Yen‐Tsung Huang, Nai‐Wan Hsiao, Ming‐Shiang Wu, Yi‐Ya Liu, Chun‐Ying Wu Tags: Original Source Type: research

Fecal incontinence epidemiology and help seeking among older people in Taiwan
ConclusionSelf‐reported FI is a prevalent condition with various etiologies among older people in Taiwan. Understanding the epidemiology and comorbidity of FI, and investigating the factors associated with help seeking, is beneficial in devising and implementing prevention and management strategies. Neurourol. Urodynam. © 2013 Wiley Periodicals, Inc.
Source: Neurourology and Urodynamics - September 1, 2013 Category: Urology & Nephrology Authors: Shiow‐Shiun Horng, Yiing‐Jenq Chou, Nicole Huang, Yi‐Ting Fang, Pesus Chou Tags: Original Clinical Article Source Type: research

Association between nutrition and the evolution of multimorbidity: The importance of fruits and vegetables and whole grain products
Summary: Background & aims: Multimorbidity is a common health status. The impact of nutrition on the development of multimorbidity remains to be determined. The aim of this study is to determine the association between foods, macronutrients and micronutrients and the evolution of multimorbidity.Methods: Data from 1020 Chinese who participated in the Jiangsu longitudinal Nutrition Study (JIN) were collected in 2002 (baseline) and 2007 (follow-up). Three-day weighted food records and status for 11 chronic diseases was determined using biomedical measures (hypertension, diabetes, hypercholesterolemia and anemia) or self-repor...
Source: Clinical Nutrition - July 24, 2013 Category: Nutrition Authors: Guillaume Ruel, Zumin Shi, Shiqi Zhen, Hui Zuo, Edeltraut Kröger, Caroline Sirois, Jean-Frédéric Lévesque, Anne W. Taylor Tags: Original Articles Source Type: research

Interferon‐based therapy reduces risk of stroke in chronic hepatitis C patients: a population‐based cohort study in Taiwan
ConclusionsInterferon‐based therapy may reduce the long‐term risk of stroke in patients with chronic HCV infection.
Source: Alimentary Pharmacology and Therapeutics - June 29, 2013 Category: Drugs & Pharmacology Authors: C.‐S. Hsu, J.‐H. Kao, Y.‐C. Chao, H. H. Lin, Y.‐C. Fan, C.‐J. Huang, P.‐S. Tsai Tags: Original Article Source Type: research

Diabetes is not an independent risk factor for hepatocellular carcinoma
ConclusionsDiabetes is not an independent risk factor for HCC after considering the effects of alcohol‐related diagnoses, chronic liver disease and potential detection bias. This article is protected by copyright. All rights reserved.
Source: Diabetes/Metabolism Research and Reviews - May 1, 2013 Category: Endocrinology Authors: Chin‐Hsiao Tseng Tags: Research Article Source Type: research

Associations of chronic hepatitis C with metabolic and cardiac outcomes
ConclusionsChronic hepatitis C virus infection is independently associated with presence of metabolic conditions (insulin resistance, type 2 diabetes and hypertension) and congestive heart failure.
Source: Alimentary Pharmacology and Therapeutics - February 5, 2013 Category: Drugs & Pharmacology Authors: Z. M. Younossi, M. Stepanova, F. Nader, Z. Younossi, E. Elsheikh Tags: Original Article Source Type: research

Risk of Spontaneous Intracranial Hemorrhage in HIV-infected Individuals: A Population-based Cohort Study
Background: We studied the association between HIV infection, antiretroviral medications, and the risk of spontaneous intracranial hemorrhage.Methods: We performed a cohort and nested case control study in an administrative database. We selected all HIV-positive individuals presenting between 1985 and 2007. Each HIV-positive subject was matched with 4 HIV-negative individuals. We used a Poisson regression model to calculate rates of intracranial hemorrhage according to HIV status. We conducted a case -control study nested within the cohort of HIV-positive individuals to look at the effect of antiretroviral medications. Odd...
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2012 Category: Neurology Authors: Madeleine Durand, Odile Sheehy, Jean-Guy Baril, Jacques LeLorier, Cécile L. Tremblay Tags: Original Articles Source Type: research

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